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  1. Article ; Online: Baseline use of antiarrhythmics in patients given adaptive servoventilation: SERVE-HF.

    Festic, Emir

    The Lancet. Respiratory medicine

    2017  Volume 5, Issue 1, Page(s) e4

    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Letter
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(16)30429-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
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  2. Article ; Online: Adjuvant Inhaled Corticosteroids in Community-Acquired Pneumonia: A Review Article.

    Kukhon, Faeq R / Festic, Emir

    Medical sciences (Basel, Switzerland)

    2021  Volume 9, Issue 2

    Abstract: Community-acquired pneumonia is still a major cause of morbidity and mortality worldwide. Since the inflammatory response induced by the immune system is often a major contributor to the lung injury, it becomes reasonable to assess the potential benefit ... ...

    Abstract Community-acquired pneumonia is still a major cause of morbidity and mortality worldwide. Since the inflammatory response induced by the immune system is often a major contributor to the lung injury, it becomes reasonable to assess the potential benefit of anti-inflammatory agents in treating community-acquired pneumonia. The role of corticosteroids as adjunct anti-inflammatory agents in treating community-acquired pneumonia is still controversial. Several studies have assessed the benefit of their use in patients with community-acquired pneumonia. In most of those studies, the route of corticosteroids administration was systemic. The aim of this article is to provide a concise review of the role of corticosteroids in treating community-acquired pneumonia when administered via inhalational route, with the potential benefit of avoiding systemic side effects of corticosteroids while exerting the same anti-inflammatory effects on the lungs. Conclusion: the use of inhaled corticosteroids may be of benefit in certain patient subsets with community-acquired pneumonia. Further randomized controlled trials are needed for better determination of such patient subsets.
    MeSH term(s) Adjuvants, Pharmaceutic/therapeutic use ; Adrenal Cortex Hormones/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Community-Acquired Infections/drug therapy ; Glucocorticoids/therapeutic use ; Humans ; Pneumonia/drug therapy
    Chemical Substances Adjuvants, Pharmaceutic ; Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Glucocorticoids
    Language English
    Publishing date 2021-05-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2754473-4
    ISSN 2076-3271 ; 2076-3271
    ISSN (online) 2076-3271
    ISSN 2076-3271
    DOI 10.3390/medsci9020034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adjuvant Inhaled Corticosteroids in Community-Acquired Pneumonia

    Faeq R. Kukhon / Emir Festic

    Medical Sciences, Vol 9, Iss 34, p

    A Review Article

    2021  Volume 34

    Abstract: Community-acquired pneumonia is still a major cause of morbidity and mortality worldwide. Since the inflammatory response induced by the immune system is often a major contributor to the lung injury, it becomes reasonable to assess the potential benefit ... ...

    Abstract Community-acquired pneumonia is still a major cause of morbidity and mortality worldwide. Since the inflammatory response induced by the immune system is often a major contributor to the lung injury, it becomes reasonable to assess the potential benefit of anti-inflammatory agents in treating community-acquired pneumonia. The role of corticosteroids as adjunct anti-inflammatory agents in treating community-acquired pneumonia is still controversial. Several studies have assessed the benefit of their use in patients with community-acquired pneumonia. In most of those studies, the route of corticosteroids administration was systemic. The aim of this article is to provide a concise review of the role of corticosteroids in treating community-acquired pneumonia when administered via inhalational route, with the potential benefit of avoiding systemic side effects of corticosteroids while exerting the same anti-inflammatory effects on the lungs. Conclusion: the use of inhaled corticosteroids may be of benefit in certain patient subsets with community-acquired pneumonia. Further randomized controlled trials are needed for better determination of such patient subsets.
    Keywords community-acquired pneumonia ; inhaled corticosteroids ; long-acting beta agonists ; systemic corticosteroids ; Medicine ; R
    Subject code 070
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The relationship between ventilatory function and cognitive and behavioral impairment in ALS.

    Shah, Jaimin S / Pedraza, Otto / Festic, Emir / Oskarsson, Björn

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2021  Volume 22, Issue sup1, Page(s) 62–67

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Amyotrophic Lateral Sclerosis/complications ; Cognition ; Educational Status ; Humans ; Neuropsychological Tests ; Vital Capacity
    Language English
    Publishing date 2021-08-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2021.1924206
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5874: Show issues Location:
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  5. Article ; Online: Systemic and Inhaled Corticosteroids, with or without Beta Agonists, as Adjuvant Therapy in Community Acquired Pneumonia.

    Helgeson, Scott A / Levitt, Joseph E / Festic, Emir

    Acta medica academica

    2020  Volume 49, Issue 1, Page(s) 9–20

    Abstract: The aim is to provide a narrative review of the role of corticosteroids, with and without inhaled beta agonist, in communityacquired pneumonia. Community and health-care associated pneumonia remain leading causes of morbidity and mortality despite ... ...

