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  1. Article ; Online: In Response.

    Chow, Jonathan H / Mazzeffi, Michael A

    Anesthesia and analgesia

    2021  Volume 132, Issue 5, Page(s) e90

    MeSH term(s) Aspirin ; COVID-19 ; Hospital Mortality ; Humans ; Intensive Care Units ; Respiration, Artificial ; SARS-CoV-2
    Chemical Substances Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: From Diversity, Equity, and Inclusion to an Antiracism Strategic Plan: An Academic Department of Psychiatry's Journey.

    Trinh, Nhi-Ha T / Talukder, Farhabi / Nagendra, Arun / Ali, Areeba M / Emmerich, Anne / Chow, Louis / Jenkins, Jonathan H / Okereke, Olivia I

    Psychiatric services (Washington, D.C.)

    2024  Volume 75, Issue 4, Page(s) 391–394

    Abstract: The efforts of an academic psychiatry department to embark on an antiracism strategic planning process are outlined, including the establishment of an antiracism task force charged with the development of an antiracism strategic plan. The initial process ...

    Abstract The efforts of an academic psychiatry department to embark on an antiracism strategic planning process are outlined, including the establishment of an antiracism task force charged with the development of an antiracism strategic plan. The initial process of the task force is described, recommendations are summarized, and future directions are outlined.
    MeSH term(s) Humans ; Antiracism ; Diversity, Equity, Inclusion ; Organizations ; Psychiatry ; Racism
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.20230024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In Response.

    Chow, Jonathan H / Mazzeffi, Michael A / Tanaka, Kenichi A

    Anesthesia and analgesia

    2020  Volume 130, Issue 5, Page(s) e158–e159

    MeSH term(s) Humans ; Shock
    Language English
    Publishing date 2020-03-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000004721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Factors associated with unintended perianesthesia hypothermia.

    Keneally, Ryan J / Heinz, Eric R / Jaffe, Edward M / Niak, Bhiken I / Canonico, Andrew B / Roland, Laura M / Chow, Jonathan H / Mazzeffi, Michael A

    Proceedings (Baylor University. Medical Center)

    2024  Volume 37, Issue 3, Page(s) 424–430

    Abstract: Background: Our hypothesis was that total intravenous anesthesia (TIVA) is associated with an increase in hypothermia.: Methods: Inclusion criteria were patients from the National Anesthesia Clinical Outcomes Registry undergoing a general anesthetic ... ...

    Abstract Background: Our hypothesis was that total intravenous anesthesia (TIVA) is associated with an increase in hypothermia.
    Methods: Inclusion criteria were patients from the National Anesthesia Clinical Outcomes Registry undergoing a general anesthetic during 2019. Data collected included patient age, sex, American Society of Anesthesiologists physical status classification system score (ASAPS), duration of anesthetic, use of TIVA, type of procedure, and hypothermia. Continuous variables were compared using Student's
    Results: There was a low incidence of hypothermia (1.2%). Patients who became hypothermic were older, had a higher median ASAPS, and had a higher rate of TIVA. TIVA patients had a significantly increased odds for hypothermia when controlling for covariates. Patients undergoing obstetrical, thoracic, or radiological procedures had increased odds for hypothermia. In a matched cohort subset, TIVA was associated with a greater rate and increased odds for hypothermia.
    Conclusions: The novel and noteworthy finding was the association between TIVA and perianesthesia hypothermia. Thoracic, radiologic, and obstetrical procedures were associated with greater rates of and odds for hypothermia. Other identified factors can help to stratify patients for risk for hypothermia.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2024.2314443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6987: Show issues Location:
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  5. Article ; Online: Raising the bar on fibrinogen: a retrospective assessment of critical hypofibrinogenemia in severely injured trauma patients.

    Richards, Justin / Fedeles, Benjamin T / Chow, Jonathan H / Scalea, Thomas / Kozar, Rosemary

    Trauma surgery & acute care open

    2023  Volume 8, Issue 1, Page(s) e000937

    Abstract: Objectives: Fibrinogen depletion may occur at higher levels than historically referenced. We evaluated hypofibrinogenemia and associated mortality and multiple organ failure (MOF) after severe injury.: Methods: Retrospective investigation including ... ...

    Abstract Objectives: Fibrinogen depletion may occur at higher levels than historically referenced. We evaluated hypofibrinogenemia and associated mortality and multiple organ failure (MOF) after severe injury.
    Methods: Retrospective investigation including 417 adult patients with Injury Severity Score (ISS) >15. Demographics and injury characteristics were collected. Fibrinogen within 30 minutes of admission was described: <150 mg/dL, 150 mg/dL to 200 mg/dL and >200 mg/dL. Primary outcome: 28-day mortality. Secondary outcomes: 28-day MOF and blood product transfusion. Multivariable logistic regression model evaluated association of fibrinogen categories on risk of death, after controlling for confounding variables. Results presented as OR and 95% CIs.
    Results: Fibrinogen <150 mg/dL: 4.8%, 150 mg/dL to 200 mg/dL: 18.2%, >200 mg/dL: 77.0%. 28-day mortality: 15.6%. Patients with <150 mg/dL fibrinogen had over fourfold increased 28-day mortality risk (OR: 4.9, 95% CI 1.53 to 15.7) after adjusting for age, ISS and admission Glasgow Coma Scale. Patients with lower fibrinogen were more likely to develop MOF (p=0.04) and receive larger red blood cell transfusion volumes at 3 hours and 24 hours (p<0.01).
    Conclusions: Fibrinogen <150 mg/dL is significantly associated with increased 28-day mortality. Patients with fibrinogen <150 mg/dL were more likely to develop MOF and required increased administration of blood products. The optimal threshold for critically low fibrinogen, the association with MOF and subsequent fibrinogen replacement requires further investigation.
    Level of evidence: Level III.
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article
    ISSN 2397-5776
    ISSN (online) 2397-5776
    DOI 10.1136/tsaco-2022-000937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The anti-tumoral effects of the oxygen carrier YQ23 in a triple-negative breast cancer syngeneic model.

