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Article ; Online: Characteristics of contemporary atrial fibrillation clinical trials and their association with industry sponsorship.

Lan, Roy H / Paranjpe, Ishan / Saeed, Mohammad / Perez, Marco V

2024

Abstract: Background: Industry sponsorship is an important source of funding for atrial fibrillation (AF) clinical trials, the implications of which have not been analyzed.: Objective: The purpose of this study was to determine the characteristics of ... ...

Abstract	Background: Industry sponsorship is an important source of funding for atrial fibrillation (AF) clinical trials, the implications of which have not been analyzed. Objective: The purpose of this study was to determine the characteristics of contemporary AF clinical trials and to evaluate their association with funding source. Methods: We systematically assessed all completed AF trials registered in the ClinicalTrials.gov database between conception to October 31, 2023, and extracted publicly available information including funding source, trial size, demographic distribution, intervention, location, and publication status. Trial characteristics were compared using the Wilcoxon rank-sum test and Fisher exact test for continuous and categorical variables, respectively. Results: Of the 253 clinical trials assessed, 171 (68%) reported industry funding. Industry funding was associated with a greater median number of patients enrolled (172 vs 80; P <.001), publication rate (56.7% vs 42.7%; P = .04), probability of being product-focused (48.0% vs 24.4%; P <.001), and multicontinental recruitment location (25.2% vs 2.4%; P <.001) when compared to nonindustry-funded trials. However, industry funding was not associated with a significant difference in median impact factor (7.7 vs 7.7; P = .723). The overall proportion of industry-funded trials did not change over time (P = 1). Conclusion: Industry-funded clinical trials in AF often are larger, more frequently published, multicontinental, and product-focused. Industry funding was found to be associated with significant differences in study enrollment and publication metrics.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2024.03.001
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Article ; Online: The authors reply.

Paranjpe, Ishan / Nadkarni, Girish N

Kidney international

2020 Volume 98, Issue 5, Page(s) 1347–1348

MeSH term(s)	Humans ; Urinary Calculi
Language	English
Publishing date	2020-10-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2020.08.017
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Zs.A 797: Show issues

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Article ; Online: Assessment of Price Variation in Coronary Artery Bypass Surgery at US Hospitals.

Wei, Chen / Paranjpe, Ishan / Sharma, Pranav / Milligan, Michael / Lam, Miranda / Heidenreich, Paul A / Kalwani, Neil / Schulman, Kevin / Sandhu, Alexander

Journal of the American Heart Association

2024 Volume 13, Issue 4, Page(s) e031982

Abstract: Background: Little is known about hospital pricing for coronary artery bypass grafting (CABG). Using new price transparency data, we assessed variation in CABG prices across US hospitals and the association between higher prices and hospital ... ...

Abstract	Background: Little is known about hospital pricing for coronary artery bypass grafting (CABG). Using new price transparency data, we assessed variation in CABG prices across US hospitals and the association between higher prices and hospital characteristics, including quality of care. Methods and results: Prices for diagnosis related group code 236 were obtained from the Turquoise database and linked by Medicare Facility ID to publicly available hospital characteristics. Univariate and multivariable analyses were performed to assess factors predictive of higher prices. Across 544 hospitals, median commercial and self-pay rates were 2.01 and 2.64 times the Medicare rate ($57 240 and $75 047, respectively, versus $28 398). Within hospitals, the 90th percentile insurer-negotiated price was 1.83 times the 10th percentile price. Across hospitals, the 90th percentile commercial rate was 2.91 times the 10th percentile hospital rate. Regional median hospital prices ranged from $35 624 in the East South Central to $84 080 in the Pacific. In univariate analysis, higher inpatient revenue, greater annual discharges, and major teaching status were significantly associated with higher prices. In multivariable analysis, major teaching and investor-owned status were associated with significantly higher prices (+$8653 and +$12 200, respectively). CABG prices were not related to death, readmissions, patient ratings, or overall Centers for Medicare and Medicaid Services hospital rating. Conclusions: There is significant variation in CABG pricing, with certain characteristics associated with higher rates, including major teaching status and investor ownership. Notably, higher CABG prices were not associated with better-quality care, suggesting a need for further investigation into drivers of pricing variation and the implications for health care spending and access.
MeSH term(s)	Aged ; Humans ; United States ; Medicare ; Coronary Artery Bypass ; Hospitals ; Delivery of Health Care ; Diagnosis-Related Groups
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.031982
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Article ; Online: Non-invasive ventilation versus mechanical ventilation in hypoxemic patients with COVID-19.

Forrest, Iain S / Jaladanki, Suraj K / Paranjpe, Ishan / Glicksberg, Benjamin S / Nadkarni, Girish N / Do, Ron

Infection

2021 Volume 49, Issue 5, Page(s) 989–997

Abstract: Purpose: Limited mechanical ventilators (MV) during the Coronavirus disease (COVID-19) pandemic have led to the use of non-invasive ventilation (NIV) in hypoxemic patients, which has not been studied well. We aimed to assess the association of NIV ... ...

