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Article ; Online: Associations between hypovitaminosis D and COVID-19: a narrative review.

Isaia, Giancarlo / Medico, Enzo

Aging clinical and experimental research

2020 Volume 32, Issue 9, Page(s) 1879–1881

Abstract: In the search for factors affecting incidence and lethality of the current COVID-19 pandemic, recent association studies explored the possible role of vitamin D deficiency. Altogether, these studies, in most cases based on cross-sectional analyses, could ...

Abstract	In the search for factors affecting incidence and lethality of the current COVID-19 pandemic, recent association studies explored the possible role of vitamin D deficiency. Altogether, these studies, in most cases based on cross-sectional analyses, could not yet provide a convincing demonstration of a cause-effect relationship. In this editorial, the authors describe the scientific evidence underlying a possible role of vitamin D in the prevention and development of the pandemic, considering its immunomodulatory role and antiviral effects. They conclude that further studies are needed to (1) better explore possible associations between vitamin D deficiency and COVID-19 morbidity and lethality, and (2) assess if compensating such deficiency could avoid or mitigate the worst manifestations of COVID-19. They highlight the need for public health campaigns to promote consumption of vitamin D-rich foods and proper sunlight exposition or, when this is not possible, controlled pharmaceutical supplementation, especially in countries with high prevalence of hypovitaminosis D.
MeSH term(s)	Humans ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/prevention & control ; Dietary Supplements ; Immunologic Factors/immunology ; Immunologic Factors/pharmacology ; Pandemics/prevention & control ; Prevalence ; SARS-CoV-2 ; Vitamin D/administration & dosage ; Vitamin D/immunology ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/immunology ; Vitamin D Deficiency/therapy
Chemical Substances	Immunologic Factors ; Vitamin D (1406-16-2)
Keywords	covid19
Language	English
Publishing date	2020-07-23
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-020-01650-9
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Article ; Online: Associations between hypovitaminosis D and COVID-19

Isaia, Giancarlo / Medico, Enzo

Aging Clinical and Experimental Research

a narrative review

2020 Volume 32, Issue 9, Page(s) 1879–1881

Keywords	Ageing ; Geriatrics and Gerontology ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-020-01650-9
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Article: Associations between hypovitaminosis D and COVID-19: a narrative review

Isaia, Giancarlo / Medico, Enzo

Aging Clin Exp Res

Abstract	In the search for factors affecting incidence and lethality of the current COVID-19 pandemic, recent association studies explored the possible role of vitamin D deficiency. Altogether, these studies, in most cases based on cross-sectional analyses, could not yet provide a convincing demonstration of a cause-effect relationship. In this editorial, the authors describe the scientific evidence underlying a possible role of vitamin D in the prevention and development of the pandemic, considering its immunomodulatory role and antiviral effects. They conclude that further studies are needed to (1) better explore possible associations between vitamin D deficiency and COVID-19 morbidity and lethality, and (2) assess if compensating such deficiency could avoid or mitigate the worst manifestations of COVID-19. They highlight the need for public health campaigns to promote consumption of vitamin D-rich foods and proper sunlight exposition or, when this is not possible, controlled pharmaceutical supplementation, especially in countries with high prevalence of hypovitaminosis D.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #670638
Database	COVID19

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Article ; Online: Does solar ultraviolet radiation play a role in COVID-19 infection and deaths? An environmental ecological study in Italy

Isaia, Giancarlo / Diémoz, Henri / Maluta, Francesco / Fountoulakis, Ilias / Ceccon, Daniela / di Sarra, Alcide / Facta, Stefania / Fedele, Francesca / Lorenzetto, Giuseppe / Siani, Anna Maria / Isaia, Gianluca

Science of the Total Environment. 2021 Feb., v. 757 p.143757-

2021

Abstract: A significantly stronger impact in mortality and morbidity by COVID-19 has been observed in the northern Italian regions compared to the southern ones. The reasons of this geographical pattern might involve several concurrent factors. The main objective ... ...

Abstract	A significantly stronger impact in mortality and morbidity by COVID-19 has been observed in the northern Italian regions compared to the southern ones. The reasons of this geographical pattern might involve several concurrent factors. The main objective of this work is to investigate whether any correlations exist between the spatial distribution of COVID-19 cases and deaths in the different Italian regions and the amount of solar ultraviolet (UV) radiation at the Earth's surface. To this purpose, in this environmental ecological study a mixed-effect exponential regression was built to explain the incidence of COVID-19 based on the environmental conditions, and demographic and pathophysiologic factors. Observations and estimates of the cumulative solar UV exposure have been included to quantify the amount of radiation available e.g., for pre-vitamin D3 synthesis or SARS-CoV-2 inactivation by sunlight. The analysis shows a significant correlation (p-value <5 × 10⁻²) between the response variables (death percentage, incidence of infections and positive tests) and biologically effective solar UV radiation, residents in nursing homes per inhabitant (NHR), air temperature, death percentage due to the most frequent comorbidities. Among all factors, the amount of solar UV radiation is the variable contributing the most to the observed correlation, explaining up to 83.2% of the variance of the COVID-19 affected cases per population. While the statistical outcomes of the study do not directly entail a specific cause-effect relationship, our results are consistent with the hypothesis that solar UV radiation impacted on the development of the infection and on its complications, e.g. through the effect of vitamin D on the immune system or virus inactivation by sunlight. The analytical framework used in this study, based on commonly available data, can be easily replicated in other countries and geographical domains to identify possible correlations between exposure to solar UV radiation and the spread of the pandemic.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; air temperature ; death ; ecological studies ; environment ; immune system ; morbidity ; mortality ; pandemic ; pathophysiology ; ultraviolet radiation ; variance ; viruses ; Italy ; COVID-19 ; Tropospheric Emission Monitoring Internet Service (TEMIS) ; Clinical outcomes in Italy ; Hypovitaminosis D
Language	English
Dates of publication	2021-02
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.143757
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Circulating MicroRNAs as Biomarkers of Osteoporosis and Fragility Fractures.

