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  1. Article ; Online: Circulating microRNAs as biomarkers and mediators of platelet activation.

    Gutmann, Clemens / Mayr, Manuel

    Platelets

    2022  Volume 33, Issue 4, Page(s) 512–519

    Abstract: Platelets are essential mediators of physiological hemostasis and pathological thrombosis. Currently available tests and markers of platelet activation did not prove successful in guiding treatment decisions for patients with cardiovascular disease, ... ...

    Abstract Platelets are essential mediators of physiological hemostasis and pathological thrombosis. Currently available tests and markers of platelet activation did not prove successful in guiding treatment decisions for patients with cardiovascular disease, justifying further research into novel markers of platelet reactivity. Platelets contain a variety of microRNAs (miRNAs) and are a major contributor to the extracellular circulating miRNA pool. Levels of platelet-derived miRNAs in the circulation have been associated with different measures of platelet activation as well as antiplatelet therapy and have therefore been implied as potential new markers of platelet reactivity. In contrast to the
    MeSH term(s) Biomarkers ; Blood Platelets ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/drug therapy ; Circulating MicroRNA/genetics ; Humans ; MicroRNAs/genetics ; Platelet Activation/genetics ; Platelet Aggregation Inhibitors/therapeutic use
    Chemical Substances Biomarkers ; Circulating MicroRNA ; MicroRNAs ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2022.2042236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2888: Show issues Location:
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  2. Article ; Online: Letter by Gutmann et al Regarding Article, "Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles".

    Gutmann, Clemens / Stojkovic, Stefan / Mayr, Manuel

    Circulation

    2023  Volume 147, Issue 4, Page(s) e68–e69

    MeSH term(s) Humans ; Transcatheter Aortic Valve Replacement ; Ventricular Function, Left/physiology ; Circulating MicroRNA ; Myocytes, Cardiac ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Extracellular Vesicles ; Treatment Outcome ; MicroRNAs
    Chemical Substances Circulating MicroRNA ; MIRN122 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.062334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SGLT2 inhibitors in heart failure: insights from plasma proteomics.

    Gutmann, Clemens / Zelniker, Thomas A / Mayr, Manuel

    European heart journal

    2022  Volume 43, Issue 48, Page(s) 5003–5005

    MeSH term(s) Humans ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Proteomics ; Heart Failure/drug therapy ; Glucosides
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; empagliflozin (HDC1R2M35U) ; Glucosides
    Language English
    Publishing date 2022-11-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac624
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    Zs.MO 640: Show issues

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  4. Article ; Online: At the limits of bisphosphonio-substituted stannylenes.

    Nasemann, Sina / Franz, Roman / Kargin, Denis / Bruhn, Clemens / Kelemen, Zsolt / Gutmann, Torsten / Pietschnig, Rudolf

    Chemistry, an Asian journal

    2023  Volume 19, Issue 8, Page(s) e202300950

    Abstract: Donor stabilization of Sn(II) and Pb(II) halides with 1,1'-ferrocenylene bridged bisphosphanes has been explored for Fe( ... ...

    Abstract Donor stabilization of Sn(II) and Pb(II) halides with 1,1'-ferrocenylene bridged bisphosphanes has been explored for Fe(C
    Language English
    Publishing date 2023-12-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202300950
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  5. Article ; Online: The Landscape of Coding and Noncoding RNAs in Platelets.

    Gutmann, Clemens / Joshi, Abhishek / Zampetaki, Anna / Mayr, Manuel

    Antioxidants & redox signaling

    2020  Volume 34, Issue 15, Page(s) 1200–1216

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Biomarkers/blood ; Blood Platelets/metabolism ; Hemostasis/genetics ; Humans ; Leukocytes/metabolism ; Megakaryocytes/metabolism ; Megakaryocytes/pathology ; MicroRNAs/blood ; RNA, Circular/blood ; RNA, Long Noncoding/blood ; RNA-Seq ; Single-Cell Analysis ; Thrombosis/blood ; Thrombosis/genetics
    Chemical Substances Biomarkers ; MicroRNAs ; RNA, Circular ; RNA, Long Noncoding
    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2020.8139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5488: Show issues Location:
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  6. Article ; Online: Platelet "-omics" in health and cardiovascular disease.

    Gutmann, Clemens / Joshi, Abhishek / Mayr, Manuel

    Atherosclerosis

    2020  Volume 307, Page(s) 87–96

    Abstract: The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. ... ...

    Abstract The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the contribution of platelets to vascular remodelling and extends beyond cardiovascular disease to haematological disorders and cancer. To address these gaps in our knowledge, a better understanding of the underlying molecular processes is needed. This will be enabled by technologies that capture dysregulated molecular processes and can integrate them into a broader network of biological systems. The advent of -omics technologies, such as mass spectrometry proteomics, metabolomics and lipidomics; highly multiplexed affinity-based proteomics; microarray- or RNA-sequencing-(RNA-seq)-based transcriptomics, and most recently ribosome footprint-based translatomics, has enabled a more holistic understanding of platelet biology. Most of these methods have already been applied to platelets, and this review will summarise this information and discuss future developments in this area of research.
    MeSH term(s) Blood Platelets ; Cardiovascular Diseases ; Humans ; Mass Spectrometry ; Metabolomics ; Proteomics
    Language English
    Publishing date 2020-06-16
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2020.05.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 226: Show issues Location:
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  7. Article ; Online: Venous Thrombosis Accelerates Atherosclerosis in Mice.

