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Article ; Online: Adverse Childhood Experiences: Associations with a Blunted Cortisol Stress Response During Pregnancy.

Carbone, Jason T / Hicks, Laurel M / Brown, Suzanne / Saini, Ekjyot K / Dayton, Carolyn J

2023 Volume 27, Issue 8, Page(s) 1293–1300

Abstract: Introduction: Adverse Childhood Experiences (ACEs) are associated with a range of negative physical and mental health outcomes, yet there is limited research focused on the effect of ACEs on stress responses during pregnancy. Expectant mothers ... ...

Abstract	Introduction: Adverse Childhood Experiences (ACEs) are associated with a range of negative physical and mental health outcomes, yet there is limited research focused on the effect of ACEs on stress responses during pregnancy. Expectant mothers experience an increase in cortisol levels as pregnancy progresses, with this increase having important implications for fetal and early infant development. Little is known about the impact of ACEs on maternal cortisol levels. This study explored the relationship between maternal ACEs and cortisol response among expectant mothers nearing or in the third trimester of pregnancy. Methods: 39 expectant mothers were exposed to a Baby Cry Protocol via an infant simulator, with salivary cortisol collected at five points in time (N = 181). Stepwise, multilevel model creation resulted in a random intercept and random slope model with an interaction term for total number of ACEs and week of pregnancy. Results: The repeated measures data showed that cortisol levels decreased across collection times, from arrival at the lab, through the Baby Cry Protocol, to recovery. Predictive margins for the interaction term showed that while exposure to a greater number of ACEs was associated with higher cortisol levels early in the third trimester, the expected increase in cortisol late in pregnancy was blunted for expectant mothers who were exposed to a greater number of ACEs. Discussion: These findings findings suggest the importance of ACEs screening and intervention efforts as part of prenatal care.
MeSH term(s)	Female ; Pregnancy ; Child ; Infant ; Humans ; Hydrocortisone ; Stress, Psychological ; Mothers/psychology ; Pregnancy Trimester, Third ; Adverse Childhood Experiences
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339905-6
ISSN	1573-6628 ; 1092-7875
ISSN (online)	1573-6628
ISSN	1092-7875
DOI	10.1007/s10995-023-03651-2
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Zs.A 6170: Show issues

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Article: The Effectiveness and Optimal Dose of Resistance Training in Patients With Subacute and Persistent Low Back-Related Leg Pain: A Systematic Review.

Barbari, Valerio / Carbone, Maria M / Storari, Lorenzo / Testa, Marco / Maselli, Filippo

Cureus

2024 Volume 16, Issue 3, Page(s) e57278

Abstract: ... rater agreement for full-text selection was evaluated using Cohen's Kappa (K). The search elicited ... risk of bias. The inter-examiner concordance index for the selection of full text was excellent (K=1 ...

Abstract	A subgroup of patients with low back pain (LBP) suffers from low back-related leg pain (LBLP), which can be classified as radicular pain, or somatic referred pain without nerve root involvement. LBLP is considered an obstacle to recovery and a strong negative prognostic factor for medium- and long-term disability. In this review, we aimed to investigate the effectiveness and optimal dose of resistance training (RT) in patients with subacute or persistent LBLP to provide clinical recommendations for practice. This systematic review was conducted by adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the recommendations of the Cochrane Collaboration. We conducted a literature search on PubMed, PEDro, Cochrane Library, Scopus, and Web of Science databases. Only randomized controlled trials (RCTs) involving patients ≥18 years of age were included. The risk of bias in the included studies was assessed using "the Cochrane Collaboration's tool for assessing risk of bias" (RoB) and the inter-rater agreement for full-text selection was evaluated using Cohen's Kappa (K). The search elicited a total of 4.537 records, and two RCTs involving a total of 196 participants were identified through a selection process based on title, abstract, and full-text assessment. Both studies had a low to moderate risk of bias. The inter-examiner concordance index for the selection of full text was excellent (K=1). RT seems to be an effective and safe intervention for patients with LBLP, but its long-term effectiveness, superiority over other types of exercise-based therapies, and optimal dosage still constitute a gray area in the literature.
Language	English
Publishing date	2024-03-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.57278
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Article ; Online: Accurate, Uncertainty-Aware Classification of Molecular Chemical Motifs from Multimodal X-ray Absorption Spectroscopy.

