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Article ; Online: Successful management of biliary atresia in an 834 g preterm infant.

Goto, Hiroki / Iwatani, Sota / Ikuta, Toshihiko / Nakayama, Kurita / Ueda, Masaaki / Hatakeyama, Tadashi / Yoshimoto, Seiji

Pediatrics international : official journal of the Japan Pediatric Society

2024 Volume 65, Issue 1, Page(s) e15665

MeSH term(s)	Infant ; Humans ; Infant, Newborn ; Biliary Atresia/diagnosis ; Biliary Atresia/surgery ; Infant, Premature ; Portoenterostomy, Hepatic ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2024-02-21
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15665
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Article ; Online: G-protein signaling of oxytocin receptor as a potential target for cabazitaxel-resistant prostate cancer.

Hongo, Hiroshi / Kosaka, Takeo / Takayama, Ken-Ichi / Baba, Yuto / Yasumizu, Yota / Ueda, Koji / Suzuki, Yutaka / Inoue, Satoshi / Beltran, Himisha / Oya, Mototsugu

PNAS nexus

2024 Volume 3, Issue 1, Page(s) pgae002

Abstract: Although the treatment armamentarium for patients with metastatic prostate cancer has improved recently, treatment options after progression on cabazitaxel (CBZ) are limited. To identify the mechanisms underlying CBZ resistance and therapeutic targets, ... ...

Abstract	Although the treatment armamentarium for patients with metastatic prostate cancer has improved recently, treatment options after progression on cabazitaxel (CBZ) are limited. To identify the mechanisms underlying CBZ resistance and therapeutic targets, we performed single-cell RNA sequencing of circulating tumor cells (CTCs) from patients with CBZ-resistant prostate cancer. Cells were clustered based on gene expression profiles. In silico screening was used to nominate candidate drugs for overcoming CBZ resistance in castration-resistant prostate cancer. CTCs were divided into three to four clusters, reflecting intrapatient tumor heterogeneity in refractory prostate cancer. Pathway analysis revealed that clusters in two cases showed up-regulation of the oxytocin (OXT) receptor-signaling pathway. Spatial gene expression analysis of CBZ-resistant prostate cancer tissues confirmed the heterogeneous expression of OXT-signaling molecules. Cloperastine (CLO) had significant antitumor activity against CBZ-resistant prostate cancer cells. Mass spectrometric phosphoproteome analysis revealed the suppression of OXT signaling specific to CBZ-resistant models. These results support the potential of CLO as a candidate drug for overcoming CBZ-resistant prostate cancer via the inhibition of OXT signaling.
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ISSN	2752-6542
ISSN (online)	2752-6542
DOI	10.1093/pnasnexus/pgae002
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Article ; Online: Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A > G mutation.

Ueda, Saori / Yagi, Mikako / Tomoda, Ena / Matsumoto, Shinya / Ueyanagi, Yasushi / Do, Yura / Setoyama, Daiki / Matsushima, Yuichi / Nagao, Asuteka / Suzuki, Tsutomu / Ide, Tomomi / Mori, Yusuke / Oyama, Noriko / Kang, Dongchon / Uchiumi, Takeshi

Nucleic acids research

2023 Volume 51, Issue 14, Page(s) 7480–7495

Abstract: The 3243A > G in mtDNA is a representative mutation in mitochondrial diseases ... taurinomethyluridine (τm5U) modification of the mutant mt-tRNALeu(UUR) bearing 3243A > G mutation. The 3243A > G ... with mild respiratory symptoms despite bearing high rate of 3243A > G mutation (>90%) in blood mtDNA ...

Abstract	The 3243A > G in mtDNA is a representative mutation in mitochondrial diseases. Mitochondrial protein synthesis is impaired due to decoding disorder caused by severe reduction of 5-taurinomethyluridine (τm5U) modification of the mutant mt-tRNALeu(UUR) bearing 3243A > G mutation. The 3243A > G heteroplasmy in peripheral blood reportedly decreases exponentially with age. Here, we found three cases with mild respiratory symptoms despite bearing high rate of 3243A > G mutation (>90%) in blood mtDNA. These patients had the 3290T > C haplotypic mutation in addition to 3243A > G pathogenic mutation in mt-tRNALeu(UUR) gene. We generated cybrid cells of these cases to examine the effects of the 3290T > C mutation on mitochondrial function and found that 3290T > C mutation improved mitochondrial translation, formation of respiratory chain complex, and oxygen consumption rate of pathogenic cells associated with 3243A > G mutation. We measured τm5U frequency of mt-tRNALeu(UUR) with 3243A > G mutation in the cybrids by a primer extension method assisted with chemical derivatization of τm5U, showing that hypomodification of τm5U was significantly restored by the 3290T > C haplotypic mutation. We concluded that the 3290T > C is a haplotypic mutation that suppresses respiratory deficiency of mitochondrial disease by restoring hypomodified τm5U in mt-tRNALeu(UUR) with 3243A > G mutation, implying a potential therapeutic measure for mitochondrial disease associated with pathogenic mutations in mt-tRNAs.
MeSH term(s)	Humans ; MELAS Syndrome/genetics ; MELAS Syndrome/metabolism ; RNA, Transfer, Leu/metabolism ; Taurine ; Haplotypes ; Mutation ; DNA, Mitochondrial/genetics ; Mitochondrial Diseases/genetics
Chemical Substances	RNA, Transfer, Leu ; Taurine (1EQV5MLY3D) ; DNA, Mitochondrial
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad591
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Zs.A 1067: Show issues

