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  1. Article ; Online: Middle meningeal artery embolization for the management of chronic subdural hematoma: what a difference a few years make.

    Fiorella, David / Arthur, Adam S

    Journal of neurointerventional surgery

    2023  Volume 15, Issue 6, Page(s) 515–516

    MeSH term(s) Humans ; Hematoma, Subdural, Chronic/diagnostic imaging ; Hematoma, Subdural, Chronic/therapy ; Meningeal Arteries/diagnostic imaging ; Head ; Embolization, Therapeutic
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-020498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6845: Show issues Location:
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  2. Article ; Online: In vitro comparison of middle meningeal artery embolization with Squid liquid embolic agent and Contour polyvinyl alcohol particles.

    Sadasivan, Chander / Dashti, Nakisa / Marfoglio, Samantha / Fiorella, David

    Journal of neurointerventional surgery

    2024  Volume 16, Issue 3, Page(s) 280–284

    Abstract: Background: Liquid embolic agents and polyvinyl alcohol (PVA) particles have been used for the embolization of the middle meningeal artery (MMA) for the treatment of chronic subdural hematomas. However, the vascular penetration and distribution of these ...

    Abstract Background: Liquid embolic agents and polyvinyl alcohol (PVA) particles have been used for the embolization of the middle meningeal artery (MMA) for the treatment of chronic subdural hematomas. However, the vascular penetration and distribution of these embolic agents have not yet been compared. The current study compares distribution of a liquid embolic agent (Squid) to PVA particles (Contour) in an in vitro model of the MMA.
    Methods: MMA models were embolized with Contour PVA particles 45-150 µm, Contour PVA particles 150-250 µm, and Squid-18 liquid embolic agent (n=5 each). The models were scanned and every vascular segment with embolic agent was manually marked on the images. Embolized vascular length as a percentage of control, average embolized vascular diameter, and embolization time were compared between the groups.
    Results: The 150-250 µm Contour particles primarily accumulated close to the microcatheter tip, yielding proximal branch occlusions. The 45-150 µm Contour particles achieved a more distal distribution, but in a patchy segmental pattern. However, the models embolized with Squid-18 had a consistently distal, near-complete and homogenous distribution. Embolized vascular length was significantly higher (76±13% vs 5±3%, P=0.0007) and average embolized vessel diameter was significantly smaller (405±25 µm vs 775±225 µm, P=0.0006) with Squid than with Contour. Embolization time with Squid was also lower (2.8±2.4 min vs 6.4±2.7 min, P=0.09).
    Conclusions: Squid-18 liquid results in a considerably more consistent, distal and homogeneous pattern of embolysate distribution than Contour PVA particles in an anatomical model of the MMA tree.
    MeSH term(s) Humans ; Polyvinyl Alcohol ; Meningeal Arteries/diagnostic imaging ; Embolization, Therapeutic/methods ; Polyvinyls
    Chemical Substances Polyvinyl Alcohol (9002-89-5) ; Polyvinyls
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-020132
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  3. Article ; Online: Commentary on 'Solitaire FR thrombectomy system: immediate results in 56 consecutive acute ischemic stroke patients'.

    Fiorella, David

    Journal of neurointerventional surgery

    2018  Volume 10, Issue Suppl 1, Page(s) i26

    MeSH term(s) Brain Ischemia ; Humans ; Ischemia ; Stents ; Stroke ; Thrombectomy
    Language English
    Publishing date 2018-07-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/neurintsurg-2018-014093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Betwixt and between: an idiomatic understanding of anesthesia in stroke intervention.

    Milburn, James M / Fiorella, David / Hirsch, Joshua A

    Journal of neurointerventional surgery

    2023  Volume 15, Issue 5, Page(s) 411–412

    MeSH term(s) Humans ; Stroke/surgery ; Anesthesia ; Anesthesia, General
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Editorial
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-020364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is data sharing the future of clinical trials?

    Fiorella, David

    Journal of neurointerventional surgery

    2017  Volume 9, Issue 7, Page(s) 624–625

    Language English
    Publishing date 2017
    Publishing country England
    Document type Editorial
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/neurintsurg-2016-012435
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  6. Article ; Online: Patient Perceptions on Telepsychiatry as an In-Consult Alternative During COVID-19 Pandemic: Peruvian Adaptation of the Telehealth Usability Questionnaire.

    Rosas, Fiorella / Gayoso, Alonso / Tomateo, David / Orellano, Carlos

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2024  

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2023.0428
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    Zs.A 4576: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Survival Analysis of Newly Diagnosed Multiple Myeloma Patients after Frontline Autologous Stem Cell Transplantation in a Real-Life Setting.

    Garrido, David / Bove, Virginia / Villano, Fiorella / Riva, Eloísa

    Acta medica (Hradec Kralove)

    2024  Volume 66, Issue 3, Page(s) 117–121

    Abstract: Introduction: Autologous stem cell transplantation (ASCT) is the standard consolidation option for transplant-eligible patients with multiple myeloma (MM). The aim of this study is to report the overall survival (OS) and progression-free survival (PFS) ... ...

