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Article: Renoprotective strategies.

Raikou, Vaia D

World journal of nephrology

2024 Volume 13, Issue 1, Page(s) 89637

Abstract: Kidney disease remains a condition with an increasing incidence, high morbidity and mortality associated with cardiovascular events. The incidence of end-stage renal disease is expected to increase. Despite of the technical improvement, dialysis never ... ...

Abstract	Kidney disease remains a condition with an increasing incidence, high morbidity and mortality associated with cardiovascular events. The incidence of end-stage renal disease is expected to increase. Despite of the technical improvement, dialysis never achieved a full clearance of the blood dialysis. Therefore, the demand for new renoprotective measures has never been greater. Here, we report new strategies for preventing renal damage.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Editorial
ISSN	2220-6124
ISSN	2220-6124
DOI	10.5527/wjn.v13.i1.89637
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Article: Protein intake, chronic renal disease progression and cardiovascular morbidity.

Raikou, Vaia D

Nutrition and health

2022 Volume 29, Issue 1, Page(s) 21–23

Abstract: Summary statement: It has been suggested that the lowering of dietary protein reduces the progression of CKD, despite it has been also reported that higher intake of total protein was associated with a lower risk of cardiovascular morbidity.The role of ... ...

Abstract	Summary statement: It has been suggested that the lowering of dietary protein reduces the progression of CKD, despite it has been also reported that higher intake of total protein was associated with a lower risk of cardiovascular morbidity.The role of protein intake is equivocal in clinical outcomes including the renal and cardiovascular disease worsening, metabolic acidosis and bone abnormalities.The modification of both amount and sources of protein intake could influence the renal and cardiovascular deterioration.
MeSH term(s)	Humans ; Renal Insufficiency, Chronic ; Disease Progression ; Cardiovascular Diseases
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	603215-1
ISSN	2047-945X ; 0260-1060
ISSN (online)	2047-945X
ISSN	0260-1060
DOI	10.1177/02601060221118897
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Article ; Online: Protein intake, chronic renal disease progression and cardiovascular morbidity

Raikou, Vaia D.

Nutrition and Health. 2023 Mar., v. 29, no. 1 p.21-23

2023

Abstract: We commented the recently reported insights about the equivocal role of protein intake in the progression of chronic kidney disease and cardiovascular morbidity. It has been suggested that the lowering of dietary protein reduces the progression of CKD, ... ...

Abstract	We commented the recently reported insights about the equivocal role of protein intake in the progression of chronic kidney disease and cardiovascular morbidity. It has been suggested that the lowering of dietary protein reduces the progression of CKD, despite it has been also reported that higher intake of total protein was associated with a lower risk of cardiovascular morbidity. The role of protein intake is equivocal in clinical outcomes including the renal and cardiovascular disease worsening, metabolic acidosis and bone abnormalities. The modification of both amount and sources of protein intake could influence the renal and cardiovascular deterioration.
Keywords	acidosis ; cardiovascular diseases ; dietary protein ; disease progression ; kidney diseases ; morbidity ; protein content ; protein intake ; risk ; protein ; renal disease ; cardiovascular disease ; phosphate ; protein energy wasting
Language	English
Dates of publication	2023-03
Size	p. 21-23.
Publishing place	SAGE Publications
Document type	Article ; Online
ZDB-ID	603215-1
ISSN	2047-945X ; 0260-1060
ISSN (online)	2047-945X
ISSN	0260-1060
DOI	10.1177/02601060221118897
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Article: Serum phosphate and chronic kidney and cardiovascular disease: Phosphorus potential implications in general population.

Raikou, Vaia D

World journal of nephrology

2021 Volume 10, Issue 5, Page(s) 76–87

Abstract: It has already been established that in end-stage renal disease, hyperphosphatemia causes soft tissue calcification including vascular calcifications. It has also been supported that there is a connection between increased serum phosphate and morbidity ... ...

