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  1. Article ; Online: Allium Ureteral Stent as a Treatment for Ureteral Stricture: Results and Concerns.

    Avitan, Ofir / Bahouth, Zaher / Shprits, Sagi / Gorenberg, Miguel / Halachmi, Sarel

    Urologia internationalis

    2022  Volume 106, Issue 5, Page(s) 482–486

    Abstract: Introduction: Ureteral strictures could be a chronic illness that leads to severe side effects and poor quality of life. A treatment with an Allium ureteral stent (URS), a self-expanding, large-caliber URS, was implemented in our department for ureteral ...

    Abstract Introduction: Ureteral strictures could be a chronic illness that leads to severe side effects and poor quality of life. A treatment with an Allium ureteral stent (URS), a self-expanding, large-caliber URS, was implemented in our department for ureteral stricture. Our study aim was to report the long-term results, including success rate, complications, and adverse effects.
    Methods: We retrospectively collected data on all patients who were treated with an Allium URS in our department between January 2017 and January 2021. Demographic, clinical, radiological, and perioperative parameters were retrieved and analyzed. The primary outcome was stricture resolution rates following stent removal.
    Results: Our cohort included 17 patients, 9 men and 8 women. The etiology of ureteral strictures was urolithiasis in 76.5% and pelvic procedure injury in 17.6%. The overall success rate was 35.29% in an average follow-up of 10.42 ± 2.39 months after stent removal. A higher failure rate was observed in the urolithiasis etiology group (90% vs. 66.7%, p = 0.38). The mean indwelling time of the Allium stent was 14.29 ± 1.29 months.
    Conclusions: Although an Allium URS could be considered as a feasible and attractive treatment of ureteral strictures, due to its minimal invasiveness, the success rate of this treatment is relatively low. Therefore, this option should be carefully considered and should be discouraged in young and fit patients and reserved for older unfit patients who are unwilling to undergo surgical repair of ureteral strictures.
    MeSH term(s) Allium ; Constriction, Pathologic/surgery ; Female ; Humans ; Male ; Quality of Life ; Retrospective Studies ; Stents/adverse effects ; Treatment Outcome ; Ureteral Obstruction/etiology ; Ureteral Obstruction/surgery ; Urolithiasis/complications
    Language English
    Publishing date 2022-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 204045-1
    ISSN 1423-0399 ; 0042-1138
    ISSN (online) 1423-0399
    ISSN 0042-1138
    DOI 10.1159/000522174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: First line Immunotherapy for Non-Small Cell Lung Cancer.

    Nasser, Nicola J / Gorenberg, Miguel / Agbarya, Abed

    Pharmaceuticals (Basel, Switzerland)

    2020  Volume 13, Issue 11

    Abstract: Immunotherapy for non-small cell lung cancer (NSCLC) is incorporated increasingly in first line treatments protocols. Multiple phase 3 studies have tested different medications targeting programmed death receptor 1 (PD-1), programmed death-ligand 1 (PD- ... ...

    Abstract Immunotherapy for non-small cell lung cancer (NSCLC) is incorporated increasingly in first line treatments protocols. Multiple phase 3 studies have tested different medications targeting programmed death receptor 1 (PD-1), programmed death-ligand 1 (PD-L1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), with or without chemotherapy. The inclusion criteria differ between the various clinical trials, including the cut-off levels of PD-L1 expression on tumor cells, and the tumor histology (squamous or non-squamous). Patients with tumor expression levels of PD-L1 ≥ 50% are candidates for treatment with single agent Pembrolizumab or Atezolizumab. Patients with PD-L1 < 50% are candidates for immunotherapy with pembrolizumab as a single agent if PL-1 > 1%; immunotherapy doublet, Nivolumab and Ipilimumab, or single agent immunotherapy combined with chemotherapy. Here we review phase 3 clinical trials utilizing immunotherapy in the first line for treatment of NSCLC, including Pembrolizumab in KEYNOTE-024, KEYNOTE-042, KEYNOTE-189 and KEYNOTE-407; Nivolumab and Ipilimumab in CHECKMATE-227 and CHECKMATE 9LA; and Atezolizumab in IMpower110, IMpower130 and IMpower150.
    Language English
    Publishing date 2020-11-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph13110373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Image Guided Targeted Hyperstimulation Analgesia is Superior to Placebo in Chronic Low Back Pain.

    Gorenberg, Miguel / Kanner, Ori

    Pain physician

    2017  Volume 20, Issue 2, Page(s) E338–E340

    MeSH term(s) Analgesia ; Humans ; Low Back Pain ; Pain Management ; Pain Measurement
    Language English
    Publishing date 2017-02-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2146393-1
    ISSN 2150-1149 ; 1533-3159
    ISSN (online) 2150-1149
    ISSN 1533-3159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Soleve Image-Guided Targeted Hyperstimulation Analgesia show promising clinical results in Chronic Low Back Pain.

