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  1. Article ; Online: Racial and Ethnic Disparities in Liver Transplantation for Alcohol-associated Liver Diseases in the United States.

    Elsokary, Khaled / Samuel, Sonia / Koizumi, Naoru / Ortiz, Jorge

    Transplantation

    2024  Volume 108, Issue 2, Page(s) e21

    MeSH term(s) United States/epidemiology ; Humans ; Liver Transplantation/adverse effects ; Liver Diseases
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004863
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    Zs.A 488: Show issues Location:
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    Zs.MO 509: Show issues

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  2. Article ; Online: Racial and Gender Disparities and Attrition Rates Within US Abdominal Transplant Surgeons.

    Castillo, Nathalia / Betterbed, Dominique / Acosta, Emilio / Ortiz, Alejandro C / Martin, Scott / Petrera, Patrick / Ortiz, Juan / Koizumi, Naoru / Ortiz, Jorge

    Transplantation

    2024  

    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Understanding Barriers and Facilitators to Living Kidney Donation Within a Sociotechnical Systems Framework.

    Crenshaw, Rachel / Woods, Cary / Koizumi, Naoru / Dave, Hitarth S / Gentili, Monica / Saleem, Jason J

    Qualitative health research

    2024  , Page(s) 10497323231224706

    Abstract: The objective of this study was to investigate factors influencing one's decision to become a live kidney donor under the framework of sociotechnical systems, by expanding the focus to include larger organizational influences and technological ... ...

    Abstract The objective of this study was to investigate factors influencing one's decision to become a live kidney donor under the framework of sociotechnical systems, by expanding the focus to include larger organizational influences and technological considerations. Semi-structured interviews were conducted with live kidney donors who donated through University of Louisville Health, Trager Transplant Center, a mid-scale transplant program, in the years 2017 through 2019. The interview transcripts were analyzed for barriers and facilitators to live kidney donation within a sociotechnical system. The most salient facilitators included: having an informative, caring, and available care team; the absence of any negative external pressure toward donating; donating to a family or friend; and the ability to take extra time off work for recovery. The most recurrent barriers included: short/medium-term (<1 year) negative health impacts because of donation; the need to make minor lifestyle changes (e.g., less alcohol consumption) after donation; and mental health deterioration stemming from the donation process. The sociotechnical systems framework promotes a balanced system comprised of social, technical, and environmental subsystems. Assessing the facilitators and barriers from the sociotechnical system perspective revealed the importance of and opportunities for developing strategies to promote integration of technical subsystem, such as social media apps and interactive AI platforms, with social and environmental subsystems to enable facilitators and reduce barriers effectively.
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1275716-0
    ISSN 1552-7557 ; 1049-7323
    ISSN (online) 1552-7557
    ISSN 1049-7323
    DOI 10.1177/10497323231224706
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    Zs.A 4632: Show issues Location:
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  4. Article ; Online: Unintentional Injury Death Among Solid Organ Transplant Recipients: Trends and Risk Factors.

    Serpico, Scott / Manikath James, Rosy / Koizumi, Naoru / Ortiz, Jorge

    Angiology

    2023  Volume 75, Issue 5, Page(s) 486–493

    Abstract: Unintentional injury death (UID) is a leading cause of mortality worldwide, and individuals with chronic diseases are at higher risk. Though organ transplant can improve the lives of those with chronic disease, these individuals remain in suboptimal ... ...

    Abstract Unintentional injury death (UID) is a leading cause of mortality worldwide, and individuals with chronic diseases are at higher risk. Though organ transplant can improve the lives of those with chronic disease, these individuals remain in suboptimal physical and mental health after surgery that predisposes them to UID. To quantify the scale of UID among solid organ transplant recipients, we performed a retrospective analysis using United Network of Organ Sharing data from adults who underwent kidney, liver or pancreas transplant between 2000-2021. Our study aimed to identify risk factors for UID in this cohort by comparing basic patient, donor, and transplant characteristics of the groups (UID or all other cause death). The largest proportion of UID was seen in the kidney group (.8%), followed by liver (.7%) and then pancreas (.3%). Male sex was the most significant risk factor among kidney and liver recipients. Whites had a higher risk for UID relative to their non-White counterparts in the kidney and liver groups. In both groups, advancing age conferred a protective effect, whereas higher functional status was a risk factor. Our findings shed new light on a significant source of mortality within the transplant population.
    MeSH term(s) Adult ; Humans ; Male ; Retrospective Studies ; Organ Transplantation/adverse effects ; Risk Factors ; Kidney
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/00033197231169918
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  5. Article: The Impact of the COVID-19 Pandemic on Kidney Transplant Candidate Waitlist Status across Demographic and Geographic Groups: A National Analysis of UNOS STAR Data.

