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  1. Article ; Online: Synthesis of E. faecium wall teichoic acid fragments.

    van der Es, Daan / Groenia, Nadia A / Laverde, Diana / Overkleeft, Herman S / Huebner, Johannes / van der Marel, Gijsbert A / Codée, Jeroen D C

    Bioorganic & medicinal chemistry

    2016  Volume 24, Issue 17, Page(s) 3893–3907

    Abstract: The first synthesis of different Enterococcus faecium wall teichoic acid (WTA) fragments is ... presented. The structure of these major cell wall components was elucidated recently and it was shown ...

    Abstract The first synthesis of different Enterococcus faecium wall teichoic acid (WTA) fragments is presented. The structure of these major cell wall components was elucidated recently and it was shown that these glycerolphosphate (GroP) based polymers are built up from -6-(GalNAc-α(1-3)-GalNAc-β(1-2)-GroP)- repeating units. We assembled WTA fragments up to three repeating units in length, in two series that differ in the stereochemistry of the glycerolphosphate moiety. The key GalNAc-GalNAc-GroP synthons, required for the synthesis, were generated from galactosazide building blocks that were employed in highly stereoselective glycosylation reactions to furnish both the α- and β-configured linkages. By comparing the NMR spectra of the synthesized fragments with the isolated material it appears that the hereto undefined stereochemistry of the glycerol phosphate moiety is sn-glycerol-3-phosphate. The generated fragments will be valuable tools to study their immunological activity at the molecular level.
    MeSH term(s) Carbohydrate Sequence ; Cell Wall/chemistry ; Enterococcus faecium/chemistry ; Stereoisomerism ; Teichoic Acids/chemical synthesis
    Chemical Substances Teichoic Acids
    Language English
    Publishing date 2016-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2016.03.019
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  2. Article ; Online: The transpeptidase PBP2 governs initial localization and activity of the major cell-wall synthesis machinery in E. coli

    Gizem Özbaykal / Eva Wollrab / Francois Simon / Antoine Vigouroux / Baptiste Cordier / Andrey Aristov / Thibault Chaze / Mariette Matondo / Sven van Teeffelen

    eLife, Vol

    2020  Volume 9

    Abstract: Bacterial shape is physically determined by the peptidoglycan cell wall. The cell-wall-synthesis ... that the local cell-wall architecture provides the cue for Rod-complex initiation, either through direct binding ...

    Abstract Bacterial shape is physically determined by the peptidoglycan cell wall. The cell-wall-synthesis machinery responsible for rod shape in Escherichia coli is the processive 'Rod complex'. Previously, cytoplasmic MreB filaments were thought to govern formation and localization of Rod complexes based on local cell-envelope curvature. Using single-particle tracking of the transpeptidase and Rod-complex component PBP2, we found that PBP2 binds to a substrate different from MreB. Depletion and localization experiments of other putative Rod-complex components provide evidence that none of those provide the sole rate-limiting substrate for PBP2 binding. Consistently, we found only weak correlations between MreB and envelope curvature in the cylindrical part of cells. Residual correlations do not require curvature-based Rod-complex initiation but can be attributed to persistent rotational motion. We therefore speculate that the local cell-wall architecture provides the cue for Rod-complex initiation, either through direct binding by PBP2 or through an unknown intermediate.
    Keywords cell-wall insertion ; single-enzyme dynamics ; MreB cytoskeleton ; bacterial morphogenesis ; Rod complex ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Effects of low-dose EPA-E on glycemic control, lipid profile, lipoprotein(a), platelet aggregation, viscosity, and platelet and vessel wall interaction in NIDDM.

    Westerveld, H T / de Graaf, J C / van Breugel, H H / Akkerman, J W / Sixma, J J / Erkelens, D W / Banga, J D

    Diabetes care

    1993  Volume 16, Issue 5, Page(s) 683–688

    Abstract: ... methods: In a double-blind, randomized, placebo-controlled study, 24 NIDDM subjects received 1800 mg of EPA-E, 900 mg of EPA ... E, or a placebo (1656 mg olive oil) daily for 8 wk.: Results: The EPA:arachidonic acid plasma ... induced aggregation could be attributed to EPA-E. In the 1800-mg group low-density-lipoprotein cholesterol ...

