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  1. Article: Scientific relevance of the Vademecum of Anthroposophie Medicines

    Hamre, Harald J.

    Der Merkurstab

    2018  Volume 71, Issue 2, Page(s) 120

    Language German
    Document type Article
    ZDB-ID 392536-5
    ISSN 0935-798X
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Bedeutung des Vademecum - Projekts

    Hamre, Harald J.

    Der Merkurstab

    2017  Volume 70, Issue 6, Page(s) 482

    Language German
    Document type Article
    ZDB-ID 392536-5
    ISSN 0935-798X
    Database Current Contents Medicine

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  3. Book: Amalgam

    Hamre, Harald J. / Friese, Karl-Heinz

    Probleme und Lösungen in der naturheilkundlichen Praxis

    1997  

    Author's details Harald J. Hamre. Unter Mitarb. von Karl-Heinz Friese
    Keywords Dental Amalgam / adverse effects ; Mercury Poisoning / etiology ; Amalgamfüllung ; Quecksilbervergiftung ; Sekundärkrankheit ; Naturheilverfahren
    Subject Biologische Heilweise ; Naturheilweise ; Folgekrankheit ; Erworbener Defekt ; Sekundärerkrankung ; Folgeerkrankung ; Zweiterkrankung ; Begleitkrankheit ; Komorbidität ; Begleiterkrankung ; Conduct disorder ; Comorbid disorder ; Quecksilber
    Language German
    Size 216 S.
    Publisher Hippokrates-Verl
    Publishing place Stuttgart
    Document type Book
    HBZ-ID HT007719818
    ISBN 3-7773-1247-9 ; 978-3-7773-1247-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1998 A 1801 order for loan Magazin

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  4. Article ; Online: Mercury, silver and selenium in serum before and after removal of amalgam restorations: results from a prospective cohort study in Norway.

    Björkman, Lars / Musial, Frauke / Alræk, Terje / Werner, Erik L / Hamre, Harald J

    Acta odontologica Scandinavica

    2022  Volume 81, Issue 4, Page(s) 298–310

    Abstract: Objective: A prospective cohort study on changes of health complaints after removal of amalgam restorations was carried out at the request of the Norwegian Directorate of Health. The aim was to provide and evaluate experimental treatment to patients ... ...

    Abstract Objective: A prospective cohort study on changes of health complaints after removal of amalgam restorations was carried out at the request of the Norwegian Directorate of Health. The aim was to provide and evaluate experimental treatment to patients with health complaints attributed to dental amalgam fillings.
    Methods: Patients (
    Results: Concentration of I-Hg and Ag in serum decreased significantly after removal of all amalgam restorations. Concentration of MeHg and Se in serum were not changed. Intensity of health complaints was significantly reduced after amalgam removal, but there were no statistically significant correlations between exposure indicators and health complaints.
    Conclusions: Removal of all amalgam restorations is followed by a decrease of concentration of I-Hg and Ag in serum. The results support the hypothesis that exposure to amalgam fillings causes an increase of the daily dose of both I-Hg and Ag. Even though intensity of health complaints decreased after removal of all amalgam restorations there was no clear evidence of a direct relationship between exposure and health complaints.
    MeSH term(s) Humans ; Mercury/analysis ; Selenium/analysis ; Silver/analysis ; Dental Amalgam/adverse effects ; Dental Amalgam/chemistry ; Prospective Studies ; Methylmercury Compounds ; Norway
    Chemical Substances Mercury (FXS1BY2PGL) ; Selenium (H6241UJ22B) ; Silver (3M4G523W1G) ; Dental Amalgam (8049-85-2) ; Methylmercury Compounds
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 210362-x
    ISSN 1502-3850 ; 0001-6357
    ISSN (online) 1502-3850
    ISSN 0001-6357
    DOI 10.1080/00016357.2022.2143422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is amalgam removal in patients with medically unexplained physical symptoms cost-effective? A prospective cohort and decision modelling study in Norway.

    Lamu, Admassu N / Björkman, Lars / Hamre, Harald J / Alræk, Terje / Musial, Frauke / Robberstad, Bjarne

    PloS one

    2022  Volume 17, Issue 4, Page(s) e0267236

    Abstract: There are many patients in general practice with health complaints that cannot be medically explained. Some of these patients attribute their health complaints to dental amalgam restorations. This study examined the cost-effectiveness of the removal of ... ...

