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Article ; Online: Effect of sun exposure versus oral vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in young adults: A randomized clinical trial.

Joh, Hee-Kyung / Hwang, Seung-Sik / Cho, BeLong / Lim, Chun Soo / Jung, Sung-Eun

Clinical nutrition (Edinburgh, Scotland)

2019 Volume 39, Issue 3, Page(s) 727–736

Abstract: ... the hypotheses that (1) relevant sun exposure or oral vitamin D supplementation would significantly increase ... serum 25-hydroxyvitamin D (25OHD) concentrations compared with placebo, (2) sun exposure and ... concentrations were compared between the sun exposure (daily ≥20-30 min around noon, n = 50), oral vitamin D ...

Abstract	Background: Vitamin D inadequacy is associated with a wide range of diseases. However, optimal strategies to improve vitamin D status, especially in Asian populations, remain unclear. We tested the hypotheses that (1) relevant sun exposure or oral vitamin D supplementation would significantly increase serum 25-hydroxyvitamin D (25OHD) concentrations compared with placebo, (2) sun exposure and supplementary vitamin D would be similar in serum 25OHD increases, and (3) the two interventions may have different effects on cardio-metabolic markers. Methods: In this 8-week randomized placebo-controlled clinical trial including vitamin D-deficient adults in Seoul (37 °N), Korea, changes in serum 25OHD concentrations were compared between the sun exposure (daily ≥20-30 min around noon, n = 50), oral vitamin D Results: Both sun exposure and oral vitamin D Conclusions: Enhanced sun exposure and 500 IU/d of oral vitamin D
MeSH term(s)	Adolescent ; Adult ; Dietary Supplements ; Female ; Humans ; Male ; Republic of Korea ; Students/statistics & numerical data ; Sunlight ; Vitamin D/administration & dosage ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/pharmacology ; Vitamins/administration & dosage ; Vitamins/blood ; Vitamins/pharmacology ; Young Adult
Chemical Substances	Vitamins ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2019-03-21
Publishing country	England
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2019.03.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of sun exposure versus oral vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in young adults: A randomized clinical trial

Joh, Hee-Kyung / Hwang, Seung-sik / Cho, BeLong / Lim, Chun Soo / Jung, Sung-Eun

Clinical nutrition. 2019 Mar. 14,

2019

Abstract: ... that (1) relevant sun exposure or oral vitamin D supplementation would significantly increase serum 25 ... hydroxyvitamin D (25OHD) concentrations compared with placebo, (2) sun exposure and supplementary vitamin D would ... the sun exposure (daily ≥20–30 min around noon, n = 50), oral vitamin D3 (500 IU/d, n = 50), and control ...

Abstract	Vitamin D inadequacy is associated with a wide range of diseases. However, optimal strategies to improve vitamin D status, especially in Asian populations, remain unclear. We tested the hypotheses that (1) relevant sun exposure or oral vitamin D supplementation would significantly increase serum 25-hydroxyvitamin D (25OHD) concentrations compared with placebo, (2) sun exposure and supplementary vitamin D would be similar in serum 25OHD increases, and (3) the two interventions may have different effects on cardio-metabolic markers.In this 8-week randomized placebo-controlled clinical trial including vitamin D-deficient adults in Seoul (37 °N), Korea, changes in serum 25OHD concentrations were compared between the sun exposure (daily ≥20–30 min around noon, n = 50), oral vitamin D3 (500 IU/d, n = 50), and control (placebo, n = 50) groups.Both sun exposure and oral vitamin D3 effectively increased serum 25OHD concentrations. Compared with placebo, the between-group least-squares mean (LSM) differences in changes were 2.2 ng/mL (95% CI: 0.2, 4.2) in the sun exposure group and 8.5 ng/mL (6.5, 10.5) in the oral vitamin D3 group. Increases in serum 25OHD were greater with oral vitamin D3 than with sun exposure (LSM difference in changes = 6.3 ng/mL, 95% CI: 4.3, 8.3). More participants in the oral vitamin D3 group (54.2%) achieved serum 25OHD concentrations ≥20 ng/mL at week 8 than those in the sun exposure (12.2%) or control (4.3%) groups. Compliance with sun exposure advice was relatively low, and only those with adequate compliance had a significant increase in serum 25OHD. Changes in the cardio-metabolic markers were mostly insignificant in all groups.Enhanced sun exposure and 500 IU/d of oral vitamin D3 supplementation significantly increased serum 25OHD concentrations. However, our protocol for sun exposure was not as effective as 500 IU/d of oral vitamin D3 supplementation.This trial was registered at clinicaltrials.gov as NCT03310242.
Keywords	blood serum ; cholecalciferol ; compliance ; least squares ; placebos ; randomized clinical trials ; vitamin D deficiency ; vitamin status ; young adults ; Korean Peninsula
Language	English
Dates of publication	2019-0314
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2019.03.021
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Neuro-Behçet Disease Presenting with Wall-Eyed Bilateral Internuclear Ophthalmoplegia Syndrome: A Case Report.