Abstract	Purpose: Limited mechanical ventilators (MV) during the Coronavirus disease (COVID-19) pandemic have led to the use of non-invasive ventilation (NIV) in hypoxemic patients, which has not been studied well. We aimed to assess the association of NIV versus MV with mortality and morbidity during respiratory intervention among hypoxemic patients admitted with COVID-19. Methods: We performed a retrospective multi-center cohort study across 5 hospitals during March-April 2020. Outcomes included mortality, severe COVID-19-related symptoms, time to discharge, and final oxygen saturation (SpO2) at the conclusion of the respiratory intervention. Multivariable regression of outcomes was conducted in all hypoxemic participants, 4 subgroups, and propensity-matched analysis. Results: Of 2381 participants with laboratory-confirmed SARS-CoV-2, 688 were included in the study who were hypoxemic upon initiation of respiratory intervention. During the study period, 299 participants died (43%), 163 were admitted to the ICU (24%), and 121 experienced severe COVID-19-related symptoms (18%). Participants on MV had increased mortality than those on NIV (128/154 [83%] versus 171/534 [32%], OR = 30, 95% CI 16-60) with a mean survival of 6 versus 15 days, respectively. The MV group experienced more severe COVID-19-related symptoms [55/154 (36%) versus 66/534 (12%), OR = 4.3, 95% CI 2.7-6.8], longer time to discharge (mean 17 versus 7.1 days), and lower final SpO2 (92 versus 94%). Across all subgroups and propensity-matched analysis, MV was associated with a greater OR of death than NIV. Conclusions: NIV was associated with lower respiratory intervention mortality and morbidity than MV. However, findings may be liable to unmeasured confounding and further study from randomized controlled trials is needed to definitively determine the role of NIV in hypoxemic patients with COVID-19.
MeSH term(s)	COVID-19 ; Cohort Studies ; Humans ; Noninvasive Ventilation ; Respiration, Artificial ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2021-06-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-021-01633-6
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 528: Show issues

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Article ; Online: The mechanism of MICU-dependent gating of the mitochondrial Ca

Garg, Vivek / Suzuki, Junji / Paranjpe, Ishan / Unsulangi, Tiffany / Boyman, Liron / Milescu, Lorin S / Lederer, W Jonathan / Kirichok, Yuriy

eLife

2021 Volume 10

Abstract: ... ...

Abstract	Ca
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cell Line ; Cells, Cultured ; Mice ; Mitochondria/metabolism ; Mitochondrial Membrane Transport Proteins/genetics ; Mitochondrial Membrane Transport Proteins/metabolism ; Molecular Imaging ; Patch-Clamp Techniques ; Sodium
Chemical Substances	Calcium-Binding Proteins ; MICU1 protein, mouse ; Mitochondrial Membrane Transport Proteins ; Sodium (9NEZ333N27) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-08-31
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.69312
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Article: Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer's Disease.

Paranjpe, Manish D / Belonwu, Stella / Wang, Jason K / Oskotsky, Tomiko / Gupta, Aarzu / Taubes, Alice / Zalocusky, Kelly A / Paranjpe, Ishan / Glicksberg, Benjamin S / Huang, Yadong / Sirota, Marina

Frontiers in aging neuroscience

2021 Volume 13, Page(s) 735611

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2021.735611
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Article: Clinical Trial Publication Trends Within Neurology.

Duy, Phan Q / Sreekrishnan, Anirudh / David, Wyatt / Paranjpe, Manish D / Paranjpe, Ishan / Sheth, Amar / Gültekin, Batur / Sheth, Kevin N

Translational neuroscience

2019 Volume 10, Page(s) 233–234

Abstract: Timely dissemination of results from clinical studies is crucial for the advancement of knowledge and clinical decision making. A large body of research has shown that up to half of clinical trials do not publish their findings. In this study, we sought ... ...

Abstract	Timely dissemination of results from clinical studies is crucial for the advancement of knowledge and clinical decision making. A large body of research has shown that up to half of clinical trials do not publish their findings. In this study, we sought to determine whether clinical trial publication rates within neurology have increased over time. Focusing on neurology clinical trials completed between 2008 to 2014, we found that while the overall percentage of published trials has not changed (remaining at approximately 50%), time to publication has significantly decreased. Our findings suggest that clinical trials within neurology are being published in a more timely manner.
Language	English
Publishing date	2019-08-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2581219-1
ISSN	2081-6936 ; 2081-3856
ISSN (online)	2081-6936
ISSN	2081-3856
DOI	10.1515/tnsci-2019-0037
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Article ; Online: Multi-Institutional Predictors of Antibiotic Resistance in Patients Presenting to the Emergency Department with Urosepsis Secondary to Ureteral Obstruction.

Paranjpe, Ishan / Kapoor, Arjun / Tran, Timothy / O'Hagan, Ross / Falagario, Ugo Giovanni / Paranjpe, Manish / Seiden, Benjamin / Gallante, Blair / Bamberger, Jacob / Gupta, Mantu

Journal of endourology

2020 Volume 35, Issue 1, Page(s) 97–101

Abstract: Introduction and Objective: ...

