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Article ; Online: Isolation, Identification, and Characterization of

Ben Akacha, Randa / Gdoura-Ben Amor, Maroua / Sellami, Hanen / Grosset, Noël / Jan, Sophie / Gautier, Michel / Gdoura, Radhouane

Foodborne pathogens and disease

2024

Abstract: Members of ... ...

Abstract	Members of the
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2148479-X
ISSN	1556-7125 ; 1535-3141
ISSN (online)	1556-7125
ISSN	1535-3141
DOI	10.1089/fpd.2023.0154
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Article ; Online: Epstein-Barr virus in breast carcinoma and in triple negative cases impact on clinical outcomes.

Mekrazi, Saoussen / Kallel, Imen / Jamai, Dhouha / Yengui, Mariem / Khabir, Abdelmajid / Gdoura, Radhouane

Pathology, research and practice

2023 Volume 245, Page(s) 154484

Abstract: Background: The contribution of viral infection in tumors pathogenesis has currently attracted attention. Epstein-Barr virus is an infectious agent involved in numerous human malignancies, including breast cancer. Although, their prognostic impact in ... ...

Abstract	Background: The contribution of viral infection in tumors pathogenesis has currently attracted attention. Epstein-Barr virus is an infectious agent involved in numerous human malignancies, including breast cancer. Although, their prognostic impact in breast tumor is rarely investigated. Therefore, we sought in our study to evaluate the prevalence of EBV in Tunisian breast carcinoma and to examine their potential association with clinicopathological features and overall survival. Methods: Our retrospective study included 100 formalin fixed paraffin embedded samples from Tunisian breast carcinoma. EBV infection was evaluated by immunohistochemical analysis, using monoclonal antibody against latent membrane protein 1 (LMP-1) and polymerase chain reaction. A subset of PCR positive specimens was subjected to in situ hybridization for the detection of EBER expression. Biomarker's expression was evaluated by immunohistochemistry method. Statistical analysis was also explored. Results: The expression status of ER, PR and HER2 was 81%, 71.4% and 33.7% respectively. The triple negative profile was present in 10.84% of cases. LMP-1 expression was negative in all breast cancer specimens. PCR assay showed that 44% of patients were positive for EBV genome. None of the 15 PCR positive cases showed positive results for EBV by ISH. According to the molecular phenotype, there was a statistically significant difference in EBV DNA prevalence between breast cancer subgroups including TN (67%), Lum B (64%), HER2 + (50%) and Lum A (30%). Bivariate analysis showed that EBV DNA was significantly associated with HER2 + (p = 0.035), tumor size (p = 0.018) and high SBR grade (p = 0.009). Multiple logistic regression analysis confirms the positive correlation of EBV with tumor size (p = 0.048) and SBR grade (p = 0.042). Kaplan-Meier analysis showed that patients with EBV+ had significantly shorter overall survival than those with EBV- (p = 0.032). Conclusions: Our study demonstrated the presence of EBV DNA in Tunisian breast carcinoma. EBV DNA was associated with aggressive features and poor overall survival. Further investigations will be required in large samples size to clarify the potential role of EBV in breast tumor progression.
MeSH term(s)	Humans ; Female ; Herpesvirus 4, Human/genetics ; Epstein-Barr Virus Infections/diagnosis ; Retrospective Studies ; Breast Neoplasms/pathology ; DNA ; Viral Matrix Proteins/genetics ; Viral Matrix Proteins/metabolism
Chemical Substances	DNA (9007-49-2) ; Viral Matrix Proteins
Language	English
Publishing date	2023-04-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154484
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Article ; Online: Study of Virulence Genes, Antimicrobial Resistance, and Genetic Relatedness of Foodborne Salmonella Isolates from Tunisia.

