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Article ; Online: Dynamical vaccination behavior with risk perception and vaccination rewards.

Wang, Xueying / Li, Juyi / Liu, Jie / Wu, Xiaoqun

2024 Volume 34, Issue 3

Abstract: Vaccination is the most effective way to control the epidemic spreading. However, the probability of people getting vaccinated changes with the epidemic situation due to personal psychology. Facing various risks, some people are reluctant to vaccinate ... ...

Abstract	Vaccination is the most effective way to control the epidemic spreading. However, the probability of people getting vaccinated changes with the epidemic situation due to personal psychology. Facing various risks, some people are reluctant to vaccinate and even prefer herd immunity. To encourage people to get vaccinated, many countries set up reward mechanisms. In this paper, we propose a disease transmission model combining vaccination behaviors based on the SIR (Susceptible-Infected-Recovered) model and introduce three vaccination mechanisms. We analyze the impact of the infection rate and the recovery rate on the total cost and the epidemic prevalence. Numerical simulations fit with our intuitive feelings. Then, we study the impact of vaccination rewards on the total social cost. We find that when vaccination rewards offset vaccination costs, both the total cost and the epidemic prevalence reach the lowest levels. Finally, this paper suggests that encouraging people to get vaccinated at the beginning of an epidemic has the best effect.
MeSH term(s)	Humans ; Emotions ; Epidemics ; Reward ; Vaccination ; Perception
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1472677-4
ISSN	1089-7682 ; 1054-1500
ISSN (online)	1089-7682
ISSN	1054-1500
DOI	10.1063/5.0186899
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.

Li, Juyi / Ni, Yingqun / Zhang, Yuanyuan / Liu, Huaizhen

Aging

2024 Volume 16, Issue 5, Page(s) 4591–4608

Abstract: Background: Excessive lipids accumulation and hepatocytes death are prominent characteristics of non-alcoholic fatty liver disease (NAFLD). Nonetheless, the precise pathophysiological mechanisms are not fully elucidated.: Methods: HepG2 cells ... ...

Abstract	Background: Excessive lipids accumulation and hepatocytes death are prominent characteristics of non-alcoholic fatty liver disease (NAFLD). Nonetheless, the precise pathophysiological mechanisms are not fully elucidated. Methods: HepG2 cells stimulated with palmitic acids and rats fed with high-fat diet were used as models for NAFLD. The impact of Glucosylceramidase Beta 3 (GBA3) on fatty acid oxidation (FAO) was assessed using Seahorse metabolic analyzer. Lipid content was measured both Results: GBA3 promoted FAO and enhanced the mitochondrial membrane potential without affecting glycolysis. These reduced the lipid accumulation. Rats supplemented with GBA3 exhibited lower levels of inflammatory factors and liver enzymes, resulting in a slower progression of NAFLD. GBA3 overexpression reduced ROS and the ratio of cell apoptosis. Phosphorylation level was reduced in the essential mediator, MLKL, implicated in necroptosis. Mechanistically, as a transcriptional coactivator, GBA3 promoted the expression of Carnitine Palmitoyltransferase 2 (CPT2), which resulted in enhanced FAO. Conclusions: Increased FAO resulting from GBA3 reduced oxidative stress and the production of ROS, thereby inhibiting necroptosis and delaying the progression of NAFLD. Our research offers novel insights into the potential therapeutic applications of GBA3 and FAO in the management and treatment of NAFLD.
MeSH term(s)	Rats ; Animals ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver/metabolism ; Reactive Oxygen Species/metabolism ; Carnitine O-Palmitoyltransferase/genetics ; Carnitine O-Palmitoyltransferase/metabolism ; Glucosylceramidase ; Lipid Metabolism ; Diet, High-Fat/adverse effects ; Fatty Acids/metabolism ; Lipids
Chemical Substances	Reactive Oxygen Species ; Carnitine O-Palmitoyltransferase (EC 2.3.1.21) ; Glucosylceramidase (EC 3.2.1.45) ; Fatty Acids ; Lipids
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205616
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Article ; Online: Corrigendum to "RIP3 participates in early brain injury after experimental subarachnoid hemorrhage in rats by inducing necroptosis" [Neurobiology of Disease 129(2019) 144-158].

Yuan, Shuai / Yu, Zhengquan / Zhang, Zhuwei / Zhang, Juyi / Zhang, Peng / Li, Xiang / Li, Haiying / Shen, Haitao / Chen, Gang

Neurobiology of disease

2024 , Page(s) 106507

Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2024.106507
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Zs.A 4444: Show issues

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Article: Identification of a novel CNV at the

Li, Juyi / He, Chengzhi / Gong, Jing / Wang, Xiufang / Liu, Chao / Deng, Aiping / Zhu, Lin

Frontiers in molecular biosciences

2023 Volume 10, Page(s) 1234296

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1234296
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Article: Identification and Validation of Hub Immune-Related Genes in Non-Alcoholic Fatty Liver Disease.

