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  1. Article ; Online: Root Cortical Senescence Improves Growth under Suboptimal Availability of N, P, and K.

    Schneider, Hannah M / Postma, Johannes A / Wojciechowski, Tobias / Kuppe, Christian / Lynch, Jonathan P

    Plant physiology

    2017  Volume 174, Issue 4, Page(s) 2333–2347

    Abstract: Root cortical senescence (RCS) in Triticeae reduces nutrient uptake, nutrient content, respiration, and radial hydraulic conductance of root tissue. We used the functional-structural ... ...

    Abstract Root cortical senescence (RCS) in Triticeae reduces nutrient uptake, nutrient content, respiration, and radial hydraulic conductance of root tissue. We used the functional-structural model
    MeSH term(s) Carbon/metabolism ; Cell Respiration/drug effects ; Hordeum/drug effects ; Hordeum/growth & development ; Nitrogen/pharmacology ; Phosphorus/pharmacology ; Plant Roots/drug effects ; Plant Roots/growth & development ; Potassium/pharmacology ; Soil/chemistry
    Chemical Substances Soil ; Phosphorus (27YLU75U4W) ; Carbon (7440-44-0) ; Nitrogen (N762921K75) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2017-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.17.00648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Root cortical senescence improves growth under suboptimal availability of N, P, and K

    Schneider, Hannah M. / Postma, Johannes A. / Wojciechowski, Tobias / Kuppe, Christian / Lynch, Jonathan P.

    Plant Physiology

    2017  Volume 174, Issue 4

    Abstract: Root cortical senescence (RCS) in Triticeae reduces nutrient uptake, nutrient content, respiration, and radial hydraulic conductance of root tissue. We used the functional-structural model SimRoot to evaluate the functional implications of RCS in barley ( ...

    Abstract Root cortical senescence (RCS) in Triticeae reduces nutrient uptake, nutrient content, respiration, and radial hydraulic conductance of root tissue. We used the functional-structural model SimRoot to evaluate the functional implications of RCS in barley (Hordeum vulgare) under suboptimal nitrate, phosphorus, and potassium availability. The utility of RCS was evaluated using sensitivity analyses in contrasting nutrient regimes. At flowering (80 d), RCS increased simulated plant growth by up to 52%, 73%, and 41% in nitrate-, phosphorus-, and potassium-limiting conditions, respectively. Plants with RCS had reduced nutrient requirement of root tissue for optimal plant growth, reduced total cumulative cortical respiration, and increased total carbon reserves. Nutrient reallocation during RCS had a greater effect on simulated plant growth than reduced respiration or nutrient uptake. Under low nutrient availability, RCS had greater benefit in plants with fewer tillers. RCS had greater benefit in phenotypes with fewer lateral roots at low nitrate availability, but the opposite was true in low phosphorus or potassium availability. Additionally, RCS was quantified in field-grown barley in different nitrogen regimes. Field and virtual soil coring simulation results demonstrated that living cortical volume per root length (an indicator of RCS) decreased with depth in younger plants, while roots of older plants had very little living cortical volume per root length. RCS may be an adaptive trait for nutrient acquisition by reallocating nutrients from senescing tissue and secondarily by reducing root respiration. These simulated results suggest that RCS merits investigation as a breeding target for enhanced soil resource acquisition and edaphic stress tolerance.
    Keywords Life Science
    Subject code 580
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope.

    Pires, J R / Taha-Nejad, F / Toepert, F / Ast, T / Hoffmüller, U / Schneider-Mergener, J / Kühne, R / Macias, M J / Oschkinat, H

    Journal of molecular biology

    2001  Volume 314, Issue 5, Page(s) 1147–1156

    Abstract: The single mutation L30 K in the Hu-Yap65 WW domain increased the stability of the complex ... with the peptide GTPPPPYTVG (K(d)=40(+/-5) microM). Here we report the refined solution structure of this complex ... binding peptide (K(d)=60 microM). The structures of two new complexes with weaker binding ligands chosen ...

