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Article: Twinkle R 3D Appliance - An Innovative Functional Skeletal Class ll Corrector.

Rai, Rohan / Joseph, Jacob / Mithun, K / Harshitha, V / Shetty, Suhani

2020 Volume 11, Issue 4, Page(s) 382–386

Abstract: ... simultaneously for better results. In the hindsight of the results, we could get in this case using Twinkle R 3D ...

Abstract	Functional appliances are widely used for regulating and directing growth in which commonly used are Frankel regulator and twinblock. Frankel regulator expands the orofacial arena for allowing growth by passive expansion, whereas twin block aids sagittal correction in retrusive mandible. Heres, an attempt to bring about both the changes in a single appliance where sagittal correction as well as keeping away constricted musculature is desired. In this appliance, passive and active expansion has been used simultaneously for better results. In the hindsight of the results, we could get in this case using Twinkle R 3D appliance, we hope that this appliance will be helpful in many more similar cases and act as adundum in clinician's armamentarium.
Language	English
Publishing date	2020-12-20
Publishing country	India
Document type	Case Reports
ZDB-ID	2582352-8
ISSN	0976-2361 ; 0976-237X
ISSN (online)	0976-2361
ISSN	0976-237X
DOI	10.4103/ccd.ccd_18_20
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts.

Liu, Zhiyan Silvia / Sinha, Sayantani / Bannister, Maxwell / Song, Axia / Arriaga-Gomez, Erica / McKeeken, Alexander J / Bonner, Elizabeth A / Hanson, Benjamin K / Sarchi, Martina / Takashima, Kouhei / Zong, Dawei / Corral, Victor M / Nguyen, Evan / Yoo, Jennifer / Chiraphapphaiboon, Wannasiri / Leibson, Cassandra / McMahon, Matthew C / Rai, Sumit / Swisher, Elizabeth M /

Sachs, Zohar / Chatla, Srinivas / Stirewalt, Derek L / Deeg, H Joachim / Skorski, Tomasz / Papapetrou, Eirini P / Walter, Matthew J / Graubert, Timothy A / Doulatov, Sergei / Lee, Stanley C / Nguyen, Hai Dang

Cancer research

2023 Volume 84, Issue 4, Page(s) 577–597

Abstract: ... exhibited R-loop accumulation that elicited an R-loop-associated PARP1 response, rendering cells dependent ... leukemias in an R-loop-dependent manner. PARPi further increased aberrant R-loop levels, causing higher ... the level of PARP1 activity at R-loops correlated with PARPi sensitivity, suggesting that R-loop-associated ...

Abstract	RNA splicing factor (SF) gene mutations are commonly observed in patients with myeloid malignancies. Here we showed that SRSF2- and U2AF1-mutant leukemias are preferentially sensitive to PARP inhibitors (PARPi), despite being proficient in homologous recombination repair. Instead, SF-mutant leukemias exhibited R-loop accumulation that elicited an R-loop-associated PARP1 response, rendering cells dependent on PARP1 activity for survival. Consequently, PARPi induced DNA damage and cell death in SF-mutant leukemias in an R-loop-dependent manner. PARPi further increased aberrant R-loop levels, causing higher transcription-replication collisions and triggering ATR activation in SF-mutant leukemias. Ultimately, PARPi-induced DNA damage and cell death in SF-mutant leukemias could be enhanced by ATR inhibition. Finally, the level of PARP1 activity at R-loops correlated with PARPi sensitivity, suggesting that R-loop-associated PARP1 activity could be predictive of PARPi sensitivity in patients harboring SF gene mutations. This study highlights the potential of targeting different R-loop response pathways caused by spliceosome gene mutations as a therapeutic strategy for treating cancer. Significance: Spliceosome-mutant leukemias accumulate R-loops and require PARP1 to resolve transcription-replication conflicts and genomic instability, providing rationale to repurpose FDA-approved PARP inhibitors for patients carrying spliceosome gene mutations.
MeSH term(s)	Humans ; Spliceosomes/genetics ; R-Loop Structures ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; DNA Repair ; Leukemia/drug therapy ; Leukemia/genetics ; RNA Splicing Factors/genetics ; Poly (ADP-Ribose) Polymerase-1/genetics
Chemical Substances	Poly(ADP-ribose) Polymerase Inhibitors ; RNA Splicing Factors ; PARP1 protein, human (EC 2.4.2.30) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30)
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-23-3239
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Article: Role of Laser Excitation Wavelength and Power in the Fano Resonance Scattering in RFe₀.₅₀Cr₀.₅₀O₃ (R = Sm, Er, and Eu): A Brief Raman Study