    Abstract There are many patients in general practice with health complaints that cannot be medically explained. Some of these patients attribute their health complaints to dental amalgam restorations. This study examined the cost-effectiveness of the removal of amalgam restorations in patients with medically unexplained physical symptoms (MUPS) attributed to amalgam fillings compared to usual care, based on a prospective cohort study in Norway. Costs were determined using a micro-costing approach at the individual level. Health outcomes were documented at baseline and approximately two years later for both the intervention and the usual care using EQ-5D-5L. Quality adjusted life year (QALY) was used as a main outcome measure. A decision analytical model was developed to estimate the incremental cost-effectiveness of the intervention. Both probabilistic and one-way sensitivity analyses were conducted to assess the impact of uncertainty in costs and effectiveness. In patients who attribute health complaints to dental amalgam restorations and fulfil the inclusion and exclusion criteria, amalgam removal is associated with modest increase in costs at societal level as well as improved health outcomes. In the base-case analysis, the mean incremental cost per patient in the amalgam group was NOK 19 416 compared to the MUPS group, while mean incremental QALY was 0.119 with a time horizon of two years. Thus, the incremental costs per QALY of the intervention was NOK 162 680, which is usually considered cost effective in Norway. The estimated incremental cost per QALY decreased with increasing time horizon, and amalgam removal was found to be cost saving over both 5 and 10 years. This study provides insight into the costs and health outcomes associated with the removal of amalgam restorations in patients who attribute health complaints to dental amalgam fillings, which are appropriate instruments to inform health care priorities.
    MeSH term(s) Cohort Studies ; Cost-Benefit Analysis ; Decision Support Techniques ; Dental Amalgam/adverse effects ; Humans ; Prospective Studies
    Chemical Substances Dental Amalgam (8049-85-2)
    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0267236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Antibiotic use in children with acute respiratory or ear infections: prospective observational comparison of anthroposophic and conventional treatment under routine primary care conditions

    Hamre, Harald J.

    Der Merkurstab

    2015  Volume 68, Issue 1, Page(s) 69

    Language German
    Document type Article
    ZDB-ID 392536-5
    ISSN 0935-798X
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Whole Medical Systems versus the System of Conventional Biomedicine: A Critical, Narrative Review of Similarities, Differences, and Factors That Promote the Integration Process.

    Baars, Erik W / Hamre, Harald J

    Evidence-based complementary and alternative medicine : eCAM

    2017  Volume 2017, Page(s) 4904930

    Abstract: Background: There is an increasing need for a worldwide professional integration of conventional medicine and traditional/complementary whole medical systems (WMSs). However, the integration is perceived by conventional medicine as problematic or ... ...

    Abstract Background: There is an increasing need for a worldwide professional integration of conventional medicine and traditional/complementary whole medical systems (WMSs). However, the integration is perceived by conventional medicine as problematic or unacceptable, because of a supposed lack of evidence for specific effects of WMSs therapies and supposed prescientific or unscientific paradigms of WMSs.
    Objectives: To review the literature on the features of WMSs, similarities and differences between conventional medicine and WMSs, and scientific and clinical practice issues that should be dealt with in order to promote the integration process.
    Methods: A critical, narrative review of the literature on six WMSs.
    Results and conclusions: Key factors for the integration of WMSs and conventional medicine are as follows: legal frameworks, quality standards, high-quality research on safety and efficacy of WMS interventions, infrastructure, and financial resources. For scientific assessment of WMSs, there are unresolved ontological, epistemological, and methodological issues and issues of diagnostics, therapy delivery, and outcome assessment in clinical practice. Future research not only should be directed at quality assurance and generating the necessary data on safety and efficacy/effectiveness but also should address more fundamental (ontological, epistemological, and methodological) issues, in order to overcome the differences between WMSs and conventional medicine.
    Language English
    Publishing date 2017-07-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2017/4904930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Systematik ärztlicher Anwendungserfahrungen mit Arzneimitteln aus ganzheitlichen Therapiesystemen: Eine deskriptive Analyse des Vademecum Anthroposophische Arzneimittel

    Hamre, Harald J. / Glockmann, Anja / Marti, Jakob / Soldner, Georg

    Der Merkurstab

    2021  Volume 74, Issue 3, Page(s) 261

    Language German
    Document type Article
    ZDB-ID 392536-5
    ISSN 0935-798X
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Is amalgam removal in patients with medically unexplained physical symptoms cost-effective? A prospective cohort and decision modelling study in Norway.

