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  1. Article ; Online: Klotho: A Possible Role in the Pathophysiology of Nephrotic Syndrome.

    Tomo, Sojit / Birdi, Amandeep / Yadav, Dharmveer / Chaturvedi, Manish / Sharma, Praveen

    EJIFCC

    2022  Volume 33, Issue 1, Page(s) 3–10

    Abstract: Klotho, encoded by ... ...

    Abstract Klotho, encoded by the
    Language English
    Publishing date 2022-04-11
    Publishing country Italy
    Document type Journal Article ; Review
    ISSN 1650-3414
    ISSN (online) 1650-3414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Modified PVA membrane for separation of micro-emulsion.

    Yadav, Dharmveer / Karunanithi, Arthi / Saxena, Sumit / Shukla, Shobha

    The Science of the total environment

    2022  Volume 822, Page(s) 153610

    Abstract: Release of liquefied hydrocarbons in domestic and industrial effluents, along with oil spills cause significant adverse effects on the soil, water, aquatic ecosystem, and humans. Thus, selective and cost-effective technology to address this challenge is ... ...

    Abstract Release of liquefied hydrocarbons in domestic and industrial effluents, along with oil spills cause significant adverse effects on the soil, water, aquatic ecosystem, and humans. Thus, selective and cost-effective technology to address this challenge is highly desirable. Here, we report the fabrication of electrospun polyvinyl alcohol (PVA) membrane, modified with glutaraldehyde (GA) and a device thereof, for treatment of oil emulsions and recovery of precious fossil fuel. The modified PVA membranes are super-oleophobic with a high static underwater oil contact angle of 163 ± 3° for motor oil. Investigation of wetting properties suggests that the membrane can efficiently separate different oils such as sesame oil, motor oil, mustard oil, and sunflower oil from their emulsions. The motor oil emulsion with separation efficiency of >99% at an excellent permeate flux of 5128 L/m
    MeSH term(s) Ecosystem ; Emulsions ; Humans ; Membranes, Artificial ; Polyvinyl Alcohol ; Water Purification
    Chemical Substances Emulsions ; Membranes, Artificial ; Polyvinyl Alcohol (9002-89-5)
    Language English
    Publishing date 2022-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.153610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Modified PVA membrane for separation of micro-emulsion

    Yadav, Dharmveer / Karunanithi, Arthi / Saxena, Sumit / Shukla, Shobha

    Science of the total environment. 2022 May 20, v. 822

    2022  

    Abstract: Release of liquefied hydrocarbons in domestic and industrial effluents, along with oil spills cause significant adverse effects on the soil, water, aquatic ecosystem, and humans. Thus, selective and cost-effective technology to address this challenge is ... ...

    Abstract Release of liquefied hydrocarbons in domestic and industrial effluents, along with oil spills cause significant adverse effects on the soil, water, aquatic ecosystem, and humans. Thus, selective and cost-effective technology to address this challenge is highly desirable. Here, we report the fabrication of electrospun polyvinyl alcohol (PVA) membrane, modified with glutaraldehyde (GA) and a device thereof, for treatment of oil emulsions and recovery of precious fossil fuel. The modified PVA membranes are super-oleophobic with a high static underwater oil contact angle of 163 ± 3° for motor oil. Investigation of wetting properties suggests that the membrane can efficiently separate different oils such as sesame oil, motor oil, mustard oil, and sunflower oil from their emulsions. The motor oil emulsion with separation efficiency of >99% at an excellent permeate flux of 5128 L/m²·h·bar has been achieved. Thus, the prepared modified PVA membrane construes an easy solution for not only effective treatment of oily wastewater but also for oil recovery with high flux.
    Keywords aquatic ecosystems ; contact angle ; cost effectiveness ; emulsions ; environment ; fossil fuels ; glutaraldehyde ; mustard oil ; polyvinyl alcohol ; sesame oil ; soil ; sunflower oil ; wastewater
    Language English
    Dates of publication 2022-0520
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.153610
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Support Vector Machine based eHealth Cloud System for Diabetes Classification

    Chandrashekhar Azad / Ashok Mehta / Dindayal Mahto / Dharmveer Yadav

    EAI Endorsed Transactions on Pervasive Health and Technology, Vol 6, Iss

    2020  Volume 22

    Abstract: INTRODUCTION: Diabetes is a major health issue because it leaves people with physical disabilities. Therefore, methodologies with a reduced error rate must be used to diagnose this dangerous disease. Data Mining techniques such as Artificial Neural ... ...

