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  1. Article ; Online: Use of a fluoroscopy-based robotic-assisted total hip arthroplasty system produced greater improvements in patient-reported outcomes at one year compared to manual, fluoroscopic-assisted technique.

    Buchan, Graham B J / Ong, Christian B / Hecht Ii, Christian J / DeCook, Charles A / Spencer-Gardner, Luke S / Kamath, Atul F

    Archives of orthopaedic and trauma surgery

    2024  Volume 144, Issue 4, Page(s) 1843–1850

    Abstract: Introduction: The adoption of new technology should be supported by improvements in patient-reported outcomes (PROMs). The purpose of this study was to assess the one-year PROMs of patients who underwent total hip arthroplasty (THA) using a novel, ... ...

    Abstract Introduction: The adoption of new technology should be supported by improvements in patient-reported outcomes (PROMs). The purpose of this study was to assess the one-year PROMs of patients who underwent total hip arthroplasty (THA) using a novel, fluoroscopy-based, robotic-assisted (RA-THA) system when compared to a manual, fluoroscopic-assisted technique (mTHA).
    Materials and methods: A review of 91 consecutive mTHA and 85 consecutive RA-THA via a direct anterior approach was conducted. All cases were performed by the same surgeon at the same institution, for a pre-operative diagnosis of osteoarthritis, avascular necrosis, or rheumatoid arthritis. Outcomes included one-year Veterans RAND-12 (VR-12) Physical/Mental, Hip Disability and Osteoarthritis Outcome (HOOS) Pain/Physical Function/Joint Replacement, and University of California Los Angeles (UCLA) Activity scores, as well as the difference between pre-operative and one-year post-operative PROMs.
    Results: Patients in the RA-THA cohort had lower pre-operative HOOS-JR scores compared to patients in the mTHA cohort (37.0 vs. 43.1; p = 0.031). Cohorts experienced similar one-year post-operative VR-12, HOOS, and UCLA Activity scores. Patients in the RA-THA cohort experienced greater improvements across all pre- and post-operative HOOS scores compared to patients in the mTHA cohort: Pain (+ 54.7 vs. +42.1; p = 0.009), Physical Function (-41.6 vs. -28.7; p = 0.007), and Joint Replacement (+ 46.6 vs. +33.0; p = 0.002). These differences exceeded minimum clinically important difference (MCID).
    Conclusions: Both manual and robotic cohorts experienced benefit from THA at one-year post-operative. Importantly, the use of a novel, fluoroscopy-based robotic assistance system for primary THA resulted in greater improvements in PROMs at one-year relative to manual technique.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Hip/methods ; Robotic Surgical Procedures/methods ; Treatment Outcome ; Osteoarthritis ; Patient Reported Outcome Measures ; Pain ; Fluoroscopy
    Language English
    Publishing date 2024-02-24
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 80407-1
    ISSN 1434-3916 ; 0003-9330 ; 0344-8444
    ISSN (online) 1434-3916
    ISSN 0003-9330 ; 0344-8444
    DOI 10.1007/s00402-024-05230-8
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  2. Article ; Online: Assessing the evolutionary persistence of ecological relationships: A review and preview.

    Hecht, Luke B B / Thompson, Peter C / Rosenthal, Benjamin M

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2020  Volume 84, Page(s) 104441

    Abstract: Species interactions, such as pollination, parasitism and predation, form the basis of functioning ecosystems. The origins and resilience of such interactions therefore merit attention. However, fossils only occasionally document ancient interactions, ... ...

    Abstract Species interactions, such as pollination, parasitism and predation, form the basis of functioning ecosystems. The origins and resilience of such interactions therefore merit attention. However, fossils only occasionally document ancient interactions, and phylogenetic methods are blind to recent interactions. Is there some other way to track shared species experiences? "Comparative demography" examines when pairs of species jointly thrived or declined. By forging links between ecology, epidemiology, and evolutionary biology, this method sheds light on biological adaptation, species resilience, and ecosystem health. Here, we describe how this method works, discuss examples, and suggest future directions in hopes of inspiring interest, imitators, and critics.
    MeSH term(s) Animals ; Biological Evolution ; Ecosystem ; Genomics ; Host-Parasite Interactions ; Humans
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2020.104441
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  3. Article ; Online: Comparative demography elucidates the longevity of parasitic and symbiotic relationships.