    Abstract The aim is to provide a narrative review of the role of corticosteroids, with and without inhaled beta agonist, in communityacquired pneumonia. Community and health-care associated pneumonia remain leading causes of morbidity and mortality despite appropriate antibiotic therapy. The pneumonia-associated adverse outcomes are not only related to the infectious organism, but also to a dysfunctional host-immune response resulting in overwhelming inflammation. Use of systemic corticosteroids as adjuvant therapy in pneumonia remains controversial. Multiple randomized clinical trials evaluating corticosteroids in patients with community acquired pneumonia have found discrepant results in terms of benefits and adverse effects. Inhaled delivery of corticosteroids offer the potential advantage of providing therapeutic benefits directly to the lung, with minimal to no adverse systemic effects. CONCLUSION: Although meta-analyses suggest potential benefits in a select group of patients with more severe pneumonia, the ideal timing, dose, route of delivery, duration, and patient selection remain to be established. A smaller body of literature suggests benefit of inhaled corticosteroids, with or without inhaled beta agonists, but future large scale clinical trials are needed to establish clinical benefit with inhaled delivery.
    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Adrenergic beta-Agonists/therapeutic use ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/therapeutic use ; Humans ; Inflammation/drug therapy ; Inflammation/etiology ; Lung/pathology ; Pneumonia/complications ; Pneumonia/drug therapy
    Chemical Substances Adrenal Cortex Hormones ; Adrenergic beta-Agonists ; Anti-Inflammatory Agents
    Language English
    Publishing date 2020-07-05
    Publishing country Bosnia and Herzegovina
    Document type Journal Article ; Review
    ZDB-ID 2558604-X
    ISSN 1840-2879 ; 1840-1848
    ISSN (online) 1840-2879
    ISSN 1840-1848
    DOI 10.5644/ama2006-124.279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correlation Between Oxygen Saturation and Pulse Tracing Patterns on Overnight Oximetry With Normal Desaturation Index Is an Independent Predictor of Obstructive Sleep Apnea.

    Festic, Nura / Zuberi, Muhammad / Bansal, Vikas / Fredrickson, Paul / Festic, Emir

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2019  Volume 15, Issue 2, Page(s) 195–200

    Abstract: Study objectives: Overnight pulse oximetry (OPO) is commonly used as a screening test for obstructive sleep apnea. Heart rate variability (HRV) correlates well with apnea-hypopnea index during polysomnography (PSG). We hypothesized that visual ... ...

    Abstract Study objectives: Overnight pulse oximetry (OPO) is commonly used as a screening test for obstructive sleep apnea. Heart rate variability (HRV) correlates well with apnea-hypopnea index during polysomnography (PSG). We hypothesized that visual correlation of episodic increase in HRV with minimal oxygen desaturations on normal OPO (oxygen desaturation index less than 5 events/h) is predictive of OSA.
    Methods: A retrospective analysis of patients undergoing OPO and PSG in 1 year was performed. We included only OPO performed on room air and interpreted as normal. Visual correlation between simultaneous increase in HRV and minimal oxygen desaturation was independently assessed by three raters, resulting in the consensus agreement. The primary outcome was presence of OSA on the subsequent PSG.
    Results: Of 936 patients with OPO and PSG, 109 patients had normal overnight oximetry study on room air. Of these, 65 (60%) were females, median (interquartile range) age was 54 years (44, 67), body mass index was 29 kg/m
    Conclusions: Visual correlation between episodic increase in HRV and minimal oxygen desaturations on OPO is an independent predictor of OSA, and promising marker for clinical use.
    MeSH term(s) Adult ; Aged ; Correlation of Data ; Female ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; Oximetry ; Polysomnography/methods ; Predictive Value of Tests ; Reference Values ; Retrospective Studies ; Sleep Apnea, Obstructive/blood ; Sleep Apnea, Obstructive/diagnosis
    Language English
    Publishing date 2019-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.7614
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6590: Show issues Location:
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  7. Article: New Diagnosis of Obstructive Sleep Apnea Following Anterior Cervical Discectomy Complicated by Rheumatoid Arthritis: A Case Report.

    Wasey, Waiz / Festic, Emir / Sapra, Amit / Rafi, Taaha / Bhandari, Priyanka

    Cureus

    2020  Volume 12, Issue 3, Page(s) e7439

    Abstract: Obstructive sleep apnea (OSA) is the most common variant of sleep-disordered breathing that often goes undiagnosed. OSA is characterized mainly by anatomical obstruction or partial collapse of upper airways during sleep. The obstruction is multifactorial, ...

    Abstract Obstructive sleep apnea (OSA) is the most common variant of sleep-disordered breathing that often goes undiagnosed. OSA is characterized mainly by anatomical obstruction or partial collapse of upper airways during sleep. The obstruction is multifactorial, and a lesser-known fact is that damage to the pharyngeal plexus during head and neck procedures or placement of hardware in the cervical area can lead to narrowing or collapse of the upper airway. We present such a case of a 59-year-old female who developed new-onset OSA after undergoing anterior cervical discectomy and fusion (ACDF). The severity of OSA worsened with the progression of her rheumatoid arthritis (RA) in the cervical region. This case report aims to raise awareness of such an association among clinicians to enable them to screen appropriate patients for sleep-disordered breathing and treat them accordingly.
    Language English
    Publishing date 2020-03-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.7439
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  8. Article ; Online: Emerging therapies for the prevention of acute respiratory distress syndrome.

