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  1. Article ; Online: Deciphering RNA m

    Wu, Zeming / Ren, Jie / Liu, Guang-Hui

    Aging cell

    2023  Volume 22, Issue 10, Page(s) e13972

    Abstract: ... ...

    Abstract N
    MeSH term(s) Cellular Senescence/genetics ; RNA
    Chemical Substances RNA (63231-63-0) ; N-methyladenosine (CLE6G00625)
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13972
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    Zs.A 6581: Show issues Location:
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  2. Article ; Online: Pr

    Liu, Binbin / Li, Zeming / Xiao, Guoping / Du, Xian-Long / Yao, Huichao / Dai, Ruoyun / Wang, Xiulin / Wang, Jian-Qiang / Li, Tao

    RSC advances

    2024  Volume 14, Issue 19, Page(s) 13251–13257

    Abstract: The solid oxide electrolysis cell (SOEC) is an advanced electrochemical device with a promising future in reducing ... ...

    Abstract The solid oxide electrolysis cell (SOEC) is an advanced electrochemical device with a promising future in reducing CO
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra01848f
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  3. Article ; Online: Emerging epigenetic insights into aging mechanisms and interventions.

    Wu, Zeming / Zhang, Weiqi / Qu, Jing / Liu, Guang-Hui

    Trends in pharmacological sciences

    2024  Volume 45, Issue 2, Page(s) 157–172

    Abstract: Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although still an evolving field with much to explore, it has rapidly gained significance by providing valuable insights into the mechanisms of aging and potential ... ...

    Abstract Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although still an evolving field with much to explore, it has rapidly gained significance by providing valuable insights into the mechanisms of aging and potential therapeutic opportunities for age-related diseases. Recent years have witnessed remarkable strides in our understanding of the epigenetic landscape of aging, encompassing pivotal elements, such as DNA methylation, histone modifications, RNA modifications, and noncoding (nc) RNAs. Here, we review the latest discoveries that shed light on new epigenetic mechanisms and critical targets for predicting and intervening in aging and related disorders. Furthermore, we explore burgeoning interventions and exemplary clinical trials explicitly designed to foster healthy aging, while contemplating the potential ramifications of epigenetic influences.
    MeSH term(s) Humans ; Epigenesis, Genetic ; DNA Methylation ; Aging/genetics ; Protein Processing, Post-Translational
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2023.12.002
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    Zs.A 1513: Show issues Location:
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  4. Article ; Online: An experimental workflow for identifying RNA m

    Shi, Yue / Wu, Zeming / Zhang, Weiqi / Qu, Jing / Ci, Weimin / Liu, Guang-Hui

    Journal of biological methods

    2023  Volume 10, Page(s) e99010004

    Abstract: ... ...

    Abstract N
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 2326-9901
    ISSN (online) 2326-9901
    DOI 10.14440/jbm.2023.403
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  5. Article ; Online: Bibliometric and visualization analysis of research trend in mental health problems of children and adolescents during the COVID-19 pandemic.

    Guo, Zeming / Zhang, Yiran / Liu, Qin

    Frontiers in public health

    2023  Volume 10, Page(s) 1040676

    Abstract: Objectives: To analyze the evolution of research on children and adolescents mental health issues during COVID-19 pandemic and discuss research hotspots and cutting-edge developments.: Methods: The literature obtained from the web of science core ... ...

    Abstract Objectives: To analyze the evolution of research on children and adolescents mental health issues during COVID-19 pandemic and discuss research hotspots and cutting-edge developments.
    Methods: The literature obtained from the web of science core collection as of June 28, 2022, was analyzed using Citespace, VOSviewer bibliometric visualization mapping software.
    Results: A total of 6,039 relevant papers were found, of which 5,594 were included in the study. The number of literatures is growing since 2020; and the country, institution, and journal publications were analyzed. The co-citation analysis shows that there are more research articles among the highly cited articles and a lack of systematic reviews that use critical thinking for review. In the cluster analysis, mental health and life change were the most representative. The timeline view of the keywords shows that Online learning (#0), Public health (#1), and Mental health (#2) are the three largest clusters and shows the change over time.
    Conclusion: This study helped analyze the mental health of children and adolescents during the COVID-19 pandemic and identified hot trends and shortcomings, which are important references for the theoretical basis of future research and decision making and technical guidance for systematic reviews.
    MeSH term(s) Humans ; Adolescent ; Child ; COVID-19/epidemiology ; Mental Health ; Pandemics ; Systematic Reviews as Topic ; Bibliometrics
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1040676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Efficacies of anlotinib monotherapy versus gemcitabine-based chemotherapy for patients with advanced soft tissue sarcoma after the failure of anthracycline-based chemotherapy.