Jung, Jin Wook / Kim, Young-Eun / Oh, Sun-Young / Lee, Haeng-Jin

Korean journal of ophthalmology : KJO

2024 Volume 38, Issue 1, Page(s) 88–90

MeSH term(s)	Humans ; Ocular Motility Disorders/diagnosis ; Ocular Motility Disorders/etiology ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; Eye ; Head ; Ophthalmoplegia/diagnosis ; Ophthalmoplegia/etiology
Language	English
Publishing date	2024-01-03
Publishing country	Korea (South)
Document type	Case Reports ; Journal Article
ZDB-ID	639346-9
ISSN	2092-9382 ; 1011-8942
ISSN (online)	2092-9382
ISSN	1011-8942
DOI	10.3341/kjo.2023.0098
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Article ; Online: Factors associated with the use of traditional doses of amitriptyline for chronic pain management: A cross-sectional study.

Koo, Hyunji / Jeong, Kyeong Hye / Jeon, Nakyung / Jung, Sun-Young

Medicine

2024 Volume 103, Issue 1, Page(s) e36790

Abstract: There are studies on the effect of low-dose amitriptyline on pain control, but there is a lack of studies on the use of amitriptyline for chronic pain and the factors associated with the prescription of traditional doses. We used a national sample cohort ...

Abstract	There are studies on the effect of low-dose amitriptyline on pain control, but there is a lack of studies on the use of amitriptyline for chronic pain and the factors associated with the prescription of traditional doses. We used a national sample cohort of patients aged ≥ 18 years who were prescribed amitriptyline along with chronic pain, without psychiatric disorders, between 2002 to 2015. We categorized the prescriptions into 2 groups according to the daily dose: low doses (≤25 mg) and traditional doses (>25 mg). Multivariable logistic regression models were used to identify factors associated with traditional dose prescriptions. Among 177,769 prescriptions for amitriptyline, 15,119 (8.5%) were prescribed for chronic pain. The prevalence of prescriptions and proportion of traditional doses of amitriptyline tended to decrease during the study period. Male sex (odds ratio [OR] 1.09, 95% confidence interval [CI] 1.05-1.13); age 65-80 years (OR 1.12, 95% CI 1.08-1.16), especially ≥ 80 years (OR 1.55, 95% CI 1.45-1.65); headaches (OR 1.18, 95% CI 1.10-1.27), receiving medical aids (OR 2.58, 95% CI 2.46-2.71); and being prescribed benzodiazepines or zolpidem concomitantly (OR 1.10, 95% CI 1.06-1.15) were significantly associated with traditional dose prescriptions of amitriptyline. Although traditional dose prescriptions of amitriptyline have been declining, close monitoring is still required in the presence of the above-mentioned factors.
MeSH term(s)	Humans ; Male ; Cross-Sectional Studies ; Amitriptyline/therapeutic use ; Chronic Pain/drug therapy ; Benzodiazepines ; Headache
Chemical Substances	Amitriptyline (1806D8D52K) ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036790
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Article ; Online: Prediction of dysphagia aspiration through machine learning-based analysis of patients' postprandial voices.

Kim, Jung-Min / Kim, Min-Seop / Choi, Sun-Young / Ryu, Ju Seok

Journal of neuroengineering and rehabilitation

2024 Volume 21, Issue 1, Page(s) 43

Abstract: Background: Conventional diagnostic methods for dysphagia have limitations such as long wait times, radiation risks, and restricted evaluation. Therefore, voice-based diagnostic and monitoring technologies are required to overcome these limitations. ... ...

