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  1. Article: Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.

    Qian, Lichao / Ren, Shuai / Xu, Zhongchi / Zheng, Yawei / Wu, Lihua / Yang, Ying / Wang, Yixuan / Li, Jie / Yan, Shihai / Fang, Zhuyuan

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 667433

    Abstract: ... nephropathy. In this study, the effects of Qian Yang Yu Yin granule (QYYY) on spontaneously hypertensive rats ...

    Abstract Protection against hypoxia injury is an important therapeutic strategy for treating hypertensive nephropathy. In this study, the effects of Qian Yang Yu Yin granule (QYYY) on spontaneously hypertensive rats fed with high salt diet and HEK293T cells exposed to hypoxia were investigated. After eight weeks' treatment of QYYY, blood pressure, serum creatinine, serum cystatin C, blood urea nitrogen, urinary β2-microglobulin, urinary N-acetyl-β-glucosaminidase, and urinary microalbumin were assessed. The changes of hypoxia-inducible factor-1α (HIF-1α), pyruvate kinase M2 (PKM2), glucose transport 1 (GLUT1), lactate dehydrogenase A (LDH-A), connective tissue growth factor (CTGF), transforming growth factor-β1 (TGF-β1), ATP, lactate, pyruvate, and pathology were also assessed
    Language English
    Publishing date 2021-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.667433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Qian Yang Yu Yin granule improves hypertensive renal damage: A potential role for TRPC6-CaMKKβ-AMPK-mTOR-mediated autophagy.

    Ma, Siqi / Xu, Junyao / Zheng, Yawei / Li, Yin / Wang, Yixuan / Li, Haitao / Fang, Zhuyuan / Li, Jie

    Journal of ethnopharmacology

    2022  Volume 302, Issue Pt A, Page(s) 115878

    Abstract: Ethnopharmacological relevance: Qian Yang Yu Yin granules (QYYYG) have a long history ...

    Abstract Ethnopharmacological relevance: Qian Yang Yu Yin granules (QYYYG) have a long history in the treatment of hypertensive renal damage (HRD) in China. Clinical studies have found that QYYYG stabilizes blood pressure and prevents early renal damage. However, the exact mechanism is not entirely clear.
    Aim of the study: To evaluate the therapeutic effect and further explore the therapeutic mechanism of QYYYG against HRD.
    Materials and methods: The efficacy of QYYYG in treating HRD was assessed in spontaneous hypertension rats (SHR). Renal autophagy and the TRPC6-CaMKKβ-AMPK pathway in rats were evaluated. The regulatory role of QYYYG in angiotensin II (Ang II) induced abnormal autophagy in rat podocytes was determined by detecting autophagy-related proteins, intracellular Ca
    Results: QYYYG alleviated HRD and reversed the abnormal expression of autophagy-related genes in the SHR. In vitro, QYYYG protected against Ang II-induced podocyte damage. Furthermore, treatment of podocytes with QYYYG reversed Ang II-induced autophagy and inhibited Ang II-stimulated TRPC6 activation, Ca
    Conclusions: The present study suggested that QYYYG may exert its HRD protective effects in part by regulating the abnormal autophagy of podocytes through the TRPC6-CaMKKβ-AMPK-mTOR pathway.
    MeSH term(s) Animals ; Rats ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; TRPC6 Cation Channel/metabolism ; AMP-Activated Protein Kinases/metabolism ; Calcium/metabolism ; Autophagy ; TOR Serine-Threonine Kinases/metabolism ; Podocytes ; Angiotensin II/metabolism ; Hypertension/drug therapy ; Hypertension/metabolism ; TRPC Cation Channels/genetics ; TRPC Cation Channels/metabolism ; TRPC Cation Channels/pharmacology
    Chemical Substances Calcium-Calmodulin-Dependent Protein Kinase Kinase (EC 2.7.11.17) ; TRPC6 Cation Channel ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; qian yang yu yin granule ; Calcium (SY7Q814VUP) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Angiotensin II (11128-99-7) ; mTOR protein, rat (EC 2.7.1.1) ; Trpc6 protein, rat ; TRPC Cation Channels
    Language English
    Publishing date 2022-10-29
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Poverty Mapping in the Dian-Gui-Qian Contiguous Extremely Poor Area of Southwest China Based on Multi-Source Geospatial Data

    Yongming Xu / Yaping Mo / Shanyou Zhu

    Sustainability, Vol 13, Iss 8717, p

    2021  Volume 8717

    Abstract: ... in the Dian-Gui-Qian contiguous extremely poor area of southwest China. Based on multiple independent spatial ... of poverty in the Dian-Gui-Qian contiguous extremely poor area well, which provided a good reference ...

