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  1. Article ; Online: Letter to the editor in response to the article "COVID-19 and diabetes: Can DPP4 inhibition play a role?"

    Kokic Males, Visnja

    Diabetes research and clinical practice

    2020  Volume 163, Page(s) 108163

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus ; Dipeptidyl Peptidase 4 ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances DPP4 protein, human (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2020.108163
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  2. Article ; Online: Why Should Metformin Not Be Given in Advanced Kidney Disease? Potential Leads from Computer Simulations

    Visnja Kokic Males / Martina Požar

    ACS Omega, Vol 6, Iss 23, Pp 15382-

    2021  Volume 15391

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
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  3. Article ; Online: Why Should Metformin Not Be Given in Advanced Kidney Disease? Potential Leads from Computer Simulations.

    Kokic Males, Visnja / Požar, Martina

    ACS omega

    2021  Volume 6, Issue 23, Page(s) 15382–15391

    Abstract: Metformin is considered as the go-to drug in the treatment of diabetes. However, it is either prescribed in lower doses or not prescribed at all to patients with kidney problems. To find a potential explanation for this practice, we employed atomistic- ... ...

    Abstract Metformin is considered as the go-to drug in the treatment of diabetes. However, it is either prescribed in lower doses or not prescribed at all to patients with kidney problems. To find a potential explanation for this practice, we employed atomistic-level computer simulations to simulate the transport of metformin through multidrug and toxin extrusion 1 (MATE1), a protein known to play a key role in the expulsion of metformin into urine. Herein, we examine the hydrogen bonding between MATE1 and one or more metformin molecules. The simulation results indicate that metformin continuously forms and breaks off hydrogen bonds with MATE1 residues. However, the mean hydrogen bond lifetimes increase for an order of magnitude when three metformin molecules are inserted instead of one. This new insight into the metformin transport process may provide the molecular foundation behind the clinical practice of not prescribing metformin to kidney disease patients.
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c01744
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  5. Article ; Online: Letter to the editor in response to the article “COVID-19 and diabetes

    Kokic Males, Visnja

    Diabetes Research and Clinical Practice

    Can DPP4 inhibition play a role?”

    2020  Volume 163, Page(s) 108163

    Keywords Internal Medicine ; Endocrinology, Diabetes and Metabolism ; Endocrinology ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2020.108163
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  6. Article: Association between COVID-19 Infection or Vaccination Outcomes and Methylenetetrahydrofolate Reductase Gene Polymorphism: A Systematic Review of the Literature.

    Jukic, Ivana / Heffernan, Aisling / Schelling, Alisa Franceska / Kokic Males, Visnja / Savicevic, Nora Josipa / Kovacic, Vedran

    Journal of personalized medicine

    2023  Volume 13, Issue 12

    Abstract: Background: Thrombosis is a detrimental sequala of COVID-19 infection; thus, prophylactic anti-coagulant therapy has been deemed mandatory in treatment unless serious contraindications are present. Susceptibility to thromboembolic events in COVID-19, or ...

    Abstract Background: Thrombosis is a detrimental sequala of COVID-19 infection; thus, prophylactic anti-coagulant therapy has been deemed mandatory in treatment unless serious contraindications are present. Susceptibility to thromboembolic events in COVID-19, or following COVID-19 vaccination, is likely attributable to an interplay of factors, including a patient's baseline clinical status and comorbidities, alongside genetic risk factors. In Europe, 8-20% of the population are homozygous for the MTHFR (methylene tetrahydrofolate reductase) variant, which compromises folate metabolism and elevates homocysteine levels. While heightened homocysteine levels are considered a risk factor for thromboembolic events, the precise clinical significance remains a contentious issue. However, recent research suggests elevated homocysteine levels may predict the course and severity of COVID-19 infection. Given the lack of reliable biomarkers predictive of COVID-19 thrombotic risk existing in practice, and the accessibility of MTHFR screening, we established two main outcomes for this study: (1) to determine the association between hereditary MTHFR mutations and COVID-19 severity and thromboembolic events and (2) to determine the link between MTHFR variants and adverse thrombotic events following COVID-19 vaccination.
    Methods: The review was conducted in accordance with PRISMA guidelines. Medline, Scopus, and Web of Science databases were searched from pandemic inception (11 March 2020) to 30 October 2023. Eligibility criteria were applied, and data extraction performed.
    Results: From 63 citations identified, a total of 14 articles met the full inclusion criteria (8 of which were cross-sectional or observational studies, and 6 were case studies or reports). Among the eight observational and cross-sectional studies evaluating the relationship between MTHFR variants (C667T; A1298C) and thromboembolic events in COVID-19 infection, four studies established a connection (
    Conclusions: This systematic review demonstrated a possible association between the MTHFR gene variants and COVID-19 severity, thromboembolic events, and adverse events following vaccination. However, the paucity of robust data precluded any firm conclusions being drawn. Further prospective trials are required to determine the connection between the MTHFR gene variant and COVID-19 infection and vaccination outcomes.
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13121687
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  7. Article ; Online: Association between COVID-19 Infection or Vaccination Outcomes and Methylenetetrahydrofolate Reductase Gene Polymorphism