Abstract	Background: Conventional diagnostic methods for dysphagia have limitations such as long wait times, radiation risks, and restricted evaluation. Therefore, voice-based diagnostic and monitoring technologies are required to overcome these limitations. Based on our hypothesis regarding the impact of weakened muscle strength and the presence of aspiration on vocal characteristics, this single-center, prospective study aimed to develop a machine-learning algorithm for predicting dysphagia status (normal, and aspiration) by analyzing postprandial voice limiting intake to 3 cc. Methods: Conducted from September 2021 to February 2023 at Seoul National University Bundang Hospital, this single center, prospective cohort study included 198 participants aged 40 or older, with 128 without suspected dysphagia and 70 with dysphagia-aspiration. Voice data from participants were collected and used to develop dysphagia prediction models using the Multi-Layer Perceptron (MLP) with MobileNet V3. Male-only, female-only, and combined models were constructed using 10-fold cross-validation. Through the inference process, we established a model capable of probabilistically categorizing a new patient's voice as either normal or indicating the possibility of aspiration. Results: The pre-trained models (mn40_as and mn30_as) exhibited superior performance compared to the non-pre-trained models (mn4.0 and mn3.0). Overall, the best-performing model, mn30_as, which is a pre-trained model, demonstrated an average AUC across 10 folds as follows: combined model 0.8361 (95% CI 0.7667-0.9056; max 0.9541), male model 0.8010 (95% CI 0.6589-0.9432; max 1.000), and female model 0.7572 (95% CI 0.6578-0.8567; max 0.9779). However, for the female model, a slightly higher result was observed with the mn4.0, which scored 0.7679 (95% CI 0.6426-0.8931; max 0.9722). Additionally, the other models (pre-trained; mn40_as, non-pre-trained; mn4.0 and mn3.0) also achieved performance above 0.7 in most cases, and the highest fold-level performance for most models was approximately around 0.9. The 'mn' in model names refers to MobileNet and the following number indicates the 'width_mult' parameter. Conclusions: In this study, we used mel-spectrogram analysis and a MobileNetV3 model for predicting dysphagia aspiration. Our research highlights voice analysis potential in dysphagia screening, diagnosis, and monitoring, aiming for non-invasive safer, and more effective interventions. Trial registration: This study was approved by the IRB (No. B-2109-707-303) and registered on clinicaltrials.gov (ID: NCT05149976).
MeSH term(s)	Humans ; Male ; Female ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Prospective Studies ; Respiratory Aspiration/diagnosis ; Respiratory Aspiration/etiology ; Machine Learning ; Algorithms
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2164377-5
ISSN	1743-0003 ; 1743-0003
ISSN (online)	1743-0003
ISSN	1743-0003
DOI	10.1186/s12984-024-01329-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Work-Family Balance among Dual-Earner Couples in South Korea: A Latent Profile Analysis.

Ji, Sun-Young / Jung, Hye-Sun

International journal of environmental research and public health

2021 Volume 18, Issue 11

Abstract: The declining birth rate in South Korea is concerning and linked to stress in the work-family balance, which is known to affect family planning. Therefore, providing proper support to double-earner couples might help improve the fertility rate. Work- ... ...

Abstract	The declining birth rate in South Korea is concerning and linked to stress in the work-family balance, which is known to affect family planning. Therefore, providing proper support to double-earner couples might help improve the fertility rate. Work-family balance refers to the ability of individuals to perform their roles at work and home with equal involvement. This study identifies two aspects: gains and strains. Latent profile analysis is employed to create a typology that can account for the diversity in work-family balance. This approach is person-centered rather than variable-centered, and it identifies clusters of individuals that differ qualitatively, thereby examining the strains and gains experienced by double-earner couples. We classify the types of work-family balance and identify the attributes of each profile. The findings showed that men were more likely to belong to the high-gain class when they had a temporary position, multiple children, good health, low depression, higher life satisfaction levels, and strong social support. Women were more likely to belong to the high-gain class when they experienced high happiness levels and strong social support. Based on these profiles, we provide recommendations to enhance work-family balance, thereby contributing to strategies to overcome low birth rates.
MeSH term(s)	Child ; Female ; Humans ; Male ; Republic of Korea ; Social Support
Language	English
Publishing date	2021-06-06
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18116129
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Internet-Based Interventions for Preventing Premature Birth Among Pregnant Women: Systematic Review.