    Abstract INTRODUCTION: Diabetes is a major health issue because it leaves people with physical disabilities. Therefore, methodologies with a reduced error rate must be used to diagnose this dangerous disease. Data Mining techniques such as Artificial Neural Network are common tools adopted for the classification of diabetes and one of the core components of the eHealth system. Data Mining techniques aim to provide reliable and timely diagnostic outcomes during the diagnosis of the disease. OBJECTIVE: The objective of the research work is to propose a Support Vector Machine based eHealth Cloud System for Diabetes Classification. This work aims to improve the diagnostic accuracy of computer-assisted diagnostic systems. METHOD: The proposed methodology implemented in two-phase, In the first phase system is trained using different Support Vector Machine (SVM) kernel functions and in the second phase effectiveness of the system is tested in terms of classification accuracy and error. Different SVMs have the ability to diagnose this disease. PIMA Indian Diabetes Dataset (PIDD) has been used in our experiments for training and testing. Kernel functions are usually used to refer to the kernel trick, a method of using a linear classifier to solve a non-linear problem. RESULT: In this classification accuracy and classification error are used for performance evaluation. It is worth mentioning that the system giving remarkable accuracy of 77.50% in Coarse Gaussian SVM in 10-fold validation whereas fine Gaussian SVM gives 98.8% accuracy in No validation set. CONCLUSION: This paper introduces the SVM eHealth Cloud System for Diabetes Classification. The system is trained using the PIDD. Such a system can be used as “Application-as-a-Service” in cloud computing. It is therefore believed that the system will enhance the process of clinical decision-making and also assist physicians concerning Diabetes Diagnosis. It is worth to mention that the SVM kernel-based system performed well in comparison to the different systems.
    Keywords data mining ; ehealth ; medical mining ; pidd ; support vector machine ; Medicine ; R ; Medical technology ; R855-855.5
    Subject code 006
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher European Alliance for Innovation (EAI)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Association of Vitamin D Status with COVID-19 Infection and Mortality in the Asia Pacific region: A Cross-Sectional Study.

    Yadav, Dharmveer / Birdi, Amandeep / Tomo, Sojit / Charan, Jaykaran / Bhardwaj, Pankaj / Sharma, Praveen

    Indian journal of clinical biochemistry : IJCB

    2021  Volume 36, Issue 4, Page(s) 492–497

    Abstract: COVID-19 has been declared a global pandemic by WHO on 11 March 2020. Still, very little is known about the potential protective dietary factors for the prevention of infection and mortality due to COVID-19. Keeping in view the scarcity of literature/ ... ...

    Abstract COVID-19 has been declared a global pandemic by WHO on 11 March 2020. Still, very little is known about the potential protective dietary factors for the prevention of infection and mortality due to COVID-19. Keeping in view the scarcity of literature/studies available, in this regards present study was undertaken to assess if there is any correlation between mean levels of Vitamin D in various Asia Pacific countries with the infection and mortality caused by COVID-19. We collected data for mean levels of Vitamin D for 37 Asia Pacific countries for which we have also got the data regarding the morbidity and mortality of COVID-19. The mean levels of Vitamin D were found to have a significant association with the number of cases/million(r =  - 0.394,
    Language English
    Publishing date 2021-02-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-020-00950-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immunomodulation by epigenome alterations in Mycobacterium tuberculosis infection.

    Gauba, Kavya / Gupta, Shruti / Shekhawat, Jyoti / Sharma, Praveen / Yadav, Dharmveer / Banerjee, Mithu

    Tuberculosis (Edinburgh, Scotland)

    2021  Volume 128, Page(s) 102077

    Abstract: Mycobacterium tuberculosis (MTB) has co-evolved with humans for decades and developed several mechanisms to evade host immunity. It can efficiently alter the host epigenome, thus playing a major role in immunomodulation by either activating or ... ...

