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  1. Article ; Online: Synthetic soldiers: Turning T cells into immortal warriors.

    Restifo, Nicholas P / Gattinoni, Luca

    The Journal of experimental medicine

    2024  Volume 221, Issue 5

    Abstract: The creation of synthetic T cell states has captivated the field of cell-based therapies. Wang et al. (https://doi.org/10.1084/jem.20232368) describe how disruption of BCOR and ZC3H12A unleashes anti-tumor T cells with unprecedented lifespan and killer ... ...

    Abstract The creation of synthetic T cell states has captivated the field of cell-based therapies. Wang et al. (https://doi.org/10.1084/jem.20232368) describe how disruption of BCOR and ZC3H12A unleashes anti-tumor T cells with unprecedented lifespan and killer instinct. Are we witnessing the birth of immortal super-soldiers in medicine?
    MeSH term(s) Humans ; Military Personnel ; T-Lymphocytes ; Longevity
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20240258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fine-tuning T cell function through engineered orthogonal chimeric cytokine receptors.

    Kishton, Rigel J / Restifo, Nicholas P

    Cell research

    2022  Volume 32, Issue 11, Page(s) 967–968

    MeSH term(s) Humans ; T-Lymphocytes ; Receptors, Cytokine ; Receptors, Antigen, T-Cell ; Immunotherapy, Adoptive ; Neoplasms
    Chemical Substances Receptors, Cytokine ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2022-08-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-022-00715-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5283: Show issues Location:
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  3. Article ; Online: Big bang theory of stem-like T cells confirmed.

    Restifo, Nicholas P

    Blood

    2014  Volume 124, Issue 4, Page(s) 476–477

    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Cytomegalovirus Infections/immunology ; Graft vs Host Disease/immunology ; Humans ; Immunotherapy, Adoptive ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Severe Combined Immunodeficiency/immunology
    Language English
    Publishing date 2014-07-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2014-06-578989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Strength in Numbers: Identifying Neoantigen Targets for Cancer Immunotherapy.

    Kishton, Rigel J / Lynn, Rachel C / Restifo, Nicholas P

    Cell

    2020  Volume 183, Issue 3, Page(s) 591–593

    Abstract: Targeting cancer neoantigens generated by tumor-exclusive somatic mutations is an attractive yet challenging strategy for the robust and specific elimination of tumor cells by cellular immunotherapy. In this issue of Cell, Wells et al. describe a ... ...

    Abstract Targeting cancer neoantigens generated by tumor-exclusive somatic mutations is an attractive yet challenging strategy for the robust and specific elimination of tumor cells by cellular immunotherapy. In this issue of Cell, Wells et al. describe a consortium-based approach to optimize bioinformatics pipelines to sensitively and accurately predict immunogenic neoantigens from next-generation sequencing data.
    MeSH term(s) Antigens, Neoplasm/genetics ; Epitopes ; High-Throughput Nucleotide Sequencing ; Humans ; Immunotherapy ; Neoplasms/genetics ; Neoplasms/therapy
    Chemical Substances Antigens, Neoplasm ; Epitopes
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Next generation immunotherapy: enhancing stemness of polyclonal T cells to improve anti-tumor activity.

    Kishton, Rigel J / Vodnala, Suman K / Vizcardo, Raul / Restifo, Nicholas P

    Current opinion in immunology

    2021  Volume 74, Page(s) 39–45

    Abstract: The administration of T cells as cellular therapy against advanced cancers has brought clinical benefit to many patients and has progressed the field of cancer research. However, current cell therapy treatments are not curative in most patients, ... ...

    Abstract The administration of T cells as cellular therapy against advanced cancers has brought clinical benefit to many patients and has progressed the field of cancer research. However, current cell therapy treatments are not curative in most patients, particularly in those with solid tumors, and it remains to be seen how broadly and efficaciously they may be applied going forward. Recent research has begun to elucidate key factors that regulate the efficacy of cell therapy in cancer patients, including T cell stemness and the ability to effectively target tumor antigens and overcome tumor heterogeneity. In this review, we discuss key properties of clinically effective anti-cancer T cell therapies along with strategies to improve T cell characteristics to augment clinical efficacy in solid tumors.
    MeSH term(s) Antigens, Neoplasm ; Cell- and Tissue-Based Therapy ; Humans ; Immunologic Factors/therapeutic use ; Immunotherapy ; Immunotherapy, Adoptive ; Neoplasms/pathology ; T-Lymphocytes
    Chemical Substances Antigens, Neoplasm ; Immunologic Factors
    Language English
    Publishing date 2021-10-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2021.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Identifying the source of tumour-infiltrating T cells.

