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  1. Article ; Online: Reduced tubuloglomerular feedback activity and absence of its synchronization in a connexin40 knockout rat.

    More, Heather L / Braam, Branko / Cupples, William A

    Frontiers in network physiology

    2023  Volume 3, Page(s) 1208303

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2674-0109
    ISSN (online) 2674-0109
    DOI 10.3389/fnetp.2023.1208303
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  2. Article ; Online: Modulation of the expression of connexins 37, 40, and 43 in endothelial cells in a culture.

    Zhuang, Wenqing / Mitrou, Nick G A / Kulak, Steve / Cupples, William A / Braam, Branko

    Frontiers in network physiology

    2024  Volume 4, Page(s) 1199198

    Abstract: Connexin (Cx) 37, 40, and 43 are implicated in vascular function, specifically in the electrical coupling of endothelial cells and vascular smooth-muscle cells. In the present study, we investigated whether factors implicated in vascular dysfunction can ... ...

    Abstract Connexin (Cx) 37, 40, and 43 are implicated in vascular function, specifically in the electrical coupling of endothelial cells and vascular smooth-muscle cells. In the present study, we investigated whether factors implicated in vascular dysfunction can modulate the gene expression of Cx37, Cx40, and Cx43 and whether this is associated with changes in endothelial layer barrier function in human microvascular endothelial cells (HMEC-1). First, HMEC-1 were subjected to stimuli for 4 and 8 h. We tested their responses to DETA-NONOate, H
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2674-0109
    ISSN (online) 2674-0109
    DOI 10.3389/fnetp.2024.1199198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: At last! Quantitative cortical vascular anatomy.

    Cupples, William A

    American journal of physiology. Renal physiology

    2017  Volume 314, Issue 5, Page(s) F928–F929

    MeSH term(s) Kidney
    Language English
    Publishing date 2017-12-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00623.2017
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  4. Article ; Online: Tubuloglomerular Feedback Synchronization in Nephrovascular Networks.

    Zehra, Tayyaba / Cupples, William A / Braam, Branko

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 6, Page(s) 1293–1304

    Abstract: To perform their functions, the kidneys maintain stable blood perfusion in the face of fluctuations in systemic BP. This is done through autoregulation of blood flow by the generic myogenic response and the kidney-specific tubuloglomerular feedback (TGF) ...

    Abstract To perform their functions, the kidneys maintain stable blood perfusion in the face of fluctuations in systemic BP. This is done through autoregulation of blood flow by the generic myogenic response and the kidney-specific tubuloglomerular feedback (TGF) mechanism. The central theme of this paper is that, to achieve autoregulation, nephrons do not work as single units to manage their individual blood flows, but rather communicate electrically over long distances to other nephrons
    MeSH term(s) Animals ; Arterioles ; Blood Pressure ; Connexins/metabolism ; Feedback, Physiological ; Homeostasis ; Humans ; Kidney Diseases/physiopathology ; Kidney Glomerulus/physiology ; Kidney Tubules/physiology ; Nephrons/physiology ; Renal Circulation/physiology ; Signal Transduction
    Chemical Substances Connexins
    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2020040423
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    Zs.A 3344: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Myoendothelial communication in the renal vasculature and the impact of drugs used clinically to treat hypertension.

    Sorensen, Charlotte Mehlin / Cupples, William A

    Current opinion in pharmacology

    2019  Volume 45, Page(s) 49–56

    Abstract: The renal vasculature has many peculiarities including highly irregular branching. Renal blood flow must sustain adequate perfusion and maintain a high glomerular filtration. Renal autoregulation helps control renal blood flow. The local autoregulatory ... ...

