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  1. Article ; Online: Primary Hyperparathyroidism in a Patient With Bilateral Pheochromocytoma and a Mutation in the Tumor Suppressor

    Charoenngam, Nipith / Mannstadt, Michael

    JCEM case reports

    2023  Volume 1, Issue 1, Page(s) luad006

    Abstract: Rare heterozygous loss-of-function mutations of ... ...

    Abstract Rare heterozygous loss-of-function mutations of the
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luad006
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  2. Article ; Online: Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence.

    Charoenngam, Nipith

    International journal of molecular sciences

    2021  Volume 22, Issue 19

    Abstract: Vitamin D plays an important role in maintaining a healthy mineralized skeleton. It is also considered an immunomodulatory agent that regulates innate and adaptive immune systems. The aim of this narrative review is to provide general concepts of vitamin ...

    Abstract Vitamin D plays an important role in maintaining a healthy mineralized skeleton. It is also considered an immunomodulatory agent that regulates innate and adaptive immune systems. The aim of this narrative review is to provide general concepts of vitamin D for the skeletal and immune health, and to summarize the mechanistic, epidemiological, and clinical evidence on the relationship between vitamin D and rheumatic diseases. Multiple observational studies have demonstrated the association between a low level of serum 25-hydroxyvitamin D [25(OH)D] and the presence and severity of several rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), spondyloarthropathies, and osteoarthritis (OA). Nevertheless, the specific benefits of vitamin D supplements for the treatment and prevention of rheumatic diseases are less accepted as the results from randomized clinical trials are inconsistent, although some conceivable benefits of vitamin D for the improvement of disease activity of RA, SLE, and OA have been demonstrated in meta-analyses. It is also possible that some individuals might benefit from vitamin D differently than others, as inter-individual difference in responsiveness to vitamin D supplementation has been observed in genomic studies. Although the optimal level of serum 25(OH)D is still debatable, it is advisable it is advisable that patients with rheumatic diseases should maintain a serum 25(OH)D level of at least 30 ng/mL (75 nmol/L) to prevent osteomalacia, secondary osteoporosis, and fracture, and possibly 40-60 ng/mL (100-150 nmol/L) to achieve maximal benefit from vitamin D for immune health and overall health.
    MeSH term(s) Biomarkers ; Disease Management ; Disease Susceptibility ; Humans ; Immune System/immunology ; Immune System/metabolism ; Lupus Erythematosus, Systemic/etiology ; Lupus Erythematosus, Systemic/metabolism ; Metabolic Networks and Pathways/radiation effects ; Muscle, Skeletal/metabolism ; Rheumatic Diseases/diagnosis ; Rheumatic Diseases/drug therapy ; Rheumatic Diseases/etiology ; Rheumatic Diseases/metabolism ; Sunlight ; Treatment Outcome ; Vitamin D/analogs & derivatives ; Vitamin D/metabolism ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications
    Chemical Substances Biomarkers ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2021-10-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms221910659
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  3. Article ; Online: Vitamin D and Rheumatic Diseases

    Nipith Charoenngam

    International Journal of Molecular Sciences, Vol 22, Iss 10659, p

    A Review of Clinical Evidence

    2021  Volume 10659

    Abstract: Vitamin D plays an important role in maintaining a healthy mineralized skeleton. It is also considered an immunomodulatory agent that regulates innate and adaptive immune systems. The aim of this narrative review is to provide general concepts of vitamin ...

    Abstract Vitamin D plays an important role in maintaining a healthy mineralized skeleton. It is also considered an immunomodulatory agent that regulates innate and adaptive immune systems. The aim of this narrative review is to provide general concepts of vitamin D for the skeletal and immune health, and to summarize the mechanistic, epidemiological, and clinical evidence on the relationship between vitamin D and rheumatic diseases. Multiple observational studies have demonstrated the association between a low level of serum 25-hydroxyvitamin D [25(OH)D] and the presence and severity of several rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), spondyloarthropathies, and osteoarthritis (OA). Nevertheless, the specific benefits of vitamin D supplements for the treatment and prevention of rheumatic diseases are less accepted as the results from randomized clinical trials are inconsistent, although some conceivable benefits of vitamin D for the improvement of disease activity of RA, SLE, and OA have been demonstrated in meta-analyses. It is also possible that some individuals might benefit from vitamin D differently than others, as inter-individual difference in responsiveness to vitamin D supplementation has been observed in genomic studies. Although the optimal level of serum 25(OH)D is still debatable, it is advisable it is advisable that patients with rheumatic diseases should maintain a serum 25(OH)D level of at least 30 ng/mL (75 nmol/L) to prevent osteomalacia, secondary osteoporosis, and fracture, and possibly 40–60 ng/mL (100–150 nmol/L) to achieve maximal benefit from vitamin D for immune health and overall health.
    Keywords vitamin D ; 25-hydroxyvitamin D ; 1,25-dihydroxyvitamin D ; rheumatic diseases ; rheumatology ; rheumatoid arthritis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Current issues in evaluation and management of osteoporosis in Thailand.