    Hecht, Luke B B / Thompson, Peter C / Rosenthal, Benjamin M

    Proceedings. Biological sciences

    2018  Volume 285, Issue 1888

    Abstract: Parasitic and symbiotic relationships govern vast nutrient and energy flows, yet controversy surrounds their longevity. Enduring relationships may engender parallel phylogenies among hosts and parasites, but so may ephemeral relationships when parasites ... ...

    Abstract Parasitic and symbiotic relationships govern vast nutrient and energy flows, yet controversy surrounds their longevity. Enduring relationships may engender parallel phylogenies among hosts and parasites, but so may ephemeral relationships when parasites colonize related hosts. An understanding of whether symbiont and host populations have grown and contracted in concert would be useful when considering the temporal durability of these relationships. Here, we devised methods to compare demographic histories derived from genomic data. We compared the historical growth of the agent of severe human malaria,
    MeSH term(s) Animals ; Anopheles/parasitology ; Anopheles/physiology ; Demography/methods ; Dinoflagellida/physiology ; Host-Parasite Interactions ; Humans ; Mosquito Vectors/parasitology ; Mosquito Vectors/physiology ; Phytophthora infestans/physiology ; Plasmodium falciparum/physiology ; Population Growth ; Primates/physiology ; Sea Anemones/parasitology ; Solanum tuberosum/microbiology ; Solanum tuberosum/physiology ; Swine/parasitology ; Swine/physiology ; Symbiosis ; Trichinella spiralis/physiology
    Language English
    Publishing date 2018-10-03
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2018.1032
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  4. Article: Assessing the evolutionary persistence of ecological relationships: A review and preview

    Hecht, Luke B B / Thompson, Peter C / Rosenthal, Benjamin M

    Infect Genet Evol

    Abstract: Species interactions, such as pollination, parasitism and predation, form the basis of functioning ecosystems. The origins and resilience of such interactions therefore merit attention. However, fossils only occasionally document ancient interactions, ... ...

    Abstract Species interactions, such as pollination, parasitism and predation, form the basis of functioning ecosystems. The origins and resilience of such interactions therefore merit attention. However, fossils only occasionally document ancient interactions, and phylogenetic methods are blind to recent interactions. Is there some other way to track shared species experiences? "Comparative demography" examines when pairs of species jointly thrived or declined. By forging links between ecology, epidemiology, and evolutionary biology, this method sheds light on biological adaptation, species resilience, and ecosystem health. Here, we describe how this method works, discuss examples, and suggest future directions in hopes of inspiring interest, imitators, and critics.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #621917
    Database COVID19

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  5. Article: Assessing the evolutionary persistence of ecological relationships: A review and preview

    Hecht, Luke B.B / Thompson, Peter C / Rosenthal, Benjamin M

    Infection, genetics, and evolution. 2020 Oct., v. 84

    2020  

    Abstract: Species interactions, such as pollination, parasitism and predation, form the basis of functioning ecosystems. The origins and resilience of such interactions therefore merit attention. However, fossils only occasionally document ancient interactions, ... ...

    Abstract Species interactions, such as pollination, parasitism and predation, form the basis of functioning ecosystems. The origins and resilience of such interactions therefore merit attention. However, fossils only occasionally document ancient interactions, and phylogenetic methods are blind to recent interactions. Is there some other way to track shared species experiences? “Comparative demography” examines when pairs of species jointly thrived or declined. By forging links between ecology, epidemiology, and evolutionary biology, this method sheds light on biological adaptation, species resilience, and ecosystem health. Here, we describe how this method works, discuss examples, and suggest future directions in hopes of inspiring interest, imitators, and critics.
    Keywords environmental health ; epidemiology ; genetics ; infection ; parasitism ; phylogeny ; pollination ; predation
    Language English
    Dates of publication 2020-10
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2020.104441
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Potential Neuroprotective Effects of Dietary Omega-3 Fatty Acids on Stress in Alzheimer's Disease.

