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Article: Dietary supplements used by otolaryngology patients in Turkey during the COVID-19 pandemic: A cross-sectional survey.

Koparal, Mehtap / Ege, Miray

European journal of integrative medicine

2023 Volume 60, Page(s) 102249

Abstract: Introduction: This study investigated the characteristics of dietary supplement (DS) use of patients who attended the otolaryngology clinic at a university training and research hospital in Turkey during the pandemic, including patients who had ... ...

Abstract	Introduction: This study investigated the characteristics of dietary supplement (DS) use of patients who attended the otolaryngology clinic at a university training and research hospital in Turkey during the pandemic, including patients who had experienced Coronavirus disease 2019 (COVID-19). Methods: This cross-sectional study was conducted between March and September 2021. 277 literate patients aged ≥ 18 years who attended the otolaryngology clinic were enrolled. A questionnaire was used to collect sociodemographic data, as well as data on DS use during the pandemic. The questionnaire was administered in a face-to-face setting by a single researcher. Results: Approximately half of the participants (50.18%) took DSs during the pandemic and 67.18% of those who experienced COVID-19 infection used DSs during their illness. The most commonly used supplements were vitamin C (43.16%) and D (33.09%), along with herbal supplements such as lemon (54.68%), garlic (46.76%), ginger (46.04%), and thyme (43.88%). In total, 85.23% of the patients primarily used DSs to enhance their immunity, while 32.95% used them to prevent cough, and 26.14% to improve breathing. The majority of the patients (85.23%) felt benefit from DSs. Typically, the patients obtained information about DSs from doctors (32.37%) or friends and relatives (29.49%), and most of them used the supplements without first consulting a doctor (63.64%). Conclusion: DSs were commonly used by otolaryngology patients during the COVID-19 pandemic, particularly to enhance immunity. Although the majority of patients reportedly benefited from these products, most of them did not inform their physicians that they were using them and often obtained information from unofficial sources.
Language	English
Publishing date	2023-04-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2467260-9
ISSN	1876-3839 ; 1876-3820
ISSN (online)	1876-3839
ISSN	1876-3820
DOI	10.1016/j.eujim.2023.102249
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Article: Evaluation of Nasal Mucociliary Clearance Time in Patients with Schizophrenia.

Kapıcı, Yaşar / Koparal, Mehtap / Aslan, Sefer

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 76, Issue 2, Page(s) 1580–1585

Abstract: Nasal mucociliary clearance time (NMCT) is prolonged in patients with olfactory disorders. It is essential to differentially diagnose conductive and neural olfactory disorders. Here, we used the mucociliary clearance test to investigate a disease ... ...

Abstract	Nasal mucociliary clearance time (NMCT) is prolonged in patients with olfactory disorders. It is essential to differentially diagnose conductive and neural olfactory disorders. Here, we used the mucociliary clearance test to investigate a disease associated with neural olfactory disorders, i.e. schizophrenia. Data on age, gender, and duration of disease were collected. The study involved 56 schizophrenia patients and 56 healthy controls. There was no significant difference between the groups regarding age and gender (p = 0.459 and p = 0.768 respectively). Mean NMCT of patients with schizophrenia was 13.82 ± 3.22 min and mean NMCT of healthy controls was 10.15 ± 2.94 min. There was significant difference between the groups regarding NMCT (p < 0.001). In the patient group, there was a significant positive correlation between duration of disease, age, and NMCT (Pearson r = 0.286, p = 0.032, and Pearson r = 0.522, p < 0.001 respectively). This study has shown a prolonged NMCT in patients with schizophrenia compared to the healthy control group.
Language	English
Publishing date	2023-11-25
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-04363-3
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Article ; Online: Evaluation of Postinfection Hearing with Audiological Tests in Patients with COVID-19: A Case-Control Study.

Koparal, Mehtap / Yılmazer, Cuneyt

Journal of the American Academy of Audiology

2021 Volume 32, Issue 7, Page(s) 464–468

Abstract: Background: Some viral infections can cause congenital or acquired unilateral or bilateral hearing loss. It is predicted that the coronavirus disease 2019 (COVID-19) virus, which can affect many systems in the body, may also have a negative effect on ... ...