Abstract	It has already been established that in end-stage renal disease, hyperphosphatemia causes soft tissue calcification including vascular calcifications. It has also been supported that there is a connection between increased serum phosphate and morbidity in subjects, who suffer from renal disease. However, studies in these populations conferred mixed results. Several warnings are included in the role of serum phosphorus on cardiovascular disease in normal populations. Homeostasis of serum phosphate is obtained by the cooperation between regulatory hormones, cellular receptors and bone metabolic factors. There is the probability that one or more phosphate regulatory factors, rather than phosphate directly, may be responsible for observed associations with calcification and cardiovascular events in normal populations. Experimental studies have shown that the restriction of dietary phosphate prevents the progression of kidney dysfunction, although high dietary phosphate aggravates the renal function. In the current review, we discuss the role of serum phosphorus on progression of renal dysfunction and cardiovascular outcomes in chronic kidney disease patients and its involvement in important health risks in the general population.
Language	English
Publishing date	2021-09-19
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2220-6124
ISSN	2220-6124
DOI	10.5527/wjn.v10.i5.76
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Article: The Role of Chronic Renal Disease on the Linking Obesity/Hypertension.

Raikou, Vaia D / Gavriil, Sotiris

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2022 Volume 32, Issue 6, Page(s) 1637–1645

Abstract: Obesity is accompanied by several disorders. This study investigated the role of chronic renal disease on the linking obesity/hypertension (HTN). It also considered the importance of visceral obesity on renal disease with or without HTN. One hundred and ... ...

Abstract	Obesity is accompanied by several disorders. This study investigated the role of chronic renal disease on the linking obesity/hypertension (HTN). It also considered the importance of visceral obesity on renal disease with or without HTN. One hundred and forty seven subjects on mean age 68.9 ± 14.2 years old with visceral obesity were enclosed and they matched for the age, gender, estimated glomerular filtration rate (eGFR), diabetes mellitus, and hypertriglyceridemia to 52 people without visceral obesity as a control group. Visceral obesity was defined by the measurement of waist circumference. Our participants were classified in both eGFR and albuminuria categories according to the Kidney Disease Improving Global Outcomes 2012 criteria. The HTN ratio was equal to 89.1% in the patients' group. Ratios of 72.1% and 70.1% of our patients and 67.3% and 23.1% of our control group had a low eGFR and albuminuria respectively. The relationship between central obesity and HTN was found to be nonsignificant, but in our subjects without an advanced renal disease (eGFR >60 mL/min/1.73 m
MeSH term(s)	Aged ; Aged, 80 and over ; Albuminuria/complications ; Albuminuria/etiology ; Glomerular Filtration Rate ; Humans ; Hypertension ; Kidney Failure, Chronic/complications ; Middle Aged ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology ; Obesity, Abdominal/complications ; Obesity, Abdominal/diagnosis ; Obesity, Abdominal/epidemiology ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors
Language	English
Publishing date	2022-08-10
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.352424
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Article ; Online: The Role of Chronic Renal Disease on the Linking Obesity/Hypertension

