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Article ; Online: Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits.

Karami, Ahmad / Fakhri, Sajad / Kooshki, Leila / Khan, Haroon

2022 Volume 27, Issue 19

Abstract: Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin possesses potential biological activities predominantly through the modulation of pivotal signaling pathways involved in ... ...

Abstract	Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin possesses potential biological activities predominantly through the modulation of pivotal signaling pathways involved in inflammation, oxidative stress, and apoptosis. Various imperative biological activities have been suggested for polydatin towards promising therapeutic effects, including anticancer, cardioprotective, anti-diabetic, gastroprotective, hepatoprotective, neuroprotective, anti-microbial, as well as health-promoting roles on the renal system, the respiratory system, rheumatoid diseases, the skeletal system, and women's health. In the present study, the therapeutic targets, biological activities, pharmacological mechanisms, and health benefits of polydatin are reviewed to provide new insights to researchers. The need to develop further clinical trials and novel delivery systems of polydatin is also considered to reveal new insights to researchers.
MeSH term(s)	Female ; Glucosides/pharmacology ; Glucosides/therapeutic use ; Humans ; Polyphenols ; Resveratrol ; Stilbenes/pharmacology ; Stilbenes/therapeutic use
Chemical Substances	Glucosides ; Polyphenols ; Stilbenes ; Resveratrol (Q369O8926L) ; polydatin (XM261C37CQ)
Language	English
Publishing date	2022-10-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27196474
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Zs.MO 81: Show issues

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Article ; Online: Exploiting pivotal mechanisms behind the senescence-like cell cycle arrest in cancer.

Zarneshan, Seyede Nazanin / Fakhri, Sajad / Bachtel, Gabrielle / Bishayee, Anupam

Advances in protein chemistry and structural biology

2023 Volume 135, Page(s) 1–19

Abstract: Senescence-like cell cycle arrest is a critical state of cancer initiation and progression. Senescence is an irreversible cell cycle arrest in response to stress induced by extrinsic and intrinsic stimuli, including oxidative/genotoxic stress, oncogenic ... ...

Abstract	Senescence-like cell cycle arrest is a critical state of cancer initiation and progression. Senescence is an irreversible cell cycle arrest in response to stress induced by extrinsic and intrinsic stimuli, including oxidative/genotoxic stress, oncogenic activation, irradiation, mitochondrial malfunction, or chemotherapeutic drugs. Several signaling pathways are involved in senescence-like cell cycle arrest, which is primarily induced by the activation of p53/p21-dependent apoptotic pathways and suppressing p16INK4A/retinoblastoma protein (pRB)-dependent oncogenic pathways. p21 is necessary for proper cell cycle advancement, is involved in cell death, and mediates p53-dependent cell cycle arrest caused by DNA damage. pRB's role in tumor suppression is through modulation of the G1 checkpoint in the cell cycle, as it has the ability to block S-phase entry and cell growth. The aforementioned pathways are also highly interconnected with significant crosstalk, such as cyclin-dependent kinases (CDK)/cyclin complexes, and the dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex. The primary regulators of transcription are p53 and pRB, which maintain the senescent state through negative control of the cell cycle and process of tumorigenesis. Because CDK inhibitors comprise negative regulators of cell cycle progress, they are fundamental parts of each route. Prolonged overexpression of any of these four fundamental elements (p16, p53, p21, and pRB) suffices to induce senescence, demonstrating how the regulatory DREAM complex causes senescence and how its malfunction results in cell cycle progression. The present chapter aims at revealing the pivotal mechanisms behind the senescence-like cell cycle arrest in cancer.
MeSH term(s)	Humans ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Cell Cycle Checkpoints ; Cell Cycle ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Retinoblastoma Protein/metabolism ; Neoplasms/genetics
Chemical Substances	Tumor Suppressor Protein p53 ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclin-Dependent Kinase Inhibitor p16 ; Retinoblastoma Protein
Language	English
Publishing date	2023-01-30
Publishing country	Netherlands
Document type	Journal Article
ISSN	1876-1631 ; 1876-1623
ISSN (online)	1876-1631
ISSN	1876-1623
DOI	10.1016/bs.apcsb.2022.11.007
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Article ; Online: Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach.

Zarneshan, Seyede Nazanin / Fakhri, Sajad / Khan, Haroon

Pharmacological research

2022 Volume 177, Page(s) 106099

Abstract: Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation, and apoptosis are responsible for the etiology of neuronal diseases, and play ... ...

