Result 1 - 10 of total 135
Archivos de Bronconeumología
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #799108 |
| Database | COVID19 |
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2024 Volume 96, Issue 3, Page(s) e29499
Abstract: Respiratory syncytial virus is associated with lower respiratory tract infections. As several types and genotypes can circulate at the same time, genomic characterization is important for timely epidemiological control and treatment measures. In the last ...
| Abstract | Respiratory syncytial virus is associated with lower respiratory tract infections. As several types and genotypes can circulate at the same time, genomic characterization is important for timely epidemiological control and treatment measures. In the last 6 seasons (2017-2023), 191 236 nasopharyngeal swabs were processed for respiratory viruses to determine the etiology of acute respiratory infections, describe the incidence and distribution of RSV types and enrich the data of epidemiological molecular studies on RSV in Spain. The incidence of RSV reached 7% in the pre-pandemic season. RSV was most frequent in children under 5 years of age (12.6%), but was also significant in those over 70 years of age (5.63%). The measures taken to control SARS-CoV-2 infection were useful for RSV control and the incidence decreased to 1.8%, but caused a change in the types. Pre-pandemic, the majority circulating types were RSV-B/RSV-B/RSV-A and in the pandemic it was RSV-B/RSV-B. In the last season, RSV-B and RSV-A were detected in the same proportion. Genetic characterization showed three new clades. This has been taken into account to understand the epidemiology as well as the development of therapeutic and preventive strategies. |
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| MeSH term(s) | Child ; Humans ; Infant ; Child, Preschool ; Aged ; Aged, 80 and over ; Seasons ; SARS-CoV-2/genetics ; Respiratory Syncytial Virus Infections/epidemiology ; Spain/epidemiology ; Incidence ; Pandemics ; COVID-19/epidemiology ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Tract Infections |
| Language | English |
| Publishing date | 2024-03-11 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 752392-0 |
| ISSN | 1096-9071 ; 0146-6615 |
| ISSN (online) | 1096-9071 |
| ISSN | 0146-6615 |
| DOI | 10.1002/jmv.29499 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1320: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 59, Issue 8, Page(s) 497–501
Abstract: Introduction: Patients with obesity hypoventilation syndrome (OHS) need treatment with positive pressure either with continuous (CPAP) or double pressure (NIV). The apnea-hypopnea index (AHI) is considered a key data for making therapeutic decisions. We ...
| Abstract | Introduction: Patients with obesity hypoventilation syndrome (OHS) need treatment with positive pressure either with continuous (CPAP) or double pressure (NIV). The apnea-hypopnea index (AHI) is considered a key data for making therapeutic decisions. We hypothesized that HR may be an useful tool to establish different phenotypes and individualize treatment in patients with OHS. Our objective was to analyze the role of the respiratory center response to hypercapnia (HR) in the adequacy of positive airway pressure therapy. Method: We included subjects with OHS treated with CPAP or NIV according to AHI and baseline pCO Results: 67 subjects were included of 68(11) years old, 37 (55%) males, initially 45 (67%) treated with NIV and 22 (33%) with CPAP, one case was excluded and in 25 (38%) the treatment was changed. Finally, CPAP was adequate for 29 subjects (44%) and NIV for 37 (56%). The CPAP group showed AHI 57/h (24) and p0.1/pEtCO Conclusion: Measuring the RH of the respiratory center helps to select the most appropriate treatment for patients with OHS. |
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| MeSH term(s) | Male ; Female ; Humans ; Obesity Hypoventilation Syndrome/therapy ; Respiratory Center ; Continuous Positive Airway Pressure ; Noninvasive Ventilation ; Respiratory Physiological Phenomena ; Hypercapnia/etiology ; Hypercapnia/therapy |
| Language | Spanish |
| Publishing date | 2023-06-01 |
| Publishing country | Spain |
| Document type | Journal Article |
| ZDB-ID | 733126-5 |
| ISSN | 1579-2129 ; 0300-2896 |
| ISSN (online) | 1579-2129 |
| ISSN | 0300-2896 |
| DOI | 10.1016/j.arbres.2023.05.013 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 2655: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 14, Page(s) 1267315
Abstract: Background: ...