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Article ; Online: Lysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34.

Nature communications

2023 Volume 14, Issue 1, Page(s) 4494

Abstract: Heart failure is a leading cause of mortality in developed countries. Cell death is a key player in the development of heart failure. Calcium-independent phospholipase ... ...

Abstract	Heart failure is a leading cause of mortality in developed countries. Cell death is a key player in the development of heart failure. Calcium-independent phospholipase A
MeSH term(s)	Rats ; Mice ; Male ; Animals ; Myocytes, Cardiac/metabolism ; Heart Failure/metabolism ; Necrosis/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Ventricular Remodeling ; Mice, Knockout
Chemical Substances	lysophosphatidylserine ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40201-4
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Article: Different Heterotrimeric G Protein Dynamics for Wide-Range Chemotaxis in Eukaryotic Cells.

Kamimura, Yoichiro / Ueda, Masahiro

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 724797

Abstract: Chemotaxis describes directional motility along ambient chemical gradients and has important roles in human physiology and pathology. Typical chemotactic cells, such as neutrophils ... ...

Abstract	Chemotaxis describes directional motility along ambient chemical gradients and has important roles in human physiology and pathology. Typical chemotactic cells, such as neutrophils and
Language	English
Publishing date	2021-08-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.724797
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Article ; Online: Acute arteritis after G-CSF administration.

Kinjo, Yasuyuki / Kurita, Tomoko / Ueda, Taeko / Kagami, Seiji / Matsuura, Yusuke / Yoshino, Kiyoshi

International cancer conference journal

2019 Volume 8, Issue 2, Page(s) 77–80

Abstract: Granulocyte colony-stimulating factor (G-CSF) is commonly used in clinical practice to accelerate ... neutropenia recovery after chemotherapy. G-CSF is a myeloid growth factor produced by monocytes, macrophages ... fibroblasts and endothelial cells. Generally, aortitis and arteritis are not a known side effect of G-CSF and ...

Abstract	Granulocyte colony-stimulating factor (G-CSF) is commonly used in clinical practice to accelerate neutropenia recovery after chemotherapy. G-CSF is a myeloid growth factor produced by monocytes, macrophages, fibroblasts and endothelial cells. Generally, aortitis and arteritis are not a known side effect of G-CSF and is thought to be extremely rare. Here, we present a case of a 77-year-old woman who underwent adjuvant chemotherapy (combined paclitaxel and carboplatin) for ovarian cancer, and then developed acute arteritis after receiving G-CSF. She developed grade 4 neutropenia on day 7 of the third chemotherapy cycle and received six G-CSF administrations. Two days after G-CSF administration, she came down with a high-grade fever that persisted for 2 weeks. Laboratory tests revealed a white blood cell count of 8700 UI, neutrophilic sequestration of 61.5%, and C-reactive protein of 8.43 mg/dl at the highest point of her fever. Considering that we were initially treating neutropenia, we diagnosed a bacterial infection, and she was treated with a course of antibiotics. However, her blood and urinalysis cultures were negative, and antibiotics were ineffective; thus, we performed a computed tomography scan to search for the cause of her persistent fever. The computed tomography scan showed remarkable thickness of the bilateral common carotid artery and the left subclavian artery consistent with arteritis. With cessation of the antibiotics course, she was followed closely without therapy, and her condition resolved in a few days. We conclude that G-CSF induced arteritis due to our exclusion of other probable etiologies.
Language	English
Publishing date	2019-02-13
Publishing country	Singapore
Document type	Case Reports
ISSN	2192-3183
ISSN (online)	2192-3183
DOI	10.1007/s13691-018-00357-z
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Article: Microscopic mechanism of contraction of tension wood G-fiber due to boiling

Yamamoto, Hiroyuki / Sujan, K. C. / Matsuo-Ueda, Miyuki / Yoshida, Masato / Chen, Shuoye

Cellulose. 2022 Sept., v. 29, no. 14

2022

Abstract: Many woody eudicot plants form a secondary xylem composed of gelatinous fibers (G-fibers) called ... gravitropism in response to the strong gravitational stimulus. This is because the G-fiber tends to contract ... in the longitudinal direction as it matures. The matured G-fiber also contracts upon boiling in water (= hygrothermal ...