    Gorenberg, Miguel / Kanner, Ori

    Pain physician

    2017  Volume 20, Issue 2, Page(s) E340–E342

    MeSH term(s) Analgesia ; Humans ; Low Back Pain ; Pain Management
    Language English
    Publishing date 2017-02-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2146393-1
    ISSN 2150-1149 ; 1533-3159
    ISSN (online) 2150-1149
    ISSN 1533-3159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects.

    Gorenberg, Miguel / Agbarya, Abed / Groshar, David / Volovik, Ilya / Avitan, Ofir / Sukhotnik, Igor

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 5315

    Abstract: Ionizing radiation (IR) exposure results in oxidative damage causing cytotoxic and genotoxic effects. Double-strand breaks (DSBs) are considered the most significant DNA lesions induced by ionizing radiation. The present study evaluates the radio ... ...

    Abstract Ionizing radiation (IR) exposure results in oxidative damage causing cytotoxic and genotoxic effects. Double-strand breaks (DSBs) are considered the most significant DNA lesions induced by ionizing radiation. The present study evaluates the radio protective effect of a novel antioxidant cocktail through quantification of DSB in peripheral blood lymphocytes (PBL) in vivo. The study included 16 consecutive patients who were divided into 2 groups, 6 patients received the novel antioxidant cocktail and 10 control patients. Blood samples were drawn from the patients undergoing bone scan, before the injection of the
    MeSH term(s) Adult ; Aged ; Antioxidants/administration & dosage ; DNA Breaks, Double-Stranded/drug effects ; Female ; Humans ; Lymphocytes/drug effects ; Lymphocytes/pathology ; Male ; Middle Aged ; Neoplasms/diagnostic imaging ; Neoplasms/radiotherapy ; Radiation Injuries/drug therapy ; Young Adult
    Chemical Substances Antioxidants
    Language English
    Publishing date 2021-03-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-84596-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: First Line Immunotherapy for Non-Small Cell Lung Cancer

    Nicola J. Nasser / Miguel Gorenberg / Abed Agbarya

    Pharmaceuticals, Vol 13, Iss 373, p

    2020  Volume 373

    Abstract: Immunotherapy for non-small cell lung cancer (NSCLC) is incorporated increasingly in first line treatments protocols. Multiple phase 3 studies have tested different medications targeting programmed death receptor 1 (PD-1), programmed death-ligand 1 (PD- ... ...

    Abstract Immunotherapy for non-small cell lung cancer (NSCLC) is incorporated increasingly in first line treatments protocols. Multiple phase 3 studies have tested different medications targeting programmed death receptor 1 (PD-1), programmed death-ligand 1 (PD-L1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), with or without chemotherapy. The inclusion criteria differ between the various clinical trials, including the cut-off levels of PD-L1 expression on tumor cells, and the tumor histology (squamous or non-squamous). Patients with tumor expression levels of PD-L1 ≥ 50% are candidates for treatment with single agent Pembrolizumab or Atezolizumab. Patients with PD-L1 < 50% are candidates for immunotherapy with pembrolizumab as a single agent if PL-1 > 1%; immunotherapy doublet, Nivolumab and Ipilimumab, or single agent immunotherapy combined with chemotherapy. Here we review phase 3 clinical trials utilizing immunotherapy in the first line for treatment of NSCLC, including Pembrolizumab in KEYNOTE-024, KEYNOTE-042, KEYNOTE-189 and KEYNOTE-407; Nivolumab and Ipilimumab in CHECKMATE-227 and CHECKMATE 9LA; and Atezolizumab in IMpower110, IMpower130 and IMpower150.
    Keywords lung cancer ; monoclonal recombinant antibodies ; chemotherapy ; immune checkpoints inhibitors ; programmed death receptor ; CTLA-4 ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 610
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Prostate cancer evaluation using PET quantification in

    Domachevsky, Liran / Goldberg, Natalia / Gorenberg, Miguel / Bernstine, Hanna / Groshar, David / Catalano, Onofrio A

    Quantitative imaging in medicine and surgery

    2020  Volume 10, Issue 1, Page(s) 40–47

    Abstract: Background: Tissues with low magnetic resonance (MR) signals, such as bones and lungs differ considerably in their attenuation properties, requiring special considerations for attenuation correction. We evaluated the impact of using the five-compartment ...

    Abstract Background: Tissues with low magnetic resonance (MR) signals, such as bones and lungs differ considerably in their attenuation properties, requiring special considerations for attenuation correction. We evaluated the impact of using the five-compartment segmentation model, which incorporates bones, in
    Methods: Prostate cancer patients underwent dedicated prostate
    Results: Twenty-six patients (mean age 69.4±9.3 years) were included in the study. Twenty-five patients presented for prostate cancer staging and one patient was evaluated for recurrent disease. There was a statistically significant difference between SUVs of the gluteus, sacrum, prostatic lesions and normal prostate tissue measured by the four-compartment
    Conclusions: 68
    Language English
    Publishing date 2020-01-11
    Publishing country China
    Document type Journal Article
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.21037/qims.2019.11.19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [TREATMENT OF ONCOLOGY PATIENTS DURING THE CORONA VIRUS ERA].