| Abstract | Background: |
|---|---|
| Language | English |
| Publishing date | 2023-10-11 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2564217-0 |
| ISSN | 1664-042X |
| ISSN | 1664-042X |
| DOI | 10.3389/fphys.2023.1267315 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2022 Volume 58, Issue 10, Page(s) 718–721
| MeSH term(s) | Bronchoscopy ; Humans ; Lymph Nodes/pathology ; Mediastinum |
|---|---|
| Language | Spanish |
| Publishing date | 2022-05-30 |
| Publishing country | Spain |
| Document type | Case Reports |
| ZDB-ID | 733126-5 |
| ISSN | 1579-2129 ; 0300-2896 |
| ISSN (online) | 1579-2129 |
| ISSN | 0300-2896 |
| DOI | 10.1016/j.arbres.2022.05.006 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 2655: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Journal of fungi (Basel, Switzerland)
2022 Volume 8, Issue 2
Abstract: Our study aims to assess the prevalence of CAPA (COVID-19-associated pulmonary aspergillosis) and describe the associated risk factors and their impact on mortality. A prospective study was conducted. We included patients with COVID-19 disease who were ... ...
| Abstract | Our study aims to assess the prevalence of CAPA (COVID-19-associated pulmonary aspergillosis) and describe the associated risk factors and their impact on mortality. A prospective study was conducted. We included patients with COVID-19 disease who were admitted to the ICU with a diagnosis of respiratory failur. Mycological culture and other biomarkers (calcofluor staining, LFD, LFA, PCR, GM, and B-D-glucan) were performed. A total of 300 patients were included in the study. Thirty-five patients were diagnosed with CAPA (prevalence 11.7%). During admission, 57 patients died (19%), and, in the group of CAPA patients, mortality was 31.4%. In multivariate analysis, independent risk factors associated with CAPA diagnosis were age (OR: 1.05; 95% CI 1.01-1.09; |
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| Language | English |
| Publishing date | 2022-01-19 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2784229-0 |
| ISSN | 2309-608X ; 2309-608X |
| ISSN (online) | 2309-608X |
| ISSN | 2309-608X |
| DOI | 10.3390/jof8020097 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 9, Issue 2
Abstract: Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the technique of choice in the study of mediastinal and hilar lesions; however, it can be affected by the insufficiency of intact biopsy samples, which might ... ...
| Abstract | Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the technique of choice in the study of mediastinal and hilar lesions; however, it can be affected by the insufficiency of intact biopsy samples, which might decrease its diagnostic yield for certain conditions, thus requiring re-biopsies or additional diagnostic procedures such as mediastinoscopy when the probability of malignancy remains high. Our objectives were to 1) attempt to reproduce this technique in the same conditions that we performed EBUS-TBNA, Methods: This was a prospective study of 50 patients who underwent EBUS-TBNA and EBUS-guided transbronchial mediastinal cryobiopsy (TMC) in a single procedure using a 22-G TBNA needle and a 1.1-mm cryoprobe subsequently between January and August 2022. Patients with mediastinal lesions >1 cm were recruited, and EBUS-TBNA and TMC were performed in the same lymph node station. Results: The diagnostic yield was 82% and 96% for TBNA and TMC, respectively. Diagnostic yields were similar for sarcoidosis, while cryobiopsy was more sensitive than TBNA in lymphomas and metastatic lymph nodes. As for complications, there was no pneumothorax and in no case was there significant bleeding. There were no complications during the procedure or in the follow-up of these patients. Conclusions: TMC following our method is a minimally invasive, rapid and safe technique that can be performed in a bronchoscopy suite under moderate sedation, with a higher diagnostic yield than EBUS-TBNA, especially in cases of lymphoproliferative disorders and metastatic lymph nodes or when more biopsy sample is needed for molecular determinations. |
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| Language | English |
| Publishing date | 2023-04-17 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2827830-6 |
| ISSN | 2312-0541 |
| ISSN | 2312-0541 |
| DOI | 10.1183/23120541.00448-2022 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Translational lung cancer research
2023 Volume 12, Issue 7, Page(s) 1414–1424
Abstract: Background: Surgery is regarded as the treatment's cornerstone for early stage and locally advanced non-small cell lung cancer (NSCLC) whenever the tumor is considered resectable. Liquid biopsy is one of the most promising research areas in oncology in ... ...