    Hartnett, Kaitlyn B / Ferguson, Bradley J / Hecht, Patrick M / Schuster, Luke E / Shenker, Joel I / Mehr, David R / Fritsche, Kevin L / Belury, Martha A / Scharre, Douglas W / Horwitz, Adam J / Kille, Briana M / Sutton, Briann E / Tatum, Paul E / Greenlief, C Michael / Beversdorf, David Q

    Biomolecules

    2023  Volume 13, Issue 7

    Abstract: Background: A large number of individual potentially modifiable factors are associated with risk for Alzheimer's disease (AD). However, less is known about the interactions between the individual factors.: Methods: In order to begin to examine the ... ...

    Abstract Background: A large number of individual potentially modifiable factors are associated with risk for Alzheimer's disease (AD). However, less is known about the interactions between the individual factors.
    Methods: In order to begin to examine the relationship between a pair of factors, we performed a pilot study, surveying patients with AD and controls for stress exposure and dietary omega-3 fatty acid intake to explore their relationship for risk of AD.
    Results: For individuals with the greatest stress exposure, omega-3 fatty acid intake was significantly greater in healthy controls than in AD patients. There was no difference among those with low stress exposure.
    Conclusions: These initial results begin to suggest that omega-3 fatty acids may mitigate AD risk in the setting of greater stress exposure. This will need to be examined with larger populations and other pairs of risk factors to better understand these important relationships. Examining how individual risk factors interact will ultimately be important for learning how to optimally decrease the risk of AD.
    MeSH term(s) Humans ; Alzheimer Disease/prevention & control ; Alzheimer Disease/complications ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Pilot Projects ; Fatty Acids, Omega-3/pharmacology ; Diet ; Fatty Acids
    Chemical Substances Neuroprotective Agents ; Fatty Acids, Omega-3 ; Fatty Acids
    Language English
    Publishing date 2023-07-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13071096
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  7. Article ; Online: Comparative demography elucidates the longevity of parasitic and symbiotic relationships

    Hecht, Luke B. B. / Thompson, Peter C. / Rosenthal, Benjamin M.

    Proceedings of the Royal Society B: Biological Sciences. 2018 Oct. 3 v. 258, no. 1888

    2018  

    Abstract: Parasitic and symbiotic relationships govern vast nutrient and energy flows, yet controversy surrounds their longevity. Enduring relationships may engender parallel phylogenies among hosts and parasites, but so may ephemeral relationships when parasites ... ...

    Abstract Parasitic and symbiotic relationships govern vast nutrient and energy flows, yet controversy surrounds their longevity. Enduring relationships may engender parallel phylogenies among hosts and parasites, but so may ephemeral relationships when parasites colonize related hosts. An understanding of whether symbiont and host populations have grown and contracted in concert would be useful when considering the temporal durability of these relationships. Here, we devised methods to compare demographic histories derived from genomic data. We compared the historical growth of the agent of severe human malaria, Plasmodium falciparum, and its mosquito vector, Anopheles gambiae, to human and primate histories, thereby discerning long-term parallels and anthropogenic population explosions. The growth history of Trichinella spiralis, a zoonotic parasite disseminated by swine, proved regionally specific, paralleling distinctive growth histories for wild boar in Asia and Europe. Parallel histories were inferred for an anemone and its algal symbiont (Exaiptasia pallida and Symbiodinium minutum). Concerted growth in potatoes and the agent of potato blight (Solanum tuberosum and Phytophthora infestans) did not commence until the age of potato domestication. Through these examples, we illustrate the utility of comparative historical demography as a new exploratory tool by which to interrogate the origins and durability of myriad ecological relationships. To facilitate future use of this approach, we introduce a tool called C-PSMC to align and evaluate the similarity of demographic history curves.
    Keywords Anopheles gambiae ; Phytophthora infestans ; Plasmodium falciparum ; Solanum tuberosum ; Symbiodinium ; Trichinella spiralis ; algae ; demography ; domestication ; durability ; genomics ; humans ; longevity ; malaria ; mosquito vectors ; parasites ; phylogeny ; potato blight ; potatoes ; swine ; symbionts ; wild boars ; Asia ; Europe
    Language English
    Dates of publication 2018-1010
    Publishing place The Royal Society
    Document type Article ; Online
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2018.1032
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Hybridization is limited between two lineages of freeze-resistant Trichinella during coinfection in a mouse model.