    Charoenngam, Nipith / Pongchaiyakul, Chatlert

    Osteoporosis and sarcopenia

    2023  Volume 9, Issue 2, Page(s) 53–59

    Abstract: Osteoporosis is a major public health issue in Thailand, which increased morbidity, mortality, and health-care utilization. The objective of this review is to provide current perspectives on epidemiology, evaluation and management of osteoporosis in ... ...

    Abstract Osteoporosis is a major public health issue in Thailand, which increased morbidity, mortality, and health-care utilization. The objective of this review is to provide current perspectives on epidemiology, evaluation and management of osteoporosis in Thailand. According to epidemiologic data, the prevalence of osteoporosis and the incidence of hip fracture were comparable to the rest of the world. However, among Thai postmenopausal women, the prevalence of asymptomatic vertebral fracture was disproportionately high. In addition to established risk factors, conditions that may affect the risk of osteoporosis in the Thai population include certain genetic variants, thalassemia, vitamin D deficiency, and low dietary calcium intake, which requires further investigations to draw conclusions. In 2021, the Thai Osteoporosis Foundation released a new Clinical Practice Guideline that provides up-to-date evidence-based recommendations for evaluation and management of osteoporosis. Nonetheless, more research is required to provide local evidence in a variety of areas to guide management of osteoporosis in Thailand. These include epidemiology of distal radial fracture, the optimal intervention threshold of the Thai-specific Fracture Risk Assessment Tool model, screening for asymptomatic vertebral fracture, and the economic evaluation of osteoporosis management options, including fracture liaison service.
    Language English
    Publishing date 2023-06-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2405-5263
    ISSN (online) 2405-5263
    DOI 10.1016/j.afos.2023.05.002
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  5. Article ; Online: Aging and Adiposity-Focus on Biological Females at Midlife and Beyond.

    Rehman, Amna / Lathief, Sanam / Charoenngam, Nipith / Pal, Lubna

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Menopause is a physiological phase of life of aging women, and more than 1 billion women worldwide will be in menopause by 2025. The processes of global senescence parallel stages of reproductive aging and occur alongside aging-related changes in the ... ...

    Abstract Menopause is a physiological phase of life of aging women, and more than 1 billion women worldwide will be in menopause by 2025. The processes of global senescence parallel stages of reproductive aging and occur alongside aging-related changes in the body. Alterations in the endocrine pathways accompany and often predate the physiologic changes of aging, and interactions of these processes are increasingly being recognized as contributory to the progression of senescence. Our goal for this review is to examine, in aging women, the complex interplay between the endocrinology of menopause transition and post-menopause, and the metabolic transition, the hallmark being an increasing tendency towards central adiposity that begins in tandem with reproductive aging and is often exacerbated post menopause. For the purpose of this review, our choice of the terms 'female' and 'woman' refer to genetic females.
    MeSH term(s) Female ; Humans ; Adiposity ; Aging/metabolism ; Menopause/physiology ; Postmenopause ; Reproduction ; Obesity
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052972
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  6. Article ; Online: Vitamin D and uric acid: Is parathyroid hormone the missing link?

    Ponvilawan, Ben / Charoenngam, Nipith

    Journal of clinical & translational endocrinology

    2021  Volume 25, Page(s) 100263

    Language English
    Publishing date 2021-07-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834222-7
    ISSN 2214-6237 ; 2214-6237
    ISSN (online) 2214-6237
    ISSN 2214-6237
    DOI 10.1016/j.jcte.2021.100263
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  7. Article: Increased fat mass negatively influences femoral neck bone mineral density in men but not women.

    Charoenngam, Nipith / Apovian, Caroline M / Pongchaiyakul, Chatlert

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1035588

    Abstract: Background: Obesity is known to be a protective factor against osteoporosis. However, recent studies have shown that excessive adiposity may be detrimental for bone health.: Objective: To determine the association of lean mass (LM) and fat mass (FM) ... ...