Ciuffi, Simone / Marini, Francesca / Fossi, Caterina / Donati, Simone / Giusti, Francesca / Botta, Annalisa / Masi, Laura / Isaia, Giancarlo / Marcocci, Claudio / Migliaccio, Silvia / Minisola, Salvatore / Nuti, Ranuccio / Tarantino, Umberto / Iantomasi, Teresa / Brandi, Maria Luisa

The Journal of clinical endocrinology and metabolism

2022 Volume 107, Issue 8, Page(s) 2267–2285

Abstract: Context: Measurement of circulating microRNAs (miRNAs) as potential biomarkers of fragility fracture risk has recently become a subject of investigation.: Objective: Measure by next-generation sequencing (NGS), global miRNA expression in serum ... ...

Abstract	Context: Measurement of circulating microRNAs (miRNAs) as potential biomarkers of fragility fracture risk has recently become a subject of investigation. Objective: Measure by next-generation sequencing (NGS), global miRNA expression in serum samples of osteoporotic subjects vs individuals with normal bone mineral density (BMD). Design: Samples were collected from patients with different bone phenotypes and/or fragility fractures who did not receive any antiresorptive and/or bone-forming drug at the time of blood collection. Setting: Samples and data were collected at 7 medical centers in Italy. Patients: NGS prescreening: 50 osteoporotic patients vs 30 individuals with normal BMD. Droplet digital polymerase chain reaction (ddPCR) validation: 213 patients with different bone phenotypes, including the NGS-analyzed cohort. Results: NGS identified 5 miRNAs (miR-8085, miR-320a-3p, miR-23a-3p, miR-4497, miR-145-5p) differentially expressed in osteoporosis cases without fractures vs controls. ddPCR validation confirmed lower c-miR-23a-3p expression in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects and increased c-miR-320a-3p expression in osteoporotic patients with fracture and lower expression in osteoporotic patients without fracture. ddPCR analysis showed a significantly increased expression of miR-21-5p in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects, not evidenced by the NGS prescreening. Discussion: Our study confirmed levels of c-miR-23a-3p and c-miR-21-5p as able to distinguish osteoporotic patients and subjects with normal BMD. Increased levels of c-miR-320a-3p specifically associated with fractures, independently by BMD, suggesting c-miR-320a-3p as a prognostic indicator of fracture risk in osteoporotic patients, to be confirmed in prospective studies on incident fractures.
MeSH term(s)	Circulating MicroRNA/blood ; Circulating MicroRNA/genetics ; Genetic Markers ; Humans ; Osteoporosis/blood ; Osteoporosis/genetics ; Osteoporotic Fractures/blood ; Osteoporotic Fractures/genetics ; Prospective Studies
Chemical Substances	Circulating MicroRNA ; Genetic Markers ; MIRN145 microRNA, human
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgac293
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Article ; Online: Does solar ultraviolet radiation play a role in COVID-19 infection and deaths? An environmental ecological study in Italy.

The Science of the total environment

2020 Volume 757, Page(s) 143757

Abstract	A significantly stronger impact in mortality and morbidity by COVID-19 has been observed in the northern Italian regions compared to the southern ones. The reasons of this geographical pattern might involve several concurrent factors. The main objective of this work is to investigate whether any correlations exist between the spatial distribution of COVID-19 cases and deaths in the different Italian regions and the amount of solar ultraviolet (UV) radiation at the Earth's surface. To this purpose, in this environmental ecological study a mixed-effect exponential regression was built to explain the incidence of COVID-19 based on the environmental conditions, and demographic and pathophysiologic factors. Observations and estimates of the cumulative solar UV exposure have been included to quantify the amount of radiation available e.g., for pre-vitamin D3 synthesis or SARS-CoV-2 inactivation by sunlight. The analysis shows a significant correlation (p-value <5 × 10
MeSH term(s)	COVID-19 ; Humans ; Italy/epidemiology ; Pandemics ; SARS-CoV-2 ; Ultraviolet Rays
Language	English
Publishing date	2020-11-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.143757
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Article ; Online: Stature estimation based on vertebral morphometry by dual energy X-rays absorptiometry imaging in Italian females

Chantal Milani / Marco Di Stefano / Giancarlo Isaia / Gian Luigi Panattoni

Journal of Biological Research, Vol 90, Iss

2017 Volume 1

Abstract: Anthropological profile in forensic context includes the assessment of parameters as ancestry, sex, age and stature of an individual by the analysis of skeletal remains. Stature can be estimated from decomposed and fully or partially skeletonized remains ...