    Kumar Vodnala, Suman / Restifo, Nicholas P

    Nature

    2019  Volume 576, Issue 7787, Page(s) 385–386

    MeSH term(s) CD8-Positive T-Lymphocytes ; Humans ; Lymphocytes, Tumor-Infiltrating ; Neoplasms
    Language English
    Publishing date 2019-12-16
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-019-03670-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A "big data" view of the tumor "immunome".

    Restifo, Nicholas P

    Immunity

    2013  Volume 39, Issue 4, Page(s) 631–632

    Abstract: Tumors are complex masses containing not just neoplastic cells but also stromal cells, neovasculature, and a gamut of immune cells. In this issue, Bindea et al. (2013) identify a surprising new "immune landscape" associated with prolonged disease-free ... ...

    Abstract Tumors are complex masses containing not just neoplastic cells but also stromal cells, neovasculature, and a gamut of immune cells. In this issue, Bindea et al. (2013) identify a surprising new "immune landscape" associated with prolonged disease-free survival.
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; Carcinoma/immunology ; Chemokine CXCL13/immunology ; Colorectal Neoplasms/immunology ; Humans ; Interleukins/immunology ; Neoplasm Recurrence, Local/immunology ; T-Lymphocytes, Helper-Inducer/immunology
    Chemical Substances CXCL13 protein, human ; Chemokine CXCL13 ; Interleukins ; interleukin-21 (MKM3CA6LT1)
    Language English
    Publishing date 2013-10-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2013.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Developing neoantigen-targeted T cell-based treatments for solid tumors.

    Yamamoto, Tori N / Kishton, Rigel J / Restifo, Nicholas P

    Nature medicine

    2019  Volume 25, Issue 10, Page(s) 1488–1499

    Abstract: Stimulating an immune response against cancer through adoptive transfer of tumor-targeting lymphocytes has shown great promise in hematological malignancies, but clinical efficacy against many common solid epithelial cancers remains low. Targeting ' ... ...

    Abstract Stimulating an immune response against cancer through adoptive transfer of tumor-targeting lymphocytes has shown great promise in hematological malignancies, but clinical efficacy against many common solid epithelial cancers remains low. Targeting 'neoantigens'-the somatic mutations expressed only by tumor cells-might enable tumor destruction without causing undue damage to vital healthy tissues. Major challenges to targeting neoantigens with T cells include heterogeneity and variability in antigen processing and presentation of targets by tumors, and an incomplete understanding of which T cell qualities are essential for clinically effective therapies. Finally, the prospect of targeting somatic tumor mutations to promote T cell destruction of cancer must contend with the biology that not all tumor-expressed 'neoepitopes' actually generate neoantigens that can be functionally recognized and provoke an effective immune response. In this Review, we discuss the promise, progress and challenges for improving neoantigen-targeted T cell-based immunotherapies for cancer.
    MeSH term(s) Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Antigens, Neoplasm/therapeutic use ; Epitopes/genetics ; Epitopes/immunology ; Humans ; Immunotherapy ; Mutation ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy ; T-Lymphocytes/immunology
    Chemical Substances Antigens, Neoplasm ; Epitopes
    Language English
    Publishing date 2019-10-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-019-0596-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Silencing stemness in T cell differentiation.

    Henning, Amanda N / Klebanoff, Christopher A / Restifo, Nicholas P

    Science (New York, N.Y.)

    2018  Volume 359, Issue 6372, Page(s) 163–164

    MeSH term(s) Cell Differentiation ; Humans ; Neoplastic Stem Cells
    Language English
    Publishing date 2018-01-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aar5541
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  10. Article ; Online: Can antitumor immunity help to explain "oncogene addiction"?

    Restifo, Nicholas P

    Cancer cell

    2010  Volume 18, Issue 5, Page(s) 403–405

    Language English
    Publishing date 2010-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccr.2010.11.002
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