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Article ; Online: Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism.

Liao, Zhihao / Cai, Xuepei / Zheng, Yifan / Lin, Jiayu / Yang, Xia / Lin, Weiyin / Zhang, Ying / He, Xin / Liu, Chufeng

2024 Volume 202, Page(s) 107141

Abstract: Osteoarthritis (OA) is a degenerative disease characterised by articular cartilage destruction, and its complex aetiology contributes to suboptimal clinical treatment outcomes. A close association exists between glucose metabolism dysregulation and OA ... ...

Abstract	Osteoarthritis (OA) is a degenerative disease characterised by articular cartilage destruction, and its complex aetiology contributes to suboptimal clinical treatment outcomes. A close association exists between glucose metabolism dysregulation and OA pathogenesis. Owing to the unique environment of low oxygen and glucose concentrations, chondrocytes rely heavily on their glycolytic capacity, exhibiting distinct spatiotemporal differences. However, under pathological stimulation, chondrocytes undergo excessive glycolytic activity while mitochondrial respiration and other branches of glucose metabolism are compromised. This metabolic change induces cartilage degeneration by reprogramming the inflammatory responses. Sirtuins, a highly conserved family of nicotinamide adenine dinucleotide (NAD
MeSH term(s)	Animals ; Humans ; Cartilage, Articular/pathology ; Glucose/metabolism ; Osteoarthritis/metabolism ; Sirtuin 1/metabolism ; Sirtuins/metabolism
Chemical Substances	Glucose (IY9XDZ35W2) ; Sirtuin 1 (EC 3.5.1.-) ; Sirtuins (EC 3.5.1.-) ; SIRT1 protein, human (EC 3.5.1.-)
Language	English
Publishing date	2024-03-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2024.107141
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Zs.A 721: Show issues

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Article ; Online: OralExplorer: a web server for exploring the mechanisms of oral inflammatory diseases.

Lin, Weiyin / Yang, Hong / Lin, Jiayu / Yang, Xia / Liao, Zhihao / Zheng, Yifan / Luo, Peng / Liu, Chufeng

Journal of translational medicine

2024 Volume 22, Issue 1, Page(s) 282

Abstract: Background: Oral inflammatory diseases are localized infectious diseases primarily caused by oral pathogens with the potential for serious systemic complications. However, publicly available datasets for these diseases are underutilized. To address this ...

Abstract	Background: Oral inflammatory diseases are localized infectious diseases primarily caused by oral pathogens with the potential for serious systemic complications. However, publicly available datasets for these diseases are underutilized. To address this issue, a web tool called OralExplorer was developed. This tool integrates the available data and provides comprehensive online bioinformatic analysis. Methods: Human oral inflammatory disease-related datasets were obtained from the GEO database and normalized using a standardized process. Transcriptome data were then subjected to differential gene expression analysis, immune infiltration analysis, correlation analysis, pathway enrichment analysis, and visualization. The single-cell sequencing data was visualized as cluster plot, feature plot, and heatmaps. The web platform was primarily built using Shiny. The biomarkers identified in OralExplorer were validated using local clinical samples through qPCR and IHC. Results: A total of 35 human oral inflammatory disease-related datasets, covering 6 main disease types and 901 samples, were included in the study to identify potential molecular signatures of the mechanisms of oral diseases. OralExplorer consists of 5 main analysis modules (differential gene expression analysis, immune infiltration analysis, correlation analysis, pathway enrichment analysis and single-cell analysis), with multiple visualization options. The platform offers a simple and intuitive interface, high-quality images for visualization, and detailed analysis results tables for easy access by users. Six markers (IL1β, SRGN, CXCR1, FGR, ARHGEF2, and PTAFR) were identified by OralExplorer. qPCR- and IHC-based experimental validation showed significantly higher levels of these genes in the periodontitis group. Conclusions: OralExplorer is a comprehensive analytical platform for oral inflammatory diseases. It allows users to interactively explore the molecular mechanisms underlying the action and regression of these diseases. It also aids dental researchers in unlocking the potential value of transcriptomics data related to oral diseases. OralExplorer can be accessed at https://smuonco.shinyapps.io/OralExplorer/ (Alternate URL: http://robinl-lab.com/OralExplorer ).
MeSH term(s)	Humans ; Software ; Computational Biology/methods ; Gene Expression Profiling/methods ; Transcriptome/genetics ; Databases, Factual ; Rho Guanine Nucleotide Exchange Factors
Chemical Substances	ARHGEF2 protein, human ; Rho Guanine Nucleotide Exchange Factors
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-024-05019-8
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Article ; Online: Study on the intestinal permeability of lamivudine using Caco-2 cells monolayer and Single-pass intestinal perfusion

Weiyin Huang / Shuang Chen / Lin Sun / Hubin Wwang / Hongqun Qiao

Saudi Journal of Biological Sciences, Vol 29, Iss 4, Pp 2247-

2022 Volume 2252

Abstract: Background: The aim of this work is to investigate the intestinal permeability of lamivudine and explore its absorption mechanism. Method: Caco-2 cells monolayer and single-pass intestinal perfusion (SPIP) were selected for the investigation of ... ...