Vaia D. Raikou / Sotiris Gavriil

Saudi Journal of Kidney Diseases and Transplantation, Vol 32, Iss 6, Pp 1637-

2021 Volume 1645

Abstract	Obesity is accompanied by several disorders. This study investigated the role of chronic renal disease on the linking obesity/hypertension (HTN). It also considered the importance of visceral obesity on renal disease with or without HTN. One hundred and forty seven subjects on mean age 68.9 ± 14.2 years old with visceral obesity were enclosed and they matched for the age, gender, estimated glomerular filtration rate (eGFR), diabetes mellitus, and hypertriglyceridemia to 52 people without visceral obesity as a control group. Visceral obesity was defined by the measurement of waist circumference. Our participants were classified in both eGFR and albuminuria categories according to the Kidney Disease Improving Global Outcomes 2012 criteria. The HTN ratio was equal to 89.1% in the patients’ group. Ratios of 72.1% and 70.1% of our patients and 67.3% and 23.1% of our control group had a low eGFR and albuminuria respectively. The relationship between central obesity and HTN was found to be nonsignificant, but in our subjects without an advanced renal disease (eGFR >60 mL/min/1.73 m2, n= 58) it was found to be significant (χ2 = 5.4, P = 0.02, likelihood ratio = 5.1). Albuminuria was significantly associated with both visceral obesity and visceral obesity with HTN (χ2 =34.7, P =, respectively) and it was supported by a built adjusted model. Chronic renal disease may influence the linki001 and χ2 = 37.7, P = 0.001ng obesity/HTN in elderly participants with obesity in contrast to the general population with obesity but without renal disease. Visceral obesity was significantly associated with albuminuria independently on HTN.
Keywords	Medicine ; R
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
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Article: Metabolic acidosis status and mortality in patients on the end stage of renal disease.

Raikou, Vaia D

Journal of translational internal medicine

2016 Volume 4, Issue 4, Page(s) 170–177

Abstract: Background and objectives: Uncorrected metabolic acidosis leads to higher death risk in dialysis patients. We observed the relationship between metabolic acidosis status and mortality rate in patients on renal replacement therapy during a median follow ... ...

Abstract	Background and objectives: Uncorrected metabolic acidosis leads to higher death risk in dialysis patients. We observed the relationship between metabolic acidosis status and mortality rate in patients on renal replacement therapy during a median follow up time of 60 months. Methods: We studied 76 patients on an on-line hemodiafiltration. The dialysis adequacy was defined by Kt/V for urea. The Framingham risk score (FRS) points were used to determine the 10-year risk for coronary heart disease. We examined the impact of high or low serum bicarbonate concentrations on mortality rate and on 10-year risk for coronary heart disease via the Kaplan-Meier method. Cox's model was used to evaluate a combination of prognostic variables, such as dialysis adequacy defined by Kt/V for urea, age and serum bicarbonate concentrations. Results: We divided the enrolled patients in three groups according to serum bicarbonate concentrations (< 20 mmol/L, 20-22 mmol/L and > 22 mmol/L). Kaplan-Meier survival curve for the impact of serum bicarbonate concentrations on overall mortality was found significant (log-rank = 7.8, Conclusion: Uncorrected severe metabolic acidosis, defined by serum bicarbonate concentrations less than 20 mmol/L, is associated with a 10-year risk for coronary heart disease more than 20% and high overall mortality in patients on renal replacement therapy.
Language	English
Publishing date	2016-12-30
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2861892-0
ISSN	2224-4018 ; 2450-131X
ISSN (online)	2224-4018
ISSN	2450-131X
DOI	10.1515/jtim-2016-0036
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Article ; Online: Factors related to peripheral arterial disease in patients undergoing hemodialysis: the potential role of monocyte chemoattractant protein-1.

Raikou, Vaia D / Kyriaki, Despina

Hypertension research : official journal of the Japanese Society of Hypertension

2019 Volume 42, Issue 10, Page(s) 1528–1535

Abstract: Peripheral arterial disease (PAD) is substantially prevalent among patients in the end stage of renal disease (ESRD). We considered factors related to peripheral arterial disease in patients undergoing hemodialysis including the important role of ... ...

