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  1. Book ; Online ; E-Book: Adipocytic, vascular and skeletal muscle tumors

    Gerosa, Clara / Faa, Gavino / Sciot, Raf

    a practical diagnostic approach

    (Current Clinical Pathology,)

    2020  

    Abstract: This book focuses on the subsets of soft tissue tumors that show adipocytic, vascular or skeletal muscle differentiation. It reviews the surgical pathologists’ approach to diagnosing soft tissue tumors guided by vital morphological and ... ...

    Author's details Raf Sciot; Clara Gerosa; Gavino Faa
    Series title Current Clinical Pathology,
    Abstract This book focuses on the subsets of soft tissue tumors that show adipocytic, vascular or skeletal muscle differentiation. It reviews the surgical pathologists’ approach to diagnosing soft tissue tumors guided by vital morphological and immunohistochemical data in the differential diagnosis of this family of tumors. Written by experts in the field, the text contains a concise yet comprehensive summary of the current status of the field that helps guide diagnosis and patient management, and stimulates investigative efforts. The book is filled with high-quality drawings of the salient histologic features of these various tumors, alongside photomicrographs and tips and tricks that help the relatively untrained or inexperienced eye to recognize the various structures or cell types that comprise each of these lesions. This innovative approach seeks to make recognition of these tumors easier. Adipocytic, Vascular and Skeletal Muscle Tumors serves as a valuable resource for pathologists, oncologists, surgeons, and researchers dealing with and interested in these complex and challenging tumors.
    Keywords Pathology ; Oncology ; Tumors/Diagnosis
    Subject code 616.07
    Language English
    Size 1 online resource (XI, 182 p.)
    Edition 1st ed. 2020.
    Publisher Humana Press
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-37460-2 ; 3-030-37459-9 ; 978-3-030-37460-0 ; 978-3-030-37459-4
    DOI 10.1007/978-3-030-37460-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Kidney development in renal pathology

    Faa, Gavino / Fanos, Vassilios

    (Current clinical pathology)

    2014  

    Author's details Gavino Faa ; Vassilios Fanos ed
    Series title Current clinical pathology
    Keywords Kidneys/Growth ; Kidneys/Diseases/Pathophysiology
    Subject code 616.6107
    Language English
    Size XII, 105 S. : Ill., graph. Darst., 26 cm
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018402422
    ISBN 978-1-4939-0946-9 ; 9781493909476 ; 1-4939-0946-0 ; 1493909479
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Editorial: Looking for a culprit: The role of environmental co-factors in complex neuropsychiatric disorders.

    Manchia, Mirko / Zai, Clement C / Fanni, Daniela / Faa, Gavino

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 1000783

    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.1000783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The fascinating theory of fetal programming of adult diseases: A review of the fundamentals of the Barker hypothesis.

    Faa, Gavino / Fanos, Vassilios / Manchia, Mirko / Van Eyken, Peter / Suri, Jasjit S / Saba, Luca

    Journal of public health research

    2024  Volume 13, Issue 1, Page(s) 22799036241226817

    Abstract: The theory of fetal programming of adult diseases was first proposed by David J.P. Barker in the eighties of the previous century, to explain the higher susceptibility of some people toward the development of ischemic heart disease. According to his ... ...