Carbone, Matthew R / Maffettone, Phillip M / Qu, Xiaohui / Yoo, Shinjae / Lu, Deyu

The journal of physical chemistry. A

2024 Volume 128, Issue 10, Page(s) 1948–1957

Abstract: ... from simulated C, N, and O K-edge X-ray absorption near-edge structure (XANES) spectra. Our classifiers not only ...

Abstract	Accurate classification of molecular chemical motifs from experimental measurement is an important problem in molecular physics, chemistry, and biology. In this work, we present neural network ensemble classifiers for predicting the presence (or lack thereof) of 41 different chemical motifs on small molecules from simulated C, N, and O K-edge X-ray absorption near-edge structure (XANES) spectra. Our classifiers not only achieve class-balanced accuracies of more than 0.95 but also accurately quantify uncertainty. We also show that including multiple XANES modalities improves predictions notably on average, demonstrating a "multimodal advantage" over any single modality. In addition to structure refinement, our approach can be generalized to broad applications with molecular design pipelines.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.3c06910
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Article: Case Report: Post-gastrectomy reactive hyperinsulinemic hypoglicaemia: glucose trends before and after canagliflozin treatment.

Bellastella, G / Caruso, P / Carbone, C / di Nuzzo, M / Scappaticcio, L / Paglionico, V Amoresano / Maiorino, M I / Esposito, K

Frontiers in endocrinology

2023 Volume 14, Page(s) 1193696

Abstract: The pathogenesis of post-gastrectomy reactive hyperinsulinaemic hypoglycaemia is not yet fully clarified. Recent studies suggest an up-regulation of the intestinal glucose transporter SGLT-1 aimed to prevent carbohydrate malabsorption. The overexpression ...

Abstract	The pathogenesis of post-gastrectomy reactive hyperinsulinaemic hypoglycaemia is not yet fully clarified. Recent studies suggest an up-regulation of the intestinal glucose transporter SGLT-1 aimed to prevent carbohydrate malabsorption. The overexpression of SGLT-1 could therefore represents one of the mechanisms underlying the wide glycemic excursions found in patients after gastrectomy, but studies investigating the use of SGLT-1/SGLT-2 inhibitors in patients with post-gastrectomy reactive hyperinsulinemic hypoglycaemia are very scant in the literature. We report the case of a 37-year-old non diabetic man who frequently presented symptoms of hypoglycaemia in the postprandial period. In 2012, he underwent Roux en-Y gastric bypass (RYGB) and after two years, he started to experience typical symptoms of reactive hyperinsulinaemic hypoglycaemia. We suggested healthy modifications of dietary habits and periodic follow-up visits with a dietitian. After three months, the patient still presented symptoms of reactive hypoglycaemia; we provided him with Flash Glucose Monitoring (FGM) to assess trend of glucose levels in interstitial fluid during the day and we decided to introduce canagliflozin 300 mg/day before the main meal. Hypoglycaemic events previously referred by the patient and clearly recorded by FGM completely disappeared taking canagliflozin. We found a reduction of time spent in hypoglycaemia, an improvement of glycemic variability and an increase of time in target range. It was also noted a reduction of time spent in hyperglicemia with consequent improvement of average glucose values and of glucose main indicator. This is the first report with FGM supporting a role of canagliflozin in the management of post-gastrectomy reactive hyperinsulinaemic hypoglycaemia. Our preliminary results are very limited but in line with those of the literature and showed for the first time a reduction of hypoglycaemic events and an improvement of glycemic variability through a flash glucose monitoring system. Further studies are mandatory to confirm this therapeutic opportunity.
MeSH term(s)	Humans ; Male ; Adult ; Glucose ; Canagliflozin ; Blood Glucose Self-Monitoring ; Blood Glucose ; Hypoglycemia/etiology ; Sodium-Glucose Transporter 2 Inhibitors ; Gastrectomy/adverse effects ; Hyperinsulinism ; Hypoglycemic Agents
Chemical Substances	Glucose (IY9XDZ35W2) ; Canagliflozin (0SAC974Z85) ; Blood Glucose ; Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents
Language	English
Publishing date	2023-08-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1193696
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Article ; Online: Moderate-intensity endurance training improves late phase β-cell function in adults with type 2 diabetes.