Abstract	Many woody eudicot plants form a secondary xylem composed of gelatinous fibers (G-fibers) called "tension wood" (TW) along the upper side of the tilted stem or branch. TW generates a large tensile growth stress in the longitudinal direction, allowing the tilted stem or a branch to develop negative-gravitropism in response to the strong gravitational stimulus. This is because the G-fiber tends to contract in the longitudinal direction as it matures. The matured G-fiber also contracts upon boiling in water (= hygrothermal treatment, i.e., HT-treatment), and moisture desorption (= drying treatment). These contractions occur in the cellulose-rich gelatinous layer (G-layer) as an innermost layer of the G-fiber. It is still an unsolved mystery how the G-layer, which is composed of highly crystallized and longitudinally oriented cellulose microfibrils (CMFs), contracts during maturation, boiling, and drying. In the present study, TW specimen of Konara oak (Quercus serrata L.) was subjected to HT-treatment under different temperature and time conditions, and strain due to treatment was followed. Besides, the mass loss due to HT-treatment was also followed. Obtained results are summarized as follows. (1) Green TW specimen of Konara oak contracted in the longitudinal direction when subjected to the HT-treatment at a treatment temperature higher than 40 °C, which eventually converged to a constant value according to each treatment temperature. Magnitude of the longitudinal HTR-strain in the TW specimen was positively correlated with the treatment temperature in the range from 40 to 120 °C, whereas in the normal wood (NW) specimen, it does not occur explicitly when the temperature is less than 100 °C. (2) Both TW and NW specimens showed mass loss when subjected to the HT-treatment. The mass loss rate increased rapidly by the HT-treatment at 120 °C, while it was only slight below 100 °C. There was no significant difference between the mass loss behavior of TW and NW by the HT-treatment. From analyzing those results, physical behavior of CMF and other non-cellulosic matrix components in the G-layer during the HT-treatment was estimated. The discussion was further developed to associate HT-contraction with microscopic mechanisms of the other two characteristic contractions of the G-fiber, i.e., maturation strain and drying shrinkage.
Keywords	Quercus serrata ; cellulose ; cellulose microfibrils ; desorption ; shrinkage ; temperature ; tension wood ; wood
Language	English
Dates of publication	2022-09
Size	p. 7935-7954.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1496831-9
ISSN	1572-882X ; 0969-0239
ISSN (online)	1572-882X
ISSN	0969-0239
DOI	10.1007/s10570-022-04742-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Base editors for simultaneous introduction of C-to-T and A-to-G mutations.

Sakata, Rina C / Ishiguro, Soh / Mori, Hideto / Tanaka, Mamoru / Tatsuno, Kenji / Ueda, Hiroki / Yamamoto, Shogo / Seki, Motoaki / Masuyama, Nanami / Nishida, Keiji / Nishimasu, Hiroshi / Arakawa, Kazuharu / Kondo, Akihiko / Nureki, Osamu / Tomita, Masaru / Aburatani, Hiroyuki / Yachie, Nozomu

Nature biotechnology

2020 Volume 38, Issue 7, Page(s) 865–869

Abstract: ... ACEmax) showed a high median simultaneous C-to-T and A-to-G editing activity at 47 genomic targets ...

Abstract	We describe base editors that combine both cytosine and adenine base-editing functions. A codon-optimized fusion of the cytosine deaminase PmCDA1, the adenosine deaminase TadA and a Cas9 nickase (Target-ACEmax) showed a high median simultaneous C-to-T and A-to-G editing activity at 47 genomic targets. On-target as well as DNA and RNA off-target activities of Target-ACEmax were similar to those of existing single-function base editors.
MeSH term(s)	Adenine/metabolism ; Adenosine Deaminase/genetics ; CRISPR-Associated Protein 9/genetics ; CRISPR-Cas Systems/genetics ; Cytosine/metabolism ; DNA/genetics ; Deoxyribonuclease I/genetics ; Gene Editing ; Genome, Human/genetics ; Glycoproteins/genetics ; Guanine/metabolism ; HEK293 Cells ; Humans ; Mutation/genetics ; Nuclear Proteins/genetics ; RNA/genetics
Chemical Substances	CDAN1 protein, human ; Glycoproteins ; Nuclear Proteins ; Guanine (5Z93L87A1R) ; RNA (63231-63-0) ; Cytosine (8J337D1HZY) ; DNA (9007-49-2) ; CRISPR-Associated Protein 9 (EC 3.1.-) ; Deoxyribonuclease I (EC 3.1.21.1) ; Adenosine Deaminase (EC 3.5.4.4) ; Adenine (JAC85A2161)
Language	English
Publishing date	2020-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1311932-1
ISSN	1546-1696 ; 1087-0156
ISSN (online)	1546-1696
ISSN	1087-0156
DOI	10.1038/s41587-020-0509-0
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Zs.A 2167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 137: Show issues
Zs.MG 43: Show issues

