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Article: A review of custom implants for glenoid bone deficiency in reverse shoulder arthroplasty.

Burton, R / Adam, J / Holland, P / Rangan, A

2022 Volume 36, Page(s) 65–71

Abstract: Reverse Total Shoulder Arthroplasty is being increasingly performed, with indications in both elective and trauma settings. Accordingly, there are an increasing number of revision cases where glenoid bone loss is a concern. There are well recognised ... ...

Abstract	Reverse Total Shoulder Arthroplasty is being increasingly performed, with indications in both elective and trauma settings. Accordingly, there are an increasing number of revision cases where glenoid bone loss is a concern. There are well recognised surgical techniques for dealing with mild to moderate glenoid wear, including eccentric reaming and impaction grafting. In cases of severe wear or uncontained glenoid defects these may not be suitable, and the surgeon may look to a customised implant to deal with such bone loss. There are several implant manufacturers who currently market and produce patient specific instrumentation and customised glenoid baseplates to achieve the best possible fixation in cases of severe bone loss. This article outlines some examples of custom implants currently available to surgeons, and the process by which they may be procured and used. Implant and surgical considerations, and key aspects of surgical technique are also covered. Literature on outcomes and complications following custom shoulder arthroplasty shows promising results, but at present is limited to relatively small case series with no long-term outcome data.
Language	English
Publishing date	2022-12-22
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2240839-3
ISSN	0972-978X
ISSN	0972-978X
DOI	10.1016/j.jor.2022.11.016
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Article ; Online: Time is of the essence: the molecular mechanisms of primary microcephaly.

Phan, Thao P / Holland, Andrew J

Genes & development

2021 Volume 35, Issue 23-24, Page(s) 1551–1578

Abstract: Primary microcephaly is a brain growth disorder characterized by a severe reduction of brain size and thinning of the cerebral cortex. Many primary microcephaly mutations occur in genes that encode centrosome proteins, highlighting an important role for ... ...

Abstract	Primary microcephaly is a brain growth disorder characterized by a severe reduction of brain size and thinning of the cerebral cortex. Many primary microcephaly mutations occur in genes that encode centrosome proteins, highlighting an important role for centrosomes in cortical development. Centrosomes are microtubule organizing centers that participate in several processes, including controlling polarity, catalyzing spindle assembly in mitosis, and building primary cilia. Understanding which of these processes are altered and how these disruptions contribute to microcephaly pathogenesis is a central unresolved question. In this review, we revisit the different models that have been proposed to explain how centrosome dysfunction impairs cortical development. We review the evidence supporting a unified model in which centrosome defects reduce cell proliferation in the developing cortex by prolonging mitosis and activating a mitotic surveillance pathway. Finally, we also extend our discussion to centrosome-independent microcephaly mutations, such as those involved in DNA replication and repair.
MeSH term(s)	Cell Cycle ; Centrosome/metabolism ; Humans ; Microcephaly/genetics ; Mitosis/genetics ; Neurogenesis ; Spindle Apparatus/genetics
Language	English
Publishing date	2021-12-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.348866.121
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Article ; Online: Robotic transversus abdominis release (TAR) for ventral hernia repairs is associated with low surgical site occurrence rates and length of stay despite increasing modifiable comorbidities.

Skoczek, A C / Ruane, P W / Holland, A B / Hamilton, J K / Fernandez, D L

Hernia : the journal of hernias and abdominal wall surgery

2024

Abstract: ... however, having 2 + MCMs was significantly associated with increased odds of SSO (odds ratio 3.25, P = .019 ... increased odds of SSO (odds ratio 3.54, P = .02). No group showed significantly increased odds of prolonged ...

Abstract	Purpose: Modifiable comorbidities (MCMs) have previously been shown to complicate postoperative wound healing occasionally leading to surgeon hesitancy to repair ventral hernias prior to preoperative optimization of comorbidities. This study describes the effects of MCMs on surgical site occurrences (SSOs) and hospital length of stay (LOS) following robotic transversus abdominis release (TAR) with poly-4-hydroxybutyrate (P4HB) resorbable biosynthetic mesh retromuscular sublay for ventral hernia repair in patients who had not undergone preoperative optimization. Methods: A single-surgeon retrospective review was performed for patients who underwent the robotic TAR procedure with P4HB mesh between January 2015 and May 2022. Patients were stratified by the amount of MCMs present: 0, 1, or 2 + . MCMs included obesity, diabetes, and current tobacco use. Patient data was analyzed for the first 60 days following their operation. Primary outcomes included 60-day SSO rates and hospital LOS. Results: Three hundred and thirty-four subjects met the inclusion criteria for SSO and prolonged LOS analysis. 16.8% had no MCM, 56.1% had 1 MCM, and 27% had 2 + MCMs. No significant difference in SSO was seen between the 3 groups; however, having 2 + MCMs was significantly associated with increased odds of SSO (odds ratio 3.25, P = .019). When the groups were broken down, only having a history of diabetes plus obesity was associated with significantly increased odds of SSO (odds ratio 3.54, P = .02). No group showed significantly increased odds of prolonged LOS. Conclusion: 2 + MCMs significantly increase the odds of SSO, specifically in patients who have a history of diabetes and obesity. However, the presence of any number of MCMs was not associated with increased odds of prolonged LOS.
Language	English
Publishing date	2024-05-01
Publishing country	France
Document type	Journal Article
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-024-03044-6
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Conference proceedings ; Online: Gaining a three-dimensional picture of recent Antarctic sea ice variability