    Ruthman, Carl A / Festic, Emir

    Therapeutic advances in respiratory disease

    2015  Volume 9, Issue 4, Page(s) 173–187

    Abstract: The development of acute respiratory distress syndrome (ARDS) carries significant risk of morbidity and mortality. To date, pharmacological therapy has been largely ineffective for patients with ARDS. We present our personal review aimed at outlining ... ...

    Abstract The development of acute respiratory distress syndrome (ARDS) carries significant risk of morbidity and mortality. To date, pharmacological therapy has been largely ineffective for patients with ARDS. We present our personal review aimed at outlining current and future directions for the pharmacological prevention of ARDS. Several available risk-stratification or prediction score strategies for identification of patients at risk of ARDS have been reported. Although not ready for clinical everyday use, they are and will be instrumental in the ongoing and future trials of pharmacoprevention of ARDS.Several systemic medications established the potential role in ARDS prevention based on the preclinical studies and observational data. Due to potential for systemic adverse effects to neutralize any pharmacological benefits of systemic therapy, inhaled medications appear particularly attractive candidates for ARDS prevention. This is because of their direct delivery to the site of proposed action (lungs), while the pulmonary epithelial surface is still functional.We postulate that overall morbidity and mortality rates from ARDS in the future will be contingent upon decreasing the overall incidence of ARDS through effective identification of those at risk and early application of proven supportive care and pharmacological interventions.
    MeSH term(s) Administration, Inhalation ; Animals ; Drug Delivery Systems ; Drug Design ; Humans ; Pharmaceutical Preparations/administration & dosage ; Respiratory Distress Syndrome, Adult/mortality ; Respiratory Distress Syndrome, Adult/physiopathology ; Respiratory Distress Syndrome, Adult/prevention & control ; Risk Factors
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2015-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2476459-0
    ISSN 1753-4666 ; 1753-4658
    ISSN (online) 1753-4666
    ISSN 1753-4658
    DOI 10.1177/1753465815585716
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    Zs.A 6753: Show issues Location:
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  9. Article ; Online: Incident pneumonia and mortality in patients with chronic obstructive pulmonary disease. A double effect of inhaled corticosteroids?

    Festic, Emir / Scanlon, Paul D

    American journal of respiratory and critical care medicine

    2015  Volume 191, Issue 2, Page(s) 141–148

    Abstract: Inhaled corticosteroids are commonly prescribed for patients with severe chronic obstructive pulmonary disease. Although their use improves quality of life and reduces exacerbations, it is associated with increased risk of pneumonia. Curiously, their use ...

    Abstract Inhaled corticosteroids are commonly prescribed for patients with severe chronic obstructive pulmonary disease. Although their use improves quality of life and reduces exacerbations, it is associated with increased risk of pneumonia. Curiously, their use has not been associated with increased risk of pneumonia-related or overall mortality. We review pertinent literature to further explore the effects of inhaled corticosteroids on incident pneumonia and mortality in patients with chronic obstructive pulmonary disease. The association of use of inhaled corticosteroids and incident pneumonia is substantial and has been present in the majority of the studies on the topic. This includes both randomized controlled trials and observational studies. However, all of the studies have substantial risk of bias. Most randomized trials are limited by lack of systematic ascertainment of pneumonia; they depended on adverse event reporting. Many observational studies included proper radiographic assessment of pneumonia, but they are limited by their retrospective, observational design. The unadjusted higher risk of pneumonia is associated with longer duration of use, more potent ICS compounds, and higher doses. That implies a dose-effect relationship. Unlike pneumonia, mortality is a precise outcome. Despite the robust association of inhaled corticosteroid use with increased risk of pneumonia, all studies find either no difference or a reduction in pulmonary-related and overall mortality associated with the use of inhaled corticosteroids. These observations suggest a double effect of inhaled corticosteroids (i.e., an adverse effect plus an unexplained mitigating effect).
    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/adverse effects ; Adrenal Cortex Hormones/therapeutic use ; Cause of Death/trends ; Disease Progression ; Dose-Response Relationship, Drug ; Humans ; Incidence ; Observational Studies as Topic/statistics & numerical data ; Pneumonia/chemically induced ; Pneumonia/mortality ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/mortality ; Quality of Life ; Randomized Controlled Trials as Topic/statistics & numerical data ; Risk
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2015-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201409-1654PP
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    Uh II Zs.80: Show issues Location:
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  10. Article ; Online: Images in clinical medicine. Catastrophic gastroduodenal pneumatosis.

    Ramos, Juan A / Festic, Emir

    The New England journal of medicine

    2014  Volume 371, Issue 13, Page(s) e19

    MeSH term(s) Abdominal Pain/etiology ; Aged ; Duodenum/diagnostic imaging ; Fatal Outcome ; Humans ; Incidental Findings ; Male ; Pancreatic Neoplasms/complications ; Pneumatosis Cystoides Intestinalis/complications ; Pneumatosis Cystoides Intestinalis/diagnostic imaging ; Radiography ; Stomach/diagnostic imaging
    Language English
    Publishing date 2014-09-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm1313058
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