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Article ; Online: Different Heterotrimeric G Protein Dynamics for Wide-Range Chemotaxis in Eukaryotic Cells

Yoichiro Kamimura / Masahiro Ueda

Frontiers in Cell and Developmental Biology, Vol

2021 Volume 9

Abstract: ... of Dictyostelium cells have elucidated the molecular mechanisms of gradient sensing involving G protein coupled ... receptor (GPCR) signaling. GPCR transduces spatial information through its cognate heterotrimeric G protein ... of heterotrimeric G protein in the gradient sensing. In this review, we explain how multiple mechanisms of GPCR ...

Abstract	Chemotaxis describes directional motility along ambient chemical gradients and has important roles in human physiology and pathology. Typical chemotactic cells, such as neutrophils and Dictyostelium cells, can detect spatial differences in chemical gradients over a background concentration of a 105 scale. Studies of Dictyostelium cells have elucidated the molecular mechanisms of gradient sensing involving G protein coupled receptor (GPCR) signaling. GPCR transduces spatial information through its cognate heterotrimeric G protein as a guanine nucleotide change factor (GEF). More recently, studies have revealed unconventional regulation of heterotrimeric G protein in the gradient sensing. In this review, we explain how multiple mechanisms of GPCR signaling ensure the broad range sensing of chemical gradients in Dictyostelium cells as a model for eukaryotic chemotaxis.
Keywords	chemotaxis ; GPCR signaling ; heterotrimeric G protein ; gradient sensing ; dynamic range ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Involvement of G-CSF, IL-6, and cortisol in transient neutrophilia after marathon races.

Ueda, Naho / Musashi, Manabu / Shimoda, Taeko / Kawaguchi, Yuichi / Ohkubo, Iwao / Nakagawa, Yukie

European journal of haematology

2021 Volume 107, Issue 5, Page(s) 583–591

Abstract: ... in all runners just after they reached the goal (mean neutrophils: 13 226/μL). IL-6, G-CSF, and cortisol, but not ... sensitivity C-reactive protein (hsCRP), G-CSF, IL-6, and cortisol. The increase in hsCRP was delayed 6 hours ... from the first increase in neutrophils. Correlations were observed between the neutrophil count and G-CSF, IL-6 ...

Abstract	Objectives: The aim of this study was to clarify the mechanisms of the transient increase in neutrophils after running standard marathon races by measurement of cytokines involved in the production and survival of neutrophils, and cortisol. Methods: Fourteen male runners who participated in the Hokkaido Marathon, which is the sole marathon race held in summer in Japan, and finished the standard marathon were analyzed sequentially from the start until a maximum of 8 days after the finish. Results: Neutrophilia was observed in all runners just after they reached the goal (mean neutrophils: 13 226/μL). IL-6, G-CSF, and cortisol, but not GM-CSF, increased at the same time. Time-course studies with complete blood counts, biochemical markers, cytokines, and cortisol showed transient increases in neutrophils, monocytes, myoglobin, high-sensitivity C-reactive protein (hsCRP), G-CSF, IL-6, and cortisol. The increase in hsCRP was delayed 6 hours from the first increase in neutrophils. Correlations were observed between the neutrophil count and G-CSF, IL-6, and cortisol (G-CSF; r = .667, IL-6; r = .667, cortisol; r = .623). Conclusion: These results suggest that G-CSF is directly involved, and IL-6 is involved via cortisol in the transient neutrophilia that occurs after marathon races.
MeSH term(s)	Adult ; Granulocyte Colony-Stimulating Factor/blood ; Humans ; Hydrocortisone/blood ; Interleukin-6/blood ; Male ; Marathon Running ; Neutrophils/metabolism ; Young Adult
Chemical Substances	IL6 protein, human ; Interleukin-6 ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2021-09-03
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13695
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