Kim, Sun-Hee / Park, Jin-Hwa / Jung, Sun-Young / De Gagne, Jennie C

JMIR pediatrics and parenting

2024 Volume 7, Page(s) e54788

Abstract: Background: Premature birth rates have slightly increased globally, making its prevention critical for both short-term and long-term health outcomes. Various interventions have been developed in response to the multifaceted risk factors for premature ... ...

Abstract	Background: Premature birth rates have slightly increased globally, making its prevention critical for both short-term and long-term health outcomes. Various interventions have been developed in response to the multifaceted risk factors for premature birth, including internet-based programs. These programs offer accessibility and enhanced engagement; however, their overall efficacy in preventing premature births requires thorough evaluation. Objective: This systematic review aims to identify the study designs and assess the effectiveness of internet-based interventions in preventing premature birth among pregnant women. Methods: A comprehensive search of the MEDLINE, Embase, CINAHL, and Cochrane Library databases was conducted to identify randomized trials and quasi-experimental studies evaluating internet-based interventions for premature birth prevention in pregnant women. The search was inclusive, with no restrictions based on language or geographical location, allowing for a comprehensive global perspective. The time frame for the inclusion of studies extended until February 2023. The risk of bias (RoB) in each study was independently assessed by 3 authors forming pairs, using the revised Cochrane RoB tool (RoB 2) for randomized trials, as per the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Owing to heterogeneity in populations, measurements, and interventions, a meta-analysis was not conducted. Results: This review included 26 articles, comprising 12 intention-to-treat and 14 per-protocol studies. The overall RoB was high in most intention-to-treat studies and of some concern in most per-protocol studies. The target populations varied, including nonspecific pregnant women, those with gestational diabetes mellitus (GDM) or those at risk of GDM, individuals with anxiety or depression, and those experiencing preterm labor. Psychosocial, physiological, and wellness health outcomes were evaluated. Internet-based interventions effectively reduced stress/distress in nonspecific pregnant women but not in those experiencing preterm labor. Their effectiveness in reducing anxiety and depression varied, with inconsistent results among different groups. In women with GDM or those at risk of GDM, interventions successfully controlled fasting plasma glucose and 2-hour postprandial plasma glucose levels but did not consistently manage glycated hemoglobin levels. These interventions did not reduce the incidence of premature births across the various populations studied. The effectiveness of these internet-based interventions in addressing substance or alcohol abuse and insomnia also varied. Conclusions: Internet-based interventions show promise in improving psychosocial health and managing blood sugar to prevent premature birth, highlighting variability in effectiveness across different risk factors. Further research, including clinical trials, is vital for developing, evaluating, and disseminating effective, safe internet-based interventions. Establishing standardized measurement tools and rigorous evaluation processes is crucial for enhancing these interventions' effectiveness and reliability in clinical practice, significantly contributing to preventing premature births and improving maternal health outcomes. Trial registration: PROSPERO CRD42021278847; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021278847.
Language	English
Publishing date	2024-04-02
Publishing country	Canada
Document type	Journal Article ; Review
ISSN	2561-6722
ISSN (online)	2561-6722
DOI	10.2196/54788
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association of Nursing Work Environment, Relationship with the Head Nurse, and Resilience with Post-Traumatic Growth in Emergency Department Nurses.

Jung, Sun-Young / Park, Jin-Hwa

International journal of environmental research and public health

2021 Volume 18, Issue 6

Abstract: Emergency department nurses are confronted with unpredictable diseases and disasters and work-related traumatic stress events. This study aimed to examine the relationship between nursing work environment, relationship with the head nurse, resilience, ... ...

Abstract	Emergency department nurses are confronted with unpredictable diseases and disasters and work-related traumatic stress events. This study aimed to examine the relationship between nursing work environment, relationship with the head nurse, resilience, and posttraumatic growth among emergency department nurses. Data were collected from December 2018 to February 2019 through a self-administered survey questionnaire. Participants comprised 127 nurses working in the emergency department. The collected data were analyzed using
MeSH term(s)	Cross-Sectional Studies ; Emergency Service, Hospital ; Humans ; Nursing Staff, Hospital ; Nursing, Supervisory ; Posttraumatic Growth, Psychological ; Surveys and Questionnaires ; Workplace
Language	English
Publishing date	2021-03-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18062857
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Atlantoaxial joint stabilization using patient-specific 3-D-printed drill guides and 3-D-printed titanium plates or polymethyl methacrylate is effective in toy-breed dogs.