Li, Juyi / Kou, Chunjia / Sun, Tiantian / Liu, Jia / Zhang, Haiqing

International journal of general medicine

2023 Volume 16, Page(s) 2609–2621

Abstract: Background: Nonalcoholic fatty liver disease (NAFLD) is the most common progressive liver disease worldwide. It can cause liver cancer and possibly death. Abnormal immune infiltration is involved in the progression of NAFLD. The aim of this study was to ...

Abstract	Background: Nonalcoholic fatty liver disease (NAFLD) is the most common progressive liver disease worldwide. It can cause liver cancer and possibly death. Abnormal immune infiltration is involved in the progression of NAFLD. The aim of this study was to identify and validate the hub immune-related genes in NAFLD. Methods: Microarray data were downloaded from Gene Expression Omnibus, and immune-related differentially expressed genes (IRDEGs) were obtained. A protein-protein interaction network was used to further screen. The diagnostic value of the IRDEGs was evaluated by receiver operating characteristic curves. Differences in immune infiltration levels were analyzed using single-sample gene set enrichment analysis. Hub IRDEGs were identified by correlation analysis with immune infiltration levels. Finally, molecular experiments were used to confirm the expression of the hub IRDEGs and explore their roles in NAFLD. Results: We obtained 18 IRDEGs. Five hub genes were further identified by protein-protein interaction network, receiver operating characteristic curves and correlation analysis: AQP9, BACH2, CD4, IL17RE and S100A9. Based on functional enrichment analysis, the hub genes were enriched primarily in many immune-related pathways. In NAFLD, AQP9, CD4, and IL17RE expression was significantly reduced, whereas BACH2 and S100A9 expression was elevated. PCR, oil red O staining and triglyceride detection revealed that the knock-down of BACH2 and S100A9 reduced lipid accumulation in NAFLD cells. Conclusion: This study provided insight into the profile of immune infiltration underlying NAFLD and identified AQP9, BACH2, CD4, IL17RE and S100A9 as ancillary diagnostic indicators of NAFLD. And BACH2 and S100A9 might be therapeutic targets for NAFLD.
Language	English
Publishing date	2023-06-19
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S413545
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Article ; Online: ERBB1 alleviates secondary brain injury induced by experimental intracerebral hemorrhage in rats by modulating neuronal death via PLC-γ/PKC pathway.

Li, Bing / Wu, Jiang / Cao, Demao / Cao, Cheng / Zhang, Juyi / Li, Xiang / Li, Haiying / Shen, Haitao / Yu, Zhengquan

CNS neuroscience & therapeutics

2024 Volume 30, Issue 3, Page(s) e14679

Abstract: Aims: Intracerebral hemorrhage (ICH) is a disease with high rates of disability and mortality. The role of epidermal growth factor receptor 1 (ERBB1) in ICH was elucidated in this study.: Methods: ICH model was constructed by injecting autologous ... ...

Abstract	Aims: Intracerebral hemorrhage (ICH) is a disease with high rates of disability and mortality. The role of epidermal growth factor receptor 1 (ERBB1) in ICH was elucidated in this study. Methods: ICH model was constructed by injecting autologous arterial blood into the right basal ganglia. The protein level of ERBB1 was detected by western blot analysis. To up- and downregulation of ERBB1 in rats, intraventricular injection of a lentivirus overexpression vector of ERBB1 and AG1478 (a specific inhibitor of ERBB1) was used. The cell apoptosis, neuronal loss, and pro-inflammatory cytokines were assessed by TUNEL, Nissl staining, and ELISA. Meanwhile, behavioral cognitive impairment of ICH rats was evaluated after ERBB1-targeted interventions. Results: ERBB1 increased significantly in brain tissue of ICH rats. Overexpression of ERBB1 remarkably reduced cell apoptosis and neuronal loss induced by ICH, as well as pro-inflammatory cytokines and oxidative stress. Meanwhile, the behavioral and cognitive impairment of ICH rats were alleviated after upregulation of ERBB1; however, the secondary brain injury (SBI) was aggravated by AG1478 treatment. Furthermore, the upregulation of PLC-γ and PKC in ICH rats was reversed by AG1478 treatment. Conclusions: ERBB1 can improve SBI and has a neuroprotective effect in experimental ICH rats via PLC-γ/PKC pathway.
MeSH term(s)	Animals ; Rats ; Apoptosis ; Brain Injuries/metabolism ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/metabolism ; Cytokines/metabolism ; Phospholipase C gamma/metabolism ; Quinazolines ; Rats, Sprague-Dawley ; Tyrphostins ; ErbB Receptors/metabolism ; Protein Kinase C/metabolism
Chemical Substances	Cytokines ; Phospholipase C gamma (EC 3.1.4.3) ; Quinazolines ; RTKI cpd (170449-18-0) ; Tyrphostins ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase C (EC 2.7.11.13)
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2423461-8
ISSN	1755-5949 ; 1755-5930
ISSN (online)	1755-5949
ISSN	1755-5930
DOI	10.1111/cns.14679
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Zs.A 4537: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Risk factors for diaphragmatic injury in subxiphoid video-assisted thoracoscopic surgery.

