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  1. Article ; Online: Microcapsules of Sacha Inchi seed oil (Plukenetia volubilis L.) obtained by spray drying as a potential ingredient to formulate functional foods.

    Rodríguez-Cortina, A / Hernández-Carrión, M

    Food research international (Ottawa, Ont.)

    2023  Volume 170, Page(s) 113014

    Abstract: ... Emulsions were prepared using high-speed (Dispermat D-51580, 18,000 rpm, 10 min), conventional (Mixer K ...

    Abstract Sacha Inchi seed oil (SIO) is rich in omega 3, 6, and 9 fatty acids with important health benefits, but is temperature sensitive. Spray drying is a technology that improves the long-term stability of bioactive compounds. This work aimed to study the effect of three different homogenization techniques on some physical properties and bioavailability of microcapsules of Sacha Inchi seed oil (SIO) emulsions obtained by spray drying. Emulsions were formulated with SIO (5%, w/w), maltodextrin:sodium caseinate as wall material (10%, w/w; 85:15), Tween 20 (1%, w/w) and Span 80 (0.5%, w/w) as surfactants and water up to 100% (w/w). Emulsions were prepared using high-speed (Dispermat D-51580, 18,000 rpm, 10 min), conventional (Mixer K-MLIM50N01, Turbo speed, 5 min), and ultrasound probe (Sonics Materials VCX 750, 35% amplitude, 750 W, 30 min) homogenization. SIO microcapsules were obtained in a Mini Spray B-290 (Büchi) using two inlet temperatures of the drying air (150 and 170 °C). Moisture, density, dissolution rate, hygroscopicity, drying efficiency (EY), encapsulation efficiency (EE), loading capacity, and oil release in digestive fluids in vitro were studied. Results showed that the microcapsules obtained by spray-drying had low moisture values and high encapsulation yield and efficiency values (greater than 50% and 70%, respectively). The thermogravimetric analysis indicates that heat protection was assured, enhancing the shelf life and the ability to withstand thermal food processing. Results suggest that spray-drying encapsulation could be a suitable technology to successfully microencapsulate SIO and enhance the absorption of bioactive compounds in the intestine. This work highlights the use of Latin American biodiversity and spray drying technology to ensure the encapsulation of bioactive compounds. This technology represents an opportunity for the development of new functional foods, improving the safety and quality of conventional foods.
    MeSH term(s) Functional Food ; Capsules ; Emulsions ; Spray Drying ; Euphorbiaceae ; Plant Oils
    Chemical Substances Capsules ; Emulsions ; Plant Oils
    Language English
    Publishing date 2023-05-20
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2023.113014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cortical astrocyte N-methyl-D-aspartate receptors influence whisker barrel activity and sensory discrimination in mice.

    Ahmadpour, Noushin / Kantroo, Meher / Stobart, Michael J / Meza-Resillas, Jessica / Shabanipour, Shahin / Parra-Nuñez, Jesus / Salamovska, Tetiana / Muzaleva, Anna / O'Hara, Finnegan / Erickson, Dustin / Di Gaetano, Bruno / Carrion-Falgarona, Sofia / Weber, Bruno / Lamont, Alana / Lavine, Natalie E / Kauppinen, Tiina M / Jackson, Michael F / Stobart, Jillian L

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1571

    Abstract: Astrocytes express ionotropic receptors, including N-methyl-D-aspartate receptors (NMDARs ...

    Abstract Astrocytes express ionotropic receptors, including N-methyl-D-aspartate receptors (NMDARs). However, the contribution of NMDARs to astrocyte-neuron interactions, particularly in vivo, has not been elucidated. Here we show that a knockdown approach to selectively reduce NMDARs in mouse cortical astrocytes decreases astrocyte Ca
    MeSH term(s) Mice ; Animals ; Astrocytes/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Vibrissae/metabolism ; Neurons/metabolism ; Signal Transduction
    Chemical Substances Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45989-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Importance of Bacteroidetes in host-microbe interactions and ecosystem functioning.