    Abstract Mycobacterium tuberculosis (MTB) has co-evolved with humans for decades and developed several mechanisms to evade host immunity. It can efficiently alter the host epigenome, thus playing a major role in immunomodulation by either activating or suppressing genes responsible for mounting an immune response against the pathogen. Epigenetic modifications such as DNA methylation and chromatin remodelling regulate gene expression and influence several cellular processes. The involvement of epigenetic factors in disease onset and development had been overlooked upon in comparison to genetic mutations. It is now believed that assessment of epigenetic changes hold great potential in diagnosis, prevention and treatment strategies for a wide range of diseases. In this review, we unravel the principles of epigenetics and the numerous ways by which MTB re-shapes the host epigenetic landscape as a strategy to overpower the host immune system for its survival and persistence.
    MeSH term(s) DNA Methylation ; Epigenesis, Genetic ; Epigenome ; Host-Pathogen Interactions ; Humans ; Immunomodulation ; Mycobacterium tuberculosis/genetics ; Tuberculosis/genetics
    Language English
    Publishing date 2021-03-12
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 2046804-0
    ISSN 1873-281X ; 1472-9792
    ISSN (online) 1873-281X
    ISSN 1472-9792
    DOI 10.1016/j.tube.2021.102077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Clinical Laboratory: A Key Player in Diagnosis and Management of COVID-19.

    Tomo, Sojit / Karli, Sreenivasulu / Dharmalingam, Karthick / Yadav, Dharmveer / Sharma, Praveen

    EJIFCC

    2020  Volume 31, Issue 4, Page(s) 326–346

    Abstract: The Coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had emerged as a pandemic affecting almost all countries in the world in a short span after it was first reported in December. ... ...

    Abstract The Coronavirus disease 2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had emerged as a pandemic affecting almost all countries in the world in a short span after it was first reported in December. Clinical laboratory have a crucial role in mitigating this new pandemic. Timely and accurate diagnosis of COVID-19 is of paramount importance for detecting cases early and to prevent transmission. Clinical Laboratories have adopted different test modalities and processes to tackle this unprecedented situation with directives from regulatory bodies such as the WHO. The varying presentations, as well as complications attributed to comorbidities in COVID-19, have created hurdles in the management of these patients. Various clinical laboratory parameters have been investigated for their potential for diagnosis and prognosis of the disease, prediction of complications and monitoring of treatment response. Different routine and uncommon parameters have been shown to have the diagnostic and prognostic capacity. This update discusses the role of the laboratory in diagnosis, prognosis and monitoring of treatment response. Different methodologies for diagnostic testing as well as various clinical laboratory parameters having diagnostic and predictive powers have been discussed. This compilation organises relevant available information on various clinical laboratory parameters and their role in COVID-19 mitigating pandemic.
    Language English
    Publishing date 2020-11-20
    Publishing country Italy
    Document type Journal Article ; Review
    ISSN 1650-3414
    ISSN (online) 1650-3414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Role of Klotho Protein in Neuropsychiatric Disorders: A Narrative Review.

    Birdi, Amandeep / Tomo, Sojit / Yadav, Dharmveer / Sharma, Praveen / Nebhinani, Naresh / Mitra, Prasenjit / Banerjee, Mithu / Purohit, Purvi

    Indian journal of clinical biochemistry : IJCB

    2022  Volume 38, Issue 1, Page(s) 13–21

    Abstract: Neuropsychiatric disorders are comprised of diseases having both the neurological and psychiatric manifestations. The increasing burden of the disease on the population worldwide makes it necessary to adopt measures to decrease the prevalence. The Klotho ...

    Abstract Neuropsychiatric disorders are comprised of diseases having both the neurological and psychiatric manifestations. The increasing burden of the disease on the population worldwide makes it necessary to adopt measures to decrease the prevalence. The Klotho is a single pass transmembrane protein that decreases with age, has been associated with various pathological diseases, like reduced bone mineral density, cardiac problems and cognitive impairment. However, multiple studies have explored its role in different neuropsychiatric disorders. A comprehensive search was undertaken in the Pubmed database for articles with the keywords "Klotho" and "neuropsychiatric disorders". The available literature, based on the above search strategy, has been compiled in this brief narrative review to describe the emerging role of Klotho in various neuropsychiatric disorders. The Klotho levels were decreased in various neuropsychiatric disorders except for bipolar disorder. A suppressed Klotho protein levels induced oxidative stress and incited pro-inflammatory conditions significantly contributing to the pathophysiology of neuropsychiatric disorder. The increasing evidence of altered Klotho protein levels in cognition-decrement-related disorders warrants its consideration as a biomarker in various neuropsychiatric diseases. However, further evidence is required to understand its role as a therapeutic target.
    Language English
    Publishing date 2022-08-13
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-022-01078-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Role of interleukin-22 in tuberculosis patients.

