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Article ; Online: Hepatitis E vaccine-Illuminating the barriers to use.

Lynch, Julia A / Lim, Jacqueline Kyungah / Asaga, Philomena E Peter / Wartel, T Anh / Marti, Melanie / Yakubu, Beno / Rees, Helen / Talaat, Kawsar / Kmush, Brittany / Aggarwal, Rakesh / Ciglenecki, Iza / Gurley, Emily / Labrique, Alain B

PLoS neglected tropical diseases

2023 Volume 17, Issue 1, Page(s) e0010969

MeSH term(s)	Humans ; Hepatitis E/epidemiology ; Hepatitis E/prevention & control ; Viral Hepatitis Vaccines ; Hepatitis E virus/genetics ; Hepatitis B Vaccines ; Vaccines, Synthetic
Chemical Substances	Viral Hepatitis Vaccines ; Hepatitis B Vaccines ; Vaccines, Synthetic
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0010969
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hepatitis E vaccine-Illuminating the barriers to use.

Julia A Lynch / Jacqueline Kyungah Lim / Philomena E Peter Asaga / T Anh Wartel / Melanie Marti / Beno Yakubu / Helen Rees / Kawsar Talaat / Brittany Kmush / Rakesh Aggarwal / Iza Ciglenecki / Emily Gurley / Alain B Labrique

PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e

2023 Volume 0010969

Keywords	Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes.

Pérez-Martí, Albert / Ramakrishnan, Suresh / Li, Jiayi / Dugourd, Aurelien / Molenaar, Martijn R / De La Motte, Luigi R / Grand, Kelli / Mansouri, Anis / Parisot, Mélanie / Lienkamp, Soeren S / Saez-Rodriguez, Julio / Simons, Matias

eLife

2022 Volume 11

Abstract: In diabetic patients, dyslipidemia frequently contributes to organ damage such as diabetic kidney disease (DKD). Dyslipidemia is associated with both excessive deposition of triacylglycerol (TAG) in lipid droplets (LDs) and lipotoxicity. Yet, it is ... ...

Abstract	In diabetic patients, dyslipidemia frequently contributes to organ damage such as diabetic kidney disease (DKD). Dyslipidemia is associated with both excessive deposition of triacylglycerol (TAG) in lipid droplets (LDs) and lipotoxicity. Yet, it is unclear how these two effects correlate with each other in the kidney and how they are influenced by dietary patterns. By using a diabetes mouse model, we find here that high-fat diet enriched in the monounsaturated oleic acid (OA) caused more lipid storage in LDs in renal proximal tubular cells (PTCs) but less tubular damage than a corresponding butter diet with the saturated palmitic acid (PA). This effect was particularly evident in S2/S3 but not S1 segments of the proximal tubule. Combining transcriptomics, lipidomics, and functional studies, we identify endoplasmic reticulum (ER) stress as the main cause of PA-induced PTC injury. Mechanistically, ER stress is caused by elevated levels of saturated TAG precursors, reduced LD formation, and, consequently, higher membrane order in the ER. Simultaneous addition of OA rescues the cytotoxic effects by normalizing membrane order and increasing both TAG and LD formation. Our study thus emphasizes the importance of monounsaturated fatty acids for the dietary management of DKD by preventing lipid bilayer stress in the ER and promoting TAG and LD formation in PTCs.
MeSH term(s)	Animals ; Diabetes Mellitus ; Endoplasmic Reticulum Stress ; Fatty Acids/pharmacology ; Fatty Acids, Monounsaturated/pharmacology ; Humans ; Kidney ; Kidney Tubules, Proximal ; Lipid Bilayers ; Mice ; Palmitic Acid/pharmacology ; Triglycerides
Chemical Substances	Fatty Acids ; Fatty Acids, Monounsaturated ; Lipid Bilayers ; Triglycerides ; Palmitic Acid (2V16EO95H1)
Language	English
Publishing date	2022-05-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.74391
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Emerging evidence on heterologous COVID-19 vaccine schedules-To mix or not to mix?