    Abstract Accurate information on the spatial distribution of poverty is of great significance to the formulation and implementation of the government’s targeted poverty alleviation policy. Traditional poverty mapping is mainly based on household survey data and statistical data, which cannot describe the spatial distribution of poverty well. This paper presents a study of mapping the integrated poverty index (IPI) in the Dian-Gui-Qian contiguous extremely poor area of southwest China. Based on multiple independent spatial variables extracted from NPP/VIIRS nighttime light (NTL) remote sensing data, digital elevation model (DEM), land cover information, open street map, and city accessibility data, eight algorithms were employed and compared to determine the optimal model for IPI estimation. Among these machine learning algorithms, traditional multiple linear regression had the lowest accuracy compared with the other seven machine learning algorithms and XGBoost showed the best performance. Feature selection was performed to reduce overfitting and five variables were finally selected. The final developed XGBoost model achieved an MAE of 0.0454 and an R2 of 0.68. The IPI map derived from the developed XGBoost model characterized the spatial pattern of poverty in the Dian-Gui-Qian contiguous extremely poor area well, which provided a good reference for the poverty alleviation work and public resources allocation in the study area. This study can also serve as a template for poverty mapping in other areas using remote sensing data.
    Keywords poverty mapping ; remote sensing ; contiguous extremely poor area ; integrated poverty index ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 310
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Retrotransposon "Qian" mediated segmental duplication in silkworm, Bombyx mori.

    Xu, Yunmin / Jiang, Ning / Zou, Ziliang / Tu, Zhijian / Chen, Anli / Zhao, Qiaoling / Xiang, Zhonghuai / He, Ningjia

    Insect biochemistry and molecular biology

    2014  Volume 46, Page(s) 9–16

    Abstract: ... as "Qian") was identified and the model for the Qian-mediated chromosomal segmental duplication was ...

    Abstract Transposable elements constitute a large fraction of the eukaryotic genomes. They have the potential to alter genome structure and play a major role in genome evolution. Here, we report a segmental duplication mediated by a novel long terminal repeat (LTR) retrotransposon as the cause of an egg-shell recessive lethal mutant (l-em mutant) in silkworm (Bombyx mori). The segmental duplication resulted in the duplication of six genes and the disruption of two genes. Disruption of BmEP80 (B. mori egg protein 80), a gene encoding a major egg-shell structure protein, is likely responsible for the lethal water-loss phenotype in the l-em/l-em mutant. Our data revealed that BmEP80 is present in the inner egg-shell layer and plays important roles in resistance to water efflux form eggs. A novel LTR retrotransposon (named as "Qian") was identified and the model for the Qian-mediated chromosomal segmental duplication was proposed. Detail biochemical and genomic analyses on the l-em mutant offer an opportunity to demonstrate that an LTR retrotransposon could trigger duplication of a chromosomal segment (∼96.3 kb) and confer novel phenotype.
    MeSH term(s) Animals ; Base Sequence ; Bombyx/genetics ; Bombyx/growth & development ; Bombyx/metabolism ; Egg Shell/metabolism ; Larva/genetics ; Larva/metabolism ; Molecular Sequence Data ; Phylogeny ; Polymerase Chain Reaction ; Retroelements ; Segmental Duplications, Genomic ; Terminal Repeat Sequences
    Chemical Substances Retroelements
    Language English
    Publishing date 2014-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483248-3
    ISSN 1879-0240 ; 0965-1748
    ISSN (online) 1879-0240
    ISSN 0965-1748
    DOI 10.1016/j.ibmb.2014.01.002
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  5. Article ; Online: The mystery of missing trubs revisited: a response to McGlone et al. and Qian and Ricklefs.

    Scheffer, Marten / Vergnon, Remi / Cornelissen, J Hans H C / Hantson, Stijn / Holmgren, Milena / van Nes, Egbert H / Xu, Chi

    Trends in ecology & evolution

    2015  Volume 30, Issue 1, Page(s) 7–8

    MeSH term(s) Plant Development/physiology ; Plant Physiological Phenomena ; Trees/growth & development
    Language English
    Publishing date 2015-01
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 284965-3
    ISSN 1872-8383 ; 0169-5347
    ISSN (online) 1872-8383
    ISSN 0169-5347
    DOI 10.1016/j.tree.2014.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Zs Bio TEE: Show issues
    Z 2005/711: Show issues

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  6. Article: Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease.

    Gong, Xiao-Gang / Sun, Hong-Mei / Zhang, Yi / Zhang, Shu-Jing / Gao, Yu-Shan / Feng, Jing / Hu, Jing-Hong / Gai, Cong / Guo, Zhen-Yu / Xu, Hong / Ma, Ling

    Evidence-based complementary and alternative medicine : eCAM

    2014  Volume 2014, Page(s) 729195

    Abstract: Da-Bu-Yin-Wan (DBYW) and Qian-Zheng-San (QZS), two classic traditional Chinese medicinal formulas ...

