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  1. Article ; Online: Simplicity in Medicine: For a Return to Patient-Based Care.

    Putot, Alain

    The American journal of medicine

    2022  Volume 135, Issue 7, Page(s) 813–814

    MeSH term(s) Humans ; Medicine ; Patient Care
    Language English
    Publishing date 2022-02-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.01.038
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  2. Article ; Online: Promoting diversity and equity in science: a call for triple-blind review in medical journals.

    Putot, Alain

    QJM : monthly journal of the Association of Physicians

    2022  Volume 116, Issue 5, Page(s) 399

    MeSH term(s) Humans ; Health Equity ; Periodicals as Topic
    Language English
    Publishing date 2022-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcac115
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  3. Article ; Online: Long-Term Survival After Aspiration Pneumonia in Older Inpatients: A Comparative Study.

    Putot, Alain / Putot, Sophie / Manckoundia, Patrick

    Journal of the American Medical Directors Association

    2023  Volume 24, Issue 7, Page(s) 1088–1091

    Abstract: Objectives: Aspiration pneumonia (AsP), a leading cause of death in older people, remains poorly studied. We aimed to evaluate short- and long-term prognosis after AsP in older inpatients.: Design: Retrospective cohort study.: Setting and ... ...

    Abstract Objectives: Aspiration pneumonia (AsP), a leading cause of death in older people, remains poorly studied. We aimed to evaluate short- and long-term prognosis after AsP in older inpatients.
    Design: Retrospective cohort study.
    Setting and participants: All consecutive patients aged ≥75 years hospitalized in a 62-bed acute geriatric unit during a 1-year period.
    Methods: We compared clinical characteristics and overall 2-year survival between patients with a main diagnosis of AsP, patients with other types of acute pneumonia (non-AsP), and patients hospitalized for another cause.
    Results: Among the 1774 patients hospitalized over 1 year (median age: 87 years, 41% female), 125 (7%) had a primary diagnosis of acute pneumonia, of whom 39 (31%) had AsP and 86 (69%) non-AsP. Patients with AsP were more frequently male, lived more frequently in a nursing home, and had a more frequent history of stroke or neurocognitive disorders. Mortality rates were much higher after AsP, reaching 31% at 30 days (vs 15% after Non-AsP and 11% in the rest of the cohort, P < .001), and 69% 2 years after admission (vs 56% and 49%, P < .001). After adjustment for confounders, AsP was significantly associated with mortality but non-AsP was not [adjusted hazard ratio (95% CI): 3.09 (1.72-5.57) at 30 days and 1.67 (1.13-2.45) at 2 years for AsP; 1.36 (0.77-2.39) and 1.14 (0.85-1.52) for non-AsP]. However, among patients who survived at 30 days, mortality did not significantly differ between the 3 groups (P = .1).
    Conclusions and implications: In an unselected cohort of patients hospitalized in an acute geriatric unit, a third of AsP patients died within the first month after admission. However, among those surviving at 30 days, long-term mortality did not significantly differ from the rest of the cohort. These findings underline the importance of optimizing the early management of AsP.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Aged, 80 and over ; Retrospective Studies ; Inpatients ; Pneumonia/complications ; Stroke/complications ; Pneumonia, Aspiration/diagnosis
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2023.04.014
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  4. Article ; Online: New horizons in sepsis management in older patients.

    Putot, Alain / Prendki, Virginie

    Age and ageing

    2023  Volume 52, Issue 2

    Abstract: Sepsis is a frequent disease in older people, characterised by an inappropriate systemic inflammatory response following an infection, leading to life-threatening organ dysfunctions. In the very old, sepsis is often difficult to diagnose, given the ... ...

