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  1. Article: Chronic Kidney Disease: Early Detection, Mechanisms, and Therapeutic Implications.

    Delrue, Charlotte / Speeckaert, Marijn M

    Journal of personalized medicine

    2023  Volume 13, Issue 10

    Abstract: Chronic Kidney Disease (CKD) constitutes a global health crisis, silently affecting millions worldwide [ ... ]. ...

    Abstract Chronic Kidney Disease (CKD) constitutes a global health crisis, silently affecting millions worldwide [...].
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13101447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vitamin D and Vitamin D-Binding Protein in Health and Disease.

    Delrue, Charlotte / Speeckaert, Marijn M

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Vitamin D is a fat-soluble secosteroid that exists in two forms: vitamin ... ...

    Abstract Vitamin D is a fat-soluble secosteroid that exists in two forms: vitamin D
    MeSH term(s) Cholecalciferol/metabolism ; Ergocalciferols/metabolism ; Vitamin D/metabolism ; Vitamin D-Binding Protein/metabolism
    Chemical Substances Cholecalciferol (1C6V77QF41) ; Ergocalciferols ; Vitamin D (1406-16-2) ; Vitamin D-Binding Protein
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vitamin D and Vitamin D Binding Protein in Health and Disease 2.0.

    Delrue, Charlotte / Speeckaert, Marijn M

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Vitamin D, often referred to as the "sunshine nutrient", has gained considerable attention in recent years due to its multifaceted impact on health and disease [ ... ]. ...

    Abstract Vitamin D, often referred to as the "sunshine nutrient", has gained considerable attention in recent years due to its multifaceted impact on health and disease [...].
    MeSH term(s) Humans ; Vitamin D/metabolism ; Vitamin D-Binding Protein ; Sunlight ; Vitamins ; Vitamin D Deficiency
    Chemical Substances Vitamin D (1406-16-2) ; Vitamin D-Binding Protein ; Vitamins
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The potential role of vitamin D binding protein in kidney disease: a comprehensive review.

    Delanghe, Joris R / Delrue, Charlotte / Speeckaert, Reinhart / Speeckaert, Marijn M

    Acta clinica Belgica

    2024  , Page(s) 1–13

    Abstract: Chronic kidney disease (CKD) is a growing health concern with a complex etiological landscape. Among the numerous factors implicated, vitamin D binding protein (VDBP) has emerged as a focal point of scientific studies because of its critical role in ... ...

    Abstract Chronic kidney disease (CKD) is a growing health concern with a complex etiological landscape. Among the numerous factors implicated, vitamin D binding protein (VDBP) has emerged as a focal point of scientific studies because of its critical role in vitamin D metabolism and immune modulation. The relationship between VDBP and CKD reveals a complex web of molecular and biochemical details that have great potential for improving diagnostic understanding and treatment strategies for CKD. This review summarizes the multifaceted roles of VDBP, including its molecular dynamics, interactions with vitamin D, and subsequent implications for kidney function. The main focus of the discussion is how VDBP affects bone mineral homeostasis, highlighted by the dysregulation of calcium and phosphorus metabolism, which is a part of the pathophysiology of CKD. The discussion also touches on the immunomodulatory scope of VDBP and how it may reduce the chronic inflammatory environment that accompanies CKD. The diagnostic potential of VDBP as a biomarker for CKD has been rigorously examined, highlighting its capacity to improve early detection and prognostic assessment. Modification of VDBP activity has the potential to slow the course of CKD and improve patient outcomes. Furthermore, a detailed examination of the genetic polymorphisms of
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 390201-8
    ISSN 2295-3337 ; 0001-5512 ; 1784-3286
    ISSN (online) 2295-3337
    ISSN 0001-5512 ; 1784-3286
    DOI 10.1080/17843286.2023.2301278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.283: Show issues Location:
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  5. Article ; Online: Vitamin D and Vitamin D-Binding Protein in Health and Disease

    Charlotte Delrue / Marijn M. Speeckaert

    International Journal of Molecular Sciences, Vol 24, Iss 4642, p

    2023  Volume 4642

    Abstract: Vitamin D is a fat-soluble secosteroid that exists in two forms: vitamin D 2 and vitamin D 3 [.] ...

    Abstract Vitamin D is a fat-soluble secosteroid that exists in two forms: vitamin D 2 and vitamin D 3 [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Vitamin D and Vitamin D Binding Protein in Health and Disease 2.0

    Charlotte Delrue / Marijn M. Speeckaert

    International Journal of Molecular Sciences, Vol 24, Iss 10316, p

    2023  Volume 10316

    Abstract: Vitamin D, often referred to as the “sunshine nutrient”, has gained considerable attention in recent years due to its multifaceted impact on health and disease [.] ...

    Abstract Vitamin D, often referred to as the “sunshine nutrient”, has gained considerable attention in recent years due to its multifaceted impact on health and disease [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  7. Article: Application of Machine Learning in Chronic Kidney Disease: Current Status and Future Prospects.

    Delrue, Charlotte / De Bruyne, Sander / Speeckaert, Marijn M

    Biomedicines

    2024  Volume 12, Issue 3

    Abstract: The emergence of artificial intelligence and machine learning (ML) has revolutionized the landscape of clinical medicine, offering opportunities to improve medical practice and research. This narrative review explores the current status and prospects of ... ...

