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  1. Article ; Online: Assessing Efficacy Using Variations of Olfactory Training for COVID-19-Related Smell Loss-Would a Rose by Any Other Scent Smell as Strong?

    Yan, Carol H

    JAMA otolaryngology-- head & neck surgery

    2022  Volume 149, Issue 2, Page(s) 149–150

    MeSH term(s) Humans ; Odorants ; COVID-19 ; Anosmia/etiology ; Anosmia/therapy ; Olfactory Training ; Smell ; Olfaction Disorders/etiology ; Olfaction Disorders/therapy
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2022.4113
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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.87: Show issues Location:
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  2. Article ; Online: A Consistent Endoscopic Landmark to Identify the Anterior Ethmoidal Artery.

    Mundy, David C / Yan, Carol H / Tyler, Matthew A / Patel, Zara M

    The Laryngoscope

    2023  Volume 134, Issue 3, Page(s) 1096–1099

    Abstract: Objective: The anterior ethmoidal artery (AEA) is an important structure to identify during endoscopic sinus surgery. Although identification on imaging is easily taught, a consistent endoscopic landmark for the AEA, independent of anatomic ethmoid cell ...

    Abstract Objective: The anterior ethmoidal artery (AEA) is an important structure to identify during endoscopic sinus surgery. Although identification on imaging is easily taught, a consistent endoscopic landmark for the AEA, independent of anatomic ethmoid cell variation, is lacking, leaving many surgeons unclear about the exact location without dependence on navigation. Here, we describe a consistent endoscopic landmark, regardless of anatomical ethmoid variation.
    Methods: We prospectively enrolled adult patients undergoing endoscopic surgery involving frontal and ethmoid sinuses in this observational study. The AEA landmark was defined simply as the septation or ridge one step back along the ethmoid skull base from the posterior table of the frontal sinus. The gold standard to calculate the sensitivity of our endoscopic landmark was an image-navigation system, registered to within 1.5 mm accuracy, locating the AEA within three planes. Both endoscopic and computerized tomography (CT) images of the pointer at the landmark were taken simultaneously. The concordance of endoscopic to navigation images was independently assessed by three blinded rhinologists.
    Results: Forty patients were included in our study with 73 sides analyzed. Diagnoses included chronic rhinosinusitis without polyps (52.5%), with polyps (22.5%), recurrent acute sinusitis (15%), sinonasal tumors (7.5%), and odontogenic sinusitis (2.5%). The AEA was accurately identified using our endoscopic landmark in 97.3% of the cases (71/73). Of the two cases in which the AEA was not found within the landmark, the artery was located ≤1 mm posteriorly.
    Conclusion: We describe a consistent endoscopic landmark to identify the AEA, conserved across various clinical diagnoses and anatomic variations in sinus structure.
    Level of evidence: 3 Laryngoscope, 134:1096-1099, 2024.
    MeSH term(s) Adult ; Humans ; Skull Base/surgery ; Arteries/surgery ; Ethmoid Bone ; Ethmoid Sinus/diagnostic imaging ; Ethmoid Sinus/surgery ; Ethmoid Sinus/blood supply ; Endoscopy/methods ; Sinusitis
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30963
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  3. Article ; Online: Prophylactic and therapeutic topical povidone-iodine in coronavirus disease 2019 (COVID-19): What is the evidence?

    Yan, Carol H / Bleier, Benjamin S

    International forum of allergy & rhinology

    2020  Volume 10, Issue 12, Page(s) 1271–1273

    MeSH term(s) Aerosols ; Anti-Infective Agents, Local/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/prevention & control ; COVID-19/transmission ; Centers for Disease Control and Prevention, U.S. ; Evidence-Based Medicine ; Humans ; Particulate Matter ; Povidone-Iodine/therapeutic use ; Respiratory Tract Infections/prevention & control ; Respiratory Tract Infections/transmission ; SARS-CoV-2/physiology ; United States ; Viral Load ; World Health Organization
    Chemical Substances Aerosols ; Anti-Infective Agents, Local ; Antiviral Agents ; Particulate Matter ; Povidone-Iodine (85H0HZU99M)
    Keywords covid19
    Language English
    Publishing date 2020-11-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22735
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6927: Show issues Location:
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  4. Article ; Online: Coronavirus Disease-19 and Rhinology/Facial Plastics.

    Davis, Morgan E / Yan, Carol H

    Otolaryngologic clinics of North America

    2020  Volume 53, Issue 6, Page(s) 1139–1151

    Abstract: This review summarizes the challenges and adaptations that have taken place in rhinology and facial plastics in response to the ongoing coronavirus disease-19 pandemic. In particular, the prolonged exposure and manipulation of the nasal and oral cavities ...

    Abstract This review summarizes the challenges and adaptations that have taken place in rhinology and facial plastics in response to the ongoing coronavirus disease-19 pandemic. In particular, the prolonged exposure and manipulation of the nasal and oral cavities portend a high risk of viral transmission. We discuss evidence-based recommendations to mitigate the risk of viral transmission through novel techniques and device implementation as well as increasing conservative management of certain pathologies.
    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Elective Surgical Procedures/statistics & numerical data ; Female ; Humans ; Infection Control/methods ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Male ; Mouth/virology ; Nasal Cavity/virology ; Occupational Health ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Patient Safety ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Rhinoplasty/adverse effects ; Rhinoplasty/methods ; Rhytidoplasty/adverse effects ; Rhytidoplasty/methods ; Safety Management/methods
    Keywords covid19
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 417489-6
    ISSN 1557-8259 ; 0030-6665
    ISSN (online) 1557-8259
    ISSN 0030-6665
    DOI 10.1016/j.otc.2020.08.002
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    Zs.B 183: Show issues Location:
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  5. Article ; Online: BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease.