Parker, Edward P K / Desai, Shalini / Marti, Melanie / O'Brien, Katherine L / Kaslow, David C / Kochhar, Sonali / Olayinka, Folake / Cravioto, Alejandro / Nohynek, Hanna / Hombach, Joachim / Wilder-Smith, Annelies

The Lancet. Infectious diseases

2022 Volume 22, Issue 4, Page(s) 438–440

MeSH term(s)	Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Immunization, Secondary ; Immunogenicity, Vaccine
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(22)00178-5
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Article ; Online: Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

Albert Pérez-Martí / Suresh Ramakrishnan / Jiayi Li / Aurelien Dugourd / Martijn R Molenaar / Luigi R De La Motte / Kelli Grand / Anis Mansouri / Mélanie Parisot / Soeren S Lienkamp / Julio Saez-Rodriguez / Matias Simons

eLife, Vol

2022 Volume 11

Abstract	In diabetic patients, dyslipidemia frequently contributes to organ damage such as diabetic kidney disease (DKD). Dyslipidemia is associated with both excessive deposition of triacylglycerol (TAG) in lipid droplets (LDs) and lipotoxicity. Yet, it is unclear how these two effects correlate with each other in the kidney and how they are influenced by dietary patterns. By using a diabetes mouse model, we find here that high-fat diet enriched in the monounsaturated oleic acid (OA) caused more lipid storage in LDs in renal proximal tubular cells (PTCs) but less tubular damage than a corresponding butter diet with the saturated palmitic acid (PA). This effect was particularly evident in S2/S3 but not S1 segments of the proximal tubule. Combining transcriptomics, lipidomics, and functional studies, we identify endoplasmic reticulum (ER) stress as the main cause of PA-induced PTC injury. Mechanistically, ER stress is caused by elevated levels of saturated TAG precursors, reduced LD formation, and, consequently, higher membrane order in the ER. Simultaneous addition of OA rescues the cytotoxic effects by normalizing membrane order and increasing both TAG and LD formation. Our study thus emphasizes the importance of monounsaturated fatty acids for the dietary management of DKD by preventing lipid bilayer stress in the ER and promoting TAG and LD formation in PTCs.
Keywords	diabetic nephropathy ; proximal tubules ; lipotoxicity ; ER stress ; membrane order ; lipid bilayer stress ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	571 ; 500
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Response to additional COVID-19 vaccine doses in people who are immunocompromised: a rapid review.

Parker, Edward P K / Desai, Shalini / Marti, Melanie / Nohynek, Hanna / Kaslow, David C / Kochhar, Sonali / O'Brien, Katherine L / Hombach, Joachim / Wilder-Smith, Annelies

The Lancet. Global health

2022 Volume 10, Issue 3, Page(s) e326–e328

MeSH term(s)	COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Dose-Response Relationship, Drug ; Humans ; Immunocompromised Host/immunology ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-02-18
Publishing country	England
Document type	Letter ; Systematic Review
ZDB-ID	2723488-5
ISSN	2214-109X ; 2214-109X
ISSN (online)	2214-109X
ISSN	2214-109X
DOI	10.1016/S2214-109X(21)00593-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The use of a whole inactivated PRRS virus vaccine administered in sows and impact on maternally derived immunity and timing of PRRS virus infection in piglets

Martín‐Valls, Gerard Eduard / Mortensen, Preben / Clilvert, Hepzibar / Li, Yanli / Cortey, Martí / Sno, Melanie / Barna, Timea / Terré, Marisa / Guerra, Nicolas / Mateu, Enric

Veterinary Record Open. 2022 Dec., v. 9, no. 1, p. e34

2022

Abstract: BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) vaccination is usually based on administering periodically PRRS modified live virus (MLV) in sows throughout their life. Using this schedule, transfer of maternally derived ... ...

Abstract	BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) vaccination is usually based on administering periodically PRRS modified live virus (MLV) in sows throughout their life. Using this schedule, transfer of maternally derived antibodies to the offspring is limited. The aim of the present study was to test the concept of priming with an MLV and boosting with a commercial inactivated virus vaccine in sows to reduce PRRSV incidence and improve productivity. METHODS: On two farms, all the sows were vaccinated with a MLV vaccine at week 8 of gestation. Then two groups were designated, one group was re‐vaccinated in the third week prior to farrowing and using a commercial inactivated vaccine (the PG group). The second group was the control group (C). Assays for PRRSV infection and productive parameters were evaluated. RESULTS: For both farms, the incidence of PRRSV was lower at 6 weeks of age in PG than in C (p < 0.05). At weaning the proportion of PRRSV seropositive piglets was higher for PG as well (p < 0.05). The litters from C sows from both farms showed a higher pre‐weaning mortality (odds ratio, C vs. PG = 1.18 ± 0.09; p < 0.05). CONCLUSIONS: Administration of the vaccine in sows before farrowing was safe and associated with reduced incidence of PRRSV in piglets up to 6 weeks of age.
Keywords	Betaarterivirus suid 1 ; immunity ; inactivated vaccines ; mortality ; odds ratio ; porcine reproductive and respiratory syndrome ; pregnancy ; progeny ; seroprevalence ; vaccination ; viruses
Language	English
Dates of publication	2022-12
Size	p. e34
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ISSN	2399-2050
DOI	10.1002/vro2.34
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.