Abstract	Anthropological profile in forensic context includes the assessment of parameters as ancestry, sex, age and stature of an individual by the analysis of skeletal remains. Stature can be estimated from decomposed and fully or partially skeletonized remains by means of anatomical or mathematical methods applied on the whole skeleton or single bones. Many authors calculated regression formulae for the living stature estimation by these methods, in particular based on a population similar to the remains recovered. Long bones are commonly used for stature estimation, but, when they are missing, methods involving different parts of the skeleton are needed. In this preliminary study we measured heights of the vertebral bodies in a female Caucasian Italian population, evaluated by images of morphometric X-ray absorptiometry based on dual-energy X-ray absorptiometry in living subjects investigated for routine diagnostic purposes. Thoracic and lumbar segments of the spine were measured and statistical analysis was performed, thus obtaining regression formulae for estimated living stature from thoraco-lumbar spine segments (T 6 -T 12 , L 1 -L 4 and T 6 -L 4 ). We propose this method for stature evaluation in physical or forensic anthropology when the spine is available and long bones are missing.
Keywords	Forensic anthropology ; Vertebral column ; Stature estimation ; DEXA morphometry ; Biology (General) ; QH301-705.5
Subject code	310
Language	English
Publishing date	2017-02-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Informed Consent in Older Medical Inpatients: Assessment of Decision-Making Capacity.

Porrino, Paola / Falcone, Yolanda / Agosta, Luca / Isaia, Gianluca / Zanocchi, Mauro / Mastrapasqua, Annalisa / Isaia, Giancarlo / Bo, Mario

Journal of the American Geriatrics Society

2015 Volume 63, Issue 11, Page(s) 2423–2424

MeSH term(s)	Aged, 80 and over ; Decision Making ; Female ; Geriatric Assessment ; Hospitalization ; Humans ; Informed Consent/psychology ; Male ; Mental Competency
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Letter
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.13810
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Book: Le malattie del metabolismo minerale

Isaia, Giancarlo

guida pratica alla gestione operativa

2000

Author's details	[a cura di] Giancarlo Isaia
MeSH term(s)	Bone Diseases, Metabolic ; Metabolic Diseases ; Minerals
Language	Italian
Size	xiv, 296 p. :, ill.
Publisher	Centro scientifico editore
Publishing place	Torino
Document type	Book
ISBN	9788876405099 ; 8876405097
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Circulating Long Non-Coding RNA GAS5 Is Overexpressed in Serum from Osteoporotic Patients and Is Associated with Increased Risk of Bone Fragility.

Visconti, Virginia Veronica / Fittipaldi, Simona / Ciuffi, Simone / Marini, Francesca / Isaia, Giancarlo / D'Amelio, Patrizia / Migliaccio, Silvia / Marcocci, Claudio / Minisola, Salvatore / Nuti, Ranuccio / Novelli, Giuseppe / Brandi, Maria Luisa / Botta, Annalisa / Tarantino, Umberto

International journal of molecular sciences

2020 Volume 21, Issue 18

Abstract: Osteoporosis (OP) is a multifactorial disorder in which environmental factors along with genetic variants and epigenetic mechanisms have been implicated. Long non-coding RNAs (lncRNAs) have recently emerged as important regulators of bone metabolism and ... ...

Abstract	Osteoporosis (OP) is a multifactorial disorder in which environmental factors along with genetic variants and epigenetic mechanisms have been implicated. Long non-coding RNAs (lncRNAs) have recently emerged as important regulators of bone metabolism and OP aetiology. In this study, we analyzed the expression level and the genetic association of lncRNA GAS5 in OP patients compared to controls. Quantitative RT-PCR analysis of GAS5 was performed on the serum of 56 OP patients and 28 healthy individuals. OP subjects were divided into three groups of analysis: 29 with fragility fractures of lumbar spine (OP_VF), 14 with fragility fractures of femoral neck (OP_FF) and 13 without fractures (OP_WF). Genotyping of the rs145204276 insertion/deletion polymorphism has also been performed by Restriction fragment length polymorphism (RFLP) and direct sequencing analyses. Expression of circulating GAS5 is significantly increased in OP patients compared to controls (
MeSH term(s)	Aged ; Cell-Free Nucleic Acids/blood ; Female ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; Osteoporosis/blood ; Osteoporotic Fractures/blood ; RNA, Long Noncoding/blood ; Risk Factors
Chemical Substances	Cell-Free Nucleic Acids ; GAS5 long non-coding RNA, human ; RNA, Long Noncoding
Language	English
Publishing date	2020-09-21
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article ; Multicenter Study
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21186930
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