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  1. Article ; Online: Is the current WHO classification of pituitary adenomas practical?

    Pérez-López, Carlos / Zamarrón, Álvaro / Isla, Alberto / Álvarez-Escolá, Cristina

    Endocrinologia, diabetes y nutricion

    2022  Volume 69, Issue 3, Page(s) 234–235

    MeSH term(s) Adenoma ; Humans ; Pituitary Neoplasms ; World Health Organization
    Language English
    Publishing date 2022-02-28
    Publishing country Spain
    Document type Letter ; Comment
    ISSN 2530-0180
    ISSN (online) 2530-0180
    DOI 10.1016/j.endien.2020.10.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Diagnosis of Obstructive Sleep Apnea in Patients with Associated Comorbidity.

    Del Campo, Félix / Arroyo, C Ainhoa / Zamarrón, Carlos / Álvarez, Daniel

    Advances in experimental medicine and biology

    2022  Volume 1384, Page(s) 43–61

    Abstract: Obstructive sleep apnea (OSA) is a heterogeneous disease with many physiological implications. OSA is associated with a great diversity of diseases, with which it shares common and very often bidirectional pathophysiological mechanisms, leading to ... ...

    Abstract Obstructive sleep apnea (OSA) is a heterogeneous disease with many physiological implications. OSA is associated with a great diversity of diseases, with which it shares common and very often bidirectional pathophysiological mechanisms, leading to significantly negative implications on morbidity and mortality. In these patients, underdiagnosis of OSA is high. Concerning cardiorespiratory comorbidities, several studies have assessed the usefulness of simplified screening tests for OSA in patients with hypertension, COPD, heart failure, atrial fibrillation, stroke, morbid obesity, and in hospitalized elders.The key question is whether there is any benefit in the screening for the existence of OSA in patients with comorbidities. In this regard, there are few studies evaluating the performance of the various diagnostic procedures in patients at high risk for OSA. The purpose of this chapter is to review the existing literature about diagnosis in those diseases with a high risk for OSA, with special reference to artificial intelligence-related methods.
    MeSH term(s) Aged ; Artificial Intelligence ; Atrial Fibrillation/complications ; Comorbidity ; Humans ; Polysomnography/methods ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-031-06413-5_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Should atelectasis be considered a pulmonary complication and indicator of poor prognosis in cystic fibrosis?

    Martínez Redondo, María / Carpio Segura, Carlos / Zamarrón De Lucas, Ester / Álvarez-Sala Walther, Rodolfo / Prados Sánchez, Concepción

    The Journal of international medical research

    2024  Volume 52, Issue 3, Page(s) 3000605241233520

    Abstract: Objective: This study examined whether bronchoscopy leads to clinicoradiological improvement in cystic fibrosis (CF) and the predictive factors. The study also investigated whether pulmonary atelectasis is a poor prognostic factor in CF.: Methods: ... ...

    Abstract Objective: This study examined whether bronchoscopy leads to clinicoradiological improvement in cystic fibrosis (CF) and the predictive factors. The study also investigated whether pulmonary atelectasis is a poor prognostic factor in CF.
    Methods: This multicenter, case-control, observational, retrospective study included two groups of patients with CF: a case group (patients with persistent atelectasis who were followed-up at least for 2 years) and a control group (patients without atelectasis matched 1:1 by sex and age [±3 years]). We recorded demographic data, lung function test results, pulmonary complications, comorbidities, treatments (including bronchoscopies, surgery and transplantation), and deaths.
    Results: Each group included 55 patients (case group: 20 men, mean age 25.4 ± 10.4 years; control group: 20 men, mean age 26.1 ± 11.4 years). Bronchoscopy did not lead to clinicoradiological improvement. Allergic bronchopulmonary aspergillosis (ABPA) was more frequent in the case group. Patients in the case group more frequently used inhaled steroids, their pre-atelectasis lung function was statistically worse, and they had more exacerbations during follow-up.
    Conclusion: Moderate-to-severe pulmonary disease and ABPA can favor atelectasis. Pulmonary atelectasis can be a poor prognostic factor in CF because it increases exacerbations. Despite our results, we recommend enhancing treatment, including bronchoscopy, to prevent persistent atelectasis.
    MeSH term(s) Male ; Humans ; Adolescent ; Young Adult ; Adult ; Cystic Fibrosis/complications ; Retrospective Studies ; Aspergillosis, Allergic Bronchopulmonary/complications ; Pulmonary Atelectasis/diagnosis ; Pulmonary Atelectasis/etiology ; Prognosis
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/03000605241233520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Relationship between obstructive sleep apnea and type 2 diabetes mellitus.