Kumar, Anil / Rambadey, Omkar V. / Rai, Harimohan / Sagdeo, Pankaj R.

Journal of physical chemistry. 2022 Mar. 15, v. 126, no. 12

2022

Abstract: Here in the present report, we have extensively studied the impact of the excitation laser wavelength and laser power on the Raman spectrum of mixed Fe-Cr-based rare-earth perovskites. Resonant and excitation laser power experiments carried out for these ...

Abstract	Here in the present report, we have extensively studied the impact of the excitation laser wavelength and laser power on the Raman spectrum of mixed Fe-Cr-based rare-earth perovskites. Resonant and excitation laser power experiments carried out for these samples suggest the orbital-mediated lattice rearrangement because of electronic excitation from Cr³⁺(d³)-O²–-Fe³⁺(d⁵) ions, which results in an antiresonance dip around 600 cm–¹. The presence of an antiresonance dip even at low laser power is ascribed to Fano interference between the electronic continuum and phonons. Furthermore, with increasing the laser power, the Raman modes show a systematic red shift and asymmetrically broadened Raman lines, which is understood in terms of laser-induced heating effects. Consequently, it also upraises a question about the intrinsic nature of Fano resonance observed for a sample, because it may have laser-induced origin too. Therefore, the present study provides an important outcome emphasizing the high sensitivity of Raman measurements, wherein the laser power of the incident photons plays a major role such that it can even perturb the original features of samples.
Keywords	physical chemistry ; rare earth elements ; wavelengths
Language	English
Dates of publication	2022-0315
Size	p. 5403-5410.
Publishing place	American Chemical Society
Document type	Article
ISSN	1932-7455
DOI	10.1021/acs.jpcc.1c09537
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: sTNF-R Levels

Rajnish K. Singhal / Balwant Rai

Open Access Macedonian Journal of Medical Sciences, Vol 5, Iss 1, Pp 68-

Apical Periodontitis Linked to Coronary Heart Disease

2017 Volume 71

Abstract: ... conducted to examine whether biomarker sTNF-R was elevated in apical periodontitis as sTNF-R is a systemic ... METHODS: sTNF-R levels were measured in 52 patients with apical periodontitis (M:F::25:27), aged 20-45 ... enzyme immunoassays (R&D Systems Europe, Abingdon, UK). RESULTS: The mean sTNF-R1 and sTNF-R2 levels in periodontitis ...

Abstract	BACKGROUND: Different studies have implicated the exposure to systemic conditions in the aetiology of cardiovascular diseases like chronic inflammation including chronic periodontitis. AIM: The present study has been conducted to examine whether biomarker sTNF-R was elevated in apical periodontitis as sTNF-R is a systemic marker of inflammation and has been identified as risk factors for cardiovascular diseases. MATERIAL AND METHODS: sTNF-R levels were measured in 52 patients with apical periodontitis (M:F::25:27), aged 20-45 years and in 20 control patients without periodontitis (M:F::10:10, aged 20-48 years). Measurement of sTNF-R1 and sTNF-R2 was carried out in duplicate with standardised, commercially available enzyme immunoassays (R&D Systems Europe, Abingdon, UK). RESULTS: The mean sTNF-R1 and sTNF-R2 levels in periodontitis were 820 (240) pg/ml (413 – 1620 pg/ml) and 1309 (403) pg/ml (540 – 2430 pg/ml), while in normal sTNF-R1 and sTNF – R2 levels were 740 (340) pg/ml (407-1240 pg/ml) and 1283 (414) pg (480 – 2340 pg/ml) respectively. Results indicated a positive high relationship between cardiovascular markers such as sTNF-R1 and sTNF – R2 and apical periodontitis. CONCLUSION: Elevated levels of sTNF-R1 and sTNF – R2 in apical periodontitis patients indicate an increased independent risk of coronary heart disease.
Keywords	sTNF-R ; Apical Periodontitis ; Systemic inflammatory ; coronary heart disease ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	ID Design 2012/DOOEL Skopje
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The FRS nomination of Sir Prafulla C. Ray and the correspondence of N. R. Dhar.