| Abstract | Background: Surgery is regarded as the treatment's cornerstone for early stage and locally advanced non-small cell lung cancer (NSCLC) whenever the tumor is considered resectable. Liquid biopsy is one of the most promising research areas in oncology in the last 10 years, providing a useful non-invasive tool to detect and monitor cancer. The prognostic value of circulating tumor cells (CTCs) has been studied in different cancer types and had been related with a higher risk of relapse and worse prognosis. The aim of this study is to evaluate the prognostic value of CTC detection in patients with stage I-IIIA NSCLC treated with surgery. Methods: We conducted a prospective, single-center study of 180 consecutive patients with resected and pathological confirmed stage I to IIIA (TNM AJCC/UICC 8th edition) NSCLC. Patients' blood samples were processed and CTCs were characterized before and after the surgery. A cohort of patients had CTC determination after chemotherapy and surgery. Cut-off points were established in 1 and 5 CTCs for statistical analysis. Results: A proportion of 76.7% had at least 1 CTC before the surgery, and 30.6% had 5 or more, while 55.9% had at least 1 CTC after surgery, and 8.3% had 5 or more. We found no correlation between preoperative CTC detection for a cut-off of 5 with neither overall survival (OS) [hazard ratio (HR): 0.99, P=0.887], disease-free survival (DFS) (HR: 0.95, P=0.39) nor relapse (32.7% Conclusions: Despite the large cohort of patients included in this study, CTC monitoring in the perioperative setting was not correlated with relapse, DFS or OS in our study, and therefore cannot be recommended as a reliable biomarker for minimal residual disease (MRD) after surgery. |
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| Language | English |
| Publishing date | 2023-06-21 |
| Publishing country | China |
| Document type | Journal Article |
| ZDB-ID | 2754335-3 |
| ISSN | 2226-4477 ; 2218-6751 |
| ISSN (online) | 2226-4477 |
| ISSN | 2218-6751 |
| DOI | 10.21037/tlcr-22-827 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 196, Page(s) 106938
| Language | English |
|---|---|
| Publishing date | 2023-09-23 |
| Publishing country | Netherlands |
| Document type | Letter |
| ZDB-ID | 1003347-6 |
| ISSN | 1096-1186 ; 0031-6989 ; 1043-6618 |
| ISSN (online) | 1096-1186 |
| ISSN | 0031-6989 ; 1043-6618 |
| DOI | 10.1016/j.phrs.2023.106938 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 721: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 41, Issue 3, Page(s) 407–414
Abstract: The high cure rates of Hodgkin lymphoma (HL) make this oncological disease among those with the greatest number of long-term survivors. This single-institution study including 383 HL patients with up to 45 years of follow-up, analyses the morbidity and ... ...
| Abstract | The high cure rates of Hodgkin lymphoma (HL) make this oncological disease among those with the greatest number of long-term survivors. This single-institution study including 383 HL patients with up to 45 years of follow-up, analyses the morbidity and mortality of this population after treatments in comparison with the overall Spanish population, and investigates whether it has changed over time stratifying by periods of time, as a consequence of therapeutic optimization. The median age was 34.8 years (range 15-87) with median overall survival of 30 years, significantly higher in women (HR 0.58, 95% CI 0.42-0.79) (p = 0.0002). 185 late-stage diseases were noted (35% patients), cardiovascular disease (CVD) being the most frequent (23.2%). 30% of patients developed at least one second malignant neoplasm (SMN) to give a total of 174 SMNs. 20.9% of the patients died from HL and 67.0% died from non-HL causes (32.2% from SMN, 17% from CVD). The overall standardized mortality ratio (SMR) was 3.57 (95% CI: 3.0-4.2), with striking values of 7.73 (95% CI: 5.02-8.69) and of 14.75 (95% CI: 11.38-19.12) for women and patients <30 years at diagnosis, respectively. Excluding HL as the cause of death, the SMRs of those diagnosed before 2000 and from 2000 were proved to be similar (3.88 vs 2.73), maintaining in this last period an unacceptable excess of mortality due to secondary toxicity in patients cured of HL. Our study confirm that HL treatment substantially reduces the life expectancy of patients cured of HL. In recent periods, despite therapeutic optimization, deaths from toxicity continue to occur, mainly from CVD and SMN. Risk-factor monitoring should be intensified, prevention programs developed, and therapeutic optimization of LH investigated, especially in two vulnerable groups: those aged <30 years at diagnosis, and women. |
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| MeSH term(s) | Humans ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Hodgkin Disease/epidemiology ; Neoplasms, Second Primary/epidemiology ; Lymphoma, Non-Hodgkin/complications ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/complications ; Survivors |
| Language | English |
| Publishing date | 2023-03-19 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 604884-5 |
| ISSN | 1099-1069 ; 0278-0232 |
| ISSN (online) | 1099-1069 |
| ISSN | 0278-0232 |
| DOI | 10.1002/hon.3131 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1816: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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