    Hecht, Luke B B / Thompson, Peter C / Lavin, Elizabeth S / Zarlenga, Dante S / Rosenthal, Benjamin M

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2016  Volume 38, Page(s) 146–151

    Abstract: Hybridization between two closely related but distinct genetic lineages may lead to homogenization of the two lineages with potentially novel phenotypes, or selective pressure to avoid hybridization if the two lineages are truly distinct. Trichinella ... ...

    Abstract Hybridization between two closely related but distinct genetic lineages may lead to homogenization of the two lineages with potentially novel phenotypes, or selective pressure to avoid hybridization if the two lineages are truly distinct. Trichinella nativa and Trichinella T6 are zoonotic nematode parasites which can be distinguished genetically despite occasional hybridization. Here, using an experimental murine model, we attempt to determine whether there are barriers to hybridization when sizeable numbers of each lineage are allowed to coinfect a host. Two mice were independently infected with equal numbers of T. nativa and T6. The offspring of these coinfections were genotyped at two microsatellite loci and one mitochondrial locus capable of distinguishing T. nativa from T6 genotypes. Among larvae in the F1 generation, offspring of every possible mating were encountered. Most larvae (63.6%) derived from T. nativa×T. nativa matings, while 21.1% of offspring were the product of T6×T6 matings, and only 15.3% were hybrid offspring of T. nativa×T6 crosses, differing markedly from null expectations. In this experimental model, T. nativa and Trichinella T6 were able to mate, but ratios of offspring indicated pre- or post-zygotic barriers to hybridization that may include assortative mating, genetic incompatibilities, and/or differences in the fitness of offspring. These barriers would limit gene flow between these two lineages in a natural setting, serving as a barrier to their homogenization and promoting their persistence as distinct and separate entities.
    MeSH term(s) Adaptation, Biological ; Animals ; Coinfection ; Disease Models, Animal ; Freezing ; Hybridization, Genetic ; Mice ; Microsatellite Repeats ; Quantitative Trait Loci ; Trichinella/genetics ; Trichinella/physiology ; Trichinellosis/parasitology
    Language English
    Publishing date 2016-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2015.12.016
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  9. Article: Hybridization is limited between two lineages of freeze-resistant Trichinella during coinfection in a mouse model

    Hecht, Luke B.B / Lavin, Elizabeth S / Rosenthal, Benjamin M / Thompson, Peter C / Zarlenga, Dante S

    Infection, genetics, and evolution. 2016 Mar., v. 38

    2016  

    Abstract: Hybridization between two closely related but distinct genetic lineages may lead to homogenization of the two lineages with potentially novel phenotypes, or selective pressure to avoid hybridization if the two lineages are truly distinct. Trichinella ... ...