    Abstract Background: Obesity is known to be a protective factor against osteoporosis. However, recent studies have shown that excessive adiposity may be detrimental for bone health.
    Objective: To determine the association of lean mass (LM) and fat mass (FM) with bone mineral density (BMD) in Thais.
    Methods: Bone density studies of consecutive patients of Srinagarind Hospital, Khon Kaen, Thailand between 2010 and 2015 were reviewed. LM, FM, lumbar spine (LS) and femoral neck (FN) BMD were measured. Lean mass index (LMI) and fat mass index (FMI) were calculated [LMI=LM (kg)/height (m)
    Results: A total of 831 participants were included. The mean ± SD age was 50.0 ± 16.3 years. In men, LMI (per 1 kg/m
    Conclusion: Our findings indicate that FM has a sex-specific influence on BMD in Thais.
    MeSH term(s) Male ; Female ; Humans ; Adult ; Middle Aged ; Aged ; Bone Density ; Body Mass Index ; Femur Neck/diagnostic imaging ; Absorptiometry, Photon ; Thailand ; Obesity ; Lumbar Vertebrae/diagnostic imaging
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1035588
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  8. Article ; Online: Effects of different types of allogeneic hematopoietic stem cell transplantation donors on Philadelphia chromosome-positive acute lymphoblastic leukemia during the tyrosine kinase inhibitor era: A systematic review and meta-analysis.

    Ponvilawan, Ben / Owattanapanich, Weerapat / Charoenngam, Nipith / Kungwankiattichai, Smith

    Hematology/oncology and stem cell therapy

    2023  Volume 16, Issue 3, Page(s) 197–208

    Abstract: Background: Matched donor (MD) allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the preferred choice of treatment for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph: Methods: Studies in EMBASE and MEDLINE ...

    Abstract Background: Matched donor (MD) allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the preferred choice of treatment for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph
    Methods: Studies in EMBASE and MEDLINE between inception and December 2020 were identified using search terms related to "Ph
    Results: Fourteen cohort studies were identified for the meta-analysis. Haploidentical (HID)-HSCT for Ph
    Conclusion: This systematic review and meta-analysis showed that HID-HSCT is as effective as MD-HSCT in Ph
    MeSH term(s) Humans ; Philadelphia Chromosome ; Tyrosine Kinase Inhibitors ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Hematopoietic Stem Cell Transplantation/methods ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Graft vs Host Disease ; Acute Disease ; Recurrence ; Retrospective Studies
    Chemical Substances Tyrosine Kinase Inhibitors ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-04-04
    Publishing country Saudi Arabia
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2651893-4
    ISSN 2589-0646 ; 1658-3876
    ISSN (online) 2589-0646
    ISSN 1658-3876
    DOI 10.1016/j.hemonc.2021.09.007
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  9. Article: Association between statin use & risk of diffuse large B-cell lymphoma: A systematic review & meta-analysis.

    Ponvilawan, Ben / Charoenngam, Nipith / Ungprasert, Patompong

    The Indian journal of medical research

    2023  Volume 157, Issue 6, Page(s) 543–548

    Abstract: Background & objectives: Statin use has been shown to be associated with a decreased risk of several types of cancer, however, the data on diffuse large B-cell lymphoma (DLBCL) are still inconclusive. This study aimed to systematically summarize all ... ...

    Abstract Background & objectives: Statin use has been shown to be associated with a decreased risk of several types of cancer, however, the data on diffuse large B-cell lymphoma (DLBCL) are still inconclusive. This study aimed to systematically summarize all available data on this association and conduct a meta-analysis on the same.
    Methods: A systematic review was performed using EMBASE and MEDLINE databases from inception upto October 2019 with a search strategy that included terms such as 'statin' and 'DLBCL'. Eligible studies included either case-control or cohort studies that reported the association between statin use and the risk of DLBCL. Relative risk, odds ratio (OR), hazard: risk ratio or standardized incidence ratio of this association and standard error were extracted and combined for calculating the pooled effect estimate using random-effects, generic inverse variance method.
    Results: A total of 1139 articles were screened. Of these six studies satisfied the inclusion criteria and were included for the meta-analysis. Statin use was associated with a significantly reduced risk of DLBCL with the pooled OR of 0.70 (95% confidence interval, 0.56-0.88; I
    Interpretation & conclusions: The present systematic review and meta-analysis found that statin use is associated with a 30 per cent reduced odds of DLBCL. However, the pooled analysis utilized data from observational studies so causation cannot be concluded upon. Hence, it suggested that randomized-controlled studies are still needed to confirm this potential benefit.
    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/epidemiology ; Risk ; Cohort Studies
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2023-08-02
    Publishing country India
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_2668_19
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  10. Article: Marked Underestimation of Serum 25-hydroxyvitamin D Concentrations by The Abbot Architect Chemiluminescent Microparticle Immunoassay in Patients Receiving Vitamin D

    Charoenngam, Nipith / Holick, Michael F

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2021  Volume 28, Issue 1, Page(s) 122–123

    MeSH term(s) Dietary Supplements ; Ergocalciferols ; Humans ; Immunoassay ; Immunoenzyme Techniques ; Vitamin D/analogs & derivatives
    Chemical Substances Ergocalciferols ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2021-10-15
    Publishing country United States
    Document type Letter
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2021.10.002
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