    Ivana Jukic / Aisling Heffernan / Alisa Franceska Schelling / Visnja Kokic Males / Nora Josipa Savicevic / Vedran Kovacic

    Journal of Personalized Medicine, Vol 13, Iss 12, p

    A Systematic Review of the Literature

    2023  Volume 1687

    Abstract: Background: Thrombosis is a detrimental sequala of COVID-19 infection; thus, prophylactic anti-coagulant therapy has been deemed mandatory in treatment unless serious contraindications are present. Susceptibility to thromboembolic events in COVID-19, or ... ...

    Abstract Background: Thrombosis is a detrimental sequala of COVID-19 infection; thus, prophylactic anti-coagulant therapy has been deemed mandatory in treatment unless serious contraindications are present. Susceptibility to thromboembolic events in COVID-19, or following COVID-19 vaccination, is likely attributable to an interplay of factors, including a patient’s baseline clinical status and comorbidities, alongside genetic risk factors. In Europe, 8–20% of the population are homozygous for the MTHFR (methylene tetrahydrofolate reductase) variant, which compromises folate metabolism and elevates homocysteine levels. While heightened homocysteine levels are considered a risk factor for thromboembolic events, the precise clinical significance remains a contentious issue. However, recent research suggests elevated homocysteine levels may predict the course and severity of COVID-19 infection. Given the lack of reliable biomarkers predictive of COVID-19 thrombotic risk existing in practice, and the accessibility of MTHFR screening, we established two main outcomes for this study: (1) to determine the association between hereditary MTHFR mutations and COVID-19 severity and thromboembolic events and (2) to determine the link between MTHFR variants and adverse thrombotic events following COVID-19 vaccination. Methods: The review was conducted in accordance with PRISMA guidelines. Medline, Scopus, and Web of Science databases were searched from pandemic inception (11 March 2020) to 30 October 2023. Eligibility criteria were applied, and data extraction performed. Results: From 63 citations identified, a total of 14 articles met the full inclusion criteria (8 of which were cross-sectional or observational studies, and 6 were case studies or reports). Among the eight observational and cross-sectional studies evaluating the relationship between MTHFR variants (C667T; A1298C) and thromboembolic events in COVID-19 infection, four studies established a connection ( n = 2200), while the remaining four studies failed to demonstrate any ...
    Keywords methylenetetrahydrofolate reductase gene polymorphisms ; COVID-19 infection ; SARS-CoV-2 ; MTHFR C667T ; MTHFR A1298C ; vaccine ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: A case of transient constrictive pericarditis in a 42-year-old patient.

    Gradiser, Marina / Cmrecnjak, Jasna / Ostricki, Branko / Marodi, Ivana / Kokić, Visnja / Kokić, Slaven / Pal, Andrej

    Collegium antropologicum

    2014  Volume 38, Issue 1, Page(s) 337–339

    Abstract: We report a case of 42 year old patient with acute idiopathic pericarditis in whom we describe transient cardiac constriction, consisting of the temporary development of features of constrictive pericarditis with subsequent return to normality after ... ...