Abstract	Background: Some viral infections can cause congenital or acquired unilateral or bilateral hearing loss. It is predicted that the coronavirus disease 2019 (COVID-19) virus, which can affect many systems in the body, may also have a negative effect on hearing. Purpose: This study evaluated the effects of COVID-19 infection on pure-tone average. Research design: A case-control study. Materials and methods: A total of 104 volunteers (48 control, 56 experimental group) who applied to the ENT clinic of Adıyaman University Training and Research Hospital were included in this study. After the detailed clinical examination and medical history, 13 volunteers of the experimental group and 5 volunteers from the control group were excluded from the study. In this way, each group consisted of 43 volunteers. While the experimental group consisted of patients who did not have any hearing problems before but had COVID-19. The control group consisted of healthy volunteers who did not have any hearing problems and were not infected with COVİD-19. Audiological test was applied to all volunteers to determine their pure-tone average. On the data obtained, it was analyzed whether COVID-19 affects the pure-tone average and how it changes according to variables such as age and gender. Results: The evaluation of the 43 (50.0%) COVID-19-positive patients and 43 (50.0%) healthy controls showed no significant differences (
MeSH term(s)	Audiometry, Pure-Tone ; COVID-19 ; Case-Control Studies ; Female ; Hearing ; Humans ; Male ; SARS-CoV-2
Language	English
Publishing date	2021-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1132599-9
ISSN	2157-3107 ; 1050-0545
ISSN (online)	2157-3107
ISSN	1050-0545
DOI	10.1055/s-0041-1730960
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Article ; Online: Clinical significance of Vimentin Antisense RNA 1 and its correlation with other epithelial to mesenchymal transition markers in oral cancers.

Bozgeyik, Esra / Ege, Bilal / Koparal, Mehtap / Ceylan, Onur

Pathology, research and practice

2022 Volume 232, Page(s) 153807

Abstract: Oral squamous cell carcinoma (OSCC) is the most common form of malignant tumor in the head and neck region worldwide. Hence, the identification of biological signatures with high diagnostic and therapeutic potential for OSCC will be of great clinical ... ...

Abstract	Oral squamous cell carcinoma (OSCC) is the most common form of malignant tumor in the head and neck region worldwide. Hence, the identification of biological signatures with high diagnostic and therapeutic potential for OSCC will be of great clinical importance. Epithelial to mesenchymal transition (EMT) is a key driver of malignant transformation of human tumors including OSCC. Loss of epithelial properties and gain of mesenchymal cell properties is one of the most important hallmarks of malignant tumors. Although much has been reported on the protein components of the EMT process, studies on the non-protein coding components are quite limited. Consequently, here we sought to explore biological significance of VIM antisense RNA 1 (VIM-AS1) in OSCC. A total of 36 patients diagnosed with oral cancer were recruited for the study. Formalin-fixed paraffin embedded (FFPE) tissue samples of patients were obtained from pathology archive. For the gene expression analysis, quantitative RT-PCR was used. We also analyzed the expression levels of E-cadherin and Vimentin. Notably, it was found that the expression levels of VIM-AS1 and Vimentin were significantly elevated, while the expression of E-cadherin was downregulated in OSCC. Deregulation of VIM-AS1 was associated with the clinicopathological features of OSCC patients. ROC analysis also showed that VIM-AS1 is an independent diagnostic biomarker for OSCC. Consequently, our findings suggest a chief role for VIM-AS1 in oral cancers.
MeSH term(s)	Cadherins/genetics ; Cadherins/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/genetics ; Humans ; Mouth Neoplasms/pathology ; RNA, Antisense/genetics ; Vimentin/metabolism
Chemical Substances	Cadherins ; RNA, Antisense ; Vimentin
Language	English
Publishing date	2022-02-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2022.153807
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Article ; Online: Evaluation of the Relationship between Childhood Adenoid Tissue and Subcutaneous Fat Tissue Using MRI

Mehmet ŞİRİK / Mehtap KOPARAL / İbrahim BUCAK

Ahi Evran Medical Journal, Vol 6, Iss 3, Pp 270-

2022 Volume 275

Abstract: Purpose: In this study, it was aimed to evaluate the relationship between subcutaneous fat tissue thickness in the neck region and nasopharyngeal air passage in pediatric patients with magnetic resonance imaging (MRI). Materials and Methods: In our study, ...