Abstract	Introduction and Objective:
MeSH term(s)	Drug Resistance, Microbial ; Emergency Service, Hospital ; Humans ; Sepsis ; Ureteral Calculi/complications ; Ureteral Calculi/drug therapy ; Ureteral Calculi/surgery ; Ureteral Obstruction/drug therapy ; Ureteral Obstruction/surgery ; Ureteroscopy ; Urinary Tract Infections/complications ; Urinary Tract Infections/drug therapy
Language	English
Publishing date	2020-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2020.0359
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Zs.A 2628: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 208: Show issues

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Article ; Online: Cannabis Use and CKD: Epidemiological Associations and Mendelian Randomization.

Dellepiane, Sergio / Paranjpe, Ishan / Rajagopal, Madhumitha / Kamat, Samir / O'Hagan, Ross / Gulamali, Faris / Rein, Joshua L / Charney, Alexander W / Do, Ron / Coca, Steven / Glicksberg, Benjamin S / Nadkarni, Girish N

Kidney medicine

2022 Volume 5, Issue 2, Page(s) 100582

Abstract: Rationale & objective: The association between cannabis use and chronic kidney disease (CKD) is controversial. We aimed to assess association of CKD with cannabis use in a large cohort study and then assess causality using Mendelian randomization with a ...

Abstract	Rationale & objective: The association between cannabis use and chronic kidney disease (CKD) is controversial. We aimed to assess association of CKD with cannabis use in a large cohort study and then assess causality using Mendelian randomization with a genome-wide association study (GWAS). Study design: Retrospective cohort study and genome-wide association study. Setting & participants: The retrospective study was conducted on the All of Us cohort (N=223,354). Genetic instruments for cannabis use disorder were identified from 3 GWAS: the Psychiatric Genomics Consortium Substance Use Disorders, iPSYCH, and deCODE (N=384,032). Association between genetic instruments and CKD was investigated in the CKDGen GWAS (N > 1.2 million). Exposure: Cannabis consumption. Outcomes: CKD outcomes included: cystatin-C and creatinine-based kidney function, proteinuria, and blood urea nitrogen. Analytical approach: We conducted association analyses to test for frequency of cannabis use and CKD. To evaluate causality, we performed a 2-sample Mendelian randomization. Results: In the retrospective study, compared to former users, less than monthly (OR, 1.01; 95% CI, 0.87-1.18; Limitations: Likely underreporting of cannabis use. In Mendelian randomization, genetic instruments were identified in the GWAS that included individuals primarily of European ancestry. Conclusions: Despite the epidemiological association between cannabis use and CKD, there was no evidence of a causal effect, indicating confounding in observational studies.
Language	English
Publishing date	2022-12-11
Publishing country	United States
Document type	Journal Article
ISSN	2590-0595
ISSN (online)	2590-0595
DOI	10.1016/j.xkme.2022.100582
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Article ; Online: Binary outcomes of enhancer activity underlie stable random monoallelic expression.

Kissiov, Djem U / Ethell, Alexander / Chen, Sean / Wolf, Natalie K / Zhang, Chenyu / Dang, Susanna M / Jo, Yeara / Madsen, Katrine N / Paranjpe, Ishan / Lee, Angus Y / Chim, Bryan / Muljo, Stefan A / Raulet, David H

eLife

2022 Volume 11

Abstract: Mitotically stable random monoallelic gene expression (RME) is documented for a small percentage of autosomal genes. We developed an in vivo genetic model to study the role of enhancers in RME using high-resolution single-cell analysis of natural killer ( ...

Abstract	Mitotically stable random monoallelic gene expression (RME) is documented for a small percentage of autosomal genes. We developed an in vivo genetic model to study the role of enhancers in RME using high-resolution single-cell analysis of natural killer (NK) cell receptor gene expression and enhancer deletions in the mouse germline. Enhancers of the RME NK receptor genes were accessible and enriched in H3K27ac on silent and active alleles alike in cells sorted according to allelic expression status, suggesting enhancer activation and gene expression status can be decoupled. In genes with multiple enhancers, enhancer deletion reduced gene expression frequency, in one instance converting the universally expressed gene encoding NKG2D into an RME gene, recapitulating all aspects of natural RME including mitotic stability of both the active and silent states. The results support the binary model of enhancer action, and suggest that RME is a consequence of general properties of gene regulation by enhancers rather than an RME-specific epigenetic program. Therefore, many and perhaps all genes may be subject to some degree of RME. Surprisingly, this was borne out by analysis of several genes that define different major hematopoietic lineages, that were previously thought to be universally expressed within those lineages: the genes encoding NKG2D, CD45, CD8α, and Thy-1. We propose that intrinsically probabilistic gene allele regulation is a general property of enhancer-controlled gene expression, with previously documented RME representing an extreme on a broad continuum.
MeSH term(s)	Alleles ; Animals ; Chromosomes ; Enhancer Elements, Genetic/genetics ; Gene Expression Regulation ; Mice ; NK Cell Lectin-Like Receptor Subfamily K ; Regulatory Sequences, Nucleic Acid
Chemical Substances	NK Cell Lectin-Like Receptor Subfamily K
Language	English
Publishing date	2022-05-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.74204
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