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  1. Article ; Online: Olmsted Syndrome: Response to erlotinib therapy and genotype/phenotype correlation.

    Noakes, Rowland

    The Australasian journal of dermatology

    2021  Volume 62, Issue 3, Page(s) 445–446

    MeSH term(s) Adult ; Erlotinib Hydrochloride/metabolism ; Erlotinib Hydrochloride/pharmacology ; Female ; Genetic Profile ; Humans ; Keratoderma, Palmoplantar/drug therapy ; Keratoderma, Palmoplantar/genetics ; Keratoderma, Palmoplantar/physiopathology ; Treatment Outcome
    Chemical Substances Erlotinib Hydrochloride (DA87705X9K)
    Language English
    Publishing date 2021-07-06
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.13663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 236: Show issues Location:
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  2. Article ; Online: Pruritic papules of the leg.

    Aung, Tim / Noakes, Rowland / Park, Kyungho

    Australian journal of general practice

    2024  Volume 53, Issue 1-2, Page(s) 45–47

    MeSH term(s) Humans ; Leg ; Skin ; Pruritus/etiology
    Language English
    Publishing date 2024-02-05
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2924889-9
    ISSN 2208-7958 ; 2208-794X
    ISSN (online) 2208-7958
    ISSN 2208-794X
    DOI 10.31128/AJGP/03-23-6705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2235: Show issues Location:
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  3. Article: Frontal Fibrosing Alopecia. An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin?

    Noakes, Rowland

    Clinical, cosmetic and investigational dermatology

    2020  Volume 13, Page(s) 479–484

    Abstract: Sun protection has been recommended by public health authorities to reduce the risk of keratinocyte and melanocyte tumors, yet some sun exposure is required for vitamin D synthesis. Frontal fibrosing alopecia (FFA) is a cicatricial alopecia that has been ...

    Abstract Sun protection has been recommended by public health authorities to reduce the risk of keratinocyte and melanocyte tumors, yet some sun exposure is required for vitamin D synthesis. Frontal fibrosing alopecia (FFA) is a cicatricial alopecia that has been reported to have an association with facial photoprotection. The brief review proposes the hypothesis that FFA arises as a result of excessive facial photo-protection with a resultant disturbance in immunological homeostasis mediated via the aryl hydrocarbon receptor-kynurenine pathway axis (AHR/KP) leading to the collapse of immune privilege at the hair bulge.
    Language English
    Publishing date 2020-07-27
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494852-4
    ISSN 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S262803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Scaly erythematous eruptions of intertriginous locations.

    Aung, Tim / Noakes, Rowland

    The New Zealand medical journal

    2023  Volume 136, Issue 1579, Page(s) 119–121

    Abstract: Intertriginous or flexural eruptions are common presenting problems in clinical practice, raising several differential diagnoses. A clinico-histopathological correlation is important to establish a correct diagnosis when a clinical diagnosis cannot be ... ...

    Abstract Intertriginous or flexural eruptions are common presenting problems in clinical practice, raising several differential diagnoses. A clinico-histopathological correlation is important to establish a correct diagnosis when a clinical diagnosis cannot be ascertained. We here present a case of flaky erythematous eruptions in a female adult, with a final diagnosis of granular parakeratosis, involving nonflexural area mid-back (under bra cover) in addition to flexural zones of the groin, gluteal fold, inframammary fold and axilla. It seems that mechanism of pressure and friction as well as occlusion all play a part. Management with potent topical steroid and avoidance of inciting triggers offered resolution in 4 weeks in this case.
    MeSH term(s) Adult ; Humans ; Female ; New Zealand ; Parakeratosis/diagnosis ; Diagnosis, Differential ; Axilla/pathology
    Language English
    Publishing date 2023-07-21
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 390590-1
    ISSN 1175-8716 ; 0028-8446 ; 0110-7704
    ISSN (online) 1175-8716
    ISSN 0028-8446 ; 0110-7704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.396: Show issues Location:
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  5. Article: Assessing the response of morphea and limited scleroderma to tranilast: a small prospective study comparing topical corticosteroids to a combination of topical corticosteroids and tranilast.