Abstract	Purpose: In this study, it was aimed to evaluate the relationship between subcutaneous fat tissue thickness in the neck region and nasopharyngeal air passage in pediatric patients with magnetic resonance imaging (MRI). Materials and Methods: In our study, medical imaging records of 93 children (46 male and 47 female) aged between 4-6 years, who underwent brain magnetic resonance imaging (MRI) for any reason between June 2018 and December 2018, were retrospec-tively examined on the purpose of evaluation of adenoid tissue thickness and occipital subcutaneous fat tissue thickness. Single plane (sagittal plane) rapid sequence MRI images taken from the patients within the last one year were used for this purpose. Results: A total of 93 cases, 46(49.5%) male and 47(50.5%) female, were included in the study. No statistically significant differ-ence was observed in nasopharyngeal adenoid tissue thickness and occipital region subcutaneous fat tissue thicknesses according to gender. While the mean adenoid tissue thickness was 9.8±2.13 mm in men, it was measured as 9.25±1.74 mm in women (p=0.178). The mean subcutaneous fat tissue thickness obtained from the occipital region was 5.65±1.26 mm in male, whereas it was found to be 5.84±1.28 mm in women (p=0.465). However, a significant moderate positive correlation was found between the occipital subcutaneous fat tissue thickness, adenoid tissue thickness (Rho=0.488 p=0.000) and the percentage of nasopharyngeal air passage stenosis (Rho=0.482 p=0.000). Conclusion: The nasopharyngeal air passage was observed to be significantly narrowed as occipital subcutaneous fat tissue thickness and adenoid tissue thickness increased.
Keywords	adenoid ; mri ; obesity ; pediatric ; sleep apnea ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Kirsehir Ahi Evran University
Document type	Article ; Online
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Article: Evaluation of Nasal Mucociliary Clearance as an Indicator of Nasal Function in Obsessive-Compulsive Patients: A Cross-Sectional Study.

Koparal, Mehtap / Kapici, Yasar / Aslan, Sefer / Hepkarsi, Sevinc / Karataş, Mehmet / Yılmazer, Cüneyt

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue 4, Page(s) 3263–3267

Abstract: This clinical study aimed to compare the mucociliary clearance time in patients with OCD, a disease associated with neural olfactory disorders, with a healthy control group. The mucociliary clearance time of fifty-one patients with OCD and fifty-two ... ...

Abstract	This clinical study aimed to compare the mucociliary clearance time in patients with OCD, a disease associated with neural olfactory disorders, with a healthy control group. The mucociliary clearance time of fifty-one patients with OCD and fifty-two healthy patients (control group) was compared. The saccharin nasal mucociliary clearance test (NMCT) was applied and recorded the sociodemographic data of all participants. The NMCT was longer in OCD patients than healthy controls. There was no statistically significant difference in sociodemographic data between the groups. Our results show that olfactory transmission pathways may be affected in OCD patients. Supplementary information: The online version contains supplementary material available at 10.1007/s12070-023-03972-2.
Language	English
Publishing date	2023-06-19
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-03972-2
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Article ; Online: Comparison of frontal QRS-T angle of patients with nasal septal deviation with healthy controls.

Kapıcı, Olga Bayar / Abuş, Sabri / Ayhan, Selçuk / Koparal, Mehtap / Kaya, Hakan

BMC cardiovascular disorders

2023 Volume 23, Issue 1, Page(s) 415

Abstract: Background: This study compares frontal QRS-T angle (fQRS-T) in electrocardiogram (ECG) examinations of people with nasal septal deviation (NSD) with healthy controls (HC).: Methods: Eighty-two patients whom a radiologist with paranasal computed ... ...