Hassena, Amal Ben / Belmabrouk, Sabrine / Amor, Maroua Gdoura-Ben / Zormati, Sonia / Guermazi-Toumi, Sonda / Siala-Trigui, Mariam / Gdoura, Radhouane

Journal of food protection

2022 Volume 85, Issue 12, Page(s) 1779–1789

MeSH term(s)	Animals ; Virulence/genetics ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Microbial Sensitivity Tests ; Phylogeny ; Tunisia ; Salmonella enteritidis/genetics ; Salmonella Infections/microbiology ; Electrophoresis, Gel, Pulsed-Field ; Drug Resistance, Multiple, Bacterial
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/JFP-22-167
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Article: Virulence Factors in Colorectal Cancer Metagenomes and Association of Microbial Siderophores with Advanced Stages.

Mathlouthi, Nour El Houda / Kriaa, Aicha / Keskes, Leila Ammar / Rhimi, Moez / Gdoura, Radhouane

Microorganisms

2022 Volume 10, Issue 12

Abstract: Colorectal cancer (CRC) is a growing public health challenge, featuring a multifactorial etiology and complex host-environment interactions. Recently, increasing evidence has pointed to the role of the gut microbiota in CRC development and progression. ... ...

Abstract	Colorectal cancer (CRC) is a growing public health challenge, featuring a multifactorial etiology and complex host-environment interactions. Recently, increasing evidence has pointed to the role of the gut microbiota in CRC development and progression. To explore the role of gut microbes in CRC, we retrieved metagenomic data from 156 stools from the European Nucleotide Archive database and mapped them against the VFDB database for virulence factors (VFs). GO annotations of VFs and KEGG pathways were then performed to predict the microbial functions and define functional pathways enriched in the tumor-associated microbiota. Interestingly, 306 VFs were detected in the metagenomic data. We revealed the enrichment of adenomas with VFs involved in cell adhesion, whereas in the early stages of CRC they were enriched in both adhesins and isochorismatase. Advanced stages of CRC were enriched with microbial siderophores, especially enterobactin, which was significantly associated with isochorismate synthase. We highlighted higher abundances of porins and transporters involved in antibiotic resistance and the development of biofilm in advanced stages of CRC. Most VFs detected in CRC, particularly in advanced stages, were shown to be included in siderophore biosynthesis pathways. This enrichment of predicted VFs supports the key role of the gut microbiota in the disease.
Language	English
Publishing date	2022-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10122365
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Article: Influence of environmental and seasonal factors on microbial contamination levels in clam production areas in southern Tunisia: Escherichia coli, Salmonella spp., hepatitis A virus and norovirus.

Zormati, S / Kallel, I / Sellami, H / Gdoura, R

Revue scientifique et technique (International Office of Epizootics)

2019 Volume 37, Issue 3, Page(s) 1049–1070

Abstract: To study the influence of environmental and biological factors on levels of contamination by Escherichia coli, Salmonella spp., hepatitis A virus (HAV) and norovirus in clam production areas, an epidemiological study was conducted on 791 samples of live ... ...

Title translation	Influence des facteurs environnementaux et saisonniers sur le niveau de contamination des zones de production des palourdes par Escherichia coli, Salmonella spp., le virus de l’hépatite A et les norovirus dans la région de Sfax (Sud tunisien).
Abstract	To study the influence of environmental and biological factors on levels of contamination by Escherichia coli, Salmonella spp., hepatitis A virus (HAV) and norovirus in clam production areas, an epidemiological study was conducted on 791 samples of live clams (Ruditapes decussatus), 539 of which were sent for bacteriological analysis and 252 for detection of norovirus and HAV. These samples were collected in different production areas in the Sfax region of southern Tunisia over four consecutive years, from March 2013 to December 2016. The prevalence of positive samples was 36% for E. coli, 11% for Salmonella spp., 19% for norovirus and 3% for HAV. There was a significant correlation between contamination by E. coli and by Salmonella spp., as well as between contamination by noroviruses and by HAV and between contamination by noroviruses and by Salmonella spp. Temperature, the presence of migratory birds and tourism are the main factors affecting microbial contamination levels in bivalve molluscs.
MeSH term(s)	Animals ; Bivalvia ; Escherichia coli ; Hepatitis A virus ; Norovirus ; Salmonella ; Seasons ; Tunisia
Language	French
Publishing date	2019-04-09
Publishing country	France
Document type	Journal Article
ZDB-ID	792125-1
ISSN	1608-0637 ; 0253-1933
ISSN (online)	1608-0637
ISSN	0253-1933
DOI	10.20506/rst.37.3.2906
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Article: The Archaeome's Role in Colorectal Cancer: Unveiling the DPANN Group and Investigating Archaeal Functional Signatures.

