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  1. Article ; Online: [Surfactant therapy of respiratory distress syndrome].

    Verder, Henrik / Heiring, Christian / Schousboe, Peter

    Ugeskrift for laeger

    2021  Volume 183, Issue 44

    Abstract: This review gives a summary of the development of a method to measure lung surfactant on gastric aspirate at birth in premature infants with the purpose to threat respiratory distress syndrome early with targeted surfactant. Machine learning was used to ... ...

    Abstract This review gives a summary of the development of a method to measure lung surfactant on gastric aspirate at birth in premature infants with the purpose to threat respiratory distress syndrome early with targeted surfactant. Machine learning was used to create the algorithm, and a point-of-care spectrometer was constructed for use in the delivery room. The sensitivity was 91% and specificity 79% in a clinical trial. The same method was used to measure surfactant in tracheal fluid in patients with COVID-19 since lung surfactant may be diminished in these patients.
    MeSH term(s) COVID-19 ; Humans ; Infant ; Infant, Newborn ; Pulmonary Surfactants/therapeutic use ; Respiratory Distress Syndrome, Newborn/drug therapy ; SARS-CoV-2 ; Surface-Active Agents/therapeutic use
    Chemical Substances Pulmonary Surfactants ; Surface-Active Agents
    Language Danish
    Publishing date 2021-11-16
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  2. Article ; Online: Spatial analysis of photoplethysmography in cutaneous squamous cell carcinoma.

    Rasmussen, Simon Mylius / Nielsen, Thomas / Hager, Henrik / Schousboe, Lars Peter

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 7318

    Abstract: The primary treatment of the common malignancy squamous cell carcinoma is surgical removal. In this process, sufficient tissue removal is balanced against unnecessary mutilation. We recently presented a remote photoplethysmography algorithm, which ... ...

    Abstract The primary treatment of the common malignancy squamous cell carcinoma is surgical removal. In this process, sufficient tissue removal is balanced against unnecessary mutilation. We recently presented a remote photoplethysmography algorithm, which revealed significant differences between processed video recordings of cancer biopsy areas and surrounding tissue. The aim of this study was to investigate whether spatial analyses of photoplethysmography data correlate with post-excision pathological analyses and thus have potential to assist in tumour delineation. Based on high speed video recordings of 11 patients with squamous cell carcinoma, we examined different parameters derived from temporal remote photoplethysmography variations. Signal characteristics values in sites matching histological sections were compared with pathological measures. Values were ranked and statistically tested with a Kendall correlation analysis. A moderate, negative correlation was found between signal oscillations and the width and transversal area of squamous cell carcinoma in the frequencies below 1 Hz and specifically from 0.02 to 0.15 Hz. We have presented a correlation between frequency content and prevalence of cancer based on regular video recordings of squamous cell carcinoma. We believe this is supported by published findings on malignant melanoma. Our findings indicate that photoplethysmography can be used to distinguish SCC from healthy skin.
    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Humans ; Melanoma ; Photoplethysmography ; Skin Neoplasms/pathology ; Spatial Analysis
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-10924-3
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  3. Article ; Online: Author Correction: Photoplethysmography for demarcation of cutaneous squamous cell carcinoma.

    Rasmussen, Simon Mylius / Nielsen, Thomas / Hody, Sofie / Hager, Henrik / Schousboe, Lars Peter

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3521

    Language English
    Publishing date 2022-02-25
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-06856-7
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  4. Article ; Online: Early prediction of bronchopulmonary dysplasia is possible and important.

    Verder, Henrik / Heiring, Christian / Verder, Povl / Schousboe, Peter

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 110, Issue 2, Page(s) 725

    MeSH term(s) Artificial Intelligence ; Bronchopulmonary Dysplasia/diagnosis ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Parturition ; Pregnancy
    Language English
    Publishing date 2020-09-01
    Publishing country Norway
    Document type Letter ; Comment
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15508
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  5. Article ; Online: Spatial analysis of photoplethysmography in cutaneous squamous cell carcinoma

    Simon Mylius Rasmussen / Thomas Nielsen / Henrik Hager / Lars Peter Schousboe

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 10

    Abstract: Abstract The primary treatment of the common malignancy squamous cell carcinoma is surgical removal. In this process, sufficient tissue removal is balanced against unnecessary mutilation. We recently presented a remote photoplethysmography algorithm, ... ...