    Abstract The single mutation L30 K in the Hu-Yap65 WW domain increased the stability of the complex with the peptide GTPPPPYTVG (K(d)=40(+/-5) microM). Here we report the refined solution structure of this complex by NMR spectroscopy and further derived structure-activity relationships by using ligand peptide libraries with truncated sequences and a substitution analysis that yielded acetyl-PPPPY as the smallest high-affinity binding peptide (K(d)=60 microM). The structures of two new complexes with weaker binding ligands chosen based on these results (N-(n-octyl)-GPPPYNH(2) and Ac-PLPPY) comprising the wild-type WW domain of Hu-Yap65 were determined. Comparison of the structures of the three complexes were useful for identifying the molecular basis of high-affinity: hydrophobic and specific interactions between the side-chains of Y28 and W39 and P5' and P4', respectively, and hydrogen bonds between T37 (donnor) and P5' (acceptor) and between W39 (donnor) and T2' (acceptor) stabilize the complex.The structure of the complex L30 K Hu-Yap65 WW domain/GTPPPPYTVG is compared to the published crystal structure of the dystrophin WW domain bound to a segment of the beta-dystroglycan protein and to the solution structure of the first Nedd4 WW domain and its prolin-rich ligand, suggesting that WW sequences bind proline-rich peptides in an evolutionary conserved fashion. The position equivalent to T22 in the Hu-Yap65 WW domain sequence is seen as responsible for differentiation in the binding mode among the WW domains of group I.
    MeSH term(s) Adaptor Proteins, Signal Transducing ; Amino Acid Motifs ; Amino Acid Sequence ; Amino Acid Substitution/genetics ; Binding Sites ; Carrier Proteins/chemistry ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Humans ; Ligands ; Models, Molecular ; Molecular Sequence Data ; Nuclear Magnetic Resonance, Biomolecular ; Peptide Library ; Peptides/chemistry ; Peptides/genetics ; Peptides/metabolism ; Phosphoproteins/chemistry ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Protein Structure, Tertiary ; Sequence Alignment ; Solutions ; Thermodynamics ; Transcription Factors
    Chemical Substances Adaptor Proteins, Signal Transducing ; Carrier Proteins ; Ligands ; Peptide Library ; Peptides ; Phosphoproteins ; Solutions ; Transcription Factors ; YAP1 protein, human ; polyproline (25191-13-3)
    Language English
    Publishing date 2001-10-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1006/jmbi.2000.5199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Supplementierung nach bariatrischen Operationen

    Braun, Karsten / Andress, Nadine / Jäger, Simon / Schneider, Diana

    (Verordnungsforum ; 67)

    2023  

    Title variant Einzelfallprüfungen bei unwirtschaftlichen Rezepturen ; Apps auf Rezept
    Institution Kassenärztliche Vereinigung Baden-Württemberg
    Author's details Herausgeber: KVBW, Kassenärztliche Vereinigung Baden-Württemberg ; Redaktion: Dr. med. Karsten Braun, LL. M. (verantwortlich) [und 10 andere] ; Autor*innen KVBW: Nadine Andress [und 4 andere] ; Autoren extern: Dr. med. Simon Jäger, Diana Schneider, Universitätsklinikum Tübingen, Department für Experimentelle und Klinische Pharmakologie und Pharmakogenomik, Abteilung Klinische Pharmakologie
    Series title Verordnungsforum ; 67
    Collection
    Subject code 610
    Language German
    Size 1 Online-Ressource (31 Seiten)
    Publisher KVBW Kassenärztliche Vereinigung Baden-Württemberg
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT030622358
    DOI 10.4126/FRL01-006472821
    Database Repository for Life Sciences

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  5. Article: Transcatheter closure of tubular PDA with amplatzer plug 4 in preterm infants weighing between 900 and 3,400 g: the pros and cons.

    Mini, Nathalie / Schneider, Martin B E / Schneider, Katja

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1283992

    Abstract: Objective: To our knowledge, no prior study has focused on the outcome of PDA occlusion using an Amplatzer™ Vascular Plug 4 (AP4) in ill preterm infants. This study aims to highlight the pros and cons of AP4 in this cohort.: Methods: Between 2020 and ...

