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Article ; Online: Enhancing Diradical Character of Chichibabin's Hydrocarbon through Fluoride Substitution.

Kundu, Gargi / Dash, Soumya Ranjan / Kumar, Ravi / Vanka, Kumar / Ghosh, Aryya / Sen, Sakya S

ChemPlusChem

2023 Volume 88, Issue 8, Page(s) e202300273

Abstract: In this work, 5-SIDipp [SIDipp=1,3-bis(2,6-diisopropylphenyl)-imidazolin-2-ylidene] (1) derived Chichibabin's hydrocarbon with an octafluorobiphenylene spacer (3) has been reported. The addition of two equivalents of 5-SIDipp with decafluorobiphenyl in ... ...

Abstract	In this work, 5-SIDipp [SIDipp=1,3-bis(2,6-diisopropylphenyl)-imidazolin-2-ylidene] (1) derived Chichibabin's hydrocarbon with an octafluorobiphenylene spacer (3) has been reported. The addition of two equivalents of 5-SIDipp with decafluorobiphenyl in presence of BF
Language	English
Publishing date	2023-07-05
Publishing country	Germany
Document type	Journal Article
ISSN	2192-6506
ISSN (online)	2192-6506
DOI	10.1002/cplu.202300273
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Article ; Online: Granular activated carbon assisted biocathode for effective electrotrophic denitrification in microbial fuel cells.

Thapa, Bhim Sen / Pandit, Soumya / Gurung, Anup / Ashun, Ebenezer / Ko, Seoung-Yun / Oh, Sang-Eun

Chemosphere

2024 Volume 352, Page(s) 141341

Abstract: Granular activated carbon (GAC) has been widely used at the anode of a microbial fuel cell (MFC) to enhance anode performance due to its outstanding capacitance property. To the best of our knowledge, there haven't been any studies on GAC in the cathode ... ...

Abstract	Granular activated carbon (GAC) has been widely used at the anode of a microbial fuel cell (MFC) to enhance anode performance due to its outstanding capacitance property. To the best of our knowledge, there haven't been any studies on GAC in the cathode for biofilm development and nitrate reduction in MFC. In this study, by adding GAC to biocathode, we investigated the impact of different GAC amounts and stirring speeds on power generation and nitrate reduction rate in MFC. The denitrification rate was found to be nearly two-times higher in MFCs with GAC (0.046 ± 0.0016 kg m
MeSH term(s)	Bioelectric Energy Sources ; Nitrates/chemistry ; Charcoal ; Denitrification ; Organic Chemicals ; Electrodes
Chemical Substances	Nitrates ; Charcoal (16291-96-6) ; Organic Chemicals
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141341
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Zs.A 2540: Show issues

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Article ; Online: Emergence of per- and poly-fluoroalkyl substances (PFAS) and advances in the remediation strategies.

Thapa, Bhim Sen / Pandit, Soumya / Mishra, Rahul Kumar / Joshi, Sanket / Idris, Abubakr M / Tusher, Tanmoy Roy

The Science of the total environment

2024 Volume 916, Page(s) 170142

Abstract: A group of fluorinated organic molecules known as per- and poly-fluoroalkyl substances (PFAS) have been commonly produced and circulated in the environment. PFAS, owing to multiple strong CF bonds, exhibit exceptional stability and possess a high level ... ...

Abstract	A group of fluorinated organic molecules known as per- and poly-fluoroalkyl substances (PFAS) have been commonly produced and circulated in the environment. PFAS, owing to multiple strong CF bonds, exhibit exceptional stability and possess a high level of resistance against biological or chemical degradation. Recently, PFAS have been identified to cause numerous hazardous effects on the biotic ecosystem. As a result, extensive efforts have been made in recent years to develop effective methods to remove PFAS. Adsorption, filtration, heat treatment, chemical oxidation/reduction, and soil washing are a few of the physicochemical techniques that have shown their ability to remove PFAS from contaminated matrixes. However these methods also carry significant drawbacks, including the fact that they are expensive, energy-intensive, unsuitable for in-situ treatment, and requirement to be carried under dormant conditions. The metabolic products released upon PFAS degradation are largely unknown, despite the fact that thermal disintegration methods are widely used. In contrast to physical and chemical methods, biological degradation of PFAS has been regarded as efficient method. However, PFAS are difficult to instantly and completely metabolize through biological methods due to the limitations of biocatalytic mechanisms. Nevertheless, cost, easy-to-operate and environmentally safe are some of the advantages over its counterpart. The present review comprehensively discusses the occurrence of PFAS, the state-of-the science of remediation technologies and approaches applied, and the remediation challenges. The article also focuses on the future research directions toward the development of effective methods for PFAS-contaminated site in-situ treatment.
MeSH term(s)	Ecosystem ; Adsorption ; Biocatalysis ; Filtration ; Fluorocarbons ; Water Pollutants, Chemical
Chemical Substances	Fluorocarbons ; Water Pollutants, Chemical
Language	English
Publishing date	2024-01-17
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.170142
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Zs.A 949: Show issues