    Pan, Xinya / Raaijmakers, Jos M / Carrión, Víctor J

    Trends in microbiology

    2023  Volume 31, Issue 9, Page(s) 959–971

    Abstract: Bacteroidetes are prevalent in soil ecosystems and are associated with various eukaryotic hosts, including plants, animals, and humans. The ubiquity and diversity of Bacteroidetes exemplify their impressive versatility in niche adaptation and genomic ... ...

    Abstract Bacteroidetes are prevalent in soil ecosystems and are associated with various eukaryotic hosts, including plants, animals, and humans. The ubiquity and diversity of Bacteroidetes exemplify their impressive versatility in niche adaptation and genomic plasticity. Over the past decade, a wealth of knowledge has been obtained on the metabolic functions of clinically relevant Bacteroidetes, but much less attention has been given to Bacteroidetes living in close association with plants. To improve our understanding of the functional roles of Bacteroidetes for plants and other hosts, we review the current knowledge of their taxonomy and ecology, in particular their roles in nutrient cycling and host fitness. We highlight their environmental distribution, stress resilience, genomic diversity, and functional importance in diverse ecosystems, including, but not limited to, plant-associated microbiomes.
    MeSH term(s) Animals ; Humans ; Ecosystem ; Bacteroidetes/genetics ; Host Microbial Interactions ; Ecology ; Genome ; Plants ; Soil Microbiology
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2023.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: New strategies for decision making in prostate cancer. The role of oncotypedx.

    Toribio-Vázquez, C / Gómez Rivas, J / Yebes, Á / Carrión, D M / Yagüe Barrado, M / Álvarez-Maestro, M / Martinez-Piñeiro, L

    Actas urologicas espanolas

    2022  Volume 46, Issue 7, Page(s) 385–386

    MeSH term(s) Decision Making ; Humans ; Male ; Prognosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/therapy
    Language Spanish
    Publishing date 2022-07-13
    Publishing country Spain
    Document type Editorial
    ISSN 2173-5786
    ISSN (online) 2173-5786
    DOI 10.1016/j.acuroe.2022.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Encapsulation of Menthol and Luteolin Using Hydrocolloids as Wall Material to Formulate Instant Aromatic Beverages.

    Mora-Flórez, Laura Sofía / Cabrera-Rodríguez, Daniel / Hernández-Carrión, María

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 10

    Abstract: Aromatic plants represent about 0.7% of all medicinal plants. The most common are peppermint (main active ingredient: menthol) and chamomile (main active ingredient: luteolin), which are usually consumed in "tea bags" to make infusions or herbal teas. In ...

    Abstract Aromatic plants represent about 0.7% of all medicinal plants. The most common are peppermint (main active ingredient: menthol) and chamomile (main active ingredient: luteolin), which are usually consumed in "tea bags" to make infusions or herbal teas. In this study, menthol and luteolin encapsulates using different hydrocolloids were obtained to replace the conventional preparation of these beverages. Encapsulation was carried out by feeding an infusion of peppermint and chamomile (83% aqueous phase = 75% water - 8% herbs in equal parts, and 17% dissolved solids = wall material in 2:1 ratio) into a spray dryer (180 °C-4 mL/min). A factorial experimental design was used to evaluate the effect of wall material on morphology (circularity and Feret's diameter) and texture properties of the powders using image analysis. Four formulations using different hydrocolloids were evaluated: (F1) maltodextrin-sodium caseinate (10 wt%), (F2) maltodextrin-soy protein (10 wt%), (F3) maltodextrin-sodium caseinate (15 wt%), and (F4) maltodextrin-soy protein (15 wt%). The moisture, solubility, bulk density, and bioavailability of menthol in the capsules were determined. The results showed that F1 and F2 presented the best combination of powder properties: higher circularity (0.927 ± 0.012, 0.926 ± 0.011), lower moisture (2.69 ± 0.53, 2.71 ± 0.21), adequate solubility (97.73 ± 0.76, 98.01 ± 0.50), and best texture properties. Those suggest the potential of these powders not only as an easy-to-consume and ecofriendly instant aromatic beverage but also as a functional one.
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12102080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Overcoming Women's Lifelong Hormonal Rollercoaster: A Turning Point for Cardiovascular Prevention.