    Abstract The emergence of artificial intelligence and machine learning (ML) has revolutionized the landscape of clinical medicine, offering opportunities to improve medical practice and research. This narrative review explores the current status and prospects of applying ML to chronic kidney disease (CKD). ML, at the intersection of statistics and computer science, enables computers to derive insights from extensive datasets, thereby presenting an interesting landscape for constructing statistical models and improving data interpretation. The integration of ML into clinical algorithms aims to increase efficiency and promote its adoption as a standard approach to data interpretation in nephrology. As the field of ML continues to evolve, collaboration between clinicians and data scientists is essential for defining data-sharing and usage policies, ultimately contributing to the advancement of precision diagnostics and personalized medicine in the context of CKD.
    Language English
    Publishing date 2024-03-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12030568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Commentary: Vitamin D Status in Relation to the Clinical Outcome of Hospitalized COVID-19 Patients.

    Speeckaert, Marijn M / Delanghe, Joris R

    Frontiers in medicine

    2022  Volume 9, Page(s) 922820

    Language English
    Publishing date 2022-06-16
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.922820
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  9. Article ; Online: Factors to take into account when interpreting 25-hydroxy-vitamin D serum levels.

    Delanghe, Joris R / Speeckaert, Marijn M / Maenhout, Thomas

    Acta clinica Belgica

    2024  , Page(s) 1–6

    Abstract: Background: Assessing vitamin D status, typically evaluated using serum or plasma 25-hydroxy vitamin D [25(OH)D] concentration, is complex because of various influencing factors.: Methods: Seasonality significantly affects intra-individual ... ...

    Abstract Background: Assessing vitamin D status, typically evaluated using serum or plasma 25-hydroxy vitamin D [25(OH)D] concentration, is complex because of various influencing factors.
    Methods: Seasonality significantly affects intra-individual variability in 25(OH)D levels. This variation can be addressed by employing cosinor functions that are tailored to the geographical location of the patient to correct for seasonal effects. In addition to seasonality, genetic factors, such as DBP polymorphism and body composition, particularly adiposity, play crucial roles. Dialysis patients with DBP 2-2 phenotype exhibit higher vitamin D requirements. Genotyping/phenotyping of DBP allows for better tailored vitamin D supplementation. The lipid-soluble nature of vitamin D also interacts with plasma components such as serum triglycerides, which can influence vitamin D measurements. Adiposity, which is negatively correlated with vitamin D concentration, necessitates body mass-based mathematical adjustments for accurate vitamin D assessment in subjects with extreme BMI values.
    Conclusions: Accordingly, vitamin D replacement therapy must be personalized, taking into account factors such as body size and seasonal variations, to effectively reach the target serum 25(OH)D concentrations.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 390201-8
    ISSN 2295-3337 ; 0001-5512 ; 1784-3286
    ISSN (online) 2295-3337
    ISSN 0001-5512 ; 1784-3286
    DOI 10.1080/17843286.2024.2327218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.283: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article ; Online: A meta-analysis of the placebo response in vitiligo: Causes and consequences for the interpretation of clinical trials.

    Speeckaert, Reinhart / Speeckaert, Marijn M / van Geel, Nanja

    Pigment cell & melanoma research

    2023  Volume 37, Issue 1, Page(s) 74–80

    Abstract: The current understanding of the placebo response in vitiligo is limited. Nonetheless, it is difficult to compare the outcomes of vitiligo trials if the repigmentation rates in placebo patients vary significantly. We conducted a meta-analysis of the ... ...

    Abstract The current understanding of the placebo response in vitiligo is limited. Nonetheless, it is difficult to compare the outcomes of vitiligo trials if the repigmentation rates in placebo patients vary significantly. We conducted a meta-analysis of the placebo response in vitiligo trials. Overall, repigmentation rates in patients receiving placebo were 22%, ranging substantially from 0 to 60%. Repigmentation (>25%) was still relatively common for placebo (9.35%), but fell to 5% when >50% improvement was analyzed. Higher frequencies of placebo responses correlated with more repigmentation in the intervention groups. Facial vitiligo and sunlight exposure was linked to higher placebo responses. Roughly estimating the amount of improvement using quartiles (0-25, 25%-50%, 50%-75%, 75%-100% repigmentation) resulted in higher placebo rates compared to other assessment methods. In clinical studies with older patients, the ratio of placebo reactions to treatment responses was higher. This is likely because clinical trials with older patients reported less repigmentation after treatment than studies with younger patients. The percentual difference in affected body surface area during the study period ranged from 6.2% worsening to 17.6% improvement in the placebo groups. This high variability in placebo responses illustrates the need for standardized outcome measures and more head-to-head trials in vitiligo.
    MeSH term(s) Humans ; Vitiligo/drug therapy ; Treatment Outcome
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2409570-9
    ISSN 1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
    ISSN (online) 1755-148X ; 1600-0749
    ISSN 0893-5785 ; 1755-1471
    DOI 10.1111/pcmr.13132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2444: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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