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  1. Article ; Online: Astrocytes and the modulation of sleep.

    Haydon, Philip G

    Current opinion in neurobiology

    2017  Volume 44, Page(s) 28–33

    Abstract: Astrocytes are being identified as having multiple roles in sleep. Initially they were shown to modulate the process of sleep homeostasis through the release of adenosine which acts on adenosine A1 receptors (A1R) to promote sleep drive. More recent ... ...

    Abstract Astrocytes are being identified as having multiple roles in sleep. Initially they were shown to modulate the process of sleep homeostasis through the release of adenosine which acts on adenosine A1 receptors (A1R) to promote sleep drive. More recent studies indicate that the astrocyte also plays pivotal, sleep-dependent roles in 'cleaning the brain' during sleep. This work indicates that a glymphatic pathway that critically relies on astrocytic aquaporin 4, is able to flush solutes from the brain and that deficits in this pathway may contribute to Alzheimer's disease. Finally, astrocytes are known to play important metabolic roles and provide energy on demand to neurons through an astrocyte-neuron shuttle. Given that the time course of astrocytic function is orders of magnitude slower than that of the neuron, this non-neuronal cell is perfectly tuned to modulating slow, state-dependent changes in the brain.
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2017.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3260: Show issues Location:
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  2. Article: The Evolving View of Astrocytes.

    Haydon, Philip G

    Cerebrum : the Dana forum on brain science

    2016  Volume 2016

    Abstract: Did you know that glial cells are more numerous than neurons in the brain? Scientists have found that one type of glial cell that is prevalent in the cortex-the astrocyte-communicates with its brethren, sends information to neurons, and controls blood ... ...

    Abstract Did you know that glial cells are more numerous than neurons in the brain? Scientists have found that one type of glial cell that is prevalent in the cortex-the astrocyte-communicates with its brethren, sends information to neurons, and controls blood flow to regions of brain activity. Because of all these properties, and since the cortex is believed responsible for cognition, the role of astrocytes in sleep, learning, and memory is being determined
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2251230-5
    ISSN 1524-6205
    ISSN 1524-6205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Erratum: Correction Notice: Obtaining Acute Brain Slices.

    Papouin, Thomas / Haydon, Philip G

    Bio-protocol

    2018  Volume 8, Issue 13

    Abstract: This corrects the article .]. ...

    Abstract [This corrects the article .].
    Language English
    Publishing date 2018-07-05
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.2945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Obtaining Acute Brain Slices.

    Papouin, Thomas / Haydon, Philip G

    Bio-protocol

    2018  Volume 8, Issue 2

    Abstract: Obtaining acute brain slices for electrophysiology or amperometric recordings has become a routine procedure in most labs in the field of neuroscience. Yet, protocols describing the step by step process are scarce, in particular for routine acute ... ...

    Abstract Obtaining acute brain slices for electrophysiology or amperometric recordings has become a routine procedure in most labs in the field of neuroscience. Yet, protocols describing the step by step process are scarce, in particular for routine acute preparations such as from the mouse hippocampus. Here we provide a detailed protocol for the dissection, extraction and acute slicing of the mouse brain, including tips and list of material required.
    Language English
    Publishing date 2018-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.2699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: D-serine Measurements in Brain Slices or Other Tissue Explants.

    Papouin, Thomas / Haydon, Philip G

    Bio-protocol

    2018  Volume 8, Issue 2

    Abstract: D-serine is an atypical amino acid present in the mammalian body (most amino acids in the mammalian body are L-isomers) that is mostly known in neuroscience for its role as a co-agonist controlling the N-methyl D-aspartate receptor (NMDAR). D-serine ... ...

