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  1. Article ; Online: Commentary: The Trials and Tribulations of T3 Supplementation.

    Foote, Henry P / Hill, Kevin D

    Seminars in thoracic and cardiovascular surgery

    2022  Volume 35, Issue 1, Page(s) 113–114

    MeSH term(s) Humans ; Treatment Outcome ; Dietary Supplements
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 1038278-1
    ISSN 1532-9488 ; 1043-0679
    ISSN (online) 1532-9488
    ISSN 1043-0679
    DOI 10.1053/j.semtcvs.2022.02.002
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  2. Article ; Online: Methylprednisolone for Heart Surgery in Infants. Reply.

    Hill, Kevin D / Kannankeril, Prince J / Li, Jennifer S

    The New England journal of medicine

    2023  Volume 388, Issue 10, Page(s) 959

    MeSH term(s) Infant ; Humans ; Methylprednisolone/therapeutic use ; Cardiac Surgical Procedures ; Postoperative Complications
    Chemical Substances Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2300127
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  3. Article ; Online: How should we measure research impact in paediatric cardiology?

    Hill, Kevin D / Jenkins, Kathy J

    Cardiology in the young

    2021  Volume 31, Issue 7, Page(s) 1205–1206

    MeSH term(s) Cardiology ; Child ; Humans
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951121002675
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  4. Article ; Online: Prenatal Diagnosis, Management, and Treatment of Fetal Cardiac Disease.

    Sethi, Neeta / Miller, Stephen / Hill, Kevin D

    NeoReviews

    2023  Volume 24, Issue 5, Page(s) e285–e299

    Abstract: Prenatal diagnosis of congenital heart disease makes it possible to optimize and coordinate care of the fetus and pregnant person. Benefits encompass the full spectrum of pre- and perinatal care, from counseling to optimization of pregnancy care and ... ...

    Abstract Prenatal diagnosis of congenital heart disease makes it possible to optimize and coordinate care of the fetus and pregnant person. Benefits encompass the full spectrum of pre- and perinatal care, from counseling to optimization of pregnancy care and fetal intervention. Prenatal diagnosis reduces the likelihood of postnatal hemodynamic compromise and improves long-term neurodevelopmental outcomes. Despite the benefits, prenatal diagnosis rates remain suboptimal, particularly for lesions that are not seen on standard 4-chamber imaging views. Improving prenatal diagnosis rates requires education and outreach efforts targeting community practices where most initial screening occurs.
    MeSH term(s) Pregnancy ; Female ; Humans ; Prenatal Diagnosis ; Fetal Diseases/diagnosis ; Fetal Diseases/therapy ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/therapy ; Fetus ; Prenatal Care/methods
    Language English
    Publishing date 2023-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1526-9906
    ISSN (online) 1526-9906
    DOI 10.1542/neo.24-5-e285
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  5. Article ; Online: A point-of-care pharmacokinetic/pharmacodynamic trial in critically ill children: Study design and feasibility.

    Thompson, Elizabeth J / Foote, Henry P / Hill, Kevin D / Hornik, Christoph P

    Contemporary clinical trials communications

    2023  Volume 35, Page(s) 101182

    Abstract: Background: High-quality, efficient, pharmacokinetic (PK), pharmacodynamic (PD), and safety studies in children are needed. Point-of-care trials in adults have facilitated clinical trial participation for patients and providers, minimized the disruption ...

    Abstract Background: High-quality, efficient, pharmacokinetic (PK), pharmacodynamic (PD), and safety studies in children are needed. Point-of-care trials in adults have facilitated clinical trial participation for patients and providers, minimized the disruption of clinical workflow, and capitalized on routine data collection. The feasibility and value of point-of-care trials to study PK/PD in children are unknown, but appear promising. The Opportunistic PK/PD Trial in Critically Ill Children with Heart Disease (OPTIC) is a programmatic point-of-care approach to PK/PD trials in critically ill children that seeks to overcome barriers of traditional pediatric PK/PD studies to generate safety, efficacy, PK, and PD data across multiple medications, ages, and disease processes.
    Methods: This prospective, open-label, non-randomized point-of-care trial will characterize the PK/PD and safety of multiple drugs given per routine care to critically ill children with heart disease using opportunistic and scavenged biospecimen samples and data collected from the electronic health record. OPTIC has one informed consent form with drug-specific appendices, streamlining study structure and institutional review board approval. OPTIC capitalizes on routine data collection through multiple data sources that automatically capture demographics, medications, laboratory values, vital signs, flowsheets, and other clinical data. This innovative automatic data collection minimizes the burden of data collection and facilitates trial conduct. Data will be validated across sources to ensure accuracy of dataset variables.
    Discussion: OPTIC's point-of-care trial design and automated data acquisition via the electronic health record may provide a mechanism for conducting minimal risk, minimal burden, high efficiency trials and support drug development in historically understudied patient populations.
    Trial registration: clinicaltrials.gov number: NCT05055830. Registered on September 24, 2021.
    Language English
    Publishing date 2023-07-07
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2451-8654
    ISSN (online) 2451-8654
    DOI 10.1016/j.conctc.2023.101182
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  6. Article ; Online: The Wormholes Within: A Study of 1, 3, 5-Triamino-2, 4, 6-Trinitrobenzene Crystal Morphology by Micro and Nano-scale X-Ray Computed Tomography.