Abstract	Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation, and apoptosis are responsible for the etiology of neuronal diseases, and play detrimental roles in neuronal cell death and neurodegenerative processes. The diverse pathophysiological pathways influencing NDDs necessitate the discovery of pivotal dysregulated signaling mediators. The current review describes essential functions of protein kinase B (Akt)/cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) pathway as possible therapeutic targets in the pathogenesis of NDDs. Consequently, finding new multi-target agents in regulating Akt/CREB/BDNF and thus associated downstream pathways is a critical factor in combating NDDs. Because of their neuroprotective properties, dietary phytochemicals have shown to be popular nutritional therapy methods. Ginsenosides, the most active ingredient of ginseng, and a secondary metabolite of steroid glycosides and triterpene saponins have been found to have a number of protective effects on the central nervous system (CNS). The protective roles of ginsenosides in CNS are potentially passing through Akt/CREB/BDNF pathway towards neuroprotective responses. In the present study, Akt/CREB/BDNF pathway is targeted by ginsenosides and associated nanoformulations towards potential neuroprotective effects.
MeSH term(s)	Aged ; Brain-Derived Neurotrophic Factor/metabolism ; Ginsenosides/pharmacology ; Ginsenosides/therapeutic use ; Humans ; Neurodegenerative Diseases/drug therapy ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Chemical Substances	Brain-Derived Neurotrophic Factor ; Ginsenosides ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-01-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2022.106099
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Zs.A 721: Show issues

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Article ; Online: Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals.

Fakhri, Sajad / Moradi, Seyed Zachariah / Abbaszadeh, Fatemeh / Faraji, Farahnaz / Amirian, Roshanak / Sinha, Dona / McMahon, Emily G / Bishayee, Anupam

Cancer metastasis reviews

2024 Volume 43, Issue 1, Page(s) 261–292

Abstract: Plasticity of phenotypic traits refers to an organism's ability to change in response to environmental stimuli. As a result, the response may alter an organism's physiological state, morphology, behavior, and phenotype. Phenotypic plasticity in cancer ... ...

Abstract	Plasticity of phenotypic traits refers to an organism's ability to change in response to environmental stimuli. As a result, the response may alter an organism's physiological state, morphology, behavior, and phenotype. Phenotypic plasticity in cancer cells describes the considerable ability of cancer cells to transform phenotypes through non-genetic molecular signaling activities that promote therapy evasion and tumor metastasis via amplifying cancer heterogeneity. As a result of metastable phenotypic state transitions, cancer cells can tolerate chemotherapy or develop transient adaptive resistance. Therefore, new findings have paved the road in identifying factors and agents that inhibit or suppress phenotypic plasticity. It has also investigated novel multitargeted agents that may promise new effective strategies in cancer treatment. Despite the efficiency of conventional chemotherapeutic agents, drug toxicity, development of resistance, and high-cost limit their use in cancer therapy. Recent research has shown that small molecules derived from natural sources are capable of suppressing cancer by focusing on the plasticity of phenotypic responses. This systematic, comprehensive, and critical review analyzes the current state of knowledge regarding the ability of phytocompounds to target phenotypic plasticity at both preclinical and clinical levels. Current challenges/pitfalls, limitations, and future perspectives are also discussed.
MeSH term(s)	Humans ; Epithelial-Mesenchymal Transition/physiology ; Neoplasms/drug therapy ; Neoplasms/pathology ; Signal Transduction ; Adaptation, Physiological ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use
Chemical Substances	Phytochemicals
Language	English
Publishing date	2024-01-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	604857-2
ISSN	1573-7233 ; 0167-7659
ISSN (online)	1573-7233
ISSN	0167-7659
DOI	10.1007/s10555-023-10161-8
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Zs.A 1812: Show issues

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Article ; Online: Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review.

Jalili, Cyrus / Kiani, Amir / Gholami, Mohammadreza / Bahrehmand, Fariborz / Fakhri, Sajad / Kakehbaraei, Somayeh / Kakebaraei, Seyran

IET nanobiotechnology

2023 Volume 17, Issue 3, Page(s) 154–170

Abstract: Alzheimer's disease (AD) is one of the chief neurological difficulties in the aged population, identified through dementia, memory disturbance, and reduced cognitive abilities. β-amyloid (Aβ) plaques aggregations, generation of reactive oxygen species, ... ...