    Abstract D-serine is an atypical amino acid present in the mammalian body (most amino acids in the mammalian body are L-isomers) that is mostly known in neuroscience for its role as a co-agonist controlling the N-methyl D-aspartate receptor (NMDAR). D-serine levels are decreased in patients with schizophrenia and this is thought to mediate, at least in part, the hypofunction of NMDARs that is central to the glutamate hypothesis for the etiology of this neuropsychiatric disorder. D-serine detection was first established using high performance liquid chromatography, a costly and complex technique that requires high levels of expertise. But with the increasing interest in this unconventional amino acid, there is an increasing need for easier, cheaper and more accessible detection methods. Here we describe the amperometric, biosensor-based method we employed in a recent publication (Papouin
    Language English
    Publishing date 2018-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.2698
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  6. Article ; Online: 3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease.

    Lomoio, Selene / Pandey, Ravi S / Rouleau, Nicolas / Menicacci, Beatrice / Kim, WonHee / Cantley, William L / Haydon, Philip G / Bennett, David A / Young-Pearse, Tracy L / Carter, Gregory W / Kaplan, David L / Tesco, Giuseppina

    Molecular psychiatry

    2023  Volume 28, Issue 12, Page(s) 5390–5401

    Abstract: Several iPSC-derived three-dimensional (3D) cultures have been generated to model Alzheimer's disease (AD). While some AD-related phenotypes have been identified across these cultures, none of them could recapitulate multiple AD-related hallmarks in one ... ...

    Abstract Several iPSC-derived three-dimensional (3D) cultures have been generated to model Alzheimer's disease (AD). While some AD-related phenotypes have been identified across these cultures, none of them could recapitulate multiple AD-related hallmarks in one model. To date, the transcriptomic features of these 3D models have not been compared with those of human AD brains. However, these data are crucial to understanding the pertinency of these models for studying AD-related pathomechanisms over time. We developed a 3D bioengineered model of iPSC-derived neural tissue that combines a porous scaffold composed of silk fibroin protein with an intercalated collagen hydrogel to support the growth of neurons and glial cells into complex and functional networks for an extended time, a fundamental requisite for aging studies. Cultures were generated from iPSC lines obtained from two subjects carrying the familial AD (FAD) APP London mutation, two well-studied control lines, and an isogenic control. Cultures were analyzed at 2 and 4.5 months. At both time points, an elevated Aβ42/40 ratio was detected in conditioned media from FAD cultures. However, extracellular Aβ42 deposition and enhanced neuronal excitability were observed in FAD culture only at 4.5 months, suggesting that extracellular Aβ deposition may trigger enhanced network activity. Remarkably, neuronal hyperexcitability has been described in AD patients early in the disease. Transcriptomic analysis revealed the deregulation of multiple gene sets in FAD samples. Such alterations were strikingly similar to those observed in human AD brains. These data provide evidence that our patient-derived FAD model develops time-dependent AD-related phenotypes and establishes a temporal relation among them. Furthermore, FAD iPSC-derived cultures recapitulate transcriptomic features of AD patients. Thus, our bioengineered neural tissue represents a unique tool to model AD in vitro over time.
    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Induced Pluripotent Stem Cells/metabolism ; Phenotype ; Neurons/metabolism ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Transcriptome/genetics ; Cell Differentiation ; Bioengineering/methods ; Neuroglia/metabolism
    Chemical Substances Amyloid beta-Peptides ; Amyloid beta-Protein Precursor
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02147-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4812: Show issues Location:
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  7. Article ; Online: Connexin 30 controls the extension of astrocytic processes into the synaptic cleft through an unconventional non-channel function.

    Clasadonte, Jerome / Haydon, Philip G

    Neuroscience bulletin

    2014  Volume 30, Issue 6, Page(s) 1045–1048

    MeSH term(s) Astrocytes/metabolism ; Connexins/metabolism ; Humans ; Synapses/metabolism
    Chemical Substances Connexins
    Language English
    Publishing date 2014-12
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-014-1476-6
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    Zs.A 6734: Show issues Location:
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  8. Article ; Online: Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes.

    Armbruster, Moritz / Naskar, Saptarnab / Garcia, Jacqueline P / Sommer, Mary / Kim, Elliot / Adam, Yoav / Haydon, Philip G / Boyden, Edward S / Cohen, Adam E / Dulla, Chris G

    Nature neuroscience

    2022  Volume 25, Issue 5, Page(s) 607–616

    Abstract: Astrocytes are glial cells that interact with neuronal synapses via their distal processes, where they remove glutamate and potassium ( ... ...