    Abstract The renal vasculature has many peculiarities including highly irregular branching. Renal blood flow must sustain adequate perfusion and maintain a high glomerular filtration. Renal autoregulation helps control renal blood flow. The local autoregulatory mechanism, tubuloglomerular feedback, elicits a vasoconstriction that can be found not only in neighboring nephrons but over large areas of the kidney indicating that the renal vasculature supports strong conduction of vascular responses. The basis for conduction is intercellular communication through gap junctions. The endothelium is strongly coupled and serves as a vascular conduction highway leading the signal to the vascular smooth muscle cells through myoendothelial coupling. Extensive intercellular coupling is also found in renin secreting cells where gap junctions seem to tie the cells together to improve control of renin secretion. Lack of coupling leads to dysregulation of renin secretion and hypertension. However, the activity of the renin-angiotensin system also controls gap junction expression in the kidney. Treatment reducing angiotensin II activity, as used in hypertension treatment, can affect expression of renal and vascular gap junction.
    MeSH term(s) Animals ; Antihypertensive Agents/pharmacology ; Cell Communication/drug effects ; Connexins/physiology ; Endothelial Cells/drug effects ; Endothelial Cells/physiology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiology ; Gap Junctions/drug effects ; Gap Junctions/physiology ; Humans ; Kidney/drug effects ; Kidney/physiology ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/physiology
    Chemical Substances Antihypertensive Agents ; Connexins
    Language English
    Publishing date 2019-05-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2019.04.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5608: Show issues Location:
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  6. Article ; Online: Surgical trauma is associated with renal immune cell activation in rats: A microarray study.

    Hultström, Michael / Peng, Di / Becirovic Agic, Mediha / Cupples, Claire G / Cupples, William A / Mitrou, Nicholas

    Physiological reports

    2021  Volume 9, Issue 23, Page(s) e15142

    Abstract: Acute kidney injury (AKI) is a common perioperative complication that is associated with increased mortality. This study investigates the renal gene expression in male Long-Evans rats after prolonged anesthesia and surgery to detect molecular mechanisms ... ...

    Abstract Acute kidney injury (AKI) is a common perioperative complication that is associated with increased mortality. This study investigates the renal gene expression in male Long-Evans rats after prolonged anesthesia and surgery to detect molecular mechanisms that could predispose the kidneys to injury upon further insults. Healthy and streptozotocin diabetic rats that underwent autoregulatory investigation in an earlier study were compared to rats that were sacrificed quickly for mRNA quantification in the same study. Prolonged surgery caused massive changes in renal mRNA expression by microarray analysis, which was validated by quantitative real-time PCR with good correlation. Furthermore, bioinformatics analysis using gene ontology and pathway analysis identified biological processes involved in immune system activation, such as immune system processes (p = 1.3 × 10
    MeSH term(s) Acute Kidney Injury/genetics ; Acute Kidney Injury/metabolism ; Animals ; Cytokines/metabolism ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Disease Models, Animal ; Homeostasis/physiology ; Immunity/genetics ; Inflammation/genetics ; Inflammation/metabolism ; Kidney/metabolism ; Male ; Microarray Analysis ; Rats ; Rats, Long-Evans
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15142
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  7. Article: Chronic, Combined Cardiac and Renal Dysfunction Exacerbates Renal Venous Pressure-Induced Suppression of Renal Function in Rats.

    Hamza, Shereen M / Huang, Xiaohua / Zehra, Tayyaba / Zhuang, Wenqing / Cupples, William A / Braam, Branko

    Frontiers in physiology

    2022  Volume 13, Page(s) 781504

    Abstract: Background and objective: Increased renal venous pressure (RVP) is common in combined heart and kidney failure. We previously showed that acute RVP elevation depresses renal blood flow (RBF), glomerular filtration rate (GFR), and induces renal ... ...