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Article: A retrospective analysis of the 5-year trends of antimicrobial resistance in gram-negative bacterial isolates from an intensive care unit at a tertiary care hospital.

Raj, Nikhil / Agarwal, Jyotsna / Singh, Vikramjeet / Nath, Soumya Sankar / Das, Anupam / Sen, Manodeep

International journal of critical illness and injury science

2023 Volume 13, Issue 4, Page(s) 178–183

Abstract: Background: Intensive care units (ICUs) in developing countries constitute a high risk for patients acquiring infection by multidrug-resistant organisms (MDROs). The rise in antimicrobial resistance (AMR) threatens the effective prevention and treatment ...

Abstract	Background: Intensive care units (ICUs) in developing countries constitute a high risk for patients acquiring infection by multidrug-resistant organisms (MDROs). The rise in antimicrobial resistance (AMR) threatens the effective prevention and treatment of an increasing range of infections. The present study analyzed the local trends of AMR in Gram-negative isolates of ICU patients from a tertiary care facility in North India. Methods: This retrospective study was conducted over 5 years (January 2018-December 2022). All bacterial isolates from patients admitted to ICU during the study period were included in the study, and their AMR pattern was analyzed. In addition, sensitivity trends of different antimicrobials against the common Gram-negative bacteria were analyzed, and AMR trends were analyzed over the study period. Results: Klebsiella Conclusion: The inception of integrated stewardship measures has shown a rising trend in susceptibility and is the need of the hour to prevent the spread of MDROs. Surveillance studies help us understand the impact of AMR in hospitals and help plan prevention programs.
Language	English
Publishing date	2023-12-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2638865-0
ISSN	2231-5004 ; 2229-5151
ISSN (online)	2231-5004
ISSN	2229-5151
DOI	10.4103/ijciis.ijciis_30_23
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Article ; Online: Extein residues regulate the catalytic function of Spl DnaX intein enzyme by restricting the near-attack conformations of the active-site residues.

Boral, Soumendu / Sen, Srijon / Kushwaha, Tushar / Inampudi, Krishna K / De, Soumya

Protein science : a publication of the Protein Society

2023 Volume 32, Issue 7, Page(s) e4699

Abstract: Intein enzymes catalyze the splicing of their flanking polypeptide chains and have found tremendous biotechnological applications. Their terminal residues form the catalytic core and participate in the splicing reaction. Hence, the neighboring N- and C- ... ...

Abstract	Intein enzymes catalyze the splicing of their flanking polypeptide chains and have found tremendous biotechnological applications. Their terminal residues form the catalytic core and participate in the splicing reaction. Hence, the neighboring N- and C-terminal extein residues influence the catalytic rate. As these extein residues vary depending on the substrate identity, we tested the influence of 20 amino acids at these sites in the Spl DnaX intein and observed significant variation of spliced product as well as N- and C-terminus cleavage product formation. We investigated the dependence of these reactions on the extein residues by molecular dynamics (MD) simulations on eight extein variants, and found that the conformational sampling of the active-site residues of the intein enzyme differed among these extein variants. We found that the extein variants that sample higher population of near-attack conformers (NACs) of the active-site residues undergo higher product formation in our activity assays. Ground state conformers that closely resemble the transition state are referred to as NACs. Very good correlation was observed between the NAC populations from the MD simulations of eight extein variants and the corresponding product formation from our activity assays. Furthermore, this molecular detail enabled us to elucidate the mechanistic roles of several conserved active-site residues in the splicing reaction. Overall, this study shows that the catalytic power of Spl DnaX intein enzyme, and most likely other inteins, depends on the efficiency of formation of NACs in the ground state, which is further modulated by the extein residues.
MeSH term(s)	Inteins ; Exteins ; Catalytic Domain ; Protein Splicing ; Amino Acids
Chemical Substances	Amino Acids
Language	English
Publishing date	2023-06-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1106283-6
ISSN	1469-896X ; 0961-8368
ISSN (online)	1469-896X
ISSN	0961-8368
DOI	10.1002/pro.4699
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Zs.A 3407: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Association of Stay-at-Home Orders With COVID-19 Hospitalizations in 4 States.