    Abelleira, Romina / Zamarrón, Carlos / Riveiro, Vanessa / Casal, Ana / Toubes, María Elena / Rábade, Carlos / Ricoy, Jorge / Lama, Adriana / Rodríguez-Núñez, Nuria / Ferreiro, Lucía / Rodríguez-Ozores, Juan / Valdés, Luis

    Medicina clinica

    2024  Volume 162, Issue 8, Page(s) 363–369

    Abstract: Introduction: The association between obstructive sleep apnea (OSA) and glucose metabolism remains controversial. This study investigates the relationship between OSA and incident type 2 diabetes (DM) and prediabetes (preDM), as well as the effect of ... ...

    Title translation Relación entre la apnea obstructiva del sueño y la diabetes mellitus tipo 2.
    Abstract Introduction: The association between obstructive sleep apnea (OSA) and glucose metabolism remains controversial. This study investigates the relationship between OSA and incident type 2 diabetes (DM) and prediabetes (preDM), as well as the effect of long-term CPAP (continuous positive airway pressure) treatment.
    Methods: Follow-up study in a retrospective clinical cohort of patients with OSA and randomly selected controls. Data on incident DM and preDM as well as CPAP were obtained from hospital records. The relationship between baseline OSA and incident DM was examined using COX regression models.
    Results: Three hundred and fifty-six patients, 169 with OSA and 187 controls were followed for a median of 98 months; 47 patients (13.2%) developed DM and 43 (12.1%) developed preDM. The 5-year cumulative incidence of DM was 10.7% (6.5-13.9%). 87% of subjects with preDM in the baseline sample progressed to incident DM. It is shown that body mass index (BMI), nocturnal hypoxia and apnea hypopnea index (AHI) are risk factors for the development of DM and that CPAP reduces this risk.
    Conclusions: Patients with OSA have a higher risk of developing DM. The risk factors involved are BMI, nocturnal hypoxia and AHI. Regular long-term CPAP use was associated with a decreased risk.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Retrospective Studies ; Follow-Up Studies ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/therapy ; Prediabetic State ; Continuous Positive Airway Pressure ; Hypoxia
    Language Spanish
    Publishing date 2024-01-13
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2023.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is the current WHO classification of pituitary adenomas practical?

    Pérez-López, Carlos / Zamarrón, Álvaro / Isla, Alberto / Álvarez-Escolá, Cristina

    Endocrinologia, diabetes y nutricion

    2021  

    Title translation ¿Es práctica la actual clasificación de la OMS para adenomas hipofisarios?
    Language Spanish
    Publishing date 2021-04-01
    Publishing country Spain
    Document type Letter
    ISSN 2530-0180
    ISSN (online) 2530-0180
    DOI 10.1016/j.endinu.2020.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Influenza vaccination mitigates severe complications in hospitalized patients: A ten-year observational study, Spain, 2009-2019.

    Mangas-Moro, Alberto / Zamarrón, Ester / Carpio, Carlos / Álvarez-Sala, Rodolfo / Arribas-López, José R / Prados, Concepción

    American journal of infection control

    2023  Volume 52, Issue 5, Page(s) 563–569

    Abstract: Background: Influenza epidemics annually impact a substantial portion of adults worldwide, leading to numerous hospitalizations and fatalities. While the primary goal of vaccination is to prevent influenza virus infection, breakthrough infections can ... ...

    Abstract Background: Influenza epidemics annually impact a substantial portion of adults worldwide, leading to numerous hospitalizations and fatalities. While the primary goal of vaccination is to prevent influenza virus infection, breakthrough infections can still occur despite vaccination. Evaluating the vaccine effectiveness in preventing severe cases among hospitalized patients is crucial for enhancing vaccination strategies.
    Methods: This single-center, observational, cross-sectional, and retrospective study analyzed data from 1,357 patients admitted to La Paz University Hospital for influenza infection between 2009 and 2019. Patients' demographics, clinical variables, comorbidities, vaccination status, and influenza-related outcomes were assessed. Logistic regression analysis was performed to determine the vaccine-independent protective effects.
    Results: Influenza vaccination independently prevented severe complications, including pneumonia, bacterial superinfection, acute respiratory distress syndrome, and multiple organ failure in hospitalized patients (odds ratio = 0.61, 95% confidence interval: 0.47-0.76). Vaccinated patients had significantly lower intensive care unit admission rates (odds ratio = 0.42, 95% confidence interval: 0.18-0.92). However, there were no significant differences in mortality rates between vaccinated and unvaccinated patients (P = .385).
    Conclusions: Our study provides robust evidence supporting the influenza vaccine protective effect against severe outcomes in hospitalized patients during epidemic flu. Vaccination is associated with a significant reduction in severe complications and intensive care unit admissions, emphasizing its importance as a preventive measure. Improving vaccination coverage, especially in specific comorbidities and age groups, could further enhance the vaccine effectiveness in preventing severe influenza cases.
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2023.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of systemic corticosteroids on length of hospitalization among patients with COVID-19.