Abstract	Background: The aim of this work is to investigate the intestinal permeability of lamivudine and explore its absorption mechanism. Method: Caco-2 cells monolayer and single-pass intestinal perfusion (SPIP) were selected for the investigation of lamivudine under different conditions, such as different concentration, absorption time, bidirectional transportation, and transportation with efflux transporters inhibitor. The concentration of lamivudine both in Caco-2 cells monolayer samples and SPIP samples was detected by HPLC-UV. Then the permeability parameters were calculated. Results: The established HPLC-UV method reach the requirements for detection. There is no statistically difference between absorption parameters of lamivudine both in Caco-2 cells monolayer and SPIP (P > 0.05) under different dose groups. After transportation with efflux transporters inhibitor, the efflux rate of lamivudine in three dose groups was significantly decreased from 2.67, 2.59 and 2.59 to 1.78, 1.61, and 1.81 respectively. Lamivudine exhibits an absorption mechanism of passive diffusion. Conclusion: The absorption of lamivudine may be related to efflux transporters. In addition, lamivudine is a moderate-permeability drug in Biopharmaceutics Classification System.
Keywords	Lamivudine ; Caco-2 cells monolayer ; Single-pass intestinal perfusion ; Intestinal absorption ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Insight into the molecular mechanisms of leaf coloration in

Cao, Hua / Li, Han / Chen, Xiang / Zhang, Yuying / Lu, Lin / Li, Shenchong / Tao, Xiang / Zhu, WeiYin / Wang, Jihua / Ma, Lulin

Frontiers in genetics

2022 Volume 13, Page(s) 923082

Abstract: ... ...

Abstract	Cymbidium
Language	English
Publishing date	2022-08-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.923082
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Article ; Online: E. Coli LPS-induced calcium signaling regulates the expression of hypoxia-inducible factor 1α in periodontal ligament fibroblasts in a non-hypoxia-dependent manner.

Yang, Xia / Cai, Xuepei / Lin, Jiayu / Zheng, Yifan / Liao, Zhihao / Lin, Weiyin / He, Xin / Zhang, Ying / Ren, XiaoHua / Liu, Chufeng

International immunopharmacology

2024 Volume 128, Page(s) 111418

Abstract: Periodontitis, an inflammatory disease, can cause significant damage to the oral tissues which support the teeth. During the early development of periodontitis, periodontal ligament fibroblasts (PDLFs) undergo metabolic reprogramming regulated by hypoxia- ...

Abstract	Periodontitis, an inflammatory disease, can cause significant damage to the oral tissues which support the teeth. During the early development of periodontitis, periodontal ligament fibroblasts (PDLFs) undergo metabolic reprogramming regulated by hypoxia-inducible factor 1α (HIF-1α), which is strongly linked to the progression of inflammation. However, the precise mechanisms by which PDLFs regulate HIF-1α and its associated metabolic reprogramming during early inflammation remain unclear. This study illustrated that brief and low-dose exposure to Escherichia coli (E. coli) lipopolysaccharide (LPS) can serve as a non-hypoxic stimulus, effectively replicating early periodontal inflammatory reactions. This is evidenced by the upregulation of HIF-1α expression and the activation of HIF-1α-mediated crucial glycolytic enzymes, namely lactate dehydrogenase a, pyruvate kinase, and hexokinase 2, concomitant with an augmentation in the inflammatory response within PDLFs. We observed that the effects mentioned and their impact on macrophage polarization were notably attenuated when intracellular and extracellular stores of Ca
MeSH term(s)	Humans ; Lipopolysaccharides/pharmacology ; Escherichia coli/metabolism ; Periodontal Ligament ; Calcium Signaling ; Hypoxia/metabolism ; Periodontitis/metabolism ; Cell Hypoxia ; Inflammation/metabolism ; Fibroblasts ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
Chemical Substances	Lipopolysaccharides ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2024-01-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.111418
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Zs.A 5408: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors.