Abstract	Alzheimer's disease (AD) is one of the chief neurological difficulties in the aged population, identified through dementia, memory disturbance, and reduced cognitive abilities. β-amyloid (Aβ) plaques aggregations, generation of reactive oxygen species, and mitochondrial dysfunction are among the major signs of AD. Regarding the urgent need for the development of novel treatments for neurodegenerative diseases, researchers have recently perused the function of natural phytobioactive combinations, such as resveratrol (RES), in vivo and in vitro (animal models of AD). Investigations have shown the neuroprotective action of RES. This compound can be encapsulated by several methods (e.g. polymeric nanoparticles (NPs), solid lipid nanoparticles, Micelles, and liposomes). This antioxidant compound, however, barely crosses the blood-brain barrier (BBB), thereby limiting its bioavailability and stability at the target sites in the brain. Thanks to nanotechnology, the efficiency of AD therapy can be improved by encapsulating the drugs in a NP with a controlled size (1-100 nm). This article addressed the use of RES, as a Phytobioactive compound, to decrease the oxidative stress. Encapsulation of this compound in the form of nanocarriers to treat neurological diseases to improve BBB crossing is also discussed.
MeSH term(s)	Animals ; Alzheimer Disease/drug therapy ; Resveratrol/therapeutic use ; Brain/metabolism ; Amyloid beta-Peptides ; Blood-Brain Barrier/metabolism ; Nanoparticles
Chemical Substances	Resveratrol (Q369O8926L) ; Amyloid beta-Peptides
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2264529-9
ISSN	1751-875X ; 1751-875X
ISSN (online)	1751-875X
ISSN	1751-875X
DOI	10.1049/nbt2.12127
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Article: The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases.

Iranpanah, Amin / Kooshki, Leila / Moradi, Seyed Zachariah / Saso, Luciano / Fakhri, Sajad / Khan, Haroon

Pharmaceutics

2023 Volume 15, Issue 3

Abstract: As major public health concerns associated with a rapidly growing aging population, neurodegenerative diseases (NDDs) and neurological diseases are important causes of disability and mortality. Neurological diseases affect millions of people worldwide. ... ...

Abstract	As major public health concerns associated with a rapidly growing aging population, neurodegenerative diseases (NDDs) and neurological diseases are important causes of disability and mortality. Neurological diseases affect millions of people worldwide. Recent studies have indicated that apoptosis, inflammation, and oxidative stress are the main players of NDDs and have critical roles in neurodegenerative processes. During the aforementioned inflammatory/apoptotic/oxidative stress procedures, the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway plays a crucial role. Considering the functional and structural aspects of the blood-brain barrier, drug delivery to the central nervous system is relatively challenging. Exosomes are nanoscale membrane-bound carriers that can be secreted by cells and carry several cargoes, including proteins, nucleic acids, lipids, and metabolites. Exosomes significantly take part in the intercellular communications due to their specific features including low immunogenicity, flexibility, and great tissue/cell penetration capabilities. Due to their ability to cross the blood-brain barrier, these nano-sized structures have been introduced as proper vehicles for central nervous system drug delivery by multiple studies. In the present systematic review, we highlight the potential therapeutic effects of exosomes in the context of NDDs and neurological diseases by targeting the PI3K/Akt/mTOR signaling pathway.
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15031006
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Article ; Online: The regulatory role of non-coding RNAs and their interactions with phytochemicals in neurodegenerative diseases: a systematic review.

Fakhri, Sajad / Darvish, Ebrahim / Narimani, Fatemeh / Moradi, Seyed Zachariah / Abbaszadeh, Fatemeh / Khan, Haroon

Briefings in functional genomics

2023 Volume 22, Issue 2, Page(s) 143–160

Abstract: Neurodegenerative diseases (NDDs) are on the rise in the world. Therefore, it is a critical issue to reveal the precise pathophysiological mechanisms and novel therapeutic strategies to deal with such conditions. Passing through different mechanisms, non- ...