Sen, Soumya / Karaca-Mandic, Pinar / Georgiou, Archelle

JAMA

2020 Volume 323, Issue 24, Page(s) 2522–2524

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Government Regulation ; Hospitalization/trends ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Quarantine/legislation & jurisprudence ; SARS-CoV-2 ; State Government ; United States/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-05-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2020.9176
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Article ; Online: Association Between Regulatory Submission Characteristics and Recalls of Medical Devices Receiving 510(k) Clearance.

Everhart, Alexander O / Sen, Soumya / Stern, Ariel D / Zhu, Yi / Karaca-Mandic, Pinar

JAMA

2023 Volume 329, Issue 2, Page(s) 144–156

Abstract: Importance: Most regulated medical devices enter the US market via the 510(k) regulatory submission pathway, wherein manufacturers demonstrate that applicant devices are "substantially equivalent" to 1 or more "predicate" devices (legally marketed ... ...

Abstract	Importance: Most regulated medical devices enter the US market via the 510(k) regulatory submission pathway, wherein manufacturers demonstrate that applicant devices are "substantially equivalent" to 1 or more "predicate" devices (legally marketed medical devices with similar intended use). Most recalled medical devices are 510(k) devices. Objective: To examine the association between characteristics of predicate medical devices and recall probability for 510(k) devices. Design, setting, and participants: In this exploratory cross-sectional analysis of medical devices cleared by the US Food and Drug Administration (FDA) between 2003 and 2018 via the 510(k) regulatory submission pathway, linear probability models were used to examine associations between a 510(k) device's recall status and characteristics of its predicate medical devices. Public documents for the 510(k) medical devices were collected using FDA databases. A text extraction algorithm was applied to identify predicate medical devices cited in 510(k) regulatory submissions. Algorithm-derived metadata were combined with 2003-2020 FDA recall data. Exposures: Citation of predicate medical devices with certain characteristics in 510(k) regulatory submissions, including the total number of predicate medical devices cited by the applicant device, the age of the predicate medical devices, the lack of similarity of the predicate medical devices to the applicant device, and the recall status of the predicate medical devices. Main outcomes and measures: Class I or class II recall of a 510(k) medical device between its FDA regulatory clearance date and December 31, 2020. Results: The sample included 35 176 medical devices, of which 4007 (11.4%) were recalled. The applicant devices cited a mean of 2.6 predicate medical devices, with mean ages of 3.6 years and 7.4 years for the newest and oldest, respectively, predicate medical devices. Of the applicant devices, 93.9% cited predicate medical devices with no ongoing recalls, 4.3% cited predicate medical devices with 1 ongoing class I or class II recall, 1.0% cited predicate medical devices with 2 ongoing recalls, and 0.8% cited predicate medical devices with 3 or more ongoing recalls. Applicant devices citing predicate medical devices with 3 or more ongoing recalls were significantly associated with a 9.31-percentage-point increase (95% CI, 2.84-15.77 percentage points) in recall probability compared with devices without ongoing recalls of predicate medical devices, or an 81.2% increase in recall probability relative to the mean recall probability. A 1-SD increase in the total number of predicate medical devices cited by the applicant device was significantly associated with a 1.25-percentage-point increase (95% CI, 0.62-1.87 percentage points) in recall probability, or an 11.0% increase in recall probability relative to the mean recall probability. A 1-SD increase in the newest age of a predicate medical device was significantly associated with a 0.78-percentage-point decrease (95% CI, 1.29-0.30 percentage points) in recall probability, or a 6.8% decrease in recall probability relative to the mean recall probability. Conclusions and relevance: This exploratory cross-sectional study of 510(k) medical devices cleared by the FDA between 2003 and 2018 demonstrated significant associations between 510(k) submission characteristics and recalls of medical devices. Further research is needed to understand the implications of these associations.
MeSH term(s)	Algorithms ; Cross-Sectional Studies ; Databases, Factual ; Device Approval/legislation & jurisprudence ; Device Approval/standards ; Medical Device Recalls/legislation & jurisprudence ; Medical Device Recalls/standards ; United States ; United States Food and Drug Administration
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2022.22974
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Article ; Online: Assessment of COVID-19 Hospitalizations by Race/Ethnicity in 12 States.