    Abstract Background and objective: Increased renal venous pressure (RVP) is common in combined heart and kidney failure. We previously showed that acute RVP elevation depresses renal blood flow (RBF), glomerular filtration rate (GFR), and induces renal vasoconstriction in the absence of changes in blood pressure in healthy rats. We used our established rodent model of chronic combined heart and kidney failure (H/KF) to test whether RVP elevation would impair cardiovascular stability, renal perfusion and exacerbate renal dysfunction.
    Methods: Male rats were subjected to 5/6 nephrectomy (SN
    Results: Baseline MAP, HR, RBF, and renal vascular conductance (RVC) were comparable among groups. Baseline GFR was significantly depressed in CL + SN
    Conclusion: Chronic combined heart and kidney failure primarily impairs renal hemodynamic stability in response to elevated RVP compared to healthy rats.
    Language English
    Publishing date 2022-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.781504
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  8. Article: Angiotensin II and the Renal Hemodynamic Response to an Isolated Increased Renal Venous Pressure in Rats.

    Huang, Xiaohua / Hamza, Shereen M / Zhuang, Wenqing / Cupples, William A / Braam, Branko

    Frontiers in physiology

    2021  Volume 12, Page(s) 753355

    Abstract: Elevated central venous pressure increases renal venous pressure (RVP) which can affect kidney function. We previously demonstrated that increased RVP reduces renal blood flow (RBF), glomerular filtration rate (GFR), and renal vascular conductance (RVC). ...

    Abstract Elevated central venous pressure increases renal venous pressure (RVP) which can affect kidney function. We previously demonstrated that increased RVP reduces renal blood flow (RBF), glomerular filtration rate (GFR), and renal vascular conductance (RVC). We now investigate whether the RAS and RBF autoregulation are involved in the renal hemodynamic response to increased RVP. Angiotensin II (ANG II) levels were clamped by infusion of ANG II after administration of an angiotensin-converting enzyme (ACE) inhibitor in male Lewis rats. This did not prevent the decrease in ipsilateral RBF (-1.9±0.4ml/min,
    Language English
    Publishing date 2021-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.753355
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  9. Article ; Online: Access to Transplant Care and Services Within the Veterans Health Administration.

    Gunnar, William / Bronson, Douglas A / Cupples, Sandra A

    Federal practitioner : for the health care professionals of the VA, DoD, and PHS

    2017  Volume 35, Issue 8, Page(s) 12–21

    Abstract: The VHA provides timely solid organ transplant care and services with outcomes comparable to that of nationally reported estimates. ...

    Abstract The VHA provides timely solid organ transplant care and services with outcomes comparable to that of nationally reported estimates.
    Language English
    Publishing date 2017-12-12
    Publishing country United States
    Document type Journal Article
    ISSN 1945-337X
    ISSN (online) 1945-337X
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  10. Article ; Online: Chronic elevation of renal venous pressure induces extensive renal venous collateral formation and modulates renal function and cardiovascular stability in rats.

    Hamza, Shereen M / Huang, Xiaohua / Zehra, Tayyaba / Zhuang, Wenqing / Cupples, William A / Braam, Branko

    American journal of physiology. Renal physiology

    2020  Volume 319, Issue 1, Page(s) F76–F83

    Abstract: Acutely increased renal venous pressure (RVP) impairs renal function, but the long-term impact is unknown. We investigated whether chronic RVP elevation impairs baseline renal function and prevents exacerbation of renal dysfunction and cardiovascular ... ...

    Abstract Acutely increased renal venous pressure (RVP) impairs renal function, but the long-term impact is unknown. We investigated whether chronic RVP elevation impairs baseline renal function and prevents exacerbation of renal dysfunction and cardiovascular instability upon further RVP increase. RVP elevation (20-25 mmHg) or sham operation (sham) was performed in rats. After 1 wk (
    MeSH term(s) Animals ; Blood Pressure/physiology ; Glomerular Filtration Rate/physiology ; Heart Rate/physiology ; Hemodynamics/physiology ; Hypertension, Renal/physiopathology ; Kidney/blood supply ; Kidney/physiopathology ; Male ; Rats ; Rats, Inbred Lew ; Renal Circulation/physiology ; Renal Veins/physiopathology
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00542.2019
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