Abstract	Neurodegenerative diseases (NDDs) are on the rise in the world. Therefore, it is a critical issue to reveal the precise pathophysiological mechanisms and novel therapeutic strategies to deal with such conditions. Passing through different mechanisms, non-coding RNAs (ncRNAs) play a pivotal role in NDDs through various mechanisms, by changing the expression of some genes, interference with protein translation and alterations in some signaling pathways. It urges the need to introduce novel strategies and therapeutic agents with multi-targeting potentials. Phytochemicals are hopeful antioxidants and anti-inflammatory agents with promising modulatory roles on dysregulated signaling pathways and protein translation during NDDs. In this study, the role of ncRNAs (e.g. lncRNAs, miRNA, siRNAs and piRNAs) was highlighted in NDDs. This study also aimed to investigate the role of phytochemicals (phenolic compounds, alkaloids, terpenoids and sulfur compounds) in the modulation of ncRNAs during NDDs such as Alzheimer's disease, Parkinson's disease, epilepsy, depression and amyotrophic lateral sclerosis.
MeSH term(s)	Humans ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Parkinson Disease/drug therapy ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; RNA, Untranslated/genetics ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use
Chemical Substances	RNA, Untranslated ; Phytochemicals
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2540916-5
ISSN	2041-2657 ; 2041-2649 ; 2041-2647
ISSN (online)	2041-2657
ISSN	2041-2649 ; 2041-2647
DOI	10.1093/bfgp/elac055
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Zs.A 6076: Show issues

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Article ; Online: Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review.

Fakhri, Sajad / Moradi, Seyed Zachariah / Faraji, Farahnaz / Kooshki, Leila / Webber, Kassidy / Bishayee, Anupam

Cancer metastasis reviews

2023 Volume 43, Issue 1, Page(s) 501–574

Abstract: Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia-inducible factor-1 (HIF-1) is responsible for stimulating several target ...

Abstract	Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia-inducible factor-1 (HIF-1) is responsible for stimulating several target genes and dysregulated pathways in tumor invasion and migration. Therefore, targeting HIF-1 pathway and cross-talked mediators seems to be a novel strategy in cancer prevention and treatment. In recent decades, tremendous efforts have been made to develop multi-targeted therapies to modulate several dysregulated pathways in cancer angiogenesis, invasion, and metastasis. In this line, natural compounds have shown a bright future in combating angiogenic and metastatic conditions. Among the natural secondary metabolites, we have evaluated the critical potential of phenolic compounds, terpenes/terpenoids, alkaloids, sulfur compounds, marine- and microbe-derived agents in the attenuation of HIF-1, and interconnected pathways in fighting tumor-associated angiogenesis and invasion. This is the first comprehensive review on natural constituents as potential regulators of HIF-1 and interconnected pathways against cancer angiogenesis and metastasis. This review aims to reshape the previous strategies in cancer prevention and treatment.
MeSH term(s)	Humans ; Cell Line, Tumor ; Hypoxia ; Hypoxia-Inducible Factor 1 ; Hypoxia-Inducible Factor 1, alpha Subunit ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neovascularization, Pathologic ; Signal Transduction
Chemical Substances	Hypoxia-Inducible Factor 1 ; Hypoxia-Inducible Factor 1, alpha Subunit
Language	English
Publishing date	2023-10-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	604857-2
ISSN	1573-7233 ; 0167-7659
ISSN (online)	1573-7233
ISSN	0167-7659
DOI	10.1007/s10555-023-10136-9
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Zs.A 1812: Show issues

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Article ; Online: Protective effect of a hydromethanolic extract from Fraxinus excelsior L. bark against a rat model of aluminum chloride-induced Alzheimer's disease: Relevance to its anti-inflammatory and antioxidant effects.

Iranpanah, Amin / Fakhri, Sajad / Bahrami, Gholamreza / Majnooni, Mohammad Bagher / Gravandi, Mohammad Mehdi / Taghavi, Sara / Badrbani, Mehdi Azadi / Amirian, Roshanak / Farzaei, Mohammad Hosein

Journal of ethnopharmacology

2024 Volume 323, Page(s) 117708

Abstract: Ethnopharmacological relevance: Fraxinus excelsior L. (FE), commonly known as the ash, belongs to the Oleaceae family and has shown several pharmacological and biological properties, such as antioxidant, immunomodulatory, neuroprotective, and anti- ... ...