Tang, Qian / Zhou, Qiqi / Chen, Wen / Sang, Ling / Xing, Yu / Liu, Chao / Wang, Kejun / Liu, Weiyin Vivian / Xu, Lin

Insights into imaging

2023 Volume 14, Issue 1, Page(s) 12

Abstract: Objectives: This study aimed to evaluate the feasibility of reduced full-of-view synthetic high-b value diffusion-weighted images (rFOV-syDWIs) in the clinical application of cervical cancer based on image quality and diagnostic efficacy.: Methods: ... ...

Abstract	Objectives: This study aimed to evaluate the feasibility of reduced full-of-view synthetic high-b value diffusion-weighted images (rFOV-syDWIs) in the clinical application of cervical cancer based on image quality and diagnostic efficacy. Methods: We retrospectively evaluated the data of 35 patients with cervical cancer and 35 healthy volunteers from May to November 2021. All patients and volunteers underwent rFOV-DWI scans, including a 13b-protocol: b = 0, 25, 50, 75, 100, 150, 200, 400, 600, 800, 1000, 1200, and 1500 s/mm Results: A higher inter-reader agreement between SNRs and CNRs was found in 13b-protocol and 5b-protocol rFOV-syDWI Conclusions: rFOV-syDWIs provide better lesion clarity and higher image quality than rFOV-sDWIs. 5b-protocol rFOV-syDWIs shorten scan time, and synthetic ADCs offer reliable diagnosis value as scanned 13b-protocol DWIs.
Language	English
Publishing date	2023-01-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1186/s13244-022-01350-0
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Article ; Online: Topological phononic metamaterials.

Zhu, Weiwei / Deng, Weiyin / Liu, Yang / Lu, Jiuyang / Wang, Hai-Xiao / Lin, Zhi-Kang / Huang, Xueqin / Jiang, Jian-Hua / Liu, Zhengyou

Reports on progress in physics. Physical Society (Great Britain)

2023 Volume 86, Issue 10

Abstract: The concept of topological energy bands and their manifestations have been demonstrated in condensed matter systems as a fantastic paradigm toward unprecedented physical phenomena and properties that are robust against disorders. Recent years, this ... ...

Abstract	The concept of topological energy bands and their manifestations have been demonstrated in condensed matter systems as a fantastic paradigm toward unprecedented physical phenomena and properties that are robust against disorders. Recent years, this paradigm was extended to phononic metamaterials (including mechanical and acoustic metamaterials), giving rise to the discovery of remarkable phenomena that were not observed elsewhere thanks to the extraordinary controllability and tunability of phononic metamaterials as well as versatile measuring techniques. These phenomena include, but not limited to, topological negative refraction, topological 'sasers' (i.e. the phononic analog of lasers), higher-order topological insulating states, non-Abelian topological phases, higher-order Weyl semimetal phases, Majorana-like modes in Dirac vortex structures and fragile topological phases with spectral flows. Here we review the developments in the field of topological phononic metamaterials from both theoretical and experimental perspectives with emphasis on the underlying physics principles. To give a broad view of topological phononics, we also discuss the synergy with non-Hermitian effects and cover topics including synthetic dimensions, artificial gauge fields, Floquet topological acoustics, bulk topological transport, topological pumping, and topological active matters as well as potential applications, materials fabrications and measurements of topological phononic metamaterials. Finally, we discuss the challenges, opportunities and future developments in this intriguing field and its potential impact on physics and materials science.
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	205657-4
ISSN	1361-6633 ; 0034-4885
ISSN (online)	1361-6633
ISSN	0034-4885
DOI	10.1088/1361-6633/aceeee
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Article ; Online: Serum biomarkers are altered in UK Biobank participants with mosaic chromosomal alterations.

Hubbard, Aubrey K / Brown, Derek W / Zhou, Weiyin / Lin, Shu-Hong / Genovese, Giulio / Chanock, Stephen J / Machiela, Mitchell J

Human molecular genetics

2023 Volume 32, Issue 22, Page(s) 3146–3152

Abstract: Age-related clonal expansion of cells harbouring mosaic chromosomal alterations (mCAs) is one manifestation of clonal haematopoiesis. Identifying factors that influence the generation and promotion of clonal expansion of mCAs are key to investigate the ... ...