    Zheng, Aiping / Liu, Jie / Liu, Zijing / Mo, Zeming / Fu, Yang / Deng, Yaotiao / Jiang, Yu

    Journal of cancer research and clinical oncology

    2024  Volume 150, Issue 2, Page(s) 58

    Abstract: Objective: The purpose of this study was to compare the antitumor efficacy of anlotinib with gemcitabine-based chemotherapy as subsequent treatment regimens in patients with advanced non-specific soft tissue sarcoma (STS) after the failure of ... ...

    Abstract Objective: The purpose of this study was to compare the antitumor efficacy of anlotinib with gemcitabine-based chemotherapy as subsequent treatment regimens in patients with advanced non-specific soft tissue sarcoma (STS) after the failure of anthracycline-based chemotherapy.
    Methods: Patients diagnosed with advanced STS who were treated with either anlotinib or gemcitabine-based chemotherapy between May 2009 and May 2023 in our center were eligible. All patients experienced disease progression or recurrence after the anthracycline-based chemotherapy. The primary endpoint was progression-free survival (PFS). Secondary endpoints were disease control rate (DCR), overall survival (OS) and safety.
    Results: We included 49 patients receiving anlotinib and 45 patients receiving gemcitabine-based chemotherapy. The median follow-up time was 76.9 weeks (range 2.9-678.9 weeks). The DCR (65.3% vs. 57.8%; p = 0.610), PFS (24.0 weeks vs. 18.6 weeks; p = 0.669) and OS (79.4 weeks vs. 87.0 weeks; p = 0.471) of anlotinib and gemcitabine-based chemotherapy indicated similar clinical efficacy. Moreover, exploratory subgroup analyses showed that patients with STS originating from limbs and trunk were inclined to benefit from anlotinib treatment (median PFS: 31.3 weeks vs. 12.4 weeks; p = 0.045). ECOG PS was an independent predictor of the PFS [Hazard Ratio (HR) 0.31; 95% confidence interval (CI) 0.11-0.85; p = 0.023] and OS (HR 0.26, 95%CI 0.10-0.70; p = 0.008) in the anlotinib group. While neutrophil-to-lymphocyte ratio (NLR) was an independent prognostic factor of the PFS (HR 0.33, 95%CI 0.11-0.98; p = 0.045) in the gemcitabine-based chemotherapy group. The incidence of grade 3 or higher related AEs in anlotinib and gemcitabine-based chemotherapy was 20.4% (n = 10) and 20.0% (n = 9), respectively.
    Conclusion: Our research suggested that anlotinib and gemcitabine-based chemotherapy showed similar clinical efficacy and safety in the subsequent treatment of advanced STS after the failure of anthracycline-based chemotherapy.
    MeSH term(s) Humans ; Gemcitabine ; Anthracyclines ; Indoles/adverse effects ; Antibiotics, Antineoplastic ; Polyketides ; Sarcoma/drug therapy ; Quinolines
    Chemical Substances anlotinib ; Gemcitabine ; Anthracyclines ; Indoles ; Antibiotics, Antineoplastic ; Polyketides ; Quinolines
    Language English
    Publishing date 2024-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-05575-4
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    Uh III Zs.10: Show issues Location:
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  7. Article: NcRNA: key and potential in hearing loss.

    Zhu, Keyu / Wang, Ting / Li, Sicheng / Liu, Zeming / Zhan, Yuanyuan / Zhang, Qi

    Frontiers in neuroscience

    2024  Volume 17, Page(s) 1333131

    Abstract: Hearing loss has an extremely high prevalence worldwide and brings incredible economic and social burdens. Mechanisms such as epigenetics are profoundly involved in the initiation and progression of hearing loss and potentially yield definite strategies ... ...