Abstract	Ethnopharmacological relevance: Fraxinus excelsior L. (FE), commonly known as the ash, belongs to the Oleaceae family and has shown several pharmacological and biological properties, such as antioxidant, immunomodulatory, neuroprotective, and anti-inflammatory effects. It has also attracted the most attention toward neuroinflammation. Moreover, FE bark and leaves have been used to treat neurological disorders, aging, neuropathic pain, urinary complaints, and articular pain in traditional and ethnomedicine. Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder resulting from the involvement of amyloid-beta, metal-induced oxidative stress, and neuroinflammation. Aim of the study: The objective of the current study was to assess the neuroprotective effects of hydromethanolic extract from FE bark in an AlCl Materials and methods: The maceration process was utilized to prepare the hydromethanolic extract of FE bark, and characterized by LC-MS/MS. To assess the anti-AD effects of the FE extract, rats were categorized into five different groups, AlCl Results: LC-MS/MS analysis indicated the presence of coumarins, including isofraxidin7-O-diglucoside in the methanolic extract of FE as a new isofraxidin derivative in this genus. FE significantly improved memory and cognitive function, maintained weight, prevented neuronal damages, and preserved the hippocampus's histological features, as demonstrated by behavioral tests and histopathological analysis. FE increased anti-inflammatory MMP-2 activity, whereas it decreased that of inflammatory MMP-9. Moreover, FE increased plasma antioxidant capacity by enhancing CAT and GSH while decreasing nitrite levels in the serum of treated groups. In comparison between the treated groups, the rats that received high doses of the FE extract (200 mg/kg) showed the highest therapeutic effect. Conclusion: FE rich in coumarins could be an effective anti-AD adjunct agent, passing through antioxidant and anti-inflammatory pathways. These results encourage further studies for the development of this extract as a promising agent in preventing, managing, or treating AD and related diseases.
MeSH term(s)	Rats ; Animals ; Aluminum Chloride/pharmacology ; Aluminum Chloride/therapeutic use ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Antioxidants/metabolism ; Alzheimer Disease/chemically induced ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Fraxinus/metabolism ; Neuroinflammatory Diseases ; Plant Bark/metabolism ; Chromatography, Liquid ; Rats, Wistar ; Disease Models, Animal ; Tandem Mass Spectrometry ; Oxidative Stress ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Coumarins/pharmacology ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use
Chemical Substances	Aluminum Chloride (3CYT62D3GA) ; Antioxidants ; Anti-Inflammatory Agents ; Coumarins ; Neuroprotective Agents
Language	English
Publishing date	2024-01-04
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117708
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Zs.A 1494: Show issues

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Article: Zinc Slag as a Partial or Total Replacement for Mineral Filler in Warm Mix Asphalt and Its Effects on Self-Healing Capacity and Performance Characteristics.

Fakhri, Mansour / Javadi, Sajad / Sassani, Alireza / Torabi-Dizaji, Mohsen

Materials (Basel, Switzerland)

2022 Volume 15, Issue 3

Abstract: Utilizing the self-healing properties of asphalt materials is a way to improve the service life of asphalt pavements. Enhanced self-healing capabilities can be achieved through mixture modification. Using waste or by-product materials to modify asphalt ... ...

Abstract	Utilizing the self-healing properties of asphalt materials is a way to improve the service life of asphalt pavements. Enhanced self-healing capabilities can be achieved through mixture modification. Using waste or by-product materials to modify asphalt mixtures can provide further environmental benefits. However, with a given mixture modification method, the resulting materials should be adequately vetted to ensure that enhanced self-healing capability is not attained at the expense of the mixture's overall performance. This research aims to investigate the feasibility of using zinc slag filler to enhance the self-healing properties of warm mix asphalt (WMA) and evaluates the rutting susceptibility and moisture-resistance of the slag-modified mixtures. To this end, zinc slag filler was used to replace a portion of the mineral filler at different replacement rates in WMA mixtures. Self-healing capabilities of the resulting mixtures were studied under microwave induction heating. The influence of zinc slag modification on asphalt mixture's characteristics and conventional performance indicators were evaluated by the Texas boiling test, the three-point bending test, and the Kim test (a deformation test). Also, the adhesion between bitumen and aggregate was evaluated using the broken sample from the three-point bending test and digital image analysis. The results of self-healing tests demonstrated that the heat generation capability of the specimens increased with filler replacement rate, such that the specimens with 100% of the mineral filler replaced with slag showed the highest heating performance. Zinc slag filler showed the potential to improve the moisture resistance of WMA by enhancing aggregate-bitumen adhesion and thus reducing stripping. The slag-modified WMA samples exhibited better tensile strength ratio (TSR) and deformation resistance than their non-modified equivalents.
Language	English
Publishing date	2022-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15030736
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