    Lombardi, Conner V / Lang, Jacob J / Li, Meng-Hao / Siddique, Abu Bakkar / Koizumi, Naoru / Ekwenna, Obi

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 4

    Abstract: The primary goal of this retrospective study is to understand how the COVID-19 pandemic differentially impacted transplant status across race, sex, age, primary insurance, and geographic regions by examining which candidates: (i) remained on the waitlist, ...

    Abstract The primary goal of this retrospective study is to understand how the COVID-19 pandemic differentially impacted transplant status across race, sex, age, primary insurance, and geographic regions by examining which candidates: (i) remained on the waitlist, (ii) received transplants, or (iii) were removed from the waitlist due to severe sickness or death on a national level.
    Language English
    Publishing date 2023-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11040612
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  6. Article ; Online: Chronic Health Conditions and Patient Portal Use in Caregivers of People With Alzheimer's Disease and Related Dementias.

    Oh, Kyeung Mi / Inoue, Megumi / Koizumi, Naoru / Beran, Krista / Lee, Jung-Ah Anna

    Journal of applied gerontology : the official journal of the Southern Gerontological Society

    2023  Volume 43, Issue 4, Page(s) 363–373

    Abstract: This study aimed to investigate both chronic health conditions and the utilization of patient portals, focusing particularly on caregivers responsible for individuals with Alzheimer's disease and related dementias (ADRD). Data from the Health Information ...

    Abstract This study aimed to investigate both chronic health conditions and the utilization of patient portals, focusing particularly on caregivers responsible for individuals with Alzheimer's disease and related dementias (ADRD). Data from the Health Information National Trends Survey 2018-2020 were analyzed, involving a sample of 304 family and unpaid caregivers of individuals with ADRD. Among caregivers of individuals with ADRD, 77.6% had at least one chronic disease. A significant proportion (46.6%) of ADRD caregivers had never accessed their patient portals. The limited utilization of patient portals among caregivers responsible for individuals with ADRD, particularly those with lower education, advanced age, and few chronic conditions, becomes apparent due to challenges associated with digital literacy and discomfort with computers. Recognizing the crucial role caregivers play for individuals with ADRD and their health risks, there's a need for tailored training to enhance their health management skills and caregiving capabilities.
    MeSH term(s) Humans ; Alzheimer Disease ; Caregivers ; Patient Portals ; Chronic Disease
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 155897-3
    ISSN 1552-4523 ; 0733-4648
    ISSN (online) 1552-4523
    ISSN 0733-4648
    DOI 10.1177/07334648231210677
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    Zs.A 2901: Show issues Location:
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  7. Article ; Online: Increasing Access to Kidney Transplantation for Black and Asian Patients Through Modification of the Current A2 to B Allocation Policy.

    Nayebpour, Mehdi / Ibrahim, Hanaa / Garcia, Andrew / Koizumi, Naoru / Johnson, Lynt B / Callender, Clive O / Melancon, J Keith

    Kidney360

    2023  Volume 5, Issue 1, Page(s) 88–95

    MeSH term(s) Humans ; Kidney Transplantation ; Tissue Donors ; Tissue and Organ Procurement
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000297
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  8. Article ; Online: Outcomes of de novo belatacept-based immunosuppression regimen and avoidance of calcineurin inhibitors in recipients of kidney allografts at higher risk for underutilization.

    Petrossian, Gregory / Ortiz, Jorge / Ortiz, Alejandro Chiodo / Koizumi, Naoru / Plews, Robert

    Nephrology (Carlton, Vic.)

    2022  Volume 27, Issue 12, Page(s) 1006–1007

    MeSH term(s) Humans ; Calcineurin Inhibitors/adverse effects ; Abatacept/adverse effects ; Immunosuppression Therapy ; Graft Rejection/prevention & control ; Kidney ; Allografts ; Immunosuppressive Agents/adverse effects ; Graft Survival
    Chemical Substances Calcineurin Inhibitors ; Abatacept (7D0YB67S97) ; Immunosuppressive Agents
    Language English
    Publishing date 2022-10-17
    Publishing country Australia
    Document type Letter
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14120
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    Zs.A 4822: Show issues Location:
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  9. Article ; Online: Outcomes of kidney transplantation in patients with IgA nephropathy based on induction: A UNOS data analysis.

    Aydin-Ghormoz, Emmanuel Albert / Perlmutter, Jason / Koizumi, Naoru / Ortiz, Jorge / Faddoul, Geovani

    Clinical transplantation

    2023  Volume 38, Issue 1, Page(s) e15225

    Abstract: Introduction: IgA nephropathy (IgAN) can cause end-stage kidney disease (ESKD). This study assesses the impact of induction and maintenance immunosuppression on IgAN recurrence, graft survival, and mortality in living and deceased donor kidney ... ...