    Saha, Prakash / Gutmann, Clemens / Kingdon, Jack / Dregan, Alexandru / Bertolaccini, Laura / Grover, Steven P / Patel, Ashish S / Modarai, Bijan / Lyons, Oliver / Schulz, Christian / Andia, Marcelo E / Phinikaridou, Alkystis / Botnar, René M / Smith, Alberto

    Circulation

    2023  Volume 147, Issue 25, Page(s) 1945–1947

    MeSH term(s) Animals ; Mice ; Venous Thrombosis/etiology ; Atherosclerosis ; Inflammation
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.064268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Trifunctional Silyl Groups as Anchoring Units in the Preparation of Luminescent Phosphole-Silica Hybrids.

    Klintuch, Dieter / Höfler, Mark V / Wissel, Till / Bruhn, Clemens / Gutmann, Torsten / Pietschnig, Rudolf

    Inorganic chemistry

    2021  Volume 60, Issue 18, Page(s) 14263–14274

    Abstract: A synthetic strategy to β-silylphospholes with three methoxy, ethoxy, chloro, hydrido, or phenyl substituents at silicon has been developed, starting from trimethoxy, triethoxy, or triphenyl silyl substituted phenyl phosphanides and 1,4-diphenyl-1,3- ... ...

    Abstract A synthetic strategy to β-silylphospholes with three methoxy, ethoxy, chloro, hydrido, or phenyl substituents at silicon has been developed, starting from trimethoxy, triethoxy, or triphenyl silyl substituted phenyl phosphanides and 1,4-diphenyl-1,3-butadiyne. These trifunctional silylphospholes were attached to the surface of uniform spheric silica particles (15 μm) and, for comparison, to a polyhedral silsesquioxane (POSS)-trisilanol as a molecular model to explore their luminescent properties in comparison with the free phospholes. Density functional theory calculations were performed to investigate any electronic perturbation of the phosphole system by the trifunctional silyl anchoring unit. For the immobilized phospholes, cross-polarization magic-angle-spinning NMR measurements (
    Language English
    Publishing date 2021-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.1c01775
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  9. Article ; Online: Reactive Oxygen Species in Venous Thrombosis.

    Gutmann, Clemens / Siow, Richard / Gwozdz, Adam M / Saha, Prakash / Smith, Alberto

    International journal of molecular sciences

    2020  Volume 21, Issue 6

    Abstract: Reactive oxygen species (ROS) have physiological roles as second messengers, but can also exert detrimental modifications on DNA, proteins and lipids if resulting from enhanced generation or reduced antioxidant defense (oxidative stress). Venous thrombus ...

    Abstract Reactive oxygen species (ROS) have physiological roles as second messengers, but can also exert detrimental modifications on DNA, proteins and lipids if resulting from enhanced generation or reduced antioxidant defense (oxidative stress). Venous thrombus (DVT) formation and resolution are influenced by ROS through modulation of the coagulation, fibrinolysis, proteolysis and the complement system, as well as the regulation of effector cells such as platelets, endothelial cells, erythrocytes, neutrophils, mast cells, monocytes and fibroblasts. Many conditions that carry an elevated risk of venous thrombosis, such as the Antiphospholipid Syndrome, have alterations in their redox homeostasis. Dietary and pharmacological antioxidants can modulate several important processes involved in DVT formation, but their overall effect is unknown and there are no recommendations regarding their use. The development of novel antioxidant treatments that aim to abrogate the formation of DVT or promote its resolution will depend on the identification of targets that enable ROS modulation confined to their site of interest in order to prevent off-target effects on physiological redox mechanisms. Subgroups of patients with increased systemic oxidative stress might benefit from unspecific antioxidant treatment, but more clinical studies are needed to bring clarity to this issue.
    MeSH term(s) Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Dietary Supplements ; Drug Development ; Humans ; Reactive Oxygen Species/metabolism ; Venous Thrombosis/drug therapy ; Venous Thrombosis/metabolism
    Chemical Substances Antioxidants ; Reactive Oxygen Species
    Language English
    Publishing date 2020-03-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21061918
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  10. Article ; Online: Establishing magneto-structural relationships in the solid solutions of the skyrmion hosting family of materials: GaV

    Štefančič, Aleš / Holt, Samuel J R / Lees, Martin R / Ritter, Clemens / Gutmann, Matthias J / Lancaster, Tom / Balakrishnan, Geetha

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 9813

    Abstract: ... The ... ...

    Abstract The GaV
    Language English
    Publishing date 2020-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-65676-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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