    Abstract Objective: To assess the effects of low-dose eicosapentaenoic acid-ethyl-ester on diabetes regulation, lipid metabolism, blood rheology, and platelet reactivity.
    Research design and methods: In a double-blind, randomized, placebo-controlled study, 24 NIDDM subjects received 1800 mg of EPA-E, 900 mg of EPA-E, or a placebo (1656 mg olive oil) daily for 8 wk.
    Results: The EPA:arachidonic acid plasma ratio increased over an 8-wk period, then declined after a 4-wk wash-out period in the fish-oil groups in a dose-dependent way. Platelet-activating factor-induced platelet aggregation decreased from 75 +/- 7% at wk 0 to 35 +/- 21% at wk 8 in the 900-mg group (P = 0.016) and from 72 +/- 11 to 40 +/- 30% in the 1800-mg group (P = 0.039), but did not change in the placebo group. No effects on ADP- or collagen-induced aggregation could be attributed to EPA-E. In the 1800-mg group low-density-lipoprotein cholesterol increased significantly, without concomitant rise in apolipoprotein B. Triglycerides, glycemic control, lipoprotein (a), blood and plasma viscosity, erythrocyte deformability, and platelet adhesion to and aggregate formation on extracellular endothelial cell matrix were not significantly influenced.
    Conclusions: Purified EPA-E in doses of 900 and 1800 mg reduces Platelet-activating factor-induced platelet aggregation without negatively affecting glycemic control. Low-density-lipoprotein cholesterol was elevated in the 1800-mg group.
    MeSH term(s) Adenosine Diphosphate/pharmacology ; Analysis of Variance ; Blood Glucose/metabolism ; Blood Platelets/drug effects ; Blood Platelets/physiology ; Blood Viscosity/drug effects ; Collagen/pharmacology ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/physiopathology ; Dose-Response Relationship, Drug ; Double-Blind Method ; Eicosapentaenoic Acid/analogs & derivatives ; Eicosapentaenoic Acid/therapeutic use ; Endothelium, Vascular/physiology ; Erythrocyte Deformability/drug effects ; Extracellular Matrix/physiology ; Female ; Humans ; In Vitro Techniques ; Lipoprotein(a)/blood ; Male ; Middle Aged ; Platelet Activating Factor/pharmacology ; Platelet Adhesiveness/drug effects ; Platelet Adhesiveness/physiology ; Platelet Aggregation/drug effects
    Chemical Substances Blood Glucose ; Lipoprotein(a) ; Platelet Activating Factor ; Adenosine Diphosphate (61D2G4IYVH) ; eicosapentaenoic acid ethyl ester (6GC8A4PAYH) ; Collagen (9007-34-5) ; Eicosapentaenoic Acid (AAN7QOV9EA)
    Language English
    Publishing date 1993-05
    Publishing country United States
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/diacare.16.5.683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 365: Show issues

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  4. Article ; Online: Author Correction: Possible alleviation of symptoms and side effects through clinicians' nocebo information and empathy in an experimental video vignette study.

    Meijers, M C / Stouthard, J / Evers, A W M / Das, E / Drooger, H J / Jansen, S J A J / Francke, A L / Plum, N / van der Wall, E / Nestoriuc, Y / Dusseldorp, E / van Vliet, L M

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 16392

    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42781-z
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  5. Article: Predicting response to neoadjuvant chemotherapy with liquid biopsies and multiparametric MRI in patients with breast cancer.