    Abstract Introduction: IgA nephropathy (IgAN) can cause end-stage kidney disease (ESKD). This study assesses the impact of induction and maintenance immunosuppression on IgAN recurrence, graft survival, and mortality in living and deceased donor kidney transplants (LDKT and DDKT).
    Methods: Retrospective analysis of the UNOS database in adults with ESKD secondary to IgAN who received kidney transplants between January 2000 and June 30, 2022. Patients with thymoglobulin (ATG), alemtuzumab, or basiliximab/daclizumab induction with calcineurin inhibitor (CNI) and mycophenolate mofetil (MMF) with or without prednisone maintenance were analyzed. Multivariate logistic regression was performed to identify factors correlated with IgA recurrence. Multivariable Cox regression analyses were performed for clinically suspected risk factors. Kaplan Meir Analysis was utilized for overall graft survival.
    Results: Compared to ATG with steroid maintenance, alemtuzumab with steroid increased the odds of IgAN recurrence in DDKTs (OR 1.90, p < .010, 95% CI [1.169-3.101]). Alemtuzumab with and without steroid increased the odds of recurrence by 52% (p = .036) and 56% (p = .005), respectively, in LDKTs. ATG without steroids was associated with less risk of IgAN recurrence (HR .665, p = .044, 95% CI [.447-.989]), graft failure (HR .758, p = .002, 95% CI [.633-.907]), and death (HR .619, p < .001, 95% CI [.490-.783]) in DDKTs. Recurrence was strongly associated with risks of graft failure in DDKTs and LDKTs and death in LDKTs.
    Conclusion: In patients with IgAN requiring a kidney transplant, Alemtuzumab induction correlates with increased IgAN recurrence. Relapse significantly affects graft survival and mortality. ATG without steroids is associated with the least graft loss and mortality.
    MeSH term(s) Adult ; Humans ; Immunosuppressive Agents/therapeutic use ; Alemtuzumab/therapeutic use ; Glomerulonephritis, IGA/drug therapy ; Glomerulonephritis, IGA/surgery ; Retrospective Studies ; Kidney Transplantation/adverse effects ; Kidney Failure, Chronic/surgery ; Kidney Failure, Chronic/etiology ; Steroids ; Graft Survival ; Graft Rejection/etiology
    Chemical Substances Immunosuppressive Agents ; Alemtuzumab (3A189DH42V) ; Steroids
    Language English
    Publishing date 2023-12-21
    Publishing country Denmark
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15225
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    Zs.A 2204: Show issues Location:
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  10. Article: Classifying Comments on Social Media Related to Living Kidney Donation: Machine Learning Training and Validation Study.

    Asghari, Mohsen / Nielsen, Joshua / Gentili, Monica / Koizumi, Naoru / Elmaghraby, Adel

    JMIR medical informatics

    2022  Volume 10, Issue 11, Page(s) e37884

    Abstract: Background: Living kidney donation currently constitutes approximately a quarter of all kidney donations. There exist barriers that preclude prospective donors from donating, such as medical ineligibility and costs associated with donation. A better ... ...

    Abstract Background: Living kidney donation currently constitutes approximately a quarter of all kidney donations. There exist barriers that preclude prospective donors from donating, such as medical ineligibility and costs associated with donation. A better understanding of perceptions of and barriers to living donation could facilitate the development of effective policies, education opportunities, and outreach strategies and may lead to an increased number of living kidney donations. Prior research focused predominantly on perceptions and barriers among a small subset of individuals who had prior exposure to the donation process. The viewpoints of the general public have rarely been represented in prior research.
    Objective: The current study designed a web-scraping method and machine learning algorithms for collecting and classifying comments from a variety of online sources. The resultant data set was made available in the public domain to facilitate further investigation of this topic.
    Methods: We collected comments using Python-based web-scraping tools from the New York Times, YouTube, Twitter, and Reddit. We developed a set of guidelines for the creation of training data and manual classification of comments as either related to living organ donation or not. We then classified the remaining comments using deep learning.
    Results: A total of 203,219 unique comments were collected from the above sources. The deep neural network model had 84% accuracy in testing data. Further validation of predictions found an actual accuracy of 63%. The final database contained 11,027 comments classified as being related to living kidney donation.
    Conclusions: The current study lays the groundwork for more comprehensive analyses of perceptions, myths, and feelings about living kidney donation. Web-scraping and machine learning classifiers are effective methods to collect and examine opinions held by the general public on living kidney donation.
    Language English
    Publishing date 2022-11-08
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2798261-0
    ISSN 2291-9694
    ISSN 2291-9694
    DOI 10.2196/37884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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