    Machline-Carrion, M Julia

    Arquivos brasileiros de cardiologia

    2022  Volume 118, Issue 5, Page(s) 914–915

    Title translation Superando a Montanha-Russa Hormonal ao Longo da Vida das Mulheres: Um Ponto de Virada para a Prevenção Cardiovascular.
    MeSH term(s) Cardiovascular Diseases/prevention & control ; Cardiovascular System ; Female ; Humans
    Language Portuguese
    Publishing date 2022-07-04
    Publishing country Brazil
    Document type Editorial ; Comment
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20220259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Editorial commentary on: "Reduced vs full-dose BCG therapy in bladder cancer: A systematic review and meta-analysis".

    Carrion, D M / Pradere, B / Soria, F / Del Giudice, F / Moschini, M

    Actas urologicas espanolas

    2022  

    Language Spanish
    Publishing date 2022-10-06
    Publishing country Spain
    Document type Editorial
    ISSN 2173-5786
    ISSN (online) 2173-5786
    DOI 10.1016/j.acuroe.2022.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Brain structure, phenotypic and genetic correlates of reading performance.

    Carrión-Castillo, Amaia / Paz-Alonso, Pedro M / Carreiras, Manuel

    Nature human behaviour

    2023  Volume 7, Issue 7, Page(s) 1120–1134

    Abstract: Reading is an evolutionarily recent development that recruits and tunes brain circuitry connecting primary- and language-processing regions. We investigated whether metrics of the brain's physical structure correlate with reading performance and whether ... ...

    Abstract Reading is an evolutionarily recent development that recruits and tunes brain circuitry connecting primary- and language-processing regions. We investigated whether metrics of the brain's physical structure correlate with reading performance and whether genetic variants affect this relationship. To this aim, we used the Adolescent Brain Cognitive Development dataset (n = 9,013) of 9-10-year-olds and focused on 150 measures of cortical surface area (CSA) and thickness. Our results reveal that reading performance is associated with nine measures of brain structure including relevant regions of the reading network. Furthermore, we show that this relationship is partially mediated by genetic factors for two of these measures: the CSA of the entire left hemisphere and, specifically, of the left superior temporal gyrus CSA. These effects emphasize the complex and subtle interplay between genes, brain and reading, which is a partly heritable polygenic skill that relies on a distributed network.
    MeSH term(s) Adolescent ; Humans ; Brain Mapping/methods ; Brain/diagnostic imaging ; Cognition ; Language ; Temporal Lobe/diagnostic imaging
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-023-01583-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Telemedicine use in current urologic oncology clinical practice.

    Paesano, Nahuel / Carrion, Diego M / Autrán Gomez, Ana María

    Frontiers in surgery

    2022  Volume 9, Page(s) 885260

    Abstract: Introduction: In the last fifteen years, there have been important technological advances in telehealth systems and urology, along with other specialties, has been a pioneer in the successful use of this medical care modality. Due to the COVID-19 ... ...