    Abstract Astrocytes are glial cells that interact with neuronal synapses via their distal processes, where they remove glutamate and potassium (K
    MeSH term(s) Animals ; Astrocytes/physiology ; Glutamic Acid ; Mice ; Neuroglia ; Neurons/physiology ; Synapses/physiology
    Chemical Substances Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-022-01049-x
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    Zs.A 4891: Show issues Location:
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    Zs.MG 67: Show issues

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  9. Article ; Online: How do astrocytes participate in neural plasticity?

    Haydon, Philip G / Nedergaard, Maiken

    Cold Spring Harbor perspectives in biology

    2014  Volume 7, Issue 3, Page(s) a020438

    Abstract: Work over the past 20 years has implicated electrically nonexcitable astrocytes in complex neural functions. Despite controversies, it is increasingly clear that many, if not all, neural processes involve astrocytes. This review critically examines past ... ...

    Abstract Work over the past 20 years has implicated electrically nonexcitable astrocytes in complex neural functions. Despite controversies, it is increasingly clear that many, if not all, neural processes involve astrocytes. This review critically examines past work to identify the commonalities among the many published studies of neuroglia signaling. Although several studies have shown that astrocytes can impact short-term and long-term synaptic plasticity, further work is required to determine the requirement for astrocytic Ca(2+) and other second messengers in these processes. One of the roadblocks to the field advancing at a rapid pace has been technical. We predict that the novel experimental tools that have emerged in recent years will accelerate the field and likely disclose an entirely novel path of neuroglia signaling within the near future.
    MeSH term(s) Action Potentials/physiology ; Animals ; Astrocytes/physiology ; Calcium Signaling/physiology ; Humans ; Mice ; Models, Neurological ; Neuronal Plasticity/physiology ; Neurotransmitter Agents/metabolism ; Potassium/metabolism
    Chemical Substances Neurotransmitter Agents ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2014-12-11
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a020438
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  10. Article ; Online: Astrocytic adenosine: from synapses to psychiatric disorders.

    Hines, Dustin J / Haydon, Philip G

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2014  Volume 369, Issue 1654, Page(s) 20130594

    Abstract: Although it is considered to be the most complex organ in the body, the brain can be broadly classified into two major types of cells, neuronal cells and glial cells. Glia is a general term that encompasses multiple types of non-neuronal cells that ... ...

    Abstract Although it is considered to be the most complex organ in the body, the brain can be broadly classified into two major types of cells, neuronal cells and glial cells. Glia is a general term that encompasses multiple types of non-neuronal cells that function to maintain homeostasis, form myelin, and provide support and protection for neurons. Astrocytes, a major class of glial cell, have historically been viewed as passive support cells, but recently it has been discovered that astrocytes participate in signalling activities both with the vasculature and with neurons at the synapse. These cells have been shown to release D-serine, TNF-α, glutamate, atrial natriuretic peptide (ANP) and ATP among other signalling molecules. ATP and its metabolites are well established as important signalling molecules, and astrocytes represent a major source of ATP release in the nervous system. Novel molecular and genetic tools have recently shown that astrocytic release of ATP and other signalling molecules has a major impact on synaptic transmission. Via actions at the synapse, astrocytes have now been shown to regulate complex network signalling in the whole organism with impacts on respiration and the sleep-wake cycle. In addition, new roles for astrocytes are being uncovered in psychiatric disorders, and astrocyte signalling mechanisms represents an attractive target for novel therapeutic agents.
    MeSH term(s) Adenosine/metabolism ; Adenosine Triphosphate/metabolism ; Astrocytes/metabolism ; Astrocytes/physiology ; Exocytosis/physiology ; Humans ; Mental Disorders/metabolism ; Signal Transduction/physiology ; Sleep/physiology ; Synapses/metabolism ; Synapses/physiology ; Synaptic Transmission/physiology
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2014-09-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2013.0594
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    Einzelsignatur: Show issues

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