Abstract	Background: This study compares frontal QRS-T angle (fQRS-T) in electrocardiogram (ECG) examinations of people with nasal septal deviation (NSD) with healthy controls (HC). Methods: Eighty-two patients whom a radiologist with paranasal computed tomography definitively diagnosed with NSD were included in the study. 101 individuals without NSD were selected as HC. Results: Compared to the HC group, the fQRS-T in was considerably wider in patients with NSD (p < .001). According to Spearman correlation analysis, fQRS-T and NSD angle, and platelet lymphocyte ratio (PLR) were significantly correlated (p = .021, p < .001, and p = .003, respectively). In linear regression analysis where the fQRS-T was taken as a dependent variable, NSD angle and PLR predicted the fQRS-T significantly and positively (F(5.76) = 8.451, R2 = 0.357, Adjusted R2 = 0.315 and p < .001). Conclusion: In this study, fQRS-T was significantly higher in patients with NSD. In future studies, fQRS-T can be compared before and after septoplasty in NSD patients.
MeSH term(s)	Humans ; Blood Platelets ; Electrocardiography ; Linear Models ; Patients ; Physical Examination
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-023-03421-6
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Article ; Online: Evaluation of frontal QRS-T angle values in electrocardiography in patients with chronic rhinosinusitis.

Abus, Sabri / Koparal, Mehtap / Kaya, Hakan / Kapıcı, Olga Bayar / Tasolar, Mehmet Hakan / Tibilli, Hakan

BMC cardiovascular disorders

2023 Volume 23, Issue 1, Page(s) 160

Abstract: Background: Chronic Rhinosinusitis (CRS) refers to inflammation of the paranasal sinuses and nasal mucosa. Electrocardiographic indicators of ventricular repolarization have been shown to correlate with systemic inflammation parameters. Recently, the ... ...

Abstract	Background: Chronic Rhinosinusitis (CRS) refers to inflammation of the paranasal sinuses and nasal mucosa. Electrocardiographic indicators of ventricular repolarization have been shown to correlate with systemic inflammation parameters. Recently, the frontal QRS-T (fQRS-T) angle has been accepted as a new indicator of ventricular depolarization and repolarization heterogeneity. The (fQRS-T) angle is recommended in predicting the risk of malignant ventricular arrhythmia. In this study, we aimed to evaluate the ventricular arrhythmia potential in patients with chronic rhinosinusitis by examining the relationship between fQRS-T angle on ECG and inflammation markers. Methods: Inflammatory markers as well as electrocardiographc (ECG) f(QRS-T) angle, QRS duration, QT interval and corrected QT interval were examined in 54 patients with CRS versus 56 healthy control subjects. Results: The f(QRS-T) angle was significantly higher in CRS patients than in healthy controls (p < .001). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) were significantly higher in CRS patients compared to healthy controls (p < .001, for all). Based on correlation analysis, NLR and f(QRS-T) angles were highly correlated (r = .845, p < .001), and according to the results of linear regression analysis, NLR was independently associated with the f(QRS-T) angle (t = 5.149, Beta = 0.595, p = < 0.001). Conclusion: Both f(QRS-T) angle and NLR are significantly increased in CRS patients compared to healthy controls, with increases in NLR also independently associating with increases in f(QRS-T) angle. While the increases in f(QRS-T) angle did not result in clinically alarming absolute values for f(QRS-T), CRS patients might nonetheless be at relatively higher risk for malignant cardiac arrhythmias.
MeSH term(s)	Humans ; Electrocardiography/methods ; Ventricular Premature Complexes ; Inflammation ; Regression Analysis ; Linear Models
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-023-03175-1
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Article ; Online: Evaluation of the relationship between temporomandibular joint disorders and tinnitus with computed tomography.

Koparal, Mehtap / Sirik, Mehmet / Yavuz, Gunay Yapici / Ege, Bilal

Journal of stomatology, oral and maxillofacial surgery

2022 Volume 123, Issue 4, Page(s) e199–e205

Abstract: Purpose: This study aimed to radiographically determine tinnitus and joint disorders by evaluating glenoid fossa depth and the horizontal angle of the ramus mandible in patients with isolated temporomandibular joint disorder and temporomandibular joint ... ...