    Sheng, Yan J / Kuo, Syuan-Ting A / Yang, Tingyuan / Zhang, Hanyuan E / Russell, David H / Yan, Xin / Xu, Shiqing / Liu, Wenshe R / Fierke, Carol A

    Biochemistry

    2024  

    Abstract: Numerous organic molecules are known to inhibit the main protease ( ... ...

    Abstract Numerous organic molecules are known to inhibit the main protease (M
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.3c00685
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: The use of platelet-rich plasma in treatment of olfactory dysfunction: A pilot study.

    Yan, Carol H / Mundy, David C / Patel, Zara M

    Laryngoscope investigative otolaryngology

    2020  Volume 5, Issue 2, Page(s) 187–193

    Language English
    Publishing date 2020-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.357
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  8. Article ; Online: Reply to: Self-reported olfactory loss in COVID-19: is it really a favorable prognostic factor?

    Yan, Carol H / Faraji, Farhoud / DeConde, Adam S

    International forum of allergy & rhinology

    2020  Volume 10, Issue 7, Page(s) 927–928

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Prognosis ; SARS-CoV-2 ; Self Report
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22606
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6927: Show issues Location:
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  9. Article ; Online: Surgical Management of Nonallergic Rhinitis.

    Yan, Carol H / Hwang, Peter H

    Otolaryngologic clinics of North America

    2018  Volume 51, Issue 5, Page(s) 945–955

    Abstract: Nonallergic rhinitis (NAR) describes chronic symptoms of nasal congestion, obstruction, and rhinorrhea unrelated to a specific allergen based on skin or serum testing. Vasomotor rhinitis is the most frequent subtype of NAR. Although medical management is ...

    Abstract Nonallergic rhinitis (NAR) describes chronic symptoms of nasal congestion, obstruction, and rhinorrhea unrelated to a specific allergen based on skin or serum testing. Vasomotor rhinitis is the most frequent subtype of NAR. Although medical management is the first-line treatment of NAR, there is a role for surgical therapy when medications fail to improve symptoms. Surgical options for NAR include inferior turbinate reduction and botulinum toxin injection as well as more directed targeting of the autonomic nerve supply to the nasal cavity through vidian neurectomy, posterior nasal neurectomy, and cryoablation of the posterior nerve.
    MeSH term(s) Cryosurgery/methods ; Denervation/methods ; Humans ; Nasal Cavity/surgery ; Nasal Obstruction/surgery ; Nasal Surgical Procedures ; Randomized Controlled Trials as Topic ; Rhinitis, Vasomotor/complications ; Rhinitis, Vasomotor/surgery ; Turbinates/surgery
    Language English
    Publishing date 2018-06-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 417489-6
    ISSN 1557-8259 ; 0030-6665
    ISSN (online) 1557-8259
    ISSN 0030-6665
    DOI 10.1016/j.otc.2018.05.010
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  10. Article ; Online: Development of parallel forms of a brief smell identification test useful for longitudinal testing.

    Moein, Shima T / Sacan, Ahmet / Pourrezaei, Kambiz / Yan, Carol H / Turner, Justin H / Sharetts, Ryan / Doty, Richard L

    Behavior research methods

    2023  Volume 56, Issue 3, Page(s) 1449–1458

    Abstract: Although there are numerous brief odor identification tests available for quantifying the ability to smell, none are available in multiple parallel forms that can be longitudinally administered without potential confounding from knowledge of prior test ... ...

    Abstract Although there are numerous brief odor identification tests available for quantifying the ability to smell, none are available in multiple parallel forms that can be longitudinally administered without potential confounding from knowledge of prior test items. Moreover, empirical algorithms for establishing optimal test lengths have not been generally applied. In this study, we employed and compared eight machine learning algorithms to develop a set of four brief parallel smell tests employing items from the University of Pennsylvania Smell Identification Test that optimally differentiated 100 COVID-19 patients from 132 healthy controls. Among the algorithms, linear discriminant analysis (LDA) achieved the best overall performance. The minimum number of odorant test items needed to differentiate smell loss accurately was identified as eight. We validated the sensitivity of the four developed tests, whose means and variances did not differ from one another (Bradley-Blackwood test), by sequential testing an independent group of 32 subjects that included persons with smell dysfunction not due to COVID-19. These eight-item tests clearly differentiated the olfactory compromised subjects from normosmics, with areas under the ROC curve ranging from 0.79 to 0.83. Each test was correlated with the overall UPSIT scores from which they were derived. These brief smell tests can be used separately or sequentially over multiple days in a variety of contexts where longitudinal olfactory testing is needed.
    MeSH term(s) Humans ; Smell ; Olfaction Disorders/diagnosis ; Odorants ; COVID-19 ; ROC Curve
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 231560-9
    ISSN 1554-3528 ; 0743-3808 ; 1554-351X
    ISSN (online) 1554-3528
    ISSN 0743-3808 ; 1554-351X
    DOI 10.3758/s13428-023-02102-8
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