    Noakes, Rowland

    Clinical, cosmetic and investigational dermatology

    2018  Volume 11, Page(s) 321–326

    Abstract: Background: Scleroderma is traditionally managed with immunomodulatory agents such as methotrexate, mycophenolate mofetil and corticosteroids. There are anecdotal reports for, and theoretical reasons why, the anti-fibrotic agent tranilast may provide an ...

    Abstract Background: Scleroderma is traditionally managed with immunomodulatory agents such as methotrexate, mycophenolate mofetil and corticosteroids. There are anecdotal reports for, and theoretical reasons why, the anti-fibrotic agent tranilast may provide an additional treatment modality.
    Objective: The objective of the current study was to demonstrate if the addition of topical tranilast to an established regime resulted in an improvement in the Localized Scleroderma Assessment Tool (LoSCAT) and modified Rodnan score.
    Patients and methods: A small double-blinded randomized prospective study of 11 pairs of treatment sites in four patients; three with morphea and one with limited scleroderma was performed. All patients continued with their prescribed treatment and applied 0.1% betamethasone valerate in PCCA PracaSil™ (B) to the control site with 0.1% betamethasone valerate and 1% tranilast (B/T) to the comparator site over a period of 3 months. Photographs and monthly LoSCAT scores were performed on the morphea patients and a modified Rodnan score on the limited scleroderma patient. Statistical analysis was via sign test.
    Results: The mean baseline LoScat score at the B treated sites was 6.6 which improved to 4.3 (
    Limitations: This was a small single center study. The ideal concentration of tranilast is unknown. As all patients continued with standard management the expected response may be less than would have been anticipated in a single agent trial.
    Conclusion: The role of tranilast in the management in scleroderma warrants further investigation in larger trials.
    Language English
    Publishing date 2018-07-04
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494852-4
    ISSN 1178-7015
    ISSN 1178-7015
    DOI 10.2147/CCID.S160923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Primary cutaneous amyloidosis: A review of the available studies and gaps in data.

    Aung, Tim / Noakes, Rowland / Murrell, Dedee F / Daniel, Benjamin S / Kelati, Awatef

    The Australasian journal of dermatology

    2023  Volume 64, Issue 2, Page(s) e121–e124

    MeSH term(s) Humans ; Skin Diseases ; Amyloidosis/diagnosis ; Amyloidosis, Familial/diagnosis
    Language English
    Publishing date 2023-02-24
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.14012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 236: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism.

    Noakes, Rowland

    International journal of tryptophan research : IJTR

    2015  Volume 8, Page(s) 7–18

    Abstract: The aryl hydrocarbon receptor (AHR) is a cytosolic receptor for low molecular weight molecules, of which the most widely recognized ligand is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and the most widely recognized effect, chloracne. Adverse effects of ...

    Abstract The aryl hydrocarbon receptor (AHR) is a cytosolic receptor for low molecular weight molecules, of which the most widely recognized ligand is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and the most widely recognized effect, chloracne. Adverse effects of manipulation were most recently and graphically demonstrated by the poisoning of Viktor Yushchenko during the Ukrainian presidential elections of 2004. However, recent research has revealed a receptor with wide-ranging, and at times, paradoxical actions. It was arguably among the first biological receptors to be utilized by dermatologists, dating from the time of topical tar preparations as a therapeutic agent. I provide a review outlining the role AHR plays in the development, cellular oxidation/antioxidation, responses to ultraviolet light, melanogenesis, epidermal barrier function, and immune regulation and its relationship to tryptophan metabolism. Finally, I will review the role of AHR in diseases of the integument.
    Language English
    Publishing date 2015-02-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2517435-6
    ISSN 1178-6469
    ISSN 1178-6469
    DOI 10.4137/IJTR.S19985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Effects of tranilast on the urinary excretion of kynurenic and quinolinic Acid under conditions of L tryptophan loading.

    Noakes, Rowland R

    International journal of tryptophan research : IJTR

    2013  Volume 6, Page(s) 67–71

    Abstract: The pathogenesis of morphea and other cutaneous sclerosing disorders remain poorly understood. Although they are considered to be autoimmune disorders, abnormal tryptophan metabolism may be involved. Current therapy is directed to supressing the ... ...

