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  1. Article ; Online: Coherent control of enhanced second-harmonic generation in a plasmonic nanocircuit using a transition metal dichalcogenide monolayer.

    Wu, Pei-Yuan / Lee, Wei-Qing / Liu, Chang-Hua / Huang, Chen-Bin

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1855

    Abstract: Nonlinear nanophotonic circuits, renowned for their compact form and integration capabilities, hold potential for advancing high-capacity optical signal processing. However, limited practicality arises from low nonlinear conversion efficiency. Transition ...

    Abstract Nonlinear nanophotonic circuits, renowned for their compact form and integration capabilities, hold potential for advancing high-capacity optical signal processing. However, limited practicality arises from low nonlinear conversion efficiency. Transition metal dichalcogenides (TMDs) could present a promising avenue to address this challenge, given their superior optical nonlinear characteristics and compatibility with diverse device platforms. Nevertheless, this potential remains largely unexplored, with current endeavors predominantly focusing on the demonstration of TMDs' coherent nonlinear signals via free-space excitation and collection. In this work, we perform direct integration of TMDs onto a plasmonic nanocircuitry. By controlling the polarization angle of the input laser, we show selective routing of second-harmonic generation (SHG) signals from a MoSe
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46209-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cutaneous Hydrophilic Polymer Embolism: An Important and Overlooked Clinical Entity.

    Chan, Kimberly Pei Rui / Lee, Joyce Siong See / Lim, Joel Hua Liang

    The American Journal of dermatopathology

    2024  

    Abstract: Abstract: Hydrophilic polymer embolism from vascular medical devices is an underrecognized clinical entity that can cause deleterious end-organ ischemia and culminate in mortality. This is concerning as we are in the era where minimally invasive ... ...

    Abstract Abstract: Hydrophilic polymer embolism from vascular medical devices is an underrecognized clinical entity that can cause deleterious end-organ ischemia and culminate in mortality. This is concerning as we are in the era where minimally invasive procedures are commonplace. Diagnosis is often made retrospectively after obtaining histopathological tissue samples showing endoluminal, cerebriform, amorphous, anucleate, basophilic, nonrefractile, nonpolarizable foreign body material. We detail 2 more cases of cutaneous hydrophilic polymer embolism to underscore its salient clinicopathological features and increase awareness of this important iatrogenic entity.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vulnerability of community-based isolation: a case of concurrent COVID-19 and primary varicella infection.

    Lee, Pei Hua / Lim, Poh Lian

    Singapore medical journal

    2020  Volume 63, Issue 6, Page(s) 348

    MeSH term(s) COVID-19 ; Chickenpox/complications ; Chickenpox/diagnosis ; Herpesvirus 3, Human ; Humans
    Language English
    Publishing date 2020-07-30
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 604319-7
    ISSN 2737-5935 ; 0037-5675
    ISSN (online) 2737-5935
    ISSN 0037-5675
    DOI 10.11622/smedj.2020110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: COVID-19 - where do we go from here?

    Lee, Pei Hua / Vasoo, Shawn

    Singapore medical journal

    2020  Volume 61, Issue 7, Page(s) 343–344

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Global Health ; Humans ; Morbidity/trends ; Pandemics ; Pneumonia, Viral/epidemiology ; Public Health ; SARS-CoV-2 ; Survival Rate/trends
    Keywords covid19
    Language English
    Publishing date 2020-04-17
    Publishing country Singapore
    Document type Editorial
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2020060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Transcriptome-wide association study coupled with eQTL analysis reveals the genetic connection between gene expression and flowering time in Arabidopsis.

    Chien, Pei-Shan / Chen, Pin-Hua / Lee, Cheng-Ruei / Chiou, Tzyy-Jen

    Journal of experimental botany

    2023  Volume 74, Issue 18, Page(s) 5653–5666

    Abstract: Genome-wide association study (GWAS) has improved our understanding of complex traits, but challenges exist in distinguishing causation versus association caused by linkage disequilibrium. Instead, transcriptome-wide association studies (TWAS) detect ... ...

    Abstract Genome-wide association study (GWAS) has improved our understanding of complex traits, but challenges exist in distinguishing causation versus association caused by linkage disequilibrium. Instead, transcriptome-wide association studies (TWAS) detect direct associations between expression levels and phenotypic variations, providing an opportunity to better prioritize candidate genes. To assess the feasibility of TWAS, we investigated the association between transcriptomes, genomes, and various traits in Arabidopsis, including flowering time. The associated genes formerly known to regulate growth allometry or metabolite production were first identified by TWAS. Next, for flowering time, six TWAS-newly identified genes were functionally validated. Analysis of the expression quantitative trait locus (eQTL) further revealed a trans-regulatory hotspot affecting the expression of several TWAS-identified genes. The hotspot covers the FRIGIDA (FRI) gene body, which possesses multiple haplotypes differentially affecting the expression of downstream genes, such as FLOWERING LOCUS C (FLC) and SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1). We also revealed multiple independent paths towards the loss of function of FRI in natural accessions. Altogether, this study demonstrates the potential of combining TWAS with eQTL analysis to identify important regulatory modules of FRI-FLC-SOC1 for quantitative traits in natural populations.
    MeSH term(s) Arabidopsis/metabolism ; Transcriptome ; Quantitative Trait Loci/genetics ; Genome-Wide Association Study ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism
    Chemical Substances Arabidopsis Proteins ; FRI protein, Arabidopsis
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erad262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: ARMS-NF-κB signaling regulates intracellular ROS to induce autophagy-associated cell death upon oxidative stress.