    Abstract We report a case of 42 year old patient with acute idiopathic pericarditis in whom we describe transient cardiac constriction, consisting of the temporary development of features of constrictive pericarditis with subsequent return to normality after medical therapy alone. After a mean of 6 months, there have been no recurrences of constrictive physiology or clinical symptoms. The results of our study suggest that patients who have constrictive features early in the course of their illness and are hemodynamically stable should be considered for a trial of conservative therapy before pericardiectomy is pursued.
    MeSH term(s) Acute Disease ; Adult ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Echocardiography ; Humans ; Male ; Pericarditis, Constrictive/diagnostic imaging ; Pericarditis, Constrictive/drug therapy ; Pericardium/diagnostic imaging ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2014-03
    Publishing country Croatia
    Document type Case Reports ; Journal Article
    ZDB-ID 233430-6
    ISSN 0350-6134 ; 0353-3735
    ISSN 0350-6134 ; 0353-3735
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    Zs.A 5757: Show issues Location:
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  9. Article ; Online: Association between vitamin D, oestradiol and interferon-gamma in female patients with inactive systemic lupus erythematosus: A cross-sectional study.

    Kokic, Visnja / Martinovic Kaliterna, Dusanka / Radic, Mislav / Tandara, Leida / Perkovic, Dijana

    The Journal of international medical research

    2017  Volume 46, Issue 3, Page(s) 1162–1171

    Abstract: Objectives To investigate possible associations between 25-hydroxyvitamin ... ...

    Abstract Objectives To investigate possible associations between 25-hydroxyvitamin D
    MeSH term(s) Adult ; Antibodies, Antinuclear/blood ; Calcifediol/blood ; Cross-Sectional Studies ; Estradiol/blood ; Female ; Humans ; Interferon-gamma/blood ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/immunology ; Male ; Parathyroid Hormone/blood
    Chemical Substances Antibodies, Antinuclear ; Parathyroid Hormone ; Estradiol (4TI98Z838E) ; Interferon-gamma (82115-62-6) ; Calcifediol (P6YZ13C99Q)
    Language English
    Publishing date 2017-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/0300060517734686
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    Zs.A 925: Show issues Location:
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  10. Article ; Online: Comparison of the Bacterial Inactivation Efficiency of Water Activated by a Plasma Jet Source and a Pin-to-Pin Electrode Configuration Source

    Radovan Čobanović / Dejan Maletić / Sunčica Kocić-Tanackov / Ivana Čabarkapa / Bojana Kokić / Predrag Kojić / Slobodan Milošević / Višnja Stulić / Tomislava Vukušić Pavičić / Milan Vukić

    Processes, Vol 11, Iss 12, p

    2023  Volume 3286

    Abstract: In this comparative study, the bacterial inactivation efficiency of plasma-activated water (PAW) generated by two distinct plasma reactors, one utilizing a nitrogen plasma jet electrode and the other a hybrid argon plasma reactor, was explored. The ... ...

    Abstract In this comparative study, the bacterial inactivation efficiency of plasma-activated water (PAW) generated by two distinct plasma reactors, one utilizing a nitrogen plasma jet electrode and the other a hybrid argon plasma reactor, was explored. The present study involved the assessment of antimicrobial activity against suspensions of three Gram-positive and three Gram-negative bacterial strains in their planktonic cell state. Bacterial suspensions were introduced into PAW five days after generation. Subsequently, the viability of the bacteria was assessed at various time intervals, specifically at 0.5, 1, 3, 5, 10, and 24 h, in order to evaluate the effect of inactivation. Structural changes in bacteria after PAW treatment were assessed using a scanning electron microscope (SEM). The physicochemical properties of PAW, including pH, conductivity, and concentrations of H 2 O 2 , NO 2 − , and NO 3 − during aging were measured. The present study demonstrated the effective inactivation of the tested bacterial strains by PAW. Gram-positive bacteria displayed greater resistance compared to Gram-negative species, with the lowest reductions in bacterial counts observed for B. cereus , and the highest for Escherichia coli O157:H7. Morphological damage was evident across all bacterial species examined. Physicochemical measurements showed slow decay of the reactive species in the aging process. This study illustrated the potential utility of PAW as an alternative disinfectant.
    Keywords bacteria inactivation efficiency ; Gram-positive bacteria ; Gram-negative bacteria ; PAW ; plasma activated water ; plasma jet ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Subject code 630
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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