Abstract	Purpose: This study aimed to radiographically determine tinnitus and joint disorders by evaluating glenoid fossa depth and the horizontal angle of the ramus mandible in patients with isolated temporomandibular joint disorder and temporomandibular joint disorder with tinnitus by computed tomography (CT). Methods: In total, eighty two patients with temporomandibular disorders (TMDs) (forty two patients with tinnitus; forty patients without tinnitus) were evaluated using CT. CT images were analysed according to glenoid fossa depth and the horizontal angle of the ramus. Results: A total of 82 cases 43 (52.4%) female and 39 (47.6%) male were included. The distribution of gender was not significantly different between the TMD patients and the TMD-tinnitus patients (p >0.05). The mean age of the patients with isolated TMD was 31.70 ± 9.68 years, and the mean age of the patients with TMD-tinnitus was 34.07 ± 11.72 years. Comparisons were made of the right and left glenoid fossa depths of the patients with TMD and TMD-tinnitus, respectively. There was a statistically significant difference between the right glenoid fossa depths (p = 0.016) also there was also a statistically significant difference between the left glenoid fossa depths (p = 0.049). Conclusion: Our study revealed that decreased glenoid fossa depth may be associated with an increased incidence of tinnitus in TMD patients by the way temporomandibular joint and ear can affect each other in diseases such as tinnitus due to their close anatomical relationship.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Temporomandibular Joint/diagnostic imaging ; Temporomandibular Joint Disorders/complications ; Temporomandibular Joint Disorders/diagnostic imaging ; Temporomandibular Joint Disorders/epidemiology ; Tinnitus/diagnostic imaging ; Tinnitus/epidemiology ; Tomography, X-Ray Computed ; Young Adult
Language	English
Publishing date	2022-06-18
Publishing country	France
Document type	Journal Article
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2022.06.015
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Article: Evaluation of Postinfection Hearing with Audiological Tests in Patients with COVID-19: A Case–Control Study

Koparal, Mehtap / Yılmazer, Cuneyt

Journal of the American Academy of Audiology

2021 Volume 32, Issue 07, Page(s) 464–468

Abstract	Background: Some viral infections can cause congenital or acquired unilateral or bilateral hearing loss. It is predicted that the coronavirus disease 2019 (COVID-19) virus, which can affect many systems in the body, may also have a negative effect on hearing. Purpose: This study evaluated the effects of COVID-19 infection on pure-tone average. Research Design: A case–control study. Materials and Methods: A total of 104 volunteers (48 control, 56 experimental group) who applied to the ENT clinic of Adıyaman University Training and Research Hospital were included in this study. After the detailed clinical examination and medical history, 13 volunteers of the experimental group and 5 volunteers from the control group were excluded from the study. In this way, each group consisted of 43 volunteers. While the experimental group consisted of patients who did not have any hearing problems before but had COVID-19. The control group consisted of healthy volunteers who did not have any hearing problems and were not infected with COVİD-19. Audiological test was applied to all volunteers to determine their pure-tone average. On the data obtained, it was analyzed whether COVID-19 affects the pure-tone average and how it changes according to variables such as age and gender. Results: The evaluation of the 43 (50.0%) COVID-19-positive patients and 43 (50.0%) healthy controls showed no significant differences ( p > 0.05) at 250 and 500 Hz, whereas at 4000, 6000, and 8000 Hz, the two groups differed significantly. In addition, significant differences were found in the left and right ears at 1000 and 2000 Hz ( p < 0.05). The differences between the two groups in the pure-tone average of the left and right ear were statistically significant ( p < 0.05). However, there were no significant sex-based differences in the pure-tone average between males and females ( p > 0.05) Conclusion: The pure-tone average of COVID-19 positive patients was significantly worse than those of the healthy control group. Thus, COVID-19 should also be considered in patients presenting with unexplained hearing loss. Further studies should investigate the effects of COVID-19 on hearing and the underlying pathophysiology.
Keywords	COVID-19 ; hearing loss ; cochlea function ; audiometry
Language	English
Publishing date	2021-07-01
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1132599-9
ISSN	2157-3107 ; 1050-0545
ISSN (online)	2157-3107
ISSN	1050-0545
DOI	10.1055/s-0041-1730960
Database	Thieme publisher's database

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