    Patterson, Brian M / Kuettner, Lindsey / Henderson, Kevin / Yeager, John D / Hill, Larry

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue Supplement_1, Page(s) 215–216

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.095
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  7. Article ; Online: Extending the volume-outcomes debate into the world of congenital cardiac catheterization.

    Hill, Kevin D

    American heart journal

    2016  Volume 183, Page(s) 115–117

    MeSH term(s) Cardiac Catheterization ; Heart Defects, Congenital ; Humans ; Infant
    Language English
    Publishing date 2016-10-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2016.09.017
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    Ui IV Zs.15: Show issues Location:
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  8. Article ; Online: Preoperative Hemodynamics Impact the Benefit of Fenestration on Fontan Postoperative Length of Stay.

    Hill, Garick D / Wu, Danny T Y / Ferguson, M Eric / Flores, Saul / Ginde, Salil / Hill, Kevin D / Johansen, Michael / Newburger, Jane W / Gao, Zhiqian / Cnota, James F

    JACC. Advances

    2024  Volume 3, Issue 3

    Abstract: Background: Utilization of Fontan fenestration varies considerably by center.: Objectives: Using a multicenter Pediatric Heart Network dataset linking surgical and preoperative hemodynamic variables, the authors evaluated factors associated with use ... ...

    Abstract Background: Utilization of Fontan fenestration varies considerably by center.
    Objectives: Using a multicenter Pediatric Heart Network dataset linking surgical and preoperative hemodynamic variables, the authors evaluated factors associated with use of Fontan fenestration and the impact of fenestration on post-Fontan length of stay (LOS).
    Methods: Patients 2 to 6 years old at Fontan surgery from 2010 to 2020 with catheterization<1 year prior were included. Factors associated with fenestration were evaluated using multivariable logistic regression adjusting for key covariates. Restrictive cubic spline analysis was used to evaluate potential cut-points for hemodynamic variables associated with longer postoperative LOS stratified by fenestration with multivariable linear regression to evaluate the magnitude of effect.
    Results: Fenestration was used in 465 of 702 patients (66.2%). Placement of a fenestration was associated with center (range 27%-93% use,
    Conclusions: There is wide center variability in use of Fontan fenestration that is not explained by preoperative hemodynamics. Fenestration is independently associated with shorter LOS, and those with mPAP ≥13 mm Hg at pre-Fontan catheterization benefit the most. We propose this threshold as minimal criteria for fenestration.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2772-963X
    ISSN (online) 2772-963X
    DOI 10.1016/j.jacadv.2024.100846
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  9. Article ; Online: Umbilical cord clamping among infants with a prenatal diagnosis of congenital heart disease.

    Fite, Elliott L / Rivera, Brian K / McNabb, Riley / Smith, Charles V / Hill, Kevin D / Katheria, Anup / Maitre, Nathalie / Backes, Carl H

    Seminars in perinatology

    2023  Volume 47, Issue 4, Page(s) 151747

    MeSH term(s) Pregnancy ; Female ; Humans ; Infant ; Infant, Newborn ; Umbilical Cord Clamping ; Infant, Premature ; Gestational Age ; Prenatal Diagnosis ; Heart Defects, Congenital/diagnosis ; Umbilical Cord
    Language English
    Publishing date 2023-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752403-1
    ISSN 1558-075X ; 0146-0005
    ISSN (online) 1558-075X
    ISSN 0146-0005
    DOI 10.1016/j.semperi.2023.151747
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  10. Article ; Online: Generation of Functionalized Azepinone Derivatives via a (4 + 3)-Cycloaddition of Vinyl Ketenes and α-Imino Carbenes Derived from

    Hill, Harrison M / Tucker, Zachary D / Rodriguez, Kevin X / Wendt, Katelyn A / Ashfeld, Brandon L

    The Journal of organic chemistry

    2022  Volume 87, Issue 5, Page(s) 3825–3833

    Abstract: An intermolecular ... ...

    Abstract An intermolecular Rh
    MeSH term(s) Catalysis ; Cycloaddition Reaction ; Rhodium ; Triazoles
    Chemical Substances Triazoles ; Rhodium (DMK383DSAC)
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.1c03002
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