Lawrence, I. / Shepherd, A. / Wilkinson, J. / Holland, P.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: Southern Ocean sea ice has undergone dramatic losses in extent in recent years, this year reaching a record (40-year) low of 1.91 million square kilometres in early February, weeks before its minimum annual extent. These drastic losses have garnered much ...

Abstract	Southern Ocean sea ice has undergone dramatic losses in extent in recent years, this year reaching a record (40-year) low of 1.91 million square kilometres in early February, weeks before its minimum annual extent. These drastic losses have garnered much attention from the scientific community and the media, but for the moment our understanding of these events remains two-dimensional because observations of sea ice thickness and volume are limited. Were changes in extent caused by increased convergence of the sea ice pack with a little overall change in volume? or did thermodynamic forcing during low-extent years promote thinner ice more prone to summer melt?Here we utilise data from the ESA CryoSat-2 and Copernicus Sentinel-3 radar altimetry missions, combining radar freeboard with a newly developed snow-on-Antarctic-sea-ice model to derive circumpolar sea ice thickness and volume from 2011 to 2023. We assess the variability in sea ice thickness in the run-up to the February minimum, focussing on the difference between below-average and above-average extent years to ascertain if low summer extent was facilitated by a thinner winter-spring ice pack.Using sea ice concentration and motion data, we then decompose sea ice thickness changes into dynamic and thermodynamic components to understand the principal driving mechanisms behind sea ice thickness variability between 2011-2023, and the dramatic extent losses of 2017, 2022 and 2023.This work forms part of the NERC DEFIANT project, which combines new in-situ and satellite data sets with advanced modelling techniques to better understand the drivers and effects of Antarctic sea ice variability.
Subject code	290
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
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Article ; Online: Information about fetal movements and stillbirth trends: Analysis of time series data.

Heazell, Alexander E P / Holland, Fiona / Wilkinson, Jack

BJOG : an international journal of obstetrics and gynaecology

2023 Volume 130, Issue 8, Page(s) 913–922

Abstract: ... between state and time, p < 0.001); there was a decline from 2008 to 2013 (before the launch of the app ... interaction between period and time, p = 0.06). With the exception of smoking (which fell from approx. 20 ...

Abstract	Objective: To investigate the implementation of the Count the Kicks campaign in Iowa to increase maternal awareness of fetal movements and its association with stillbirth rates. Design: Time series analysis. Setting: Iowa, Illinois, Minnesota and Missouri, USA. Sample: Women giving birth between 2005 and 2018. Methods: Data regarding campaign activity, including uptake of the app and the distribution of information materials, and population-level data on stillbirth rates and potential confounding risk factors were obtained from publicly available data for 2005-2018. Data were plotted over time and examined in relation to key implementation phases. Main outcome measure: Stillbirth. Results: App users were largely centred on Iowa, and increased over time, although the numbers were modest relative to the number of births. Only Iowa demonstrated a reduction in stillbirth (OR 0.96, 95% CI 0.96-1.00 per year; interaction between state and time, p < 0.001); there was a decline from 2008 to 2013 (before the launch of the app), an increase from 2014 to 2016 and a decrease from 2017 to 2018, which coincided with increased app use (interaction between period and time, p = 0.06). With the exception of smoking (which fell from approx. 20% in 2005 to approx. 15% in 2018 in Iowa), all risk factors increased in prevalence, so are unlikely to account for a reduction in stillbirth. Conclusions: There was a reduction in the stillbirth rate in Iowa, where an information campaign about fetal movements was active; this reduction was not present in neighbouring states. Large-scale intervention studies are needed to determine whether the temporal associations between app use and stillbirth rate are causally related.
MeSH term(s)	Pregnancy ; Female ; Humans ; Stillbirth/epidemiology ; Fetal Movement ; Time Factors ; Risk Factors ; Parturition
Language	English
Publishing date	2023-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/1471-0528.17426
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Article ; Online: Why marginal CO

Holland, Stephen P / Kotchen, Matthew J / Mansur, Erin T / Yates, Andrew J

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 8

Abstract: Marginal emissions of ... ...

Abstract	Marginal emissions of CO
Language	English
Publishing date	2022-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2116632119
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Article ; Online: Reply to Gagnon et al.: Short-run estimates vs. long-run conjectures.

Holland, Stephen P / Kotchen, Matthew J / Mansur, Erin T / Yates, Andrew J

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 49, Page(s) e2214219119

Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2214219119
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Article ; Online: The relationship between parental adverse childhood experiences and the health, well-being and development outcomes of their children: a systematic review.