    Khoury, Rasha / Gorenberg, Miguel / Lazri, Sahar / Amromin, Tatiana / Kozlener, Ella / Agbarya, Abed

    Harefuah

    2020  Volume 159, Issue 12, Page(s) 861–866

    Abstract: Background: Cancer patients are more at risk to contract SARS-CoV-2 and may develop many more severe complications, along with high mortality rates relative to the cancer-free population. The outbreak of the epidemic was characterized by a high rate of ... ...

    Abstract Background: Cancer patients are more at risk to contract SARS-CoV-2 and may develop many more severe complications, along with high mortality rates relative to the cancer-free population. The outbreak of the epidemic was characterized by a high rate of infection from person to person, however medical systems remained fully functional. Following most international guidelines, adaptations were made to the performance level of oncology treatments, and the service was to continue as usual. Moreover, the corona virus epidemic era was characterized by new challenges such as emergency work schedules, additional hygiene measures and social distancing. Furthermore, the medical staff used Personal Protection Equipment and resource preparedness for a larger outbreak and probable collapse of the health system. Therefore, changes have been made in the form and delivery of patient care and treatments. This article presents the work format employed in the Oncology Unit at Bnai Zion Medical Center during the COVID-19 epidemic. The newly adjusted protocol included four areas: staff, patients, infrastructure and malignant disease types.
    MeSH term(s) COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Neoplasms/epidemiology ; Neoplasms/therapy ; SARS-CoV-2
    Language Hebrew
    Publishing date 2020-12-23
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [MANAGING LUNG CANCER PATIENTS' CARE DURING THE COVID-19 PANDEMIC].

    Agbarya, Abed / Khoury, Rasha / Nasser, Nicola J / Lazri, Sahar / Volovik, Ilya / Gorenberg, Miguel

    Harefuah

    2020  Volume 159, Issue 7, Page(s) 470–474

    Abstract: Background: Lung cancer patients who contract the new coronavirus, appear to have a greater risk for severe COVID-19 illness along with early deterioration and death. However, the prognosis may depend on the cancer stage and the type of treatment ... ...

    Abstract Background: Lung cancer patients who contract the new coronavirus, appear to have a greater risk for severe COVID-19 illness along with early deterioration and death. However, the prognosis may depend on the cancer stage and the type of treatment administered.
    Objectives: Establishing updated treatments and care management regulations for lung cancer patients during the COVID-19 pandemic, based on worldwide clinical experience.
    Methods: This article reviews the main recommendations described by the American and European Oncology Societies managing lung cancer patients infected by COVID-19.
    Results: In the current pandemic setting, attempts should be made to avoid jeopardizing the prognosis of lung cancer patients, by maintaining current guidelines in oncology practice. In cases of patients with active infection, the recommendation is to hold treatment until recovery. For other patients, due to the aggressive nature of lung cancer, the guidelines suggest not to delay curative treatments in non-metastatic disease and provide palliative treatment in shortened protocols.
    Conclusions: The present summary of guideline recommendations provides different management strategies for patients with lung cancer. These care approaches attempt to solve new challenges raised by the COVID-19 pandemic. Each specific case must be considered individually.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Europe ; Humans ; Lung Neoplasms/therapy ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Societies, Medical ; United States
    Keywords covid19
    Language Hebrew
    Publishing date 2020-09-02
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Novel nanotech antioxidant cocktail prevents medical diagnostic procedures ionizing radiation effects

    Miguel Gorenberg / Abed Agbarya / David Groshar / Ilya Volovik / Ofir Avitan / Igor Sukhotnik

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 7

    Abstract: Abstract Ionizing radiation (IR) exposure results in oxidative damage causing cytotoxic and genotoxic effects. Double-strand breaks (DSBs) are considered the most significant DNA lesions induced by ionizing radiation. The present study evaluates the ... ...

    Abstract Abstract Ionizing radiation (IR) exposure results in oxidative damage causing cytotoxic and genotoxic effects. Double-strand breaks (DSBs) are considered the most significant DNA lesions induced by ionizing radiation. The present study evaluates the radio protective effect of a novel antioxidant cocktail through quantification of DSB in peripheral blood lymphocytes (PBL) in vivo. The study included 16 consecutive patients who were divided into 2 groups, 6 patients received the novel antioxidant cocktail and 10 control patients. Blood samples were drawn from the patients undergoing bone scan, before the injection of the 99mTc MDP tracer and 2 h after the injection. Quantification of the IR damage was done by Immunofluorescence analysis of the phosphorylated histone, γ-H2AX, used to monitor DSB induction and repair in PBL. The radiation effect of the control group was measured by 2 variables, the average DBSs foci per nucleus and the percent of the DSB bearing cells in PBL. The findings showed a significant increase in the DSBs after isotope injection with an average increment of 0.29 ± 0.13 of foci/nucleus and 17.07% ± 7.68 more DSB bearing cells (p < 0.05). The cocktail treated group showed a lower difference average of − 2.79% ± 6.13 DSB bearing cells. A paired t-test revealed a significant difference between the groups (p < 0.005) confirming the cocktail’s protective effect. The novel anti-oxidant treatment decreases the oxidative stress-induced DNA damage and can be considered as a preventative treatment before radiation exposure.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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