    Abstract Da-Bu-Yin-Wan (DBYW) and Qian-Zheng-San (QZS), two classic traditional Chinese medicinal formulas, were clinically employed to treat Parkinson's disease (PD). Our previous studies demonstrated neuroprotective effects of them on mitochondrial function in PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The purpose of this research was to investigate their possible mechanisms in the light of mitochondrial ATP-sensitive potassium (mitoKATP) channels. The neuroprotective effect of DBYW and QZS on dopamine (DA) neurons in substantia nigra (SN) in the MPTP-induced PD mice was investigated by behavioral test (pole test) and immunohistochemistry. Adenosine triphosphate (ATP) level in the midbrain tissue was detected by firefly luciferase method. MitoKATP channel subunits SUR1 and Kir6.2 mRNA and protein expressions were tested by real-time PCR (RT-PCR) and Western blot. It was observed that DBYW and/or QZS served to ameliorate MPTP-induced behavioral impairment and prevent the loss of substantia nigra dopamine neurons, as well as increase ATP level in the midbrain tissue and downregulate SUR1 expression at mRNA and protein levels with no marked influence on Kir6.2. We concluded that DBYW and QZS exhibit neuroprotective effects probably through the regulation of ATP level and mitoKATP channel subunit expressions.
    Language English
    Publishing date 2014-12-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2014/729195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Qian yan wan yu

    Xu, Anhua

    Ordinary heroes

    1999  

    Author's details [Regie: Xu Anhua]
    Language Chinese
    Size 2 VCDs, 128 Min
    Publishing place Hongkong
    Document type Book
    Note Audiosprachen: Chinesisch, Kantonesisch
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Da-Bu-Yin-Wan and Qian-Zheng-San to Neuroprotect the Mouse Model of Parkinson’s Disease

    Xiao-Gang Gong / Hong-Mei Sun / Yi Zhang / Shu-Jing Zhang / Yu-Shan Gao / Jing Feng / Jing-Hong Hu / Cong Gai / Zhen-Yu Guo / Hong Xu / Ling Ma

    Evidence-Based Complementary and Alternative Medicine, Vol

    2014  Volume 2014

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Da-Bu-Yin-Wan and Qian-Zheng-San to Neuroprotect the Mouse Model of Parkinson’s Disease

    Xiao-Gang Gong / Hong-Mei Sun / Yi Zhang / Shu-Jing Zhang / Yu-Shan Gao / Jing Feng / Jing-Hong Hu / Cong Gai / Zhen-Yu Guo / Hong Xu / Ling Ma

    Evidence-Based Complementary and Alternative Medicine, Vol

    2014  Volume 2014

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Da-Bu-Yin-Wan and Qian-Zheng-San to Neuroprotect the Mouse Model of Parkinson’s Disease

    Xiao-Gang Gong / Hong-Mei Sun / Yi Zhang / Shu-Jing Zhang / Yu-Shan Gao / Jing Feng / Jing-Hong Hu / Cong Gai / Zhen-Yu Guo / Hong Xu / Ling Ma

    Evidence-Based Complementary and Alternative Medicine, Vol

    2014  Volume 2014

    Abstract: Da-Bu-Yin-Wan (DBYW) and Qian-Zheng-San (QZS), two classic traditional Chinese medicinal formulas ...

    Abstract Da-Bu-Yin-Wan (DBYW) and Qian-Zheng-San (QZS), two classic traditional Chinese medicinal formulas, were clinically employed to treat Parkinson’s disease (PD). Our previous studies demonstrated neuroprotective effects of them on mitochondrial function in PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The purpose of this research was to investigate their possible mechanisms in the light of mitochondrial ATP-sensitive potassium (mitoKATP) channels. The neuroprotective effect of DBYW and QZS on dopamine (DA) neurons in substantia nigra (SN) in the MPTP-induced PD mice was investigated by behavioral test (pole test) and immunohistochemistry. Adenosine triphosphate (ATP) level in the midbrain tissue was detected by firefly luciferase method. MitoKATP channel subunits SUR1 and Kir6.2 mRNA and protein expressions were tested by real-time PCR (RT-PCR) and Western blot. It was observed that DBYW and/or QZS served to ameliorate MPTP-induced behavioral impairment and prevent the loss of substantia nigra dopamine neurons, as well as increase ATP level in the midbrain tissue and downregulate SUR1 expression at mRNA and protein levels with no marked influence on Kir6.2. We concluded that DBYW and QZS exhibit neuroprotective effects probably through the regulation of ATP level and mitoKATP channel subunit expressions.
    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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