Abstract	Age-related clonal expansion of cells harbouring mosaic chromosomal alterations (mCAs) is one manifestation of clonal haematopoiesis. Identifying factors that influence the generation and promotion of clonal expansion of mCAs are key to investigate the role of mCAs in health and disease. Herein, we report on widely measured serum biomarkers and their possible association with mCAs, which could provide new insights into molecular alterations that promote acquisition and clonal expansion. We performed a cross-sectional investigation of the association of 32 widely measured serum biomarkers with autosomal mCAs, mosaic loss of the Y chromosome, and mosaic loss of the X chromosome in 436 784 cancer-free participants from the UK Biobank. mCAs were associated with a range of commonly measured serum biomarkers such as lipid levels, circulating sex hormones, blood sugar homeostasis, inflammation and immune function, vitamins and minerals, kidney function, and liver function. Biomarker levels in participants with mCAs were estimated to differ by up to 5% relative to mCA-free participants, and individuals with higher cell fraction mCAs had greater deviation in mean biomarker values. Polygenic scores associated with sex hormone binding globulin, vitamin D, and total cholesterol were also associated with mCAs. Overall, we observed commonly used clinical serum biomarkers related to disease risk are associated with mCAs, suggesting mechanisms involved in these diseases could be related to mCA proliferation and clonal expansion.
MeSH term(s)	Humans ; Male ; Mosaicism ; Chromosomes, Human, Y ; Biological Specimen Banks ; Cross-Sectional Studies ; Biomarkers ; United Kingdom
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddad133
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Zs.A 3469: Show issues

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Article ; Online: Transcriptome analysis of CD4

Chen, Jingliang / He, Yaozu / Zhong, Huolin / Hu, Fengyu / Li, Yonghong / Zhang, Yeyang / Zhang, Xia / Lin, Weiyin / Li, Quanmin / Xu, Feilong / Chen, Shaozhen / Zhang, Hui / Cai, Weiping / Li, Linghua

Virologica Sinica

2023 Volume 38, Issue 3, Page(s) 398–408

Abstract: Some HIV-infected individuals receiving ART develop low-level viremia (LLV), with a plasma viral load of 50-1000 copies/mL. Persistent low-level viremia is associated with subsequent virologic failure. The peripheral blood ... ...

Abstract	Some HIV-infected individuals receiving ART develop low-level viremia (LLV), with a plasma viral load of 50-1000 copies/mL. Persistent low-level viremia is associated with subsequent virologic failure. The peripheral blood CD4
MeSH term(s)	Humans ; HIV-1/genetics ; T-Lymphocytes ; Viremia/drug therapy ; HIV Infections/drug therapy ; HIV Seropositivity/drug therapy ; Viral Load ; Transcription Factors/genetics ; Gene Expression Profiling ; CD4-Positive T-Lymphocytes ; Anti-HIV Agents/pharmacology ; DNA-Binding Proteins/genetics
Chemical Substances	Transcription Factors ; Anti-HIV Agents ; CXXC5 protein, human ; DNA-Binding Proteins
Language	English
Publishing date	2023-03-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1011219-4
ISSN	1995-820X ; 1000-3223 ; 1003-5125
ISSN (online)	1995-820X
ISSN	1000-3223 ; 1003-5125
DOI	10.1016/j.virs.2023.03.001
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Zs.A 4175: Show issues

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Article: Study on the intestinal permeability of lamivudine using Caco-2 cells monolayer and Single-pass intestinal perfusion.

Huang, Weiyin / Chen, Shuang / Sun, Lin / Wwang, Hubin / Qiao, Hongqun

Saudi journal of biological sciences

2021 Volume 29, Issue 4, Page(s) 2247–2252

Abstract: Background: The aim of this work is to investigate the intestinal permeability of lamivudine and explore its absorption mechanism.: Method: Caco-2 cells monolayer and single-pass intestinal perfusion (SPIP) were selected for the investigation of ... ...

Abstract	Background: The aim of this work is to investigate the intestinal permeability of lamivudine and explore its absorption mechanism. Method: Caco-2 cells monolayer and single-pass intestinal perfusion (SPIP) were selected for the investigation of lamivudine under different conditions, such as different concentration, absorption time, bidirectional transportation, and transportation with efflux transporters inhibitor. The concentration of lamivudine both in Caco-2 cells monolayer samples and SPIP samples was detected by HPLC-UV. Then the permeability parameters were calculated. Results: The established HPLC-UV method reach the requirements for detection. There is no statistically difference between absorption parameters of lamivudine both in Caco-2 cells monolayer and SPIP (P > 0.05) under different dose groups. After transportation with efflux transporters inhibitor, the efflux rate of lamivudine in three dose groups was significantly decreased from 2.67, 2.59 and 2.59 to 1.78, 1.61, and 1.81 respectively. Lamivudine exhibits an absorption mechanism of passive diffusion. Conclusion: The absorption of lamivudine may be related to efflux transporters. In addition, lamivudine is a moderate-permeability drug in Biopharmaceutics Classification System.
Language	English
Publishing date	2021-11-26
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2021.11.052
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