Arnold, R / Ahmed, F / Clarke, A / Quinn, N / Beenstock, J / Holland, P

Public health

2023 Volume 219, Page(s) 146–153

Abstract: Objectives: A growing body of research is emerging regarding the relationship between parental adverse childhood experiences (ACEs) and negative health, well-being and developmental outcomes in their children. This systematic review seeks to understand ... ...

Abstract	Objectives: A growing body of research is emerging regarding the relationship between parental adverse childhood experiences (ACEs) and negative health, well-being and developmental outcomes in their children. This systematic review seeks to understand the relationship between parental ACEs and the health, well-being and developmental outcomes of their children and whether the relationships differ according to the number and type of parental ACEs. Study design: Systematic review. Method: The review includes articles published between 2000 and 2021 from studies using quantitative longitudinal methods and multivariate analysis to investigate the relationship between parental ACEs and their offspring's outcomes. Relevant studies were identified through a systematic search of five databases and findings synthesised using a narrative synthesis. This review was registered on PROSPERO (CRD42021274068). Results: Nineteen studies met the inclusion criteria and were included in the review. This resulted in a combined population sample of 124,043 parents and 128,400 children. Diversity in measurement of parental ACE exposure and in the type of ACEs measured within the studies precluded a meta-analysis. Offspring of parents exposed to ACEs had a higher risk of a range of negative health, well-being and developmental outcomes. This relationship differs according to the number and type of parental ACEs, with a positive relationship observed between the number of parental ACEs and the risk of negative health, well-being and development outcomes in their children. Conclusions: These findings indicate that screening for parental ACEs by health visitors, midwives and other health or social care staff may identify an at-risk population of infants, children and adolescents and improve child outcomes.
MeSH term(s)	Infant ; Adolescent ; Child ; Humans ; Adverse Childhood Experiences ; Parents ; Risk Factors ; Surveys and Questionnaires
Language	English
Publishing date	2023-05-13
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	427333-3
ISSN	1476-5616 ; 0033-3506
ISSN (online)	1476-5616
ISSN	0033-3506
DOI	10.1016/j.puhe.2023.03.025
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Article: A Method for the Numerical Evaluation of the Second Virial Coefficient for Polyatomic Molecules.

Holland, P M / Ely, J F / Hanley, H J M

Journal of research of the National Bureau of Standards (1977)

2021 Volume 82, Issue 2, Page(s) 123–127

Abstract: A numerical integration procedure to calculate the second virial coefficient of simple polyatomic molecules is proposed. The intermolecular pair potential is assumed to be a sum of a spherically symmetric contribution and an unsymmetric, angular ... ...

Abstract	A numerical integration procedure to calculate the second virial coefficient of simple polyatomic molecules is proposed. The intermolecular pair potential is assumed to be a sum of a spherically symmetric contribution and an unsymmetric, angular dependent, contribution. The method is based on evaluating the possible different numerical values for this latter term. Quadrupolar and dipolar molecules are considered. Calculations for the virial coefficient for quadrupolar molecules are judged to be correct to within one part in 2500 or better, and to within one part in 300 or better for polar molecules. Results from the method are compared to corresponding results from the well-known Pople expansion procedure. It is shown that care must be taken to ensure this latter technique yields a convergent answer.
Language	English
Publishing date	2021-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2602408-1
ISSN	0160-1741 ; 0034-530X ; 0091-0635
ISSN	0160-1741 ; 0034-530X ; 0091-0635
DOI	10.6028/jres.082.011
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Article ; Online: Momentum-exchange interactions in a Bragg atom interferometer suppress Doppler dephasing.

Luo, Chengyi / Zhang, Haoqing / Koh, Vanessa P W / Wilson, John D / Chu, Anjun / Holland, Murray J / Rey, Ana Maria / Thompson, James K

Science (New York, N.Y.)

2024 Volume 384, Issue 6695, Page(s) 551–556

Abstract: Large ensembles of laser-cooled atoms interacting through infinite-range photon-mediated interactions are powerful platforms for quantum simulation and sensing. Here we realize momentum-exchange interactions in which pairs of atoms exchange their ... ...

Abstract	Large ensembles of laser-cooled atoms interacting through infinite-range photon-mediated interactions are powerful platforms for quantum simulation and sensing. Here we realize momentum-exchange interactions in which pairs of atoms exchange their momentum states by collective emission and absorption of photons from a common cavity mode, a process equivalent to a spin-exchange or XX collective Heisenberg interaction. The momentum-exchange interaction leads to an observed all-to-all Ising-like interaction in a matter-wave interferometer. A many-body energy gap also emerges, effectively binding interferometer matter-wave packets together to suppress Doppler dephasing in analogy to Mössbauer spectroscopy. The tunable momentum-exchange interaction expands the capabilities of quantum interaction-enhanced matter-wave interferometry and may enable the realization of exotic behaviors, including simulations of superconductors and dynamical gauge fields.
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adi1393
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