Choudhuri, Arnab Rai / Singh, Rajinder

Notes and records of the Royal Society of London

2017 Volume 72, Issue 1, Page(s) 57–73

Abstract: Sir Prafulla Chandra Ray (1861-1944) was the first Indian chemist to achieve high international reputation. Originally trained at the University of Edinburgh, he worked for many years at Presidency College in Calcutta and then at Calcutta University. He ... ...

Abstract	Sir Prafulla Chandra Ray (1861-1944) was the first Indian chemist to achieve high international reputation. Originally trained at the University of Edinburgh, he worked for many years at Presidency College in Calcutta and then at Calcutta University. He built up a remarkable school of chemical research by attracting many outstanding students to work with him and published about 150 papers-many of them in leading British and German journals. Ray was highly respected by his British peers and was the first Indian of that era to be nominated for FRS, in 1913. At the time when his nomination was being considered by the Royal Society, Ray's favourite student, Nil Ratan Dhar (1892-1986), who was to become the second Indian chemist to achieve high international reputation, worked in London and Paris for a few years. Even when Dhar was merely a 24-year-old student, he lobbied with several leading British chemists for the election of Ray and kept Ray informed in a series of fascinating letters-giving us a rare glimpse of what election to the Royal Society meant for Indian scientists of that era. During this time, Ray received a knighthood for his contributions to chemistry, and
Language	English
Publishing date	2017-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2092666-2
ISSN	1743-0178 ; 0035-9149
ISSN (online)	1743-0178
ISSN	0035-9149
DOI	10.1098/rsnr.2017.0030
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Smart Grid (r)evolution

Stephens, Jennie / Peterson, Tarla Rai / Wilson, Elizabeth J

electric power struggles

2015

Abstract: This book explores smart grid from a social perspective, for advanced students, academic researchers, and energy ... ...

Author's details	Jennie C. Stephens; Elizabeth J. Wilson; Tarla Rai Peterson
Abstract	This book explores smart grid from a social perspective, for advanced students, academic researchers, and energy professionals
Language	English
Size	Online-Ressource (218 p)
Publisher	Cambridge Univ. Press
Publishing place	New York
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9781107047280 ; 9781316207741 ; 1107047285 ; 1316207749
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease.

Singhal, Rajnish K / Rai, Balwant

publication RETRACTED

Open access Macedonian journal of medical sciences

2017 Volume 5, Issue 1, Page(s) 68–71

Abstract: ... conducted to examine whether biomarker sTNF-R was elevated in apical periodontitis as sTNF-R is a systemic ... and methods: sTNF-R levels were measured in 52 patients with apical periodontitis (M:F::25:27), aged ... enzyme immunoassays (R&D Systems Europe, Abingdon, UK).: Results: The mean sTNF-R1 and sTNF-R2 levels ...