Abstract	Peripheral arterial disease (PAD) is substantially prevalent among patients in the end stage of renal disease (ESRD). We considered factors related to peripheral arterial disease in patients undergoing hemodialysis including the important role of monocyte chemoattractant protein-1 (MCP-1) serum concentrations. We studied 150 patients in on-line-predilution hemodiafiltration. Dialysis sufficiency was defined by Kt/V for urea. PAD was defined using clinical criteria, ankle-brachial index and Doppler ultrasound in the lower limbs. MCP-1 serum concentrations were measured using enzyme-linked immunoabsorbed assay (ΕLISA). We performed chi-square tests and logistic regression analysis to investigate risk factors for the prevalence of PAD in these patients including MCP-1 serum concentrations. The patients with manifested PAD had elevated MCP-1, higher BP, higher arterial stiffness markers, higher markers of malnutrition, uncontrolled metabolic acidosis, bone disease and lower obtained dialysis adequacy than the patients without PAD. The association between PAD manifestation and high MCP-1 was found significant (x
MeSH term(s)	Aged ; Chemokine CCL2/blood ; Chemokine CCL2/physiology ; Cross-Sectional Studies ; Female ; Humans ; Lipoproteins, HDL/blood ; Lipoproteins, LDL/blood ; Male ; Middle Aged ; Peripheral Arterial Disease/blood ; Peripheral Arterial Disease/etiology ; Renal Dialysis
Chemical Substances	CCL2 protein, human ; Chemokine CCL2 ; Lipoproteins, HDL ; Lipoproteins, LDL
Language	English
Publishing date	2019-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/s41440-019-0259-x
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Article ; Online: Body-mass index and the risk of albuminuria in hypertensive patients with a poor estimated glomerular filtration rate and the potential role of diabetes mellitus.

Raikou, Vaia D / Gavriil, Sotiris

Diabetes & metabolic syndrome

2019 Volume 13, Issue 2, Page(s) 1041–1046

Abstract: Background: Obesity-related to metabolic syndrome was associated with a greater risk for development of chronic kidney disease (CKD). We aimed to assess the association between obesity and micro/macroalbuminuria in hypertensive patients with a poor ... ...

Abstract	Background: Obesity-related to metabolic syndrome was associated with a greater risk for development of chronic kidney disease (CKD). We aimed to assess the association between obesity and micro/macroalbuminuria in hypertensive patients with a poor estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m Methods: One hundred old patients (median age 79 years ± inter-quartile range 68-84.7) with manifested hypertension (systolic blood pressure ≥ 130 mmHg and/or diastolic blood pressure ≥ 85 mmHg) and a permanently poor eGFR for a duration time more than 3 months were enclosed. Albuminuria was defined as urinary albumin-to-creatinine ratio (ACR) ≥ 30 mg/gr and it was classified according to KDIGO 2012. The obesity was defined by a high body mass index (BMI>30 kg/m Results: Chi-square tests showed significant association between classified albuminuria and both obesity and high serum triglycerides (x Conclusion: Obesity defined by a high BMI was not found to be a significant risk factor for micro/macroalbuminuria in hypertensive patients with a poor estimated glomerular filtration rate, when diabetes mellitus and the low eGFR value act as confounders.
MeSH term(s)	Aged ; Aged, 80 and over ; Albuminuria/etiology ; Albuminuria/metabolism ; Albuminuria/pathology ; Biomarkers/analysis ; Body Mass Index ; Cross-Sectional Studies ; Diabetes Mellitus/etiology ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/pathology ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Hypertension/complications ; Hypertension/metabolism ; Hypertension/pathology ; Kidney Function Tests ; Male ; Obesity/physiopathology ; Prognosis ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology ; Risk Factors ; Waist Circumference
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-01-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2019.01.017
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Article: Metabolic Syndrome and Chronic Renal Disease.

Raikou, Vaia D / Gavriil, Sotiris

Diseases (Basel, Switzerland)

2018 Volume 6, Issue 1

Abstract: Background: Methods: 149 patients (77 males/72 females) were enrolled in the study. Chronic renal disease was defined according to KDIGO 2012 criteria based on eGFR category and classified albuminuria. MetS was studied as a dichotomous variable (0 to ... ...

Abstract	Background Methods: 149 patients (77 males/72 females) were enrolled in the study. Chronic renal disease was defined according to KDIGO 2012 criteria based on eGFR category and classified albuminuria. MetS was studied as a dichotomous variable (0 to 5 components) including hypertension, waist circumference, low HDL-cholesterol, high triglycerides, and high glucose.
Language	English
Publishing date	2018-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720869-2
ISSN	2079-9721
ISSN	2079-9721
DOI	10.3390/diseases6010012
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