    Zamarrón, Ester / Carpio, Carlos / Villamañán, Elena / Álvarez-Sala, Rodolfo / Borobia, Alberto M / Gómez-Carrera, Luis / Buño, Antonio / Prados, M Concepción

    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

    2023  Volume 47, Issue 2, Page(s) T55–T63

    Abstract: Objective: The COVID-19 pandemic has posed a threat to hospital capacity due to the high number of admissions, which has led to the development of various strategies to release and create new hospital beds. Due to the importance of systemic ... ...

    Title translation [Artículo traducido] Impacto de los corticoides sistémicos en el tiempo de hospitalización en pacientes con COVID-19.
    Abstract Objective: The COVID-19 pandemic has posed a threat to hospital capacity due to the high number of admissions, which has led to the development of various strategies to release and create new hospital beds. Due to the importance of systemic corticosteroids in this disease, we assessed their efficacy in reducing the length of stay (LOS) in hospitals and compared the effect of 3 different corticosteroids on this outcome. MéTHOD: We conducted a real-world, controlled, retrospective cohort study that analysed data from a hospital database that included 3934 hospitalised patients diagnosed with COVID-19 in a tertiary hospital from April to May 2020. Hospitalised patients who received systemic corticosteroids (CG) were compared with a propensity score control group matched by age, sex and severity of disease who did not receive systemic corticosteroids (NCG). The decision to prescribe CG was at the discretion of the primary medical team.
    Results: A total of 199 hospitalized patients in the CG were compared with 199 in the NCG. The LOS was shorter for the CG than for the NCG (median=3 [interquartile range=0-10] vs. 5 [2-8.5]; p=0.005, respectively), showing a 43% greater probability of being hospitalised ≤4 days than >4 days when corticosteroids were used. Moreover, this difference was only noticed in those treated with dexamethasone (76.3% hospitalised ≤4 days vs. 23.7% hospitalised >4 days [p<0.001]). Serum ferritin levels, white blood cells and platelet counts were higher in the CG. No differences in mortality or intensive care unit admission were observed.
    Conclusions: Treatment with systemic corticosteroids is associated with reduced LOS in hospitalised patients diagnosed with COVID-19. This association is significant in those treated with dexamethasone, but no for methylprednisolone and prednisone.
    MeSH term(s) Humans ; COVID-19 ; Retrospective Studies ; Pandemics ; SARS-CoV-2 ; Adrenal Cortex Hormones/therapeutic use ; Hospitalization ; Dexamethasone/therapeutic use
    Chemical Substances Adrenal Cortex Hormones ; Dexamethasone (7S5I7G3JQL)
    Language Spanish
    Publishing date 2023-02-07
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1122680-8
    ISSN 2171-8695 ; 1130-6343
    ISSN (online) 2171-8695
    ISSN 1130-6343
    DOI 10.1016/j.farma.2023.02.001
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  8. Article ; Online: Effect of an intensive tobacco cessation program on the smoker narrative: A content analysis and grounded theory.

    Rábade-Castedo, Carlos / Zamarrón-Sanz, Carlos / Hermida-Ameijeiras, Álvaro / Abelleira-Paris, Romina / Casal-Mouriño, Ana / Ferreiro-Fernández, Lucia / Rodríguez-Núñez, Nuria / Ricoy-Gabaldón, Jorge / Toubes-Navarro, María Elena / Álvarez-Dobaño, José Manuel / Valdés-Cuadrado, Luis

    Tobacco induced diseases

    2024  Volume 22

    Abstract: Introduction: The smoker's narrative during smoking quitting provides insight into aspects not fully explored in daily clinical practice. The aim of the study was to analyze the smoker narrative using two types of methodologies: content analysis and ... ...

    Abstract Introduction: The smoker's narrative during smoking quitting provides insight into aspects not fully explored in daily clinical practice. The aim of the study was to analyze the smoker narrative using two types of methodologies: content analysis and grounded theory, before and after smoking cessation intervention, provided to the smoker in a specialized Smoking Cessation Unit accredited by the Spanish Society of Pneumology and Thoracic Surgery.
    Methods: A prospective observational study of current smokers included in a tobacco cessation program between 2017 and 2020 was conducted at the Smoking Cessation Unit of Santiago de Compostela Health Area, Spain. Routine clinical variables and patient narrative data were collected. A descriptive analysis of the sample, the content of the textual corpus, and a grounded theory were performed in semi-structured interviews at baseline and at follow-up at 6 months.
    Results: A total of 116 patients were included (mean age 55.6 ± 10.6 years; 56.9% male; mean nicotine dependence score 5.7 ± 1.6). Quantitative analysis of the narrative shows that the most frequent phrases and words are associated with smoking, nicotine craving, and predisposition for smoking cessation. After the intervention, phrases related to the manifestation of abstinence, response to pharmacological treatment, and self-perception of smoking cessation were predominant. In the qualitative analysis, the most frequent categories in the smoker's textual corpus were dependence, motivation, and emotionality, which decreased after the intervention (11.4%, 21.4%, and 9.9%, respectively) accompanied by increased satisfaction (19.2%) and the manifestation of abstinence (21.5%).
    Conclusions: Motivation, nicotine dependence, and sensitivity to emotions are all closely intertwined in the current smoker narrative and can be modified as a consequence of treatment.
    Language English
    Publishing date 2024-02-15
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2194616-4
    ISSN 1617-9625 ; 1617-9625
    ISSN (online) 1617-9625
    ISSN 1617-9625
    DOI 10.18332/tid/183607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Diabetes y apnea obstructiva del sueño. Un estudio de casos y controles.