Sabath, Kevin / Stäubli, Melanie L / Marti, Sabrina / Leitner, Alexander / Moes, Murielle / Jonas, Stefanie

Nature communications

2020 Volume 11, Issue 1, Page(s) 3422

Abstract: The Integrator complex processes 3'-ends of spliceosomal small nuclear RNAs (snRNAs). Furthermore, it regulates transcription of protein coding genes by terminating transcription after unstable pausing. The molecular basis for Integrator's functions ... ...

Abstract	The Integrator complex processes 3'-ends of spliceosomal small nuclear RNAs (snRNAs). Furthermore, it regulates transcription of protein coding genes by terminating transcription after unstable pausing. The molecular basis for Integrator's functions remains obscure. Here, we show that INTS10, Asunder/INTS13 and INTS14 form a separable, functional Integrator module. The structure of INTS13-INTS14 reveals a strongly entwined complex with a unique chain interlink. Unexpected structural homology to the Ku70-Ku80 DNA repair complex suggests nucleic acid affinity. Indeed, the module displays affinity for DNA and RNA but prefers RNA hairpins. While the module plays an accessory role in snRNA maturation, it has a stronger influence on transcription termination after pausing. Asunder/INTS13 directly binds Integrator's cleavage module via a conserved C-terminal motif that is involved in snRNA processing and required for spermatogenesis. Collectively, our data establish INTS10-INTS13-INTS14 as a nucleic acid-binding module and suggest that it brings cleavage module and target transcripts into proximity.
MeSH term(s)	Carrier Proteins/metabolism ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Intracellular Signaling Peptides and Proteins/chemistry ; Intracellular Signaling Peptides and Proteins/metabolism ; Ku Autoantigen/chemistry ; Mutation/genetics ; Nucleic Acid Conformation ; Nucleic Acids/metabolism ; Protein Binding ; Protein Domains ; Protein Multimerization ; RNA/chemistry ; RNA/metabolism ; RNA Processing, Post-Transcriptional ; Structural Homology, Protein
Chemical Substances	Carrier Proteins ; Cell Cycle Proteins ; INTS10 protein, human ; INTS13 protein, human ; INTS14 protein, human ; Intracellular Signaling Peptides and Proteins ; Nucleic Acids ; RNA (63231-63-0) ; Ku Autoantigen (EC 4.2.99.-)
Language	English
Publishing date	2020-07-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-020-17232-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

Kevin Sabath / Melanie L. Stäubli / Sabrina Marti / Alexander Leitner / Murielle Moes / Stefanie Jonas

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 16

Abstract: The Integrator complex (INT) is responsible for the 3′-end processing of several classes of non-coding RNAs. Here the authors show that the INTS10-INTS13-INTS14 complex forms a distinct submodule of INT and suggest it facilitates RNA substrate targeting. ...

Abstract	The Integrator complex (INT) is responsible for the 3′-end processing of several classes of non-coding RNAs. Here the authors show that the INTS10-INTS13-INTS14 complex forms a distinct submodule of INT and suggest it facilitates RNA substrate targeting.
Keywords	Science ; Q
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

Kevin Sabath / Melanie L. Stäubli / Sabrina Marti / Alexander Leitner / Murielle Moes / Stefanie Jonas

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 16

Abstract	The Integrator complex (INT) is responsible for the 3′-end processing of several classes of non-coding RNAs. Here the authors show that the INTS10-INTS13-INTS14 complex forms a distinct submodule of INT and suggest it facilitates RNA substrate targeting.
Keywords	Science ; Q
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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