    Abstract The theory of fetal programming of adult diseases was first proposed by David J.P. Barker in the eighties of the previous century, to explain the higher susceptibility of some people toward the development of ischemic heart disease. According to his hypothesis, poor maternal living conditions during gestation represent an important risk factor for the onset of atherosclerotic heart disease later in life. The analysis of the early phases of fetal development is a fundamental tool for the risk stratification of children and adults, allowing the identification of susceptible or resistant subjects to multiple diseases later in life. Here, we provide a narrative summary of the most relevant evidence supporting the Barker hypothesis in multiple fields of medicine, including neuropsychiatric disorders, such as Parkinson disease and Alzheimer disease, kidney failure, atherosclerosis, coronary heart disease, stroke, diabetes, cancer onset and progression, metabolic syndrome, and infectious diseases including COVID-19. Given the consensus on the role of body weight at birth as a practical indicator of the fetal nutritional status during gestation, every subject with a low birth weight should be considered an "at risk" subject for the development of multiple diseases later in life. The hypothesis of the "physiological regenerative medicine," able to improve fetal organs' development in the perinatal period is discussed, in the light of recent experimental data indicating Thymosin Beta-4 as a powerful growth promoter when administered to pregnant mothers before birth.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2279-9028
    ISSN 2279-9028
    DOI 10.1177/22799036241226817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: p16 Block Type Overexpression, p53 Wild Type Reactivity, and Cervical Involvement do not Always Exclude the Diagnosis of Primary Endometrial Squamous Cell Carcinoma (PESCC).

    Fanni, Daniela / Gerosa, Clara / Peiretti, Michele / Mais, Valerio / Massa, Elena / Angioni, Stefano / Faa, Gavino

    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

    2023  Volume 43, Issue 2, Page(s) 200–201

    MeSH term(s) Female ; Humans ; Tumor Suppressor Protein p53/genetics ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/pathology ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Biomarkers, Tumor/genetics
    Chemical Substances Tumor Suppressor Protein p53 ; Cyclin-Dependent Kinase Inhibitor p16 ; Biomarkers, Tumor
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604859-6
    ISSN 1538-7151 ; 0277-1691
    ISSN (online) 1538-7151
    ISSN 0277-1691
    DOI 10.1097/PGP.0000000000000970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Commentary: Sleep Disturbance in Bipolar Disorder: Neuroglia and Circadian Rhythms.

    Carta, Mauro Giovanni / Fanni, Daniela / Orrù, Germano / Faa, Gavino

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 730360

    Language English
    Publishing date 2021-09-30
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.730360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Alpha-1-antitripsin deficiency

    Gavino Faa

    Journal of Pediatric and Neonatal Individualized Medicine, Vol 4, Iss 1, Pp e040111-e

    the need of a new diagnostic algorithm for improving the diagnostic ability of perinatologists and pediatricians

    2015  Volume 040111

    Abstract: Caution should be taken in considering immunoelectrofocusing (IEF) as the best method for the diagnosis of alpha-1-antitrypsin (A1AT) deficiency, particularly in some population, including Sardinians, in which a M-like variant represents the most ... ...

    Abstract Caution should be taken in considering immunoelectrofocusing (IEF) as the best method for the diagnosis of alpha-1-antitrypsin (A1AT) deficiency, particularly in some population, including Sardinians, in which a M-like variant represents the most frequent pathological A1AT variant. Regarding the future, my opinion is that the algorithm generally suggested for reaching a proper diagnosis of this disease should be completely changed. The cut-off of the A1AT serum values should be reconsidered, not to avoid the diagnosis of a number of heterozygous subjects who may be affected by liver and/or lung disease. Given that the two A1AT alleles are co-dominant, and since A1AT is a phase acute protein, in all heterozygous PiMZ or PiM/M-Cagliari subjects carrying an inflammation, the M allele is induced to produce high quantities of A1AT, whose serum levels may reach normal values. In these cases, PCR serum levels should be evaluated and, when increased, the diagnosis of A1AT deficiency should not be excluded even in the presence of serum A1AT levels within the normal range. Gene sequencing should be included, on the basis of our experience, in all neonates and pediatric patients with liver or lung disease of unknown origin, including asthma, avoiding IEF. Finally, for a screening in the perinatal period, I suggest the accurate examination of the electrophoresis of serum proteins. With a similar new approach, I think that we will transform A1AT deficiency from a rare disease into a previously rarely diagnosed disease, changing completely the epidemiology of this complex and fascinating metabolic disease.
    Keywords alpha-1-antitripsin deficiency ; a1at ; diagnosis ; m-like variants ; liver disease ; juvenile emphysema ; m-cagliari ; Medicine ; R ; Pediatrics ; RJ1-570
    Subject code 610
    Language English
    Publishing date 2015-02-01T00:00:00Z
    Publisher Hygeia Press di Corridori Marinella
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Corrigendum to "Artificial intelligence in computed tomography plaque characterization: A review" [Eur. J. Radiol. 140 (2021) 109767].