    Abstract Introduction: Autologous stem cell transplantation (ASCT) is the standard consolidation option for transplant-eligible patients with multiple myeloma (MM). The aim of this study is to report the overall survival (OS) and progression-free survival (PFS) outcomes after frontline ASCT in newly-diagnosed MM (NDMM) patients in a real-world setting.
    Methods: We conducted a retrospective, survival analysis of all NDMM patients included in the MM Uruguayan Registry.
    Results: We included 151 NDMM patients treated with induction therapy followed by high-dose melphalan and ASCT as consolidation. The median age at diagnosis was 59 years, and the international staging system (ISS) risk groups were ISS-III 32.9%, ISS-II 37.8%, and ISS-I 29.4%. Frontline induction regimens included bortezomib in 61.6% of cases, and maintenance therapy was used in 63.9% of reported cases. With a median follow-up of 42 months, the 36-month OS and PFS for the whole group were 82.4% (95% CI 75.9% to 89.4%) and 63.8% (95% CI 55.6% to 73.3%), respectively, median OS of 98 months and median PFS of 47 months. The 100-month OS and PFS for the entire group were 48.0% (95% CI 34.9% to 66.0%) and 17.3% (95% CI 8.4% to 35.8%), respectively.
    Conclusion: ASCT is a feasible, safe, and potent strategy that provides a prolonged median OS and PFS in NDMM patients. This approach can be implemented in low-income countries.
    MeSH term(s) Humans ; Multiple Myeloma/diagnosis ; Multiple Myeloma/drug therapy ; Hematopoietic Stem Cell Transplantation ; Retrospective Studies ; Disease-Free Survival ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Transplantation, Autologous ; Survival Analysis ; Stem Cell Transplantation
    Language English
    Publishing date 2024-03-21
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 1360995-6
    ISSN 1805-9694 ; 1211-4286
    ISSN (online) 1805-9694
    ISSN 1211-4286
    DOI 10.14712/18059694.2024.4
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    Zs.B 908: Show issues Location:
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  8. Article ; Online: The effect of actuation frequency on clot integration with the Tigertriever device: A preliminary in vitro study.

    Sadasivan, Chander / Dashti, Nakisa / Gopal, Megha / Serna, Rowan J / Fiorella, David

    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

    2024  , Page(s) 15910199241247886

    Abstract: Background: The Tigertriever stent retriever (Rapid Medical) can be actively expanded and contracted by the operator, which allows for several actuation-related parameters to be optimized to potentially improve device efficacy. These parameters have not ...

    Abstract Background: The Tigertriever stent retriever (Rapid Medical) can be actively expanded and contracted by the operator, which allows for several actuation-related parameters to be optimized to potentially improve device efficacy. These parameters have not yet been evaluated. We conducted a benchtop study to evaluate the effect of actuation frequency on clot integration within the stent.
    Methods: A Tigertriever 17 device was deployed within a biological clot analog placed in a straight tube. The device was actuated between the maximally contracted and maximally expanded states with three different frequencies: passive (one-time opening,
    Results: The clot integration factor was significantly higher (23% increase,
    Conclusions: Faster actuation frequencies may result in improved clot integration with the Tigertriever device. This effect needs to be validated by clinical data.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1354913-3
    ISSN 2385-2011 ; 1591-0199 ; 1123-9344
    ISSN (online) 2385-2011
    ISSN 1591-0199 ; 1123-9344
    DOI 10.1177/15910199241247886
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    Zs.A 6325: Show issues Location:
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  9. Article ; Online: Epidemiology and risk factors for the development of infectious complications in newly diagnosed multiple myeloma: a multicenter prospective cohort study in Uruguay.

    Riva, Eloísa / Garrido, David / Villano, Fiorella / Bove, Virginia

    Hematology, transfusion and cell therapy

    2023  

    Abstract: Introduction: Infections represent a significant cause of morbidity and mortality in patients with multiple myeloma (MM). In Latin America, data on infectious complications in newly diagnosed MM (NDMM) patients are limited.: Methods: We conducted a ... ...

    Abstract Introduction: Infections represent a significant cause of morbidity and mortality in patients with multiple myeloma (MM). In Latin America, data on infectious complications in newly diagnosed MM (NDMM) patients are limited.
    Methods: We conducted a multicenter, prospective cohort study of patients with NDMM in Uruguay between June 2019 and December 2020. Patients with active disease, on active therapy and who provided written informed consent were included. Elegible patients were followed for 6 months from the time of diagnosis and before proceeding to autologous stem cell transplantation or until death, whichever occurred first. Our primary endpoint was the number of infectious events that required hospitalization for ≥ 24 h.
    Main results: Of 124 patients with NDMM, 54 (43.5 %) had infectious complications (74 infectious events), the majority (74.3 %) within the first 3 months from diagnosis. The most common sites of infection were urinary (39.2 %) and respiratory tracts (33.8 %). The microbial agent was identified in 60.8 % of patients with Gram-negative bacteria (71.4 %) as the most common pathogen. Viral and fungal infections were infrequent. In the multivariable analysis, the Eastern Cooperative Oncology Group (ECOG) performance status was ≥ 2 (odds ratio [OR], 2.16; 95 % confidence interval [95 %CI], 1.23 - 3.79; p = 0.008) and creatinine ≥ 2 mg/dl (OR, 2.33; 95 %CI, 1.33 - 4.07; p = 0.003) were independent factors associated with bacterial infections. At 6 months, 14 patients (11.3 %) had died, 50 % related to infectious complications.
    Conclusion: Bacterial infections are a substantial cause of hospital admissions and early death in patients with NDMM. Antibiotic prophylaxis should be considered to reduce infectious complications in patients with MM.
    Language English
    Publishing date 2023-10-30
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2023.09.2362
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  10. Article ; Online: Embolization of the middle meningeal artery for the treatment of chronic subdural hematoma: considerations for pragmatic trial design.

    Fiorella, David / Hirsch, Joshua A / Arthur, Adam S

    Journal of neurointerventional surgery

    2021  Volume 13, Issue 4, Page(s) 295–297

    MeSH term(s) Embolization, Therapeutic ; Head ; Hematoma, Subdural, Chronic/diagnostic imaging ; Hematoma, Subdural, Chronic/surgery ; Humans ; Meningeal Arteries/diagnostic imaging ; Pragmatic Clinical Trials as Topic
    Language English
    Publishing date 2021-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/neurintsurg-2021-017458
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