    Abstract Abstract The primary treatment of the common malignancy squamous cell carcinoma is surgical removal. In this process, sufficient tissue removal is balanced against unnecessary mutilation. We recently presented a remote photoplethysmography algorithm, which revealed significant differences between processed video recordings of cancer biopsy areas and surrounding tissue. The aim of this study was to investigate whether spatial analyses of photoplethysmography data correlate with post-excision pathological analyses and thus have potential to assist in tumour delineation. Based on high speed video recordings of 11 patients with squamous cell carcinoma, we examined different parameters derived from temporal remote photoplethysmography variations. Signal characteristics values in sites matching histological sections were compared with pathological measures. Values were ranked and statistically tested with a Kendall correlation analysis. A moderate, negative correlation was found between signal oscillations and the width and transversal area of squamous cell carcinoma in the frequencies below 1 Hz and specifically from 0.02 to 0.15 Hz. We have presented a correlation between frequency content and prevalence of cancer based on regular video recordings of squamous cell carcinoma. We believe this is supported by published findings on malignant melanoma. Our findings indicate that photoplethysmography can be used to distinguish SCC from healthy skin.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Author Correction

    Simon Mylius Rasmussen / Thomas Nielsen / Sofie Hody / Henrik Hager / Lars Peter Schousboe

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    Photoplethysmography for demarcation of cutaneous squamous cell carcinoma

    2022  Volume 2

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Photoplethysmography for demarcation of cutaneous squamous cell carcinoma.

    Rasmussen, Simon Mylius / Nielsen, Thomas / Hody, Sofie / Hager, Henrik / Schousboe, Lars Peter

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 21467

    Abstract: A video processing algorithm designed to identify cancer suspicious skin areas is presented here. It is based on video recordings of squamous cell carcinoma in the skin. Squamous cell carcinoma is a common malignancy, normally treated by surgical removal. ...

    Abstract A video processing algorithm designed to identify cancer suspicious skin areas is presented here. It is based on video recordings of squamous cell carcinoma in the skin. Squamous cell carcinoma is a common malignancy, normally treated by surgical removal. The surgeon should always balance sufficient tissue removal against unnecessary mutilation, and therefore methods for distinction of cancer boundaries are wanted. Squamous cell carcinoma has angiogenesis and increased blood supply. Remote photoplethysmography is an evolving technique for analysis of signal variations in video recordings in order to extract vital signs such as pulsation. We hypothesize that the remote photoplethysmography signal inside the area of a squamous cell carcinoma is significantly different from the surrounding healthy skin. Based on high speed video recordings of 13 patients with squamous cell carcinoma, we have examined temporal signal differences in cancer areas versus healthy skin areas. A significant difference in temporal signal changes between cancer areas and healthy areas was found. Our video processing algorithm showed promising results encouraging further investigation to clarify how detailed distinctions can be made.
    MeSH term(s) Aged ; Aged, 80 and over ; Algorithms ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Male ; Middle Aged ; Photoplethysmography/methods ; Signal Processing, Computer-Assisted ; Skin/cytology ; Skin/diagnostic imaging ; Skin Neoplasms/diagnostic imaging ; Skin Neoplasms/pathology ; Video Recording/methods
    Language English
    Publishing date 2021-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-00645-4
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  8. Article ; Online: [Objective tinnitus].

    Shifan, Sathya S / Schousboe, Lars Peter / Marker, Frank

    Ugeskrift for laeger

    2018  Volume 180, Issue 37

    Abstract: Objective tinnitus is a known but rare otologic symptom. This is a case report about a six-year-old boy, who was referred to a hearing clinic for further investigation of an audible clicking sound. He experienced clicking sounds, and his parents were ... ...

    Abstract Objective tinnitus is a known but rare otologic symptom. This is a case report about a six-year-old boy, who was referred to a hearing clinic for further investigation of an audible clicking sound. He experienced clicking sounds, and his parents were able to hear the sounds when listening nearby. This objective tinnitus is caused by myoclonus of either the m. tensor tympani or the m. stapedius. We discuss methods to evaluate objective tinnitus including the clinical use of a stethoscope and also the possibility of using impedance measuring in patients with objective tinnitus.
    MeSH term(s) Child ; Humans ; Male ; Myoclonus/complications ; Sound ; Stethoscopes ; Tinnitus/diagnosis ; Tinnitus/etiology
    Language Danish
    Publishing date 2018-09-26
    Publishing country Denmark
    Document type Case Reports
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  9. Article ; Online: Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand. Role of ammonia-induced increased GABAergic tone.

    Sørensen, Michael / Walls, Anne Byriel / Dam, Gitte / Bak, Lasse Kristoffer / Andersen, Jens Velde / Ott, Peter / Vilstrup, Hendrik / Schousboe, Arne

    Analytical biochemistry

    2022  Volume 654, Page(s) 114766

    Abstract: Hepatic encephalopathy (HE) is a frequent and devastating but generally reversible neuropsychiatric complication secondary to chronic and acute liver failure. During HE, brain energy metabolism is markedly reduced and it remains unclear whether this is ... ...