    Abstract The pathogenesis of morphea and other cutaneous sclerosing disorders remain poorly understood. Although they are considered to be autoimmune disorders, abnormal tryptophan metabolism may be involved. Current therapy is directed to supressing the autoimmune response. Demonstration of a therapeutic response to manipulation of the kynurenine pathway would both support a role for abnormal tryptophan metabolism and offer additional targets for therapy. Tranilast is a 3-hydroxyanthranilic acid derivative known to target the kynurenine pathway. The aim of this study was to see if tranilast lowered the urinary excretion of the kynurenine metabolites kynurenic and quinolinic acid under condition of L tryptophan loading in a volunteer. Mean baseline value for kynurenic acid and quinolinic acid were 1.1 and 2.1 mmol/mol creatinine, respectively. This rose to 5.6 and 3.8 mmol/mol creatinine respectively under conditions of L tryptophan loading 2 grams daily. Adding 1 g of tranilast daily lowered the values to 2.0 and 2.9 mmol/mol creatinine, respectively. These data suggest that tranilast acts as a competitive inhibitor of either indoleamine 2, 3-dioxygenase (IDO), tryptophan 2, 3-di-oxygenase (TDO) or both. As it involved only 1 subject, the results may not be representative of the larger population and must be considered preliminary.
    Language English
    Publishing date 2013-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2517435-6
    ISSN 1178-6469
    ISSN 1178-6469
    DOI 10.4137/IJTR.S12797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Atypical presentation of livedo racemosa in a factor V Leiden heterozygous positive patient with Pseudomonas aeruginosa urosepsis.

    Johnston, Jesse / Noakes, Rowland / Davidson, Kurt

    The Australasian journal of dermatology

    2017  Volume 58, Issue 3, Page(s) e144–e147

    Abstract: Impairment of the protein C pathway, detectable by reduced plasma levels of activated protein C (APC), are risk factors for venous thrombosis. Activated protein C maintains clotting homeostasis by regulation of pro-coagulant factors Va and VIIIa. Both ... ...

    Abstract Impairment of the protein C pathway, detectable by reduced plasma levels of activated protein C (APC), are risk factors for venous thrombosis. Activated protein C maintains clotting homeostasis by regulation of pro-coagulant factors Va and VIIIa. Both infection and the factor V Leiden mutation reduce the formation of APC from protein C in the blood. With low levels of APC, excess factors Va and VIIIa exist, increasing the risk of thrombus formation. Livedo racemosa is characterised by a striking, violaceous branch-like pattering of the skin. It is similar to livedo reticularis, but with a different morphology and histopathology. In this case report we present the first case of livedo racemosa, in an 89-year-old factor V Leiden-positive patient with a Pseudomonas aeruginosa urinary tract infection. The cutaneous biopsies demonstrated vasculopathy with intraluminal thrombi in subcutaneous vessels with no evidence of inflammatory vasculitis.
    MeSH term(s) Aged, 80 and over ; Anticoagulants/therapeutic use ; Factor V/genetics ; Female ; Heterozygote ; Humans ; Mutation ; Pseudomonas Infections/complications ; Pseudomonas aeruginosa ; Skin Diseases, Vascular/complications ; Skin Diseases, Vascular/pathology ; Thrombosis/complications ; Urinary Tract Infections/complications ; Urinary Tract Infections/microbiology
    Chemical Substances Anticoagulants ; factor V Leiden ; Factor V (9001-24-5)
    Language English
    Publishing date 2017-08
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.12554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Immunohistochemical studies of the kynurenine pathway in morphea.

    Noakes, Rowland / Mellick, Nick

    International journal of tryptophan research : IJTR

    2013  Volume 6, Page(s) 97–102

    Abstract: Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of ... ...

    Abstract Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed.
    Language English
    Publishing date 2013-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2517435-6
    ISSN 1178-6469
    ISSN 1178-6469
    DOI 10.4137/IJTR.S13371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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