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  1. Article: Ethics Challenges in Pediatric Research.

    Blake, Kathryn V

    The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

    2023  Volume 28, Issue 8, Page(s) 680–686

    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028543-4
    ISSN 1551-6776
    ISSN 1551-6776
    DOI 10.5863/1551-6776-28.8.680
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  2. Article ; Online: Lack of awareness and knowledge of NHLBI 2020 Asthma Focused Updates.

    Lee, Jenny J / Baptist, Alan P / Blake, Kathryn V

    The journal of allergy and clinical immunology. In practice

    2023  Volume 12, Issue 1, Page(s) 226–228.e2

    MeSH term(s) United States/epidemiology ; Humans ; National Heart, Lung, and Blood Institute (U.S.) ; Asthma/epidemiology
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.09.035
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  3. Article ; Online: Telemedicine and adherence monitoring in children with asthma.

    Blake, Kathryn V

    Current opinion in pulmonary medicine

    2020  Volume 27, Issue 1, Page(s) 37–44

    Abstract: Purpose of review: Telemedicine, defined as synchronous video visits between a provider and a child with asthma, often takes place in the school setting. This review examines the new electronic sensors for adherence monitoring and studies that used ... ...

    Abstract Purpose of review: Telemedicine, defined as synchronous video visits between a provider and a child with asthma, often takes place in the school setting. This review examines the new electronic sensors for adherence monitoring and studies that used telemedicine in the school setting to improve asthma outcomes.
    Recent findings: School-based telemedicine provides an important service to families of school-aged children who have difficulty due to time and distance in planning and keeping in-person appointments with primary or specialty providers. Significant improvements in objective measures of asthma control are inconsistently observed although caregiver and parent quality of life and child self-management behaviors are improved and satisfaction is high. Assessment and outcomes related to adherence are mentioned in studies but results are not often reported. However, it appears that adherence interventions are beneficial while maintained but the effects are not sustained upon intervention discontinuation.
    Summary: The school setting provides a convenient and suitable environment to conduct telemedicine visits between school-aged children and their primary care or specialty provider. Electronic adherence sensors allow review of controller and rescue medication use through a cloud-based dashboard and provides an opportunity for real-time assessment and intervention by providers to improve asthma outcomes.
    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Asthma/psychology ; Asthma/therapy ; Caregivers/statistics & numerical data ; Child ; Humans ; Medication Adherence/statistics & numerical data ; Parents/education ; Quality of Life ; Telemedicine/organization & administration
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2020-10-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000739
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  4. Article ; Online: Considerations for the Child with Nonatopic Asthma.

    Vazquez Garcia, Gerardo / Blake, Kathryn

    Pediatric allergy, immunology, and pulmonology

    2021  Volume 33, Issue 1, Page(s) 39–42

    Abstract: Asthma guidelines provide clinicians with evidence-based management strategies for this chronic condition. The preferred therapy for patient with persistent asthma is inhaled corticosteroids. However, ∼40% of the patients with persistent asthma continue ... ...