    Abstract Hepatic encephalopathy (HE) is a frequent and devastating but generally reversible neuropsychiatric complication secondary to chronic and acute liver failure. During HE, brain energy metabolism is markedly reduced and it remains unclear whether this is due to external or internal energy supply limitations, or secondary to depressed neuronal cellular functions - and if so, which mechanisms that are in play. The extent of deteriorated cerebral function correlates to blood ammonia levels but the metabolic link to ammonia is not clear. Early studies suggested that high levels of ammonia inhibited key tricarboxylic acid (TCA) cycle enzymes thus limiting mitochondrial energy production and oxygen consumption; however, later studies by us and others showed that this is not the case in vivo. Here, based on a series of translational studies from our group, we advocate the view that the low cerebral energy metabolism of HE is likely to be caused by neuronal metabolic depression due to an elevated GABAergic tone rather than by restricted energy availability. The increased GABAergic tone seems to be secondary to synthesis of large amounts of glutamine in astrocytes for detoxification of ammonia with the glutamine acting as a precursor for elevated neuronal synthesis of vesicular GABA.
    MeSH term(s) Ammonia/metabolism ; Brain/metabolism ; Energy Metabolism ; Glutamine/metabolism ; Hepatic Encephalopathy/etiology ; Hepatic Encephalopathy/metabolism ; Humans ; Hyperammonemia/metabolism ; Neurons/metabolism
    Chemical Substances Glutamine (0RH81L854J) ; Ammonia (7664-41-7)
    Language English
    Publishing date 2022-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1110-1
    ISSN 1096-0309 ; 0003-2697
    ISSN (online) 1096-0309
    ISSN 0003-2697
    DOI 10.1016/j.ab.2022.114766
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  10. Article ; Online: No Detectable Coagulation Activation After Vitamin K (MK-7) Supplementation in Patients on Dialysis With Functional Vitamin K Deficiency: A One-Year Randomized, Placebo-Controlled Study.

    Bladbjerg, Else-Marie / Levy-Schousboe, Karin / Frimodt-Møller, Marie / Kjærgaard, Krista D / Strandhave, Charlotte / Brasen, Claus L / Frandsen, Niels Erik / Hansen, Ditte / Marckmann, Peter

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

    2023  

    Abstract: Objective: Patients on dialysis treatment have poor functional vitamin K status, and this may increase the risk of vascular calcification. Vitamin K supplementation may therefore be relevant in patients on dialysis, but the procoagulant effects have not ...

    Abstract Objective: Patients on dialysis treatment have poor functional vitamin K status, and this may increase the risk of vascular calcification. Vitamin K supplementation may therefore be relevant in patients on dialysis, but the procoagulant effects have not been studied. We evaluated effects of menaquinone-7 (MK-7) supplementation on biomarkers of coagulation in patients on dialysis.
    Methods: Double-blinded, placebo-controlled study in 123 patients on dialysis randomized to 52 weeks of vitamin K (MK-7, 360 μg/daily, n = 61) or placebo (n = 62). Measurements at baseline and after 52 weeks of intervention included thrombin generation (endogenous thrombin potential, peak thrombin concentration, time to peak, and lag time); clot activities of vitamin K-dependent coagulation factors (F) II, VII, IX, and X; prothrombin fragment 1 + 2 (F1+2); and proteins induced by vitamin K absence II (PIVKA-II). Between-group differences (vitamin K vs. placebo) at 52 weeks were determined with an analysis of covariance. Within-group changes in vitamin K and placebo groups were analyzed with a paired t-test. Vascular adverse events and serious adverse events were registered based on hospital records, laboratory data, and participant interviews and compared between groups using Fisher's exact test or Pearson's Chi-Squared test.
    Results: A between-group difference at 52 weeks was observed for PIVKA-II (P < .001). PIVKA-II decreased significantly from baseline to 52 weeks in the vitamin K group, but not in the placebo group. We observed no between-group differences or within-group changes for biomarkers of coagulation, except for FVII clot activity which was reduced in the placebo group (P = .04), and no between-group differences in adverse events and serious adverse events.
    Conclusion: One year of vitamin K supplementation in patients on dialysis has no detectable effects on biomarkers of coagulation activation, clot activities of vitamin K-dependent coagulation factors, and vascular events or death, indicating no procoagulant effects of this treatment.
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1080003-7
    ISSN 1532-8503 ; 1051-2276
    ISSN (online) 1532-8503
    ISSN 1051-2276
    DOI 10.1053/j.jrn.2023.11.007
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