    Janssen, L M / Janse, M H A / Penning de Vries, B B L / van der Velden, B H M / Wolters-van der Ben, E J M / van den Bosch, S M / Sartori, A / Jovelet, C / Agterof, M J / Ten Bokkel Huinink, D / Bouman-Wammes, E W / van Diest, P J / van der Wall, E / Elias, S G / Gilhuijs, K G A

    NPJ breast cancer

    2024  Volume 10, Issue 1, Page(s) 10

    Abstract: ... for pCR of 0.76, which increased to 0.82 by incorporating post-treatment radiological MRI assessment (i.e ...

    Abstract Accurate prediction of response to neoadjuvant chemotherapy (NAC) can help tailor treatment to individual patients' needs. Little is known about the combination of liquid biopsies and computer extracted features from multiparametric magnetic resonance imaging (MRI) for the prediction of NAC response in breast cancer. Here, we report on a prospective study with the aim to explore the predictive potential of this combination in adjunct to standard clinical and pathological information before, during and after NAC. The study was performed in four Dutch hospitals. Patients without metastases treated with NAC underwent 3 T multiparametric MRI scans before, during and after NAC. Liquid biopsies were obtained before every chemotherapy cycle and before surgery. Prediction models were developed using penalized linear regression to forecast residual cancer burden after NAC and evaluated for pathologic complete response (pCR) using leave-one-out-cross-validation (LOOCV). Sixty-one patients were included. Twenty-three patients (38%) achieved pCR. Most prediction models yielded the highest estimated LOOCV area under the curve (AUC) at the post-treatment timepoint. A clinical-only model including tumor grade, nodal status and receptor subtype yielded an estimated LOOCV AUC for pCR of 0.76, which increased to 0.82 by incorporating post-treatment radiological MRI assessment (i.e., the "clinical-radiological" model). The estimated LOOCV AUC was 0.84 after incorporation of computer-extracted MRI features, and 0.85 when liquid biopsy information was added instead of the radiological MRI assessment. Adding liquid biopsy information to the clinical-radiological resulted in an estimated LOOCV AUC of 0.86. In conclusion, inclusion of liquid biopsy-derived markers in clinical-radiological prediction models may have potential to improve prediction of pCR after NAC in breast cancer.
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 2374-4677
    ISSN 2374-4677
    DOI 10.1038/s41523-024-00611-z
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  6. Book ; Conference proceedings: Left ventricular hypertrophy

    Wall, Ernst E. van der

    physiology versus pathology ; [a biographical reflection of a Boerhaave Symposium held on April 9, 1999, Leiden, The Netherlands]

    (Developments in cardiovascular medicine ; 223)

    2000  

    Author's details by Ernst E. van der Wall
    Series title Developments in cardiovascular medicine ; 223
    Collection
    Keywords Linksherzhypertrophie
    Subject Linkshypertrophie ; Linksventrikuläre Herzhypertrophie
    Language English
    Size X, 182 S. : Ill., graph. Darst.
    Publisher Kluwer Acad. Publ
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT011218039
    ISBN 0-7923-6038-9 ; 978-0-7923-6038-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2000 A 647 order for loan Magazin

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  7. Article: E-Health: a novel way to redesigning healthcare.

    van der Wall, E E

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2016  Volume 24, Issue 7-8, Page(s) 439–440

    Language English
    Publishing date 2016-05-10
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
    DOI 10.1007/s12471-016-0843-5
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  8. Article: Tooth brushing for a longer and healthier life.

    van der Wall, E E

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2016  Volume 24, Issue 3, Page(s) 159–160

    Language English
    Publishing date 2016-02-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
    DOI 10.1007/s12471-016-0802-1
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  9. Article: A Farewell to Arms.

    van der Wall, E E

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2016  Volume 24, Issue 12, Page(s) 699–700

    Language English
    Publishing date 2016-07-29
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
    DOI 10.1007/s12471-016-0915-6
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  10. Article: Einthoven dissertation prizes 2015.

    van der Wall, E E

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2016  Volume 24, Issue 5, Page(s) 355–362

    Language English
    Publishing date 2016-04-15
    Publishing country Netherlands
    Document type News
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
    DOI 10.1007/s12471-016-0835-5
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