    Abstract Asthma guidelines provide clinicians with evidence-based management strategies for this chronic condition. The preferred therapy for patient with persistent asthma is inhaled corticosteroids. However, ∼40% of the patients with persistent asthma continue to present with symptoms while treated according to the guidelines. Multiple factors are being explored to explain the variability in response to inhaled corticosteroids including asthma phenotype and genetic predisposition among others. The nonatopic asthma phenotype has been described in the literature. These patients tend to have milder symptoms of asthma and typically outgrow their asthma by adolescence. They present with chronic asthma symptoms in the absence of a positive allergy test, either skin prick test or specific immunoglobulin E blood test. Although patients with nonatopic asthma share many characteristics with patients with atopic asthma, there are several studies that suggest a different inflammatory pathway may be involved in their pathophysiology. Therefore, it is possible that children with nonatopic asthma could respond differently to inhaled corticosteroids compared with those with atopic asthma. Currently there is a variable definition of this phenotype. Furthermore, there is a paucity of therapeutic trial directed toward the patients with nonatopic asthma specifically. Future research should be guided toward identifying the inflammatory pathways in nonatopic asthma and potential phenotype-guided therapies.
    MeSH term(s) Allergy and Immunology/standards ; Anti-Asthmatic Agents/administration & dosage ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/immunology ; Asthma/physiopathology ; Bronchi/drug effects ; Bronchi/immunology ; Bronchi/physiopathology ; Child ; Chronic Disease/therapy ; Diagnosis, Differential ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/drug therapy ; Gastroesophageal Reflux/immunology ; Humans ; Mometasone Furoate/administration & dosage ; Practice Guidelines as Topic ; Proton Pump Inhibitors/administration & dosage ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/immunology ; Respiratory Sounds/drug effects ; Respiratory Sounds/immunology ; Respiratory Sounds/physiopathology ; Tiotropium Bromide/administration & dosage ; Treatment Outcome
    Chemical Substances Anti-Asthmatic Agents ; Proton Pump Inhibitors ; Mometasone Furoate (04201GDN4R) ; Tiotropium Bromide (XX112XZP0J)
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2566338-0
    ISSN 2151-3228 ; 2151-321X
    ISSN (online) 2151-3228
    ISSN 2151-321X
    DOI 10.1089/ped.2019.1104
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  5. Article ; Online: A digital health application for managing pediatric asthma: Use and benefits.

    Lewis, Kandia / Zettler-Greeley, Cynthia M / Blake, Kathryn V / Milkes, Amy

    Informatics for health & social care

    2023  Volume 48, Issue 4, Page(s) 370–386

    Abstract: Childhood asthma is a common and serious chronic lung disease. Mobile health (mHealth) technologies may assist clinical providers, caregivers, and children in managing pediatric asthma. This study evaluated the Nemours app, an mHealth application. We ... ...

    Abstract Childhood asthma is a common and serious chronic lung disease. Mobile health (mHealth) technologies may assist clinical providers, caregivers, and children in managing pediatric asthma. This study evaluated the Nemours app, an mHealth application. We examined: a) frequency of data access by providers and feature use by caregivers (parents/legal guardians) of 5-11-year-old children diagnosed with asthma and b) whether utilization was related to benefits. Nine providers (allergists/pulmonologists) and 80 patient-families (caregiver/child dyads) participated. Two-years of retrospective data were obtained for asthma control, in-person urgent healthcare utilization, and app utilization. Six-months of prospective data included asthma control, in-person urgent healthcare utilization, app utilization, surveys, and health literacy screeners. Providers (56%) accessed app data and caregivers (61%) utilized the app. Caregiver use of messaging feature predicted gains in health literacy scores (
    MeSH term(s) Child ; Humans ; Child, Preschool ; Prospective Studies ; Retrospective Studies ; Asthma/therapy ; Delivery of Health Care ; Telemedicine ; Mobile Applications
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2431238-1
    ISSN 1753-8165 ; 1753-8157
    ISSN (online) 1753-8165
    ISSN 1753-8157
    DOI 10.1080/17538157.2023.2250435
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  6. Article ; Online: ASO Visual Abstract: Adjuvant Chemotherapy with or Without Radiotherapy for Resected Pancreatic Cancer Following Multiagent Neoadjuvant Chemotherapy.

    Franklin, Oskar / Sugawara, Toshitaka / Ross, Richard Blake / Franco, Salvador Rodriguez / Colborn, Kathryn / Karam, Sana / Schulick, Richard D / Chiaro, Marco Del

    Annals of surgical oncology

    2024  

    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-15335-4
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  7. Article ; Online: A Single Inhaler Combining a Corticosteroid and Long-Acting Beta-2 Agonist for Maintenance with Additional Doses for Reliever Therapy (SMART): Obstacles for Asthma Patients in the USA.

    Hendeles, Leslie / Blake, Kathryn V / Galbreath, Ashley

    Pediatric allergy, immunology, and pulmonology

    2021  Volume 34, Issue 2, Page(s) 73–75

    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; Asthma/drug therapy ; Humans ; Nebulizers and Vaporizers ; United States
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2566338-0
    ISSN 2151-3228 ; 2151-321X
    ISSN (online) 2151-3228
    ISSN 2151-321X
    DOI 10.1089/ped.2021.0052
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  8. Article ; Online: Improving adherence to asthma medications: current knowledge and future perspectives.