    Chow, Elysian / Lau, Jonathan S H / Wai, Terence / Lam, Ian P Y

    Translational cancer research

    2022  Volume 10, Issue 2, Page(s) 656–668

    Abstract: Background: Triple-negative breast cancer (TNBC), an aggressive breast cancer subtype, is associated with poor prognosis and high mortality rate. In the search for effective therapeutic options, preclinical studies have suggested using systemic ... ...

    Abstract Background: Triple-negative breast cancer (TNBC), an aggressive breast cancer subtype, is associated with poor prognosis and high mortality rate. In the search for effective therapeutic options, preclinical studies have suggested using systemic oxygenation to inhibit tumor growth and metastasis in various cancer models, including TNBC, by weakening the hypoxia-A2A adenosine receptors (A2AR)-driven immunosuppression in the tumor microenvironment (TME). In our present study, a hemoglobin-based oxygen carrier (HBOC) "YQ23" was tested for its role in modulating the TME and tumor inhibition.
    Methods: A syngeneic TNBC mouse model was established by inoculating 4T1 cells subcutaneously in BALB/c mice. Tumor (~100 mm
    Results: YQ23 significantly inhibited the tumor growth, and this suppressive effect was abolished by depleting the host immune cells. Immunohistochemical staining of xenograft sections showed YQ23 reduced the level of hypoxia and adenosine producing ecto-enzyme CD73. Although there was no significant difference in the make up of the intra-tumoral immune populations, we observed a down-regulation of the immune checkpoint PD-1. In concordance with the weakened immunosuppression, the inflammatory cytokine interferon γ and cytolytic granzyme B were upregulated.
    Conclusions: YQ23 treatment may be a potential therapeutic strategy to modulate the TME in TNBC.
    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-20-2768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Angiotensin II and Vasoplegia in Cardiac Surgery: Paradigm Changer or Costly Contender?

    Chow, Jonathan H / Strauss, Erik / Mazzeffi, Michael A

    Journal of cardiothoracic and vascular anesthesia

    2020  Volume 35, Issue 1, Page(s) 59–60

    MeSH term(s) Angiotensin II ; Blood Pressure ; Cardiac Surgical Procedures/adverse effects ; Humans ; Vasoconstrictor Agents ; Vasoplegia/diagnosis ; Vasoplegia/drug therapy ; Vasoplegia/etiology
    Chemical Substances Vasoconstrictor Agents ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2020-09-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2020.08.060
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    Zs.A 2203: Show issues Location:
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  8. Article ; Online: Evaluating the evidence for angiotensin II for the treatment of vasoplegia in critically ill cardiothoracic surgery patients.

    Chow, Jonathan H / Wittwer, Erica D / Wieruszewski, Patrick M / Khanna, Ashish K

    The Journal of thoracic and cardiovascular surgery

    2021  Volume 163, Issue 4, Page(s) 1407–1414

    MeSH term(s) Angiotensin II/therapeutic use ; Cardiopulmonary Bypass ; Clinical Trials as Topic ; Critical Illness ; Extracorporeal Membrane Oxygenation ; Humans ; Postoperative Complications/drug therapy ; Vasoconstrictor Agents/therapeutic use ; Vasoplegia/drug therapy ; Vasoplegia/etiology
    Chemical Substances Vasoconstrictor Agents ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2021.02.097
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  9. Article ; Online: Preoperative Erythropoietin in Cardiac Surgery: Evolving Standard of Care or Aggregation of Marginal Gain?

    Mazzeffi, Michael / Chow, Jonathan H / Tanaka, Kenichi

    Anesthesia and analgesia

    2019  Volume 129, Issue 3, Page(s) e110–e111

    MeSH term(s) Blood Transfusion ; Cardiac Surgical Procedures ; Erythropoietin ; Hematopoietic Stem Cell Transplantation ; Standard of Care
    Chemical Substances Erythropoietin (11096-26-7)
    Language English
    Publishing date 2019-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000004296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Understanding Extracorporeal Membrane Oxygenation Induced Coagulopathy: Many Pieces to the Puzzle.

    Mazzeffi, Michael A / Chow, Jonathan H / Wu, Zhongjun J / Tanaka, Kenichi A

    Critical care medicine

    2020  Volume 48, Issue 8, Page(s) e732–e733

    MeSH term(s) Blood Coagulation Disorders/etiology ; Extracorporeal Membrane Oxygenation/adverse effects ; Humans
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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