    Gupta, Shruti / Banerjee, Mithu / Gauba, Kavya / Mitra, Prasenjit / Shekhawat, Jyoti / Chauhan, Nishant / Borana, Hemant / Rao, Mahadev / Yadav, Dharmveer / Sharma, Praveen

    Journal of basic and clinical physiology and pharmacology

    2022  Volume 34, Issue 1, Page(s) 83–89

    Abstract: Objectives: Disease progression of tuberculosis (TB) depends on the balance between the microorganism's virulence and the host defense systems (mainly T cell-mediated immune response). Interleukin-22 (IL-22) helps in cell proliferation and regeneration ... ...

    Abstract Objectives: Disease progression of tuberculosis (TB) depends on the balance between the microorganism's virulence and the host defense systems (mainly T cell-mediated immune response). Interleukin-22 (IL-22) helps in cell proliferation and regeneration and provides protection against microbial diseases. The IL-22-producing T cells can migrate into the granulomas during TB infection. However, disparity exists in literature regarding its role. The present study aims to compare serum IL-22 levels and its' expression in TB patients and healthy controls.
    Methods: 87 TB patients and 85 healthy subjects were enrolled in the study. Under aseptic conditions, venous blood was withdrawn. Serum IL-22 levels were estimated using enzyme-linked immunosorbent assay, and its gene expression was assessed using SYBR green-based quantitative PCR technology. A statistical analysis was performed using SPSS.
    Results: The median (interquartile range) of serum IL-22 levels was significantly lower in TB patients (18.55 (5.08) pg/mL) when compared to controls (49.38 (162.88) pg/mL) (p<0.0001). The IL-22 expression was significantly upregulated with a fold change value of 29.44 in TB patients.
    Conclusions: The IL-22 levels were found to be significantly decreased in patients, contradictory to its expression, which is upregulated. It plays a crucial role for the modulation of tissues in response to TB infection.
    MeSH term(s) Humans ; Mycobacterium tuberculosis/genetics ; Tuberculosis/prevention & control ; Interleukins ; Enzyme-Linked Immunosorbent Assay ; Interleukin-22
    Chemical Substances Interleukins
    Language English
    Publishing date 2022-10-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1071737-7
    ISSN 2191-0286 ; 0792-6855 ; 0334-1534
    ISSN (online) 2191-0286
    ISSN 0792-6855 ; 0334-1534
    DOI 10.1515/jbcpp-2022-0106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Efficacy and safety of vitamin D in tuberculosis patients: a systematic review and meta-analysis.

    Goyal, Jagdish Prasad / Singh, Surjit / Bishnoi, Ramakishan / Bhardwaj, Pankaj / Kaur, Rimple Jeet / Dhingra, Sameer / Yadav, Dharmveer / Dutta, Siddhartha / Charan, Jaykaran

    Expert review of anti-infective therapy

    2022  Volume 20, Issue 7, Page(s) 1049–1059

    Abstract: Background: Evidence from the basic research and epidemiological studies indicates a beneficial effect of vitamin D in the treatment of tuberculosis (TB). However, the evidence from randomized controlled trials (RCTs) is inconsistent.: Objectives: ... ...

    Abstract Background: Evidence from the basic research and epidemiological studies indicates a beneficial effect of vitamin D in the treatment of tuberculosis (TB). However, the evidence from randomized controlled trials (RCTs) is inconsistent.
    Objectives: This systematic review and meta-analysis was performed to synthesize evidence regarding role of vitamin D versus placebo for the management of TB.
    Materials and methods: We searched PubMed and Cochrane Clinical Trial Registry for RCTs comparing vitamin D versus placebo for the treatment of TB. RCTs enrolling adult patients with TB receiving vitamin D in addition to standard treatment were included. Data were pooled using random effects model. The study was conducted according to PRISMA guidelines and protocol was registered with PROSPERO (CRD42016052841).
    Results: Of 605 identified references, 12 RCTs were included. The overall risk of bias in included studies was low or unclear. There was no significant difference between vitamin D and placebo group for any outcomes of efficacy (time to culture conversion, time to smear conversion, rate of culture conversion, and rate of smear conversion) or safety (mortality, serious adverse events, and nonserious adverse events).
    Conclusion: Vitamin D administered with standard treatment has no beneficial effect in the TB patients as compared to the placebo.
    MeSH term(s) Adult ; Humans ; Tuberculosis/drug therapy ; Vitamin D/adverse effects ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-05-10
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2022.2071702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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