Chen, Maodan / Huang, Yang / Hu, Juyi / Jia, Longfei / Wu, Yuanzhou / Feng, Jing / Zhang, Fuwei / Tong, Jian / Chen, Qunqing / Li, Hui

Surgical endoscopy

2024

Abstract: Background: Subxiphoid video-assisted thoracoscopic surgery (VATS) is considered a safe and feasible operation for anterior mediastinal mass resection. However, diaphragmatic injury, presented as tearing or puncturing, may occur during subxiphoid VATS ... ...

Abstract	Background: Subxiphoid video-assisted thoracoscopic surgery (VATS) is considered a safe and feasible operation for anterior mediastinal mass resection. However, diaphragmatic injury, presented as tearing or puncturing, may occur during subxiphoid VATS despite of low incidence. This study aims to explore risk factors for diaphragmatic injury in subxiphoid VATS, as well as strategies to reduce occurrence of the injury. Methods: We retrospectively reviewed clinical records of 44 consecutive adult patients who underwent subxiphoid VATS. These patients were divided into two groups: diaphragmatic injury group and non-injury group. Perioperative outcomes and anatomic features derived from 3D CT reconstructions were compared between the two groups. Results: Significant differences were observed in operation time (223.25 ± 92.57 vs. 136.28 ± 53.05, P = 0.006), xiphoid length (6.47 ± 0.85 vs. 4.79 ± 1.04, P = 0.001) and length of the xiphoid below the attachment point on the diaphragm (24.86 ± 12.02 vs. 14.61 ± 9.25, P = 0.029). Odds ratio for the length of the xiphoid below the attachment point on the diaphragm was 1.09 (1.001-1.186), P = 0.048 by binary logistic regression analysis. Conclusions: We identified the length of the xiphoid below the attachment point on the diaphragm as an independent risk factor for diaphragm injury during subxiphoid VATS. Prior to subxiphoid VATS, a 3D chest CT reconstruction is recommended to assess the patients' anatomic variations within the xiphoid process. For patients with longer xiphoid process, a higher incision at the middle and upper part of the xiphoid process, and partial xiphoid process resection or xiphoidectomy is preferred.
Language	English
Publishing date	2024-04-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-024-10789-9
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Zs.A 2214: Show issues

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Article ; Online: Small-conductance calcium-activated potassium channels in the heart: expression, regulation and pathological implications.

Liu, Ting / Li, Tao / Xu, Dandi / Wang, Yan / Zhou, Yafei / Wan, Juyi / Huang, Christopher L-H / Tan, Xiaoqiu

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2023 Volume 378, Issue 1879, Page(s) 20220171

Abstract: ... ...

Abstract	Ca
MeSH term(s)	Humans ; Small-Conductance Calcium-Activated Potassium Channels/genetics ; Small-Conductance Calcium-Activated Potassium Channels/metabolism ; Atrial Fibrillation/metabolism ; Heart Atria/metabolism ; Action Potentials/physiology ; Myocytes, Cardiac/metabolism
Chemical Substances	Small-Conductance Calcium-Activated Potassium Channels
Language	English
Publishing date	2023-05-01
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2022.0171
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Article ; Online: Correlation between the thyroid hormone levels and nonalcoholic fatty liver disease in type 2 diabetic patients with normal thyroid function.

Zhang, Yuanyuan / Li, Juyi / Liu, Huaizhen

BMC endocrine disorders

2022 Volume 22, Issue 1, Page(s) 144

Abstract: Background: The objective of this study is to retrospectively analyze the correlation between the thyroid hormones and nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients with normal thyroid function.: Methods: ... ...