    Liao, Yi-Hua / Wu, June-Tai / Hsieh, I-Chun / Lee, Hsiu-Hsiang / Huang, Pei-Hsin

    iScience

    2023  Volume 26, Issue 2, Page(s) 106005

    Abstract: Ankyrin repeat-rich membrane spanning (ARMS) plays roles in neural development, neuropathies, and tumor formation. Such pleiotropic function of ARMS is often attributed to diverse ARMS-interacting molecules in different cell context. However, it might be ...

    Abstract Ankyrin repeat-rich membrane spanning (ARMS) plays roles in neural development, neuropathies, and tumor formation. Such pleiotropic function of ARMS is often attributed to diverse ARMS-interacting molecules in different cell context. However, it might be achieved by ARMS' effect on global biological mediator like reactive oxygen species (ROS). We established
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Probiotic

    Ho, Shuk-Man / Tsai, Wan-Hua / Lai, Chih-Ho / Chiang, Meng-Hsuan / Lee, Wang-Po / Wu, Hui-Yu / Bai, Pei-Yi / Wu, Tony / Wu, Chia-Lin

    Gut microbes

    2024  Volume 16, Issue 1, Page(s) 2316533

    Abstract: Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the behavior of their hosts and the underlying biogenic ... ...

    Abstract Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the behavior of their hosts and the underlying biogenic effects remain unclear. Lactic acid bacteria, specifically
    MeSH term(s) Animals ; Drosophila ; Lactobacillus ; Drosophila melanogaster ; Mushroom Bodies ; Gastrointestinal Microbiome ; Brain ; Lactate Dehydrogenases
    Chemical Substances Lactate Dehydrogenases (EC 1.1.-)
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2024.2316533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells.

    Lai, Hsiao-Chi / Chen, Pei-Hsuan / Tang, Chia-Hua / Chen, Lee-Wei

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: Adipogenesis has emerged as a new therapeutic target for regulating metabolism and achieving anti-inflammatory and anti-atherosclerotic effects via the release of adiponectin. However, at present, the effects and mechanism of action of dipeptidyl ... ...

    Abstract Adipogenesis has emerged as a new therapeutic target for regulating metabolism and achieving anti-inflammatory and anti-atherosclerotic effects via the release of adiponectin. However, at present, the effects and mechanism of action of dipeptidyl peptidase 4 (DPP4) stimulation on adiponectin production and adipogenesis have not been clarified. Here, we investigated the effects of DPP4 stimulation with monocyte chemoattractant protein-1 (MCP-1) on platelet-derived growth factor receptor alpha (PDGFRα) expression in adipose tissue and blood adiponectin levels. Stromal vascular fractions (SVFs) purified from human subcutaneous adipose tissue and inguinal adipose tissue of obese and diabetic (
    MeSH term(s) Animals ; Humans ; Mice ; Adipogenesis/genetics ; Adiponectin/metabolism ; Dipeptidyl Peptidase 4/genetics ; Gene Expression ; Interleukin-10/genetics ; PPAR gamma/metabolism ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; RNA, Messenger/metabolism ; Stromal Cells/metabolism
    Chemical Substances Adiponectin ; Dipeptidyl Peptidase 4 (EC 3.4.14.5) ; Interleukin-10 (130068-27-8) ; PPAR gamma ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1) ; RNA, Messenger ; Dpp4 protein, mouse (EC 3.4.14.5)
    Language English
    Publishing date 2023-11-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Saturnispora sinensis

    Wei, Yu-Hua / Zhu, Hai-Yan / Guo, Liang-Chen / Luo, Lu-Jun / Lee, Ching-Fu / Hui, Feng-Li / Han, Ying / Zhen, Pan / Hu, Shuang / Han, Pei-Jie / Bai, Feng-Yan

    International journal of systematic and evolutionary microbiology

    2024  Volume 74, Issue 2

    Abstract: A yeast strain (CGMCC 2 ... ...

    Abstract A yeast strain (CGMCC 2.6937
    MeSH term(s) Ascomycota/classification ; Ascomycota/genetics ; Base Composition ; Phylogeny ; Sequence Analysis, DNA ; Wood/microbiology ; Soil Microbiology ; Mycological Typing Techniques
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2002336-4
    ISSN 1466-5034 ; 1466-5026
    ISSN (online) 1466-5034
    ISSN 1466-5026
    DOI 10.1099/ijsem.0.006280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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