Mathlouthi, Nour El Houda / Belguith, Imen / Yengui, Mariem / Oumarou Hama, Hamadou / Lagier, Jean-Christophe / Ammar Keskes, Leila / Grine, Ghiles / Gdoura, Radhouane

Microorganisms

2023 Volume 11, Issue 11

Abstract: Background and aims: Gut microbial imbalances are linked to colorectal cancer (CRC), but archaea's role remains underexplored. Here, using previously published metagenomic data from different populations including Austria, Germany, Italy, Japan, China, ... ...

Abstract	Background and aims: Gut microbial imbalances are linked to colorectal cancer (CRC), but archaea's role remains underexplored. Here, using previously published metagenomic data from different populations including Austria, Germany, Italy, Japan, China, and India, we performed bioinformatic and statistical analysis to identify archaeal taxonomic and functional signatures related to CRC. Methods: We analyzed published fecal metagenomic data from 390 subjects, comparing the archaeomes of CRC and healthy individuals. We conducted a biostatistical analysis to investigate the relationship between Results: Our analysis identified enrichment of methanogenic archaea in healthy subjects, with an exception for Conclusions: The archaeomes of CRC patients show identifiable alterations, including a decline in methanogens and an increase in Halobacteria species. MvhB-type polyferredoxin, linked with CRC and species like
Language	English
Publishing date	2023-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11112742
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Article ; Online: Clinical and therapeutic features of Plummer-Vinson syndrome in a Tunisian population: a case series.

Chtourou, Lassaad / Moalla, Manel / Gdoura, Hela / Smaoui, Hend / Khrouf, Ons / Kallel, Roua / Mnif, Leila / Amouri, Ali / Boudabbous, Mona / Tahri, Nabil

The Pan African medical journal

2023 Volume 44, Page(s) 21

Abstract: Plummer Vinson syndrome (PVS) is a rare entity and most publications are case or series of cases. Thus, we report a series from southern Tunisia. Our aim was to analyse the epidemiological and clinical characteristics, the therapeutic modalities as well ... ...

Abstract	Plummer Vinson syndrome (PVS) is a rare entity and most publications are case or series of cases. Thus, we report a series from southern Tunisia. Our aim was to analyse the epidemiological and clinical characteristics, the therapeutic modalities as well as the evolution of this pathology. Thus we carried out a retrospective study from 2009 until 2019. For each patient with PVS, we collected the epidemiological, clinical, paraclinical data and therapeutic modalities. A total of 23 patients were enrolled with a median age of 49.52 years [18-82 years] and a clear female predominance (M/F=2/21). The median duration of dysphagia was 42 months [4-92 months]. Moderate microcytic hypochromic anemia was noted in 16 patients. The anemia was without obvious cause in 60.8% (n=14) of cases. The main endoscopic finding was a diaphragm in the cervical area. Treatment was based on iron supplementation followed by endoscopic dilatation with Savary dilators in 90.9% (n=20) and balloons for 9.1% of patients (n=2). Dysphagia recurred in 5 patients after a median of 26.6 months [2-60 months]. Three cases of PVS were complicated by esophageal squamous cell carcinoma. In conclusion, our series confirms that PVS affects mostly women. Anemia is frequently noted in these patients. Treatment is based on endoscopic dilatation which is often an easy and risk-free procedure and iron supplementation.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Plummer-Vinson Syndrome/diagnosis ; Plummer-Vinson Syndrome/epidemiology ; Plummer-Vinson Syndrome/therapy ; Deglutition Disorders/epidemiology ; Deglutition Disorders/etiology ; Deglutition Disorders/therapy ; Esophageal Neoplasms/complications ; Retrospective Studies ; Esophageal Squamous Cell Carcinoma/complications ; Neoplasm Recurrence, Local/complications ; Neoplasm Recurrence, Local/drug therapy ; Iron/therapeutic use
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2023-01-11
Publishing country	Uganda
Document type	Case Reports
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2023.44.21.35809
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Article: Isolation, Partial Characterization and Application of Bacteriophages in Eradicating Biofilm Formation by

Gdoura-Ben Amor, Maroua / Culot, Antoine / Techer, Clarisse / AlReshidi, Mousa / Adnan, Mohd / Jan, Sophie / Baron, Florence / Grosset, Noël / Snoussi, Mejdi / Gdoura, Radhouane / Gautier, Michel

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 8

Abstract: ... ...