    Abelleira, Romina / Zamarrón, Carlos / Riveiro, Vanessa / Casal, Ana / Toubes, María E / Rábade, Carlos / Ricoy, Jorge / Lama, Adriana / Rodríguez-Núñez, Nuria / Ferreiro, Lucía / Valdés, Luis

    Medicina clinica

    2023  Volume 162, Issue 2, Page(s) 49–55

    Abstract: Introduction: Obstructive sleep apnoea (OSA) and diabetes mellitus (DM) are very prevalent diseases frequently associated. Their coexistence is independently associated with an increased prevalence of cardiovascular comorbidities. As this association is ...

    Title translation Diabetes and obstructive sleep apnoea: A case-control study.
    Abstract Introduction: Obstructive sleep apnoea (OSA) and diabetes mellitus (DM) are very prevalent diseases frequently associated. Their coexistence is independently associated with an increased prevalence of cardiovascular comorbidities. As this association is underdiagnosed, it is necessary to optimise clinical suspicion by studying independent predictors of DM or prediabetes (preDM) in patients with OSA.
    Method: A simple randomised case-control study, matched for sex, body mass index (BMI) and age, aimed to study the association of OSA with DM and preDM and to identify independent predictors for both diseases in people with OSA.
    Results: We included 208 cases with OSA and 208 controls without OSA. In the former, 18.8% had DM compared to only 10.1% in the latter (P=.00). Prevalence of preDM was 41.8% vs. 10.6%, respectively (P=.00). One hundred and twenty-four cases (59.6%) reported excessive daytime sleepiness (EDS) (Epworth scale, 10.5±3.1) vs. 24.5% of the control group (Epworth scale, 6.6±2.9). Apnoea-hypopnoea index (AHI) and O
    Conclusions: OSA is associated with DM and preDM. Age, nocturnal hypoxaemia and EDS are predictors of DM. BMI and AHI are predictors of pre-MD.
    MeSH term(s) Humans ; Case-Control Studies ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology ; Diabetes Mellitus/epidemiology ; Comorbidity ; Prediabetic State/epidemiology ; Hypoxia/epidemiology
    Language Spanish
    Publishing date 2023-10-03
    Publishing country Spain
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2023.07.031
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  10. Article ; Online: Air pollution exposure and its effects on idiopathic pulmonary fibrosis: clinical worsening, lung function decline, and radiological deterioration.

    Mariscal-Aguilar, Pablo / Gómez-Carrera, Luis / Bonilla, Gema / Díaz-Almirón, Mariana / Gayá, Francisco / Carpio, Carlos / Zamarrón, Ester / Fernández-Velilla, María / Torres, Isabel / Esteban, Isabel / Regojo, Rita / Villamañán, Elena / Prados, Concepción / Álvarez-Sala, Rodolfo

    Frontiers in public health

    2024  Volume 11, Page(s) 1331134

    Abstract: Introduction: Major urban pollutants have a considerable influence on the natural history of lung disease. However, this effect is not well known in idiopathic pulmonary fibrosis (IPF).: Aim: This study aimed to investigate the effects of air ... ...

    Abstract Introduction: Major urban pollutants have a considerable influence on the natural history of lung disease. However, this effect is not well known in idiopathic pulmonary fibrosis (IPF).
    Aim: This study aimed to investigate the effects of air pollution on clinical worsening, lung function, and radiological deterioration in patients with IPF.
    Methods: This exploratory retrospective cohort study included 69 patients with IPF, monitored from 2011 to 2020. Data on air pollution levels, including carbon monoxide (CO), nitrogen dioxide (NO
    Results: There was an association between higher O
    Conclusion: This study suggests that air pollution, specifically O
    MeSH term(s) Humans ; Nitrogen Dioxide/adverse effects ; Retrospective Studies ; Air Pollution/adverse effects ; Idiopathic Pulmonary Fibrosis ; Lung/diagnostic imaging
    Chemical Substances Nitrogen Dioxide (S7G510RUBH)
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1331134
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