    Abstract Sepsis is a frequent disease in older people, characterised by an inappropriate systemic inflammatory response following an infection, leading to life-threatening organ dysfunctions. In the very old, sepsis is often difficult to diagnose, given the frequent atypical presentation. While there is no gold standard for the diagnosis of sepsis, new definitions published in 2016, aided by clinical-biological scores, namely Sequential Organ Failure Assessment (SOFA) and quick SOFA scores, allow earlier recognition of septic states at risk of poor outcome. The management of sepsis in itself differs little in older patients compared to younger subjects. However, the key question of whether or not to admit the patient to an intensive care setting has to be anticipated, depending on the sepsis severity but also on patient's comorbidities and wishes. The earliness of acute management in older subjects with decreased immune defences and physiological reserves is an essential prognostic element. The early control of comorbidities is the main plus value of the geriatrician in the acute and post-acute management of older patients with sepsis.
    MeSH term(s) Humans ; Aged ; Sepsis/diagnosis ; Sepsis/therapy ; Critical Care ; Geriatricians ; Hospitalization ; Recognition, Psychology
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186788-x
    ISSN 1468-2834 ; 0002-0729
    ISSN (online) 1468-2834
    ISSN 0002-0729
    DOI 10.1093/ageing/afad016
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  5. Article ; Online: Transfusion in Older Anemic Patients: Should the Troponin Value Be Taken into Account?

    Thevenin, Manon / Putot, Sophie / Manckoundia, Patrick / Putot, Alain

    The American journal of medicine

    2022  Volume 135, Issue 8, Page(s) 1008–1015.e1

    Abstract: Background: Anemia is common in older individuals, but it is not known whether the prognostic impact of transfusion differs according to cardiac troponin concentration.: Methods: During this 2-year retrospective study in an acute geriatric unit, 514 ... ...

    Abstract Background: Anemia is common in older individuals, but it is not known whether the prognostic impact of transfusion differs according to cardiac troponin concentration.
    Methods: During this 2-year retrospective study in an acute geriatric unit, 514 patients with hemoglobin <10 g/dL and troponin sampling were included. Thirty-day and 1-year mortality were compared according to transfusion status and troponin and hemoglobin levels.
    Results: Of the 514 anemic patients included (median age 88 years), 157 (31%) had elevated troponin concentrations. These patients were more likely to die at 30 days (49% vs 27%, P < .001) and 1 year (65% vs 51%, P = .004) than patients with normal values. Among patients with elevated troponin concentrations, 30-day mortality tended to be lower in transfused than in not-transfused patients (hazard ratio 0.48; 95% confidence interval, 0.21-1.08; P = .07). This association was not found in patients without troponin elevation (hazard ratio 1.09; 95% CI, 0.61-1.93; P = .8). Transfusion was associated with 30-day survival in patients with hemoglobin ≤8 g/dL. It was also associated with excess 1-year mortality in patients with hemoglobin >8 g/dL.
    Conclusions: This pilot study suggests that transfusion could be associated with better 30-day outcomes in older anemic patients with anemia-related myocardial injury. Thus, troponin levels could be involved in decision-making relative to transfusion in anemic older patients. Clinical trials are needed to establish the benefit of transfusion in patients with elevated troponins.
    MeSH term(s) Aged ; Aged, 80 and over ; Anemia/complications ; Anemia/therapy ; Hemoglobins ; Humans ; Pilot Projects ; Retrospective Studies ; Troponin
    Chemical Substances Hemoglobins ; Troponin
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.03.029
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  6. Article ; Online: Beyond longevity: healthy longevity.

    Putot, Alain / Putot, Sophie / Hacquin, Arthur / Manckoundia, Patrick

    The Lancet. Healthy longevity

    2021  Volume 2, Issue 7, Page(s) e393–e394

    MeSH term(s) Health Status ; Longevity
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2666-7568
    ISSN (online) 2666-7568
    DOI 10.1016/S2666-7568(21)00141-0
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  7. Article ; Online: Association of body mass index with long-term outcomes in older adults hospitalized for COVID-19: an observational study.

    Putot, Alain / Guyot, Charline / Manckoundia, Patrick / Van Wymelbeke-Delannoy, Virginie

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7512

    Abstract: Both underweight and obesity have been associated with poor prognosis in COVID-19. In an older populations of patients hospitalized for SARS-CoV-2 infection, we aimed to evaluate the association between body mass index (BMI) and short and long-term ... ...