Abstract	The
Language	English
Publishing date	2022-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11080872
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Article ; Online: Detection of AmpC and ESBL-producing Enterobacterales isolated from urinary tract infections in Tunisia.

Ben Hassena, Amal / Guermazi-Toumi, Sonda / Gdoura-Ben Amor, Maroua / Saidani, Mabrouka / Tlili, Sonia / Khannous, Lamia / Gdoura, Radhouane / Siala-Trigui, Mariam

Acta microbiologica et immunologica Hungarica

2022

Abstract: Urinary tract infections (UTIs) are the most frequent human infections in community and hospitals. This study aimed to determine the distribution of bacterial uropathogens among urinary tract infections diagnosed within the regional hospital Houcine ... ...

Abstract	Urinary tract infections (UTIs) are the most frequent human infections in community and hospitals. This study aimed to determine the distribution of bacterial uropathogens among urinary tract infections diagnosed within the regional hospital Houcine Bouzaiene (Gafsa, South West Tunisia) during a survey of 54 days from the 8th of November to the 31st of December 2017. Enterobacterales strains were tested for antimicrobial resistance by disk diffusion method and extended-spectrum β-lactamase (ESBL) production was tested by double-disc synergy test. Strains were further subjected to a molecular assessment of ESBL and AmpC β-lactamase production by PCR. Overall, 173 bacterial isolates were studied, out of which 91.3% were Enterobacterales. Escherichia coli was the dominant pathogen, followed by Klebsiella pneumoniae. High to moderate resistance rates were observed, ranging from 66% to 90.7% for penicillins, from 6.7% to 18.6% for cephalosporins and from 16.2% to 25.4% for fluoroquinolones. Enterobacterales with decreased susceptibility to third-generation cephalosporins (3rd GC) carried several resistance genes: blaCTX-M group 1 and group 9, and ACC and FOX AmpC β-lactamase genes. Overall, ESBLs and AmpC β-lactamases were detected in 57% and 14% of the 3rd GC-resistant isolates, respectively. This study proved the high potential of K. pneumaniae species to develop resistance against commonly used antibiotics. Thus, rigorous monitoring of the antibiotic resistance of clinical pathogens have to be implemented in Tunisia. Our results are very relevant to evaluate efficiency of the Tunisian therapeutic strategies against UTIs and adapt them to the emerging problem of antimicrobial resistance.
Language	English
Publishing date	2022-01-17
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	918256-1
ISSN	1588-2640 ; 1217-8950
ISSN (online)	1588-2640
ISSN	1217-8950
DOI	10.1556/030.2022.01630
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Article ; Online: Electrochemical Detection of Dopamine and Riboflavine on a Screen-Printed Carbon Electrode Modified by AuNPs Derived from

Chelly, Sabrine / Chelly, Meryam / Zribi, Rayhane / Gdoura, Radhouane / Bouaziz-Ketata, Hanen / Neri, Giovanni

ACS omega

2021 Volume 6, Issue 37, Page(s) 23666–23675

Abstract: A AuNP-modified screen-printed carbon electrode (AuNP/SPCE) for monitoring important biomolecules, such as dopamine (DA) and riboflavin (RF), having a high potential for personalized medicine and for continuous monitoring of human health is here proposed. ...

Abstract	A AuNP-modified screen-printed carbon electrode (AuNP/SPCE) for monitoring important biomolecules, such as dopamine (DA) and riboflavin (RF), having a high potential for personalized medicine and for continuous monitoring of human health is here proposed. AuNPs were synthesized using the extract of
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c00793
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