    Abstract Hybridization between two closely related but distinct genetic lineages may lead to homogenization of the two lineages with potentially novel phenotypes, or selective pressure to avoid hybridization if the two lineages are truly distinct. Trichinella nativa and Trichinella T6 are zoonotic nematode parasites which can be distinguished genetically despite occasional hybridization. Here, using an experimental murine model, we attempt to determine whether there are barriers to hybridization when sizeable numbers of each lineage are allowed to coinfect a host. Two mice were independently infected with equal numbers of T. nativa and T6. The offspring of these coinfections were genotyped at two microsatellite loci and one mitochondrial locus capable of distinguishing T. nativa from T6 genotypes. Among larvae in the F1 generation, offspring of every possible mating were encountered. Most larvae (63.6%) derived from T. nativa×T. nativa matings, while 21.1% of offspring were the product of T6×T6 matings, and only 15.3% were hybrid offspring of T. nativa×T6 crosses, differing markedly from null expectations. In this experimental model, T. nativa and Trichinella T6 were able to mate, but ratios of offspring indicated pre- or post-zygotic barriers to hybridization that may include assortative mating, genetic incompatibilities, and/or differences in the fitness of offspring. These barriers would limit gene flow between these two lineages in a natural setting, serving as a barrier to their homogenization and promoting their persistence as distinct and separate entities.
    Keywords animal models ; assortative mating ; gene flow ; genotype ; genotyping ; homogenization ; hybridization ; hybrids ; larvae ; loci ; mice ; microsatellite repeats ; mitochondria ; mixed infection ; parasites ; phenotype ; progeny ; Trichinella
    Language English
    Dates of publication 2016-03
    Size p. 146-151.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2015.12.016
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  10. Article: Braided peridotite sills and metasomatism in the Rum Layered Suite, Scotland.

    Hepworth, Luke N / Kaufmann, Felix E D / Hecht, Lutz / Gertisser, Ralf / O'Driscoll, Brian

    Contributions to mineralogy and petrology. Beitrage zur Mineralogie und Petrologie

    2020  Volume 175, Issue 2, Page(s) 17

    Abstract: The Rum Eastern Layered Intrusion (ELI; Scotland) is an open-system layered intrusion constructed of 16 macro-rhythmic units. Each of the macro-rhythmic units consists of a peridotite base and a troctolite (± gabbro) top, previously attributed to the ... ...

    Abstract The Rum Eastern Layered Intrusion (ELI; Scotland) is an open-system layered intrusion constructed of 16 macro-rhythmic units. Each of the macro-rhythmic units consists of a peridotite base and a troctolite (± gabbro) top, previously attributed to the fractional crystallisation of a single magma batch. This classic paradigm has been challenged, however, with evidence presented for the emplacement of peridotite sills in Units 9, 10, and 14, such as cross-cutting relationships, upward-oriented apophyses, and lateral discontinuities. To test whether the other major peridotites within the ELI represent sills, we have carried out new field, petrographic, and mineral chemical analyses of the peridotites in Units 7, 8 and 9. The peridotites display large- and small-scale cross-cutting relationships with the overlying troctolite, indicative of an intrusive relationship. The peridotites also show large-scale coalescence and lateral spatial discontinuities such that the ELI unit divisions become arbitrary. Harrisite layers and Cr-spinel seams found throughout Units 7, 8, and 9 suggest the peridotites were constructed incrementally via repeated injections of picritic magma. Our observations allow for distinct subtypes of peridotite to be defined, separated by intrusive contacts, allowing for their relative chronology to be determined. Older, poikilitic peridotite, rich in clinopyroxene, is truncated by younger, well-layered peridotite, containing abundant harrisite layers. In addition to the new peridotite subtypes defined in this study, we find strong evidence for laterally oriented metasomatism within clinopyroxene-rich wehrlites at the top of the Unit 8 peridotite. The wehrlites and surrounding peridotites record a complex series of metasomatic reactions that transformed thin picrite sills into clinopyroxene-rich wehrlites without any evidence for the sort of vertical melt movement typically posited in layered intrusions. The observations presented in this study from the ELI cannot be reconciled with the classic magma chamber paradigm and are better explained by the emplacement of composite sills into pre-existing feldspathic cumulate (gabbro or troctolite). The evidence for sill emplacement presented here suggests that the layered complex was constructed by a combination of sill emplacement and metasomatism, forming many of the unusual (often clinopyroxene-rich) lithologies that surround the sills. The broad-scale formation of the layered peridotites via incremental sill emplacement, suggested by the occurrence of upward-oriented apophyses, coalescence, and lateral discontinuity, could be applied to much larger ultramafic intrusions, which might have formed by similar mechanisms.
    Language English
    Publishing date 2020-01-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1616-0
    ISSN 1432-0967 ; 0010-7999
    ISSN (online) 1432-0967
    ISSN 0010-7999
    DOI 10.1007/s00410-019-1652-9
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