    Abstract Introduction: In the last fifteen years, there have been important technological advances in telehealth systems and urology, along with other specialties, has been a pioneer in the successful use of this medical care modality. Due to the COVID-19 pandemic, the use of telemedicine has been rapidly embraced by the urology community around the world. A review of the most relevant and updated articles on telemedicine and telehealth in urology has been carried out with the aim of better understanding how it has been implemented to date, as well as reviewing concepts, current regulations, health policies and recommendations for its implementation.
    Methods: A narrative review of the current literature published up to April 2022 on the use of telemedicine in urology was performed. From the search results, 42 publications were obtained for analysis.
    Results: Telemedicine in urology has been shown to be useful in a variety of clinical scenarios within urological practice, from benign diseases to advanced cancers. This is due to the positive impact on medical consultation times, lower patient mobility costs, less work absenteeism and greater protection for both the patient and the doctor. The main limitations for the use of telemedicine lie in the impossibility of a correct physical examination, which is essential in certain situations, as well as the lack of accessibility to technology in disadvantaged populations and in elderly patients who have not adapted to the use of technology, as well as the lack of development of health policies to establish their implementation in some countries.
    Conclusion: Telemedicine is in full growth. There is much information in the current literature on the successful adoption of telemedicine for patients suffering from urological diseases. While the use and implementation of these new practices has been rapid in the urology community, more work is needed to bring more accessible specialty care to underserved and underdeveloped areas. Health policies must promote its development to reduce costs and increase access.
    Language English
    Publishing date 2022-08-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.885260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Chagas cardiomyopathy in Boston, Massachusetts: Identifying disease and improving management after community and hospital-based screening.

    Reifler, Katherine A / Wheelock, Alyse / Hall, Samantha M / Salazar, Alejandra / Hassan, Shahzad / Bostrom, John A / Barnett, Elizabeth D / Carrion, Malwina / Hochberg, Natasha S / Hamer, Davidson H / Gopal, Deepa M / Bourque, Daniel

    PLoS neglected tropical diseases

    2024  Volume 18, Issue 1, Page(s) e0011913

    Abstract: ... A and 49% (46/94) had cardiac structural disease (stages B1-D). Clinical findings that required clinical ...

    Abstract Background: Limited data exist regarding cardiac manifestations of Chagas disease in migrants living in non-endemic regions.
    Methods: A retrospective cohort analysis of 109 patients with Chagas disease seen at Boston Medical Center (BMC) between January 2016 and January 2023 was performed. Patients were identified by screening and testing migrants from endemic regions at a community health center and BMC. Demographic, laboratory, and cardiac evaluation data were collected.
    Results: Mean age of the 109 patients was 43 years (range 19-76); 61% were female. 79% (86/109) were diagnosed with Chagas disease via screening and 21% (23/109) were tested given symptoms or electrocardiogram abnormalities. Common symptoms included palpitations (25%, 27/109) and chest pain (17%, 18/109); 52% (57/109) were asymptomatic. Right bundle branch block (19%, 19/102), T-wave changes (18%, 18/102), and left anterior fascicular block (11%, 11/102) were the most common electrocardiogram abnormalities; 51% (52/102) had normal electrocardiograms. Cardiomyopathy stage was ascertained in 94 of 109 patients: 51% (48/94) were indeterminate stage A and 49% (46/94) had cardiac structural disease (stages B1-D). Clinical findings that required clinical intervention or change in management were found in 23% (25/109), and included cardiomyopathy, apical hypokinesis/aneurysm, stroke, atrial or ventricular arrhythmias, and apical thrombus.
    Conclusions: These data show high rates of cardiac complications in a cohort of migrants living with Chagas disease in a non-endemic setting. We demonstrate that Chagas disease diagnosis prompts cardiac evaluation which often identifies actionable cardiac disease and provides opportunities for prevention and treatment.
    MeSH term(s) Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Aged ; Male ; Chagas Cardiomyopathy/diagnosis ; Chagas Cardiomyopathy/epidemiology ; Chagas Cardiomyopathy/complications ; Retrospective Studies ; Electrocardiography ; Chagas Disease/complications ; Chagas Disease/diagnosis ; Chagas Disease/epidemiology ; Arrhythmias, Cardiac/etiology ; Cardiomyopathies/complications ; Massachusetts
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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