Karaca-Mandic, Pinar / Georgiou, Archelle / Sen, Soumya

JAMA internal medicine

2020 Volume 181, Issue 1, Page(s) 131–134

MeSH term(s)	African Americans/statistics & numerical data ; Asian Americans/statistics & numerical data ; COVID-19/epidemiology ; COVID-19/ethnology ; European Continental Ancestry Group/statistics & numerical data ; Healthcare Disparities/ethnology ; Hispanic Americans/statistics & numerical data ; Hospitalization/statistics & numerical data ; Humans ; Indians, North American/statistics & numerical data ; Prevalence ; SARS-CoV-2 ; United States/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2699338-7
ISSN	2168-6114 ; 2168-6106
ISSN (online)	2168-6114
ISSN	2168-6106
DOI	10.1001/jamainternmed.2020.3857
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Book ; Online: Performance assessment of vehicle interdiction strategies in a simulation based environment on a complex transportation network

Samanta, Sukanya / Uniyal, Jatin / Sen, Goutam / Ghosh, Soumya Kanti

2023

Abstract: We consider the escape interdiction problem in a transportation network. In the absence of traffic in the network, the criminal/attacker tries to escape from the city using any of the shortest paths from the crime scene to any randomly chosen exit point. ...

Abstract	We consider the escape interdiction problem in a transportation network. In the absence of traffic in the network, the criminal/attacker tries to escape from the city using any of the shortest paths from the crime scene to any randomly chosen exit point. In the presence of traffic, the attacker chooses the optimal path, which takes minimum time to reach his destination. On the contrary, police/defenders try to interdict the criminal on his escape route. This is a challenging task for police with limited resources. Again, a real city road network is also complex in nature. First, we develop a simulation-based model for the optimal allocation of resources using the SUMO simulator. Next, we focus on developing a more advanced search strategy like routing with optimal resource allocation. We develop a novel meta-heuristic approach in a simulation environment to interdict the attacker in a dynamic crime scenario. Like the previous approach, the attacker follows the path with optimal time to escape from the city. In contrast, defenders try to catch the attacker regardless of the path which the attacker takes. The defenders aim is to maximize the interdiction probability. As time plays a vital role, we choose a meta-heuristic approach to provide quality solutions in a time-efficient manner. We test the developed meta-heuristic with a case study on the IIT Kharagpur map, India. We analyze the performance of the mentioned approaches using the SUMO simulator both in the presence of traffic and without traffic. We develop a linear regression model to generate optimal path in the presence of traffic. Here traffic is generated randomly in the whole network using the SUMO simulator. Comment: 35 pages, 9 figures
Keywords	Physics - Physics and Society ; Electrical Engineering and Systems Science - Systems and Control
Subject code	000
Publishing date	2023-05-19
Publishing country	us
Document type	Book ; Online
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Article ; Online: COVID-19 Hospitalization Trends in Rural Versus Urban Areas in the United States.

Zhu, Yi / Carroll, Caitlin / Vu, Khoa / Sen, Soumya / Georgiou, Archelle / Karaca-Mandic, Pinar

Medical care research and review : MCRR

2022 Volume 80, Issue 2, Page(s) 236–244

Abstract: Since the summer of 2020, the rate of coronavirus cases in the United States has been higher in rural areas than in urban areas, raising concerns that patients with coronavirus disease 2019 (COVID-19) will overwhelm under-resourced rural hospitals. Using ...

Abstract	Since the summer of 2020, the rate of coronavirus cases in the United States has been higher in rural areas than in urban areas, raising concerns that patients with coronavirus disease 2019 (COVID-19) will overwhelm under-resourced rural hospitals. Using data from the University of Minnesota COVID-19 Hospitalization Tracking Project and the U.S. Department of Health and Human Services, we document disparities in COVID-19 hospitalization rates between rural and urban areas. We show that rural-urban differences in COVID-19 admission rates were minimal in the summer of 2020 but began to diverge in fall 2020. Rural areas had statistically higher hospitalization rates from September 2020 through early 2021, after which rural-urban admission rates re-converged. The insights in this article are relevant to policymakers as they consider the adequacy of hospital resources across rural and urban areas during the COVID-19 pandemic.
MeSH term(s)	Humans ; United States/epidemiology ; COVID-19/epidemiology ; Pandemics ; Hospitalization ; Rural Population ; Hospitals, Rural ; Urban Population
Language	English
Publishing date	2022-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1232314-7
ISSN	1552-6801 ; 1077-5587
ISSN (online)	1552-6801
ISSN	1077-5587
DOI	10.1177/10775587221111105
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