    Abstract Both underweight and obesity have been associated with poor prognosis in COVID-19. In an older populations of patients hospitalized for SARS-CoV-2 infection, we aimed to evaluate the association between body mass index (BMI) and short and long-term prognosis. Among 434 consecutive patients aged ≥ 70 years and hospitalized for suspected COVID-19 at a university hospital, 219 patients (median age of 83 years, 53% male) testing positive for COVID-19 and for whom BMI was recorded at admission, agreed to participate. Among them, 39 had a BMI < 20 kg/m
    MeSH term(s) Humans ; Male ; Aged ; Aged, 80 and over ; Female ; COVID-19/complications ; Body Mass Index ; SARS-CoV-2 ; Obesity/complications ; Obesity/epidemiology ; Risk Factors ; Retrospective Studies
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58388-x
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  8. Article: Acute Care and Medication Management in Older Adults.

    Manckoundia, Patrick / Putot, Alain

    Journal of clinical medicine

    2021  Volume 10, Issue 2

    Abstract: The number of healthy and frail older adults is increasing worldwide, especially in industrialized countries, as a result of the increase in life expectancy [ ... ]. ...

    Abstract The number of healthy and frail older adults is increasing worldwide, especially in industrialized countries, as a result of the increase in life expectancy [...].
    Language English
    Publishing date 2021-01-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10020166
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  9. Article ; Online: COVID-19-Related French Lockdown: Impact on the Physical and Psychological Health of Older Adults.

    Manckoundia, Patrick / Putot, Alain

    Gerontology

    2021  Volume 68, Issue 4, Page(s) 418–420

    MeSH term(s) Aged ; Anxiety ; COVID-19/epidemiology ; COVID-19/prevention & control ; Communicable Disease Control ; Depression ; Humans ; Mental Health
    Language English
    Publishing date 2021-08-31
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193798-4
    ISSN 1423-0003 ; 0304-324X
    ISSN (online) 1423-0003
    ISSN 0304-324X
    DOI 10.1159/000518558
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  10. Article ; Online: Prognostic impact of systolic blood pressure in acute heart failure with preserved ejection fraction in older patients.

    Putot, Sophie / Hacquin, Arthur / Manckoundia, Patrick / Putot, Alain

    ESC heart failure

    2021  Volume 8, Issue 6, Page(s) 5493–5500

    Abstract: Aims: Recent guidelines recommend a systolic blood pressure (SBP) target below 130 mmHg in heart failure patients with preserved ejection fraction (HFpEF), whatever their age. We investigated whether this intensive SBP control was associated with better ...

    Abstract Aims: Recent guidelines recommend a systolic blood pressure (SBP) target below 130 mmHg in heart failure patients with preserved ejection fraction (HFpEF), whatever their age. We investigated whether this intensive SBP control was associated with better survival in very old adults hospitalized for acute HFpEF.
    Methods and results: We conducted an observational study in an acute geriatric unit: all consecutive patients discharged from hospital for acute heart failure from 1 March 2019 to 29 February 2020 with a diagnosis of HFpEF were included. Re-hospitalization and all-cause mortality at 1 year were compared according to the mean SBP at discharge (patients with a mean SBP < 130 mmHg vs. those with SBP ≥ 130 mmHg). We included 81 patients with a mean age of 89 years. Among them, 47 (58%) were re-hospitalized and 37 (46%) died at 1 year. All-cause mortality (hazard ratio [HR] [95% confidence interval]: 1.50 [0.75-2.98], P = 0.2) and re-hospitalization rate (HR: 1.04 [0.58-1.86], P = 0.90) at 1 year did not significantly differ between patients with SBP ≥ 130 mmHg and those with SBP < 130 mmHg at discharge. However, a prescription for antihypertensive drugs at discharge was associated with a better long-term prognosis (all-cause mortality: HR: 0.42 [0.20-0.88], P = 0.02; re-hospitalization rate: HR: 0.56 [0.28-1.10], P = 0.09).
    Conclusions: Although SBP < 130 mmHg at discharge was not associated with a better prognosis among very old patients hospitalized for acute HFpEF, the prescription of antihypertensive drugs was associated with mortality and re-hospitalization rates that were reduced by half. Future prospective studies are needed to assess target blood pressure in very elderly patients with HFpEF.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Pressure/physiology ; Heart Failure ; Humans ; Prognosis ; Stroke Volume/physiology ; Ventricular Function, Left/physiology
    Language English
    Publishing date 2021-10-19
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.13650
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