Abstract	Background: Different studies have implicated the exposure to systemic conditions in the aetiology of cardiovascular diseases like chronic inflammation including chronic periodontitis. Aim: The present study has been conducted to examine whether biomarker sTNF-R was elevated in apical periodontitis as sTNF-R is a systemic marker of inflammation and has been identified as risk factors for cardiovascular diseases. Material and methods: sTNF-R levels were measured in 52 patients with apical periodontitis (M:F::25:27), aged 20-45 years and in 20 control patients without periodontitis (M:F::10:10, aged 20-48 years). Measurement of sTNF-R1 and sTNF-R2 was carried out in duplicate with standardised, commercially available enzyme immunoassays (R&D Systems Europe, Abingdon, UK). Results: The mean sTNF-R1 and sTNF-R2 levels in periodontitis were 820 (240) pg/ml (413 - 1620 pg/ml) and 1309 (403) pg/ml (540 - 2430 pg/ml), while in normal sTNF-R1 and sTNF - R2 levels were 740 (340) pg/ml (407-1240 pg/ml) and 1283 (414) pg (480 - 2340 pg/ml) respectively. Results indicated a positive high relationship between cardiovascular markers such as sTNF-R1 and sTNF - R2 and apical periodontitis. Conclusion: Elevated levels of sTNF-R1 and sTNF - R2 in apical periodontitis patients indicate an increased independent risk of coronary heart disease.
Language	English
Publishing date	2017-01-17
Publishing country	North Macedonia
Document type	Journal Article ; Retracted Publication
ISSN	1857-9655
ISSN	1857-9655
DOI	10.3889/oamjms.2017.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Phenotypic and molecular diversity-based prediction of heterosis in pearl millet ( Pennisetum glaucum L. (R.) Br.)

Gupta, S K / Nepolean, T / Shaikh, C G / Rai, K N / Hash, C T / Das, R R / Rathore, A

2018

Abstract: ... in pearl millet (Pennisetum glaucum [L.] R. Br.). Fifty-one hybrids developed using 101 hybrid parents (B and R ... of both sets was low but positive and significant (r = 0.2, P < 0.001).The correlation of ED in parents ... with better-parent heterosis for grain yield was similar in both sets (r = 0.38, P < 0.05). SM was not ...

Abstract	Genetic distances between hybrid parents based on phenotypic traits and molecular markers were investigated to assess their relationship with heterosis for grain and stover yield and other traits in pearl millet (Pennisetum glaucum [L.] R. Br.). Fifty-one hybrids developed using 101 hybrid parents (B and R lines) and showing a wide range of genetic distance between their parents based on eight phenotypic traits and 28–38 SSRs were evaluated in two sets for two seasons. The correlation between Euclidean distance (phenotypic distance, ED) and simple matching distance (molecular distance, SM) for parents of both sets was low but positive and significant (r = 0.2, P < 0.001).The correlation of ED in parents with better-parent heterosis for grain yield was similar in both sets (r = 0.38, P < 0.05). SM was not correlated with heterosis for grain yield in either set of hybrids. The results showed that phenotypic distance could be a better predictor of heterosis than molecular distance. The correlation between phenotypic distance and heterosis was not strong enough to permit the use of phenotypic diversity among parents as a major selection criterion for selection of parental lines displaying high levels of heterosis for grain and stover yield in pearl millet.
Keywords	Molecular Biology ; Pearl Millet ; Genetics and Genomics
Subject code	580
Language	English
Publisher	Crop Science Society of China and Institute of Crop Science, CAAS
Publishing country	in
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phenotypic and molecular diversity-based prediction of heterosis in pearl millet ( Pennisetum glaucum L. (R.) Br.)

Gupta, S K / Nepolean, T / Shaikh, C G / Rai, K N / Hash, C T / Das, R R / Rathore, A