    Cau, Riccardo / Flanders, Adam / Mannelli, Lorenzo / Politi, Carola / Faa, Gavino / Suri, Jasjit S / Saba, Luca

    European journal of radiology

    2022  Volume 147, Page(s) 110132

    Language English
    Publishing date 2022-01-05
    Publishing country Ireland
    Document type Published Erratum
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2021.110132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cell starvation increases uptake of extracellular Thymosin β4 and its complexes with calcium.

    Piludu, Marco / Pichiri, Giuseppina / Coni, Pierpaolo / Piras, Monica / Congiu, Terenzio / Faa, Gavino / Lachowicz, Joanna Izabela

    International immunopharmacology

    2023  Volume 116, Page(s) 109743

    Abstract: Cell metastasis is the main cause of cancer mortality. Inhibiting early events during cell metastasis and invasion could significantly improve cancer prognosis, but the initial mechanisms of cell transition and migration are barely known. Calcium ... ...

    Abstract Cell metastasis is the main cause of cancer mortality. Inhibiting early events during cell metastasis and invasion could significantly improve cancer prognosis, but the initial mechanisms of cell transition and migration are barely known. Calcium regulates cell migration, whilst Thymosin β4 is a G-actin and iron binding peptide associated with tumor metastasis and ferroptosis. Under normal cell growth conditions, intracellular free calcium ions and Thymosin β4 concentrations are strictly regulated, and are not influenced by extracellular supplementation. However, cell starvation decreases intracellular Thymosin β4 and increases extracellular peptide uptake above the normal range. Unexpectedly, cell starvation significantly increases internalization of extracellular Ca
    MeSH term(s) Humans ; Calcium ; Cell Movement ; Thymosin/metabolism ; Neoplasms
    Chemical Substances Calcium (SY7Q814VUP) ; thymosin beta(4) (549LM7U24W) ; Thymosin (61512-21-8)
    Language English
    Publishing date 2023-01-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.109743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Association between Hypomagnesemia, COVID-19, Respiratory Tract and Lung Disease.

    Faa, Gavino / Saba, Luca / Fanni, Daniela / Kalcev, Goce / Carta, Mauro

    The open respiratory medicine journal

    2021  Volume 15, Page(s) 43–45

    Abstract: The complexity of COVID-19 is also related to the multiple molecular pathways triggered by SARS-CoV-2, which is able to cause type I pneumocyte death, trigger intravascular coagulation, interfere with the renin-angiotensin system, dysregulate iron ... ...

    Abstract The complexity of COVID-19 is also related to the multiple molecular pathways triggered by SARS-CoV-2, which is able to cause type I pneumocyte death, trigger intravascular coagulation, interfere with the renin-angiotensin system, dysregulate iron metabolism, ending with the insurgence of a cytokine storm which may lead to death. Old adults with obesity, hypertension, and diabetes are among the high-risk category groups more prone to SARS-CoV-2 infection. Magnesium has been reported to play a major role both in physiology and in pathology, particularly in elderly people, regulating cytotoxic functions of natural killer (NK) cells and CD8+ T lymphocytes. In spite of the absence of controlled trials, the possibility of magnesium supplementation for supportive treatment in patients with COVID-19 should be encouraged. This could be useful in all phases of the COVID-19 disease.
    Language English
    Publishing date 2021-09-17
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2395996-4
    ISSN 1874-3064
    ISSN 1874-3064
    DOI 10.2174/1874306402115010043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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