    Abstract Hearing loss has an extremely high prevalence worldwide and brings incredible economic and social burdens. Mechanisms such as epigenetics are profoundly involved in the initiation and progression of hearing loss and potentially yield definite strategies for hearing loss treatment. Non-coding genes occupy 97% of the human genome, and their transcripts, non-coding RNAs (ncRNAs), are widely participated in regulating various physiological and pathological situations. NcRNAs, mainly including micro-RNAs (miRNAs), long-stranded non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are involved in the regulation of cell metabolism and cell death by modulating gene expression and protein-protein interactions, thus impacting the occurrence and prognosis of hearing loss. This review provides a detailed overview of ncRNAs, especially miRNAs and lncRNAs, in the pathogenesis of hearing loss. We also discuss the shortcomings and issues that need to be addressed in the study of hearing loss ncRNAs in the hope of providing viable therapeutic strategies for the precise treatment of hearing loss.
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1333131
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  8. Article ; Online: Adipose Stem Cell-Based Treatments for Wound Healing

    Ning Zeng / Hongbo Chen / Yiping Wu / Zeming Liu

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 9

    Abstract: Wound healing is one of the most complex physiological regulation mechanisms of the human body. Stem cell technology has had a significant impact on regenerative medicine. Adipose stem cells (ASCs) have many advantages, including their ease of harvesting ...

    Abstract Wound healing is one of the most complex physiological regulation mechanisms of the human body. Stem cell technology has had a significant impact on regenerative medicine. Adipose stem cells (ASCs) have many advantages, including their ease of harvesting and high yield, rich content of cell components and cytokines, and strong practicability. They have rapidly become a favored tool in regenerative medicine. Here, we summarize the mechanism and clinical therapeutic potential of ASCs in wound repair.
    Keywords adipose stem cells ; wound healing ; regenerative medicine ; skin regeneration ; inflammation ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Use of Adipose Stem Cells Against Hypertrophic Scarring or Keloid

    Hongbo Chen / Kai Hou / Yiping Wu / Zeming Liu

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 9

    Abstract: Hypertrophic scars or keloid form as part of the wound healing reaction process, and its formation mechanism is complex and diverse, involving multi-stage synergistic action of multiple cells and factors. Adipose stem cells (ASCs) have become an emerging ...

    Abstract Hypertrophic scars or keloid form as part of the wound healing reaction process, and its formation mechanism is complex and diverse, involving multi-stage synergistic action of multiple cells and factors. Adipose stem cells (ASCs) have become an emerging approach for the treatment of many diseases, including hypertrophic scarring or keloid, owing to their various advantages and potential. Herein, we analyzed the molecular mechanism of hypertrophic scar or keloid formation and explored the role and prospects of stem cell therapy, in the treatment of this condition.
    Keywords hypertrofic scars ; adipose derived stem cell ; wound healing ; stem cell therapy ; mechanism ; keloid ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Clinical efficacy and safety of composite non-cross-linked hyaluronic acid for treating tear trough-lower eyelid bag deformity.

    Zhou, Xiaomei / Yi, Yan / Liu, Zeming / Zhang, Qi / Wu, Yiping / Luo, Xiao

    Journal of cosmetic dermatology

    2024  

    Abstract: Background: Tear trough-eye bag deformities may appear in young Asian patients due to the weak support of their facial skeletons. For these patients with better periorbital skin elasticity, the injection may be more suitable than surgery for treating ... ...

    Abstract Background: Tear trough-eye bag deformities may appear in young Asian patients due to the weak support of their facial skeletons. For these patients with better periorbital skin elasticity, the injection may be more suitable than surgery for treating tear trough-lower eyelid bag deformity.
    Aims: Identify the clinical efficacy and safety of non-cross-linked HA in the treatment of tear trough-lower eyelid bag deformity.
    Methods: In this study, we analyzed pre- and postinjection photographs of 55 patients treated with non-cross-linked hyaluronic acid (HA) for tear trough-lower eyelid bag deformity.
    Results: The mean [SD] scores of modified Goldberg score suggested that the most significant improvement of preoperative and postoperative scores was in tear trough depression, followed by infraorbital triangular depression, orbital fat prolapse, loss of skin elasticity, and skin transparency. Only transient localized complications were observed, including bruising, swelling, and erythema. There were no serious complications, such as skin necrosis or visual impairment.
    Conclusions: Our study confirmed the beneficial efficacy and minor complications of composite non-cross-linked HA for the treatment of tear trough-lower eyelid bag deformity.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.16303
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    Zs.A 6539: Show issues Location:
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