Seon, Yeowool / Cho, Cheongwoon / Jung, Changsu / Lim, Ji-Hey / Kim, Sun-Young / Kang, Byung-Jae

American journal of veterinary research

2024 , Page(s) 1–8

Abstract: Objective: To report the clinical outcomes in toy-breed dogs with atlantoaxial instability (AAI) stabilized with patient-specific 3-D-printed titanium plates or polymethyl methacrylate (PMMA), both with the assistance of 3-D-printed drill guides.: ... ...

Abstract	Objective: To report the clinical outcomes in toy-breed dogs with atlantoaxial instability (AAI) stabilized with patient-specific 3-D-printed titanium plates or polymethyl methacrylate (PMMA), both with the assistance of 3-D-printed drill guides. Animals: 15 client-owned dogs undergoing surgical treatment for AAI between January 1, 2020, and October 31, 2022. Methods: The clinical characteristics, diagnostic images, and neurological outcomes of 15 dogs treated for AAI using 3-D-printing technology were reviewed. Postoperative CT images were examined to evaluate the screw placement accuracy in the atlas and axis. Clinical outcomes, including postoperative neurological improvement and screw loosening, were evaluated in dogs treated with a patient-specific titanium plate and those treated with PMMA. Results: Patient-specific titanium plates (7 dogs) and PMMA (8 dogs) were used for AAI stabilization. The mean follow-up period was 15.2 months (range 7 to 22 months). A reduction of the axis without vertebral canal violation was confirmed on postoperative CT in 14 dogs. The mean deviation from the preoperative planning ranged from 0.30 to 1.27 mm at the insertion and exit points of 84 screws using this method. The neurological grade had improved in each dog postoperatively and at the final follow-up. Screw loosening was noted in 4 dogs in the titanium plates groups without neurological deterioration. Clinical relevance: Patient-specific 3-D-printed drill guides and titanium plates or PMMA are effective for AAI stabilization in toy-breed dogs, providing accurate guidance.
Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.24.02.0023
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Article ; Online: Trends in Ambulatory Analgesic Usage after Myocardial Infarction

Sun-Young Jung / Seung Yeon Song / Eunyoung Kim

Healthcare, Vol 10, Iss 446, p

A Nationwide Cross-Sectional Study of Real-World Data

2022 Volume 446

Abstract: Although current guidelines for myocardial infarction (MI) recommend caution in using non-steroidal anti-inflammatory drugs (NSAIDs), real-world studies of ambulatory settings are rare. This study aimed to explore the patterns and trends of analgesic ... ...

Abstract	Although current guidelines for myocardial infarction (MI) recommend caution in using non-steroidal anti-inflammatory drugs (NSAIDs), real-world studies of ambulatory settings are rare. This study aimed to explore the patterns and trends of analgesic prescriptions (especially NSAIDs) among patients with a history of MI in ambulatory care settings in Korea. We analyzed real-world data from the Korea National Health Insurance Service database. Patients aged 20 years or older hospitalized with incident MI were identified between January 2007 and December 2015. Ambulatory analgesics were administered after discharge from incident hospitalization for MI, and annual trends in the prescriptions of individual analgesics were evaluated. Among the 93,597 patients with incident MI, 75,131 (80.3%) received a total of 2,081,705 ambulatory analgesic prescriptions. Prescriptions were mainly issued at primary care clinics (80.3%). Analgesics were most frequently prescribed for musculoskeletal diseases (often NSAIDs, 70.7%); aceclofenac (13.7%) and diclofenac injection (9.4%) were the frequently used NSAIDs. Additionally, significant changes were observed in the trends for some analgesics, such as loxoprofen. This study suggested that NSAIDs are commonly prescribed to patients with a history of MI. Future real-world studies are needed to elucidate the drug–disease interactions of NSAIDs prescribed after MI, especially for patients with musculoskeletal diseases.
Keywords	myocardial infarction ; non-steroidal anti-inflammatory drugs (NSAIDs) ; the Korea National Health Insurance Service (NHIS) database ; ambulatory analgesics ; patterns and trends ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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