    Abstract Objective: To our knowledge, no prior study has focused on the outcome of PDA occlusion using an Amplatzer™ Vascular Plug 4 (AP4) in ill preterm infants. This study aims to highlight the pros and cons of AP4 in this cohort.
    Methods: Between 2020 and 2022, 26 ill preterm infants underwent PDA closure in our centre. The median age, weight, and gestational age were 60 days (11-180 days), 1,900g (900-3,400 g), and 25 weeks (22-33 weeks), respectively. The indication of the intervention was hemodynamically significant PDA. A medical trial with non-steroid medication failed to close the ducts in all patients. Follow-up using echocardiography was done 24, 48, and 72 h after the intervention.
    Results: Of 26 ducts, 21 were successfully closed with AP4. Five ducts shorter than 7 mm were unsuitable for AP4 and were closed with the Amplatzer Piccolo device. The median radiation time was 4 min (3-9 min). No early plug-related complications or deaths were documented. Plug-related jailing of the left pulmonary artery as a late complication was 9.5%, and LPA reintervention was required. All ducts were closed after 48 h.
    Conclusion: Implantation of the AP4 using a 4 F 0.38 guide wire-compatible catheter without inserting a long sheath makes the closure of tubular ducts with this device feasible and uncomplicated with a short intervention time. However, the limited sizes with fixed lengths of the AP4 make it unsuitable for ducts wider than 4.5 mm and shorter than the chosen device length, which can increase the risk of significant left pulmonary stenosis. A wide range of plug diameters and lengths is required to accommodate the large and short ducts.
    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1283992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Near Tight Shortest Paths in the Hybrid Model

    Schneider, Philipp

    2023  

    Abstract: ... with algorithmic solutions for $k \geq n^{2/3}$. However, as $k$ gets smaller, the gap between the known upper and ... for the whole range of $k$ (up to terms that are polylogarithmic in $n$), by giving algorithmic solutions ... Omega(\!\sqrt{k})$ rounds in the \hybrid model for each node to learn its distance to $k$ dedicated ...

    Abstract Shortest paths problems are subject to extensive studies in classic distributed models such as the CONGEST or Congested Clique. These models dictate how nodes may communicate in order to determine shortest paths in a distributed input graph. This article focuses on shortest paths problems in the HYBRID model, which combines local communication along edges of the input graph with global communication between arbitrary pairs of nodes that is restricted in terms of bandwidth. Previous work showed that it takes $\tilde \Omega(\!\sqrt{k})$ rounds in the \hybrid model for each node to learn its distance to $k$ dedicated source nodes (aka the $k$-SSP problem), even for crude approximations. This lower bound was also matched with algorithmic solutions for $k \geq n^{2/3}$. However, as $k$ gets smaller, the gap between the known upper and lower bounds diverges and even becomes exponential for a single source. In this work we close this gap for the whole range of $k$ (up to terms that are polylogarithmic in $n$), by giving algorithmic solutions for $k$-SSP in $\tilde O\big(\!\sqrt k\big)$ rounds for any $k$.
    Keywords Computer Science - Data Structures and Algorithms ; Computer Science - Computational Complexity
    Subject code 004
    Publishing date 2023-04-14
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Dimensions of health data Integrity.

    Lennerz, Jochen K / Schneider, Nick / Lauterbach, Karl

    European journal of epidemiology

    2024  Volume 39, Issue 2, Page(s) 179–181

    Abstract: Health data integrity, as an emergent concept, stands to reshape the lifecycle of data-driven healthcare and research, ensuring a shared commitment to ethical practices and improved patient care. ...

    Abstract Health data integrity, as an emergent concept, stands to reshape the lifecycle of data-driven healthcare and research, ensuring a shared commitment to ethical practices and improved patient care.
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-024-01106-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reproductive phenology of the Chesapeake Bay blue crab population in a changing climate

    Alexandra K. Schneider / Mary C. Fabrizio / Romuald N. Lipcius

    Frontiers in Ecology and Evolution, Vol

    2024  Volume 11

    Abstract: Global temperatures are rising across marine ecosystems in response to climate change. Marine and estuarine-dependent species including the blue crab, Callinectes sapidus, may adapt to warming temperatures phenologically, by shifting the seasonal timing ... ...