    Admassu N Lamu / Lars Björkman / Harald J Hamre / Terje Alræk / Frauke Musial / Bjarne Robberstad

    PLoS ONE, Vol 17, Iss 4, p e

    2022  Volume 0267236

    Abstract: There are many patients in general practice with health complaints that cannot be medically explained. Some of these patients attribute their health complaints to dental amalgam restorations. This study examined the cost-effectiveness of the removal of ... ...

    Abstract There are many patients in general practice with health complaints that cannot be medically explained. Some of these patients attribute their health complaints to dental amalgam restorations. This study examined the cost-effectiveness of the removal of amalgam restorations in patients with medically unexplained physical symptoms (MUPS) attributed to amalgam fillings compared to usual care, based on a prospective cohort study in Norway. Costs were determined using a micro-costing approach at the individual level. Health outcomes were documented at baseline and approximately two years later for both the intervention and the usual care using EQ-5D-5L. Quality adjusted life year (QALY) was used as a main outcome measure. A decision analytical model was developed to estimate the incremental cost-effectiveness of the intervention. Both probabilistic and one-way sensitivity analyses were conducted to assess the impact of uncertainty in costs and effectiveness. In patients who attribute health complaints to dental amalgam restorations and fulfil the inclusion and exclusion criteria, amalgam removal is associated with modest increase in costs at societal level as well as improved health outcomes. In the base-case analysis, the mean incremental cost per patient in the amalgam group was NOK 19 416 compared to the MUPS group, while mean incremental QALY was 0.119 with a time horizon of two years. Thus, the incremental costs per QALY of the intervention was NOK 162 680, which is usually considered cost effective in Norway. The estimated incremental cost per QALY decreased with increasing time horizon, and amalgam removal was found to be cost saving over both 5 and 10 years. This study provides insight into the costs and health outcomes associated with the removal of amalgam restorations in patients who attribute health complaints to dental amalgam fillings, which are appropriate instruments to inform health care priorities.
    Keywords Medicine ; R ; Science ; Q
    Subject code 360
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Validity and responsiveness of GHC-index in patients with amalgam-attributed health complaints.

    Lamu, Admassu N / Robberstad, Bjarne / Hamre, Harald J / Alræk, Terje / Musial, Frauke / Björkman, Lars

    Acta odontologica Scandinavica

    2021  Volume 80, Issue 3, Page(s) 226–233

    Abstract: Objective: Many patients have medically unexplained physical symptoms (MUPS); some of them attribute their health complaints to dental amalgam fillings. The aim of this study was to assess the validity and responsiveness of General Health Complaints ... ...

    Abstract Objective: Many patients have medically unexplained physical symptoms (MUPS); some of them attribute their health complaints to dental amalgam fillings. The aim of this study was to assess the validity and responsiveness of General Health Complaints index (GHC-index) for measuring the symptom load in MUPS patients compared to the widely used symptom outcome measure, Giessen Subjective Complaints List (GBB-24).
    Methods: Three outcome measures - GHC-index, GBB-24, and Munich Amalgam Scale (MAS) - were administered at baseline and 12 months after removal of all dental amalgam restorations. The validity and responsiveness of these symptom measures were tested against external anchors: bodily distress syndrome (BDS), SF-36 vitality, and visual analogue scale (VAS). We tested both convergent and known group validities. We also examined the predictive validity and responsiveness to changes for each instrument.
    Results: All the main outcome measures showed evidence of convergent and known group validities. The GHC-index, GBB-24 and MAS were all able to detect the anticipated differences in BDS and Energy. But the GBB-24 was more efficient in discriminating the BDS compared with the GHC-index (relative efficiency: RE = 0.69; 95% CI: 0.41-0.96) and MAS (RE = 0.59; 95% CI: 0.32-0.86). Each main outcome variable revealed good predictive validity for vitality (standardized coefficient:
    Conclusion: The GHC-index is a valid and responsive instrument for assessing symptom load in MUPS patients attributing their health complaints to amalgam fillings and undergoing amalgam removal.
    MeSH term(s) Dental Amalgam/adverse effects ; Humans
    Chemical Substances Dental Amalgam (8049-85-2)
    Language English
    Publishing date 2021-10-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 210362-x
    ISSN 1502-3850 ; 0001-6357
    ISSN (online) 1502-3850
    ISSN 0001-6357
    DOI 10.1080/00016357.2021.1989032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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