2018

Abstract	Genetic distances between hybrid parents based on phenotypic traits and molecular markers were investigated to assess their relationship with heterosis for grain and stover yield and other traits in pearl millet (Pennisetum glaucum [L.] R. Br.). Fifty-one hybrids developed using 101 hybrid parents (B and R lines) and showing a wide range of genetic distance between their parents based on eight phenotypic traits and 28–38 SSRs were evaluated in two sets for two seasons. The correlation between Euclidean distance (phenotypic distance, ED) and simple matching distance (molecular distance, SM) for parents of both sets was low but positive and significant (r = 0.2, P < 0.001).The correlation of ED in parents with better-parent heterosis for grain yield was similar in both sets (r = 0.38, P < 0.05). SM was not correlated with heterosis for grain yield in either set of hybrids. The results showed that phenotypic distance could be a better predictor of heterosis than molecular distance. The correlation between phenotypic distance and heterosis was not strong enough to permit the use of phenotypic diversity among parents as a major selection criterion for selection of parental lines displaying high levels of heterosis for grain and stover yield in pearl millet.
Keywords	Molecular Biology ; Pearl Millet ; Genetics and Genomics
Subject code	580
Language	English
Publisher	Crop Science Society of China and Institute of Crop Science, CAAS
Publishing country	in
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Single Bundle Anterior Cruciate Ligament Reconstruction (ACL-R) Using Hamstring Tendon Autograft and Tibialis Anterior Tendon Allograft: A Comparative Study.

Rai, Saroj / Jin, Sheng-Yang / Rai, Bimal / Tamang, Nira / Huang, Wei / Liu, Xian-Zhe / Meng, Chun-Qing / Wang, Hong

Current medical science

2018 Volume 38, Issue 5, Page(s) 818–826

Abstract: ... bundle anterior cruciate ligament reconstruction (ACL-R) of using quadrupled hamstring (4HT) autografts ... of sports activities. We retrospectively evaluated 222 patients (male, n=167, female, n=55) undergoing ACL-R ... patients in the 2TA allograft group. Inclusion criteria were primary unilateral ACL-R with a minor MCL ...

Abstract	The main purpose of this study was to compare the clinical outcomes of patients undergoing a single bundle anterior cruciate ligament reconstruction (ACL-R) of using quadrupled hamstring (4HT) autografts and two-strand tibialis anterior (2TA) allografts, and to find out the rate of graft failure and possible causes. We hypothesized that there would be no difference in the clinical outcome, and graft failure would be associated with the use of small sized allograft in young active males with high demand of sports activities. We retrospectively evaluated 222 patients (male, n=167, female, n=55) undergoing ACL-R between January 2010 and July 2014. Of 222 patients, 115 were included in the 4HT autograft group and 107 patients in the 2TA allograft group. Inclusion criteria were primary unilateral ACL-R with a minor MCL (<grade II) injury with or without meniscus tear and had at least 2.5 years of follow-up. Subjective evaluation was performed using Tegner-Lysholm score, modified Cincinnati knee score, and IKDC knee form. Anteroposterior laxity was assessed using ADT and Lachman test whereas rotational laxity was assessed using pivot shift test. Similarly, functional assessment was performed using range of motion (ROM), Daniel's one-leg hop test, and overall IKDC score. Clinical outcomes were satisfactory and comparable in both groups with no statistically significant difference in all the respective parameters. No statistically significant difference was observed in graft re-rupture rate. However, most graft failures occurred in young active males with high demand of sports activities, graft size smaller than 8 mm, and use of allograft. An autograft with at least 8 mm diameter should be considered in a young active male with high demand of sports activities to avoid graft failure.<br />
MeSH term(s)	Adolescent ; Adult ; Allografts/transplantation ; Anterior Cruciate Ligament Injuries/physiopathology ; Anterior Cruciate Ligament Injuries/therapy ; Anterior Cruciate Ligament Reconstruction/methods ; Female ; Hamstring Tendons/physiopathology ; Hamstring Tendons/surgery ; Hamstring Tendons/transplantation ; Humans ; Knee/physiopathology ; Knee/surgery ; Male ; Middle Aged ; Quadruplets ; Rupture/physiopathology ; Rupture/surgery ; Tendons/physiopathology ; Tendons/surgery ; Tendons/transplantation ; Transplantation, Autologous ; Young Adult
Language	English
Publishing date	2018-10-20
Publishing country	China
Document type	Journal Article
ISSN	2523-899X
ISSN (online)	2523-899X
DOI	10.1007/s11596-018-1948-4
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