    Abstract Global temperatures are rising across marine ecosystems in response to climate change. Marine and estuarine-dependent species including the blue crab, Callinectes sapidus, may adapt to warming temperatures phenologically, by shifting the seasonal timing of biological events, such as reproduction. In Chesapeake Bay, average water temperatures have risen by an average 0.02°C per year since the 1980s. Extension of the blue crab spawning season, through earlier onset and later conclusion, may augment annual brood production and alter the efficacy of management strategies. The duration of the potential spawning season from 1985 to 2019 was assessed using degree days, and the observed spawning season from 1995 to 2019 was assessed using the occurrence of ovigerous crabs from the Virginia Institute of Marine Science Trawl Survey in the James River and in the mainstem of lower Chesapeake Bay. Spawning degree days (SDD) and reproductive degree days (RDD) were defined using minimum temperatures of 19°C and 12°C, respectively. The mean duration of the potential spawning season increased by 25% in SDD and 10% in RDD between 1985 and 2019 in the James River and lower Chesapeake Bay, respectively. This progressive expansion of the potential spawning season was not, however, reflected in the observed spawning season. Rather, the onset, conclusion, and duration of the observed spawning season were variable over the time series. The observed month of onset was driven by RDD in spring, whereby spawning began earlier during warmer springs. The spawning conclusion date was driven by the onset of spawning, rather than Fall temperature, such that the duration of the observed spawning season and, therefore, annual brood production did not change over time. In Chesapeake Bay, the spawning stock is protected by a sanctuary that is closed to fishing from mid-May to mid-September during the putative spawning season. An earlier start to the spawning season during warmer springs, as seen in recent years, is expected to reduce the efficacy ...
    Keywords degree days ; reproduction ; crustaceans ; climate change ; Callinectes sapidus ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Subject code 333
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Investigation of the ENVI-met model sensitivity to different wind direction forcing data in a heterogeneous urban environment

    N. Eingrüber / W. Korres / U. Löhnert / K. Schneider

    Advances in Science and Research, Vol 20, Pp 65-

    2023  Volume 71

    Abstract: As the frequency of extreme heat events in cities is significantly increasing due to climate change, the implementation of adaptation measures is important for urban planning. Microclimate modelling approaches enable scenario analyses and evaluations of ... ...

    Abstract As the frequency of extreme heat events in cities is significantly increasing due to climate change, the implementation of adaptation measures is important for urban planning. Microclimate modelling approaches enable scenario analyses and evaluations of adaptation potentials. An ENVI-met microclimate model was setup for a heterogeneous urban study area in Cologne/Germany characterized by closed building structures in the eastern part and an urban park area in the western part. The goal of this paper is to evaluate the model sensitivity and performance to different wind direction forcing and demonstrate the importance of accurate wind forcing data for precise microclimate modelling evaluated with sensor measurements. To this end, we compared simulated air temperatures at 3 m height level using measured wind direction forcing data with simulated air temperatures using constant wind direction forcing from west, north, east and south direction. All other forcing data like wind speed were kept exactly the same as in the reference run. This sensitivity study was performed for a warm summer day in 2022. The model results of all five model runs (reference plus four scenarios) were compared to microclimatological measurements derived from one station of a dense meteorological sensor network located in the study area using the simulated mean air temperatures. We found significant temperature differences between the four sensitivity tests and the reference run as well as to the sensor measurements. Temperature differences between the reference run and the measurements were small and a high statistical model fit could be determined (Nash Sutcliffe Model Efficiency Coefficient/NSE = 0.91). The four model runs with constant wind directions showed significantly larger differences to measurement data and a worse statistical correlation between simulated and observed data (NSE between 0.62 and 0.15). For constant west winds, cooler air temperatures and higher wind speeds were found in the urban park and in the streets and ...
    Keywords Science ; Q ; Physics ; QC1-999 ; Meteorology. Climatology ; QC851-999
    Subject code 551
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Copernicus Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Conference proceedings: Lebensqualitätsvergleich nach Lungentransplantation bei diffusen parenchymatösen Lungenerkrankungen des Kindesalters (ChILD)

    Schneider, H. / Ius, F. / Müller, C. / Schütz, K. / Bobylev, D. / Salman, J. / Schwerk, N. / Carlens, J.

    Klinische Pädiatrie

    2024  Volume 236, Issue 02

    Event/congress 45. Jahrestagung der Gesellschaft für Pädiatrische Pneumologie, Bochum, 2024-03-14
    Language German
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 120650-3
    ISSN 1439-3824 ; 0300-8630
    ISSN (online) 1439-3824
    ISSN 0300-8630
    DOI 10.1055/s-0044-1779418
    Database Thieme publisher's database

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