Abstract	Background: The objective of this study is to retrospectively analyze the correlation between the thyroid hormones and nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients with normal thyroid function. Methods: Totally 586 T2DM patients with normal thyroid function participated in this research and were divided into T2DM without NAFLD (240 cases) group and T2DM with NAFLD (346 cases) group. The NAFLD fibrosis score (NFS) > 0.676 was defined as progressive liver fibrosis and used to categorize the patients into T2DM without progressive liver fibrosis group (493 cases) and T2DM with progressive liver fibrosis group (93 cases). Results: The results indicated that the levels of free triiodothyronine (FT3), total triiodomethylamine (TT3) and FT3/free thyroxine ratio (FT3/FT4) were significantly higher while the FT4 level was lower in T2DM with NAFLD group than that in T2DM without NAFLD group (p < 0.05). The levels of FT3, FT4, TT3 and TT4 in patients with progressive liver fibrosis were significantly lower in patients with progressive liver fibrosis than that in patients without progressive liver fibrosis (p < 0.05). Logistic regression analysis showed a positive connection between FT3/FT4 ratio and NAFLD (p = 0.038), a negative relationship between FT4 level and NAFLD (p = 0.026), between the levels of FT4, TT3 and total thyroxine (TT4) and the risk of progressive hepatic fibrosis (p = 0.022, p = 0.007, p = 0.046). Conclusion: There is a certain correlation between thyroid hormone levels and NAFLD in T2DM patients, suggesting that the assessment of thyroid hormone levels in T2DM patients with normal thyroid function could be helpful in the prevention and treatment of NAFLD.
MeSH term(s)	Diabetes Mellitus, Type 2/complications ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Non-alcoholic Fatty Liver Disease/complications ; Retrospective Studies ; Risk Factors ; Thyroid Gland ; Thyroid Hormones ; Thyroxine
Chemical Substances	Thyroid Hormones ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2091323-0
ISSN	1472-6823 ; 1472-6823
ISSN (online)	1472-6823
ISSN	1472-6823
DOI	10.1186/s12902-022-01050-2
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Article ; Online: Association of a novel frameshift variant and a known deleterious variant in MMR genes with Lynch syndrome in Chinese families.

Li, Juyi / Ni, Haichun / Wang, Xiufang / Cheng, Wenzhuo / Li, Li / Cheng, Yong / Liu, Chao / Li, Yuanyuan / Deng, Aiping

World journal of surgical oncology

2024 Volume 22, Issue 1, Page(s) 36

Abstract: Background: Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. This condition is characterized by germline variants in DNA mismatch repair (MMR) genes, including MLH1, MSH2, MSH6, and PMS2. In this study, we analyzed the ...

Abstract	Background: Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. This condition is characterized by germline variants in DNA mismatch repair (MMR) genes, including MLH1, MSH2, MSH6, and PMS2. In this study, we analyzed the molecular defects and clinical manifestations of two families affected with CRC and proposed appropriate individual preventive strategies for all carriers of the variant. Methods: We recruited two families diagnosed with CRC and combined their family history and immunohistochemical results to analyze the variants of probands and those of other family members by using whole exome sequencing. Subsequently, gene variants in each family were screened by comparing them with the variants available in the public database. Sanger sequencing was performed to verify the variant sites. An online platform ( https://www.uniprot.org ) was used to analyze the functional domains of mutant proteins. Results: A novel frameshift variant (NM_001281492, c.1129_1130del, p.R377fs) in MSH6 and a known deleterious variant (NM_000249.4:c.1731G > A, p.S577S) in MLH1 were identified in the two families with CRC. Using bioinformatics tools, we noted that the frameshift variant reduced the number of amino acids in the MSH6 protein from 1230 to 383, thereby leading to no MSH6 protein expression. The silent variant caused splicing defects and was strongly associated with LS. 5-Fluorouracil-based adjuvant chemotherapy is not recommended for patients with LS. Conclusions: The novel frameshift variant (MSH6, c.1129_1130del, p.R377fs) is likely pathogenic to LS, and the variant (MLH1, c.1731G > A, p.S577S) has been further confirmed to be pathogenic to LS. Our findings underscore the significance of genetic testing for LS and recommend that genetic consultation and regular follow-ups be conducted to guide individualized treatment for cancer-afflicted families, especially those with a deficiency in MMR expression.
MeSH term(s)	Humans ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; DNA Mismatch Repair/genetics ; Germ-Line Mutation ; Neoplastic Syndromes, Hereditary ; DNA-Binding Proteins/genetics ; China/epidemiology ; MutL Protein Homolog 1/genetics ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism
Chemical Substances	DNA-Binding Proteins ; MutL Protein Homolog 1 (EC 3.6.1.3) ; Mismatch Repair Endonuclease PMS2 (EC 3.6.1.3)
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-024-03309-5
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