    Blake, Kathryn V

    Current opinion in pulmonary medicine

    2016  Volume 23, Issue 1, Page(s) 62–70

    Abstract: Purpose of review: Poor adherence to asthma controller medications, particularly inhaled corticosteroids, has been well known for decades and is a major cause of uncontrolled asthma and increased healthcare utilization. This review presents recent ... ...

    Abstract Purpose of review: Poor adherence to asthma controller medications, particularly inhaled corticosteroids, has been well known for decades and is a major cause of uncontrolled asthma and increased healthcare utilization. This review presents recent evidence on factors leading to nonadherence in specific age groups, parents of young children, adolescents and young adults, adults, and the elderly. Novel management strategies including electronic sensors with associated smart phone applications for adherence improvement are discussed.
    Recent findings: Interventions to promote adherence must include a focus on issues important to the patient. Parents are concerned about adverse effects and the difficulty of medication administration in their child; adolescents and young adults need help with organizational skills and social barriers; adults may be more receptive to the need for daily medication after an acute exacerbation and acceptance of their disease; the elderly may have medication misuse issues associated with cognitive decline and other comorbidities related to aging. In all age groups, a trusting relationship with the provider is the key. New digital devices to track adherence may provide feedback to the patient and provider to evaluate and to promote adherence.
    Summary: Personalized approaches are required to address adherence barriers in target populations. Research on specific needs and barriers in target populations and development of appropriate strategies for use of new digital technology for adherence monitoring is needed.
    MeSH term(s) Asthma/drug therapy ; Humans ; Medication Adherence ; Parents
    Language English
    Publishing date 2016-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000334
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  9. Article ; Online: Deep gray matter substructure volumes and depressive symptoms in a large multiple sclerosis cohort.

    Hu, Chen / Dewey, Blake E / Mowry, Ellen M / Fitzgerald, Kathryn C

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2023  Volume 29, Issue 7, Page(s) 809–818

    Abstract: Background: Consistent findings on underlying brain features or specific structural atrophy patterns contributing to depression in multiple sclerosis (MS) are limited.: Objective: To investigate how deep gray matter (DGM) features predict depressive ... ...

    Abstract Background: Consistent findings on underlying brain features or specific structural atrophy patterns contributing to depression in multiple sclerosis (MS) are limited.
    Objective: To investigate how deep gray matter (DGM) features predict depressive symptom trajectories in MS patients.
    Methods: We used data from the MS Partners Advancing Technology and Health Solutions (MS PATHS) network in which standardized patient information and outcomes are collected. We performed whole-brain segmentation using SLANT-CRUISE. We assessed if DGM structures were associated with elevated depressive symptoms over follow-up and with depressive symptom phenotypes.
    Results: We included 3844 participants (average age: 46.05 ± 11.83 years; 72.7% female) of whom 1905 (49.5%) experienced ⩾1 periods of elevated depressive symptoms over 2.6 ± 0.9 years mean follow-up. Higher caudate, putamen, accumbens, ventral diencephalon, thalamus, and amygdala volumes were associated with lower odds of elevated depressive symptoms over follow-up (odds ratio (OR) range per 1
    Conclusion: Lower DGM volumes were associated with depressive symptom trajectories in MS.
    MeSH term(s) Female ; Male ; Humans ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/pathology ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Depression/etiology ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Brain/pathology ; Atrophy/pathology
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585221148144
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  10. Article ; Online: The 2020 Focused Updates to the NIH Asthma Management Guidelines: Key Points for Pediatricians.

    Cloutier, Michelle M / Teach, Stephen J / Lemanske, Robert F / Blake, Kathryn V

    Pediatrics

    2021  Volume 147, Issue 6

    MeSH term(s) Asthma/therapy ; Child, Preschool ; Humans ; Infant ; Pediatrics
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Journal Article ; Practice Guideline ; Research Support, N.I.H., Extramural
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-050286
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