Zhang, Hui / Simpson, Laura K / Carbone, Nicholas P / Hirshman, Michael F / Nigro, Pasquale / Vamvini, Maria / Goodyear, Laurie J / Middelbeek, Roeland J W

iScience

2023 Volume 26, Issue 7, Page(s) 107226

Abstract: ... with type 2 diabetes (7F/3M, age 49 ± 5 years, BMI 30 ± 3 kg/m ...

Abstract	Physical activity is important for type 2 diabetes treatment, yet the underlying mechanisms for these beneficial effects of exercise are not fully understood. Here, we investigated the effects of exercise training on biphasic β-cell insulin secretory function, a key factor regulating blood glucose. Adults with type 2 diabetes (7F/3M, age 49 ± 5 years, BMI 30 ± 3 kg/m
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107226
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Article ; Online: Endometriosis: Cell Death and Cell Signaling Machinery.

Carbone, Ginearosa / Nelson, Katherine / Baumgartner, Claire / Bode, Ann M / Takahashi, Akimasa / Chefetz, Ilana

Endocrinology

2023 Volume 164, Issue 6

Abstract: Endometriosis is an estrogen-dependent disorder defined as the deposition and growth of endometrial tissue outside the uterus, including but not limited to the pelvic peritoneum, rectovaginal septum, and ovaries. Endometriosis is a substantial ... ...

Abstract	Endometriosis is an estrogen-dependent disorder defined as the deposition and growth of endometrial tissue outside the uterus, including but not limited to the pelvic peritoneum, rectovaginal septum, and ovaries. Endometriosis is a substantial contributor to pelvic pain and subfertility and has been associated with an increased incidence of certain cancers, including ovarian. Appropriate treatment of endometriosis can reduce morbidity, but generally is used only to address symptoms, since no cure currently exists. Multifactorial etiologies for endometriosis have been proposed, with significant evidence for genetic, immune, and environmental causes. Recent advances suggest that molecular signaling and programmed cell death pathways are involved in endometriosis, suggesting avenues for future curative treatments. The goal of this review is to examine the pathologic processes of endometriosis, focusing on cell signaling and cell death pathways, stem cells, treatment regimens, and future directions surrounding this gynecologic disorder.
MeSH term(s)	Female ; Humans ; Endometriosis/pathology ; Peritoneum/metabolism ; Peritoneum/pathology ; Uterus/metabolism ; Signal Transduction ; Cell Death
Language	English
Publishing date	2023-05-20
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	427856-2
ISSN	1945-7170 ; 0013-7227
ISSN (online)	1945-7170
ISSN	0013-7227
DOI	10.1210/endocr/bqad057
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Article ; Online: Conventional and innovative extraction technologies to produce food-grade hop extracts: Influence on bitter acids content and volatile organic compounds profile.

Santarelli, Veronica / Neri, Lilia / Carbone, Katya / Macchioni, Valentina / Faieta, Marco / Pittia, Paola

Journal of food science

2023 Volume 88, Issue 4, Page(s) 1308–1324

Abstract: Hop extracts represent a natural alternative to synthetic food additives because of their high content of bitter acids and volatile organic compounds (VOCs) with bittering, flavoring, and antimicrobial properties. However, broader uses of hop extracts as ...

Abstract	Hop extracts represent a natural alternative to synthetic food additives because of their high content of bitter acids and volatile organic compounds (VOCs) with bittering, flavoring, and antimicrobial properties. However, broader uses of hop extracts as natural techno-functional ingredients rely on the identification of sustainable and affordable extraction technologies allowing to diversify the processes and produce extracts characterized by different compositions and, consequently, qualitative properties. Thus, this study is aimed to evaluate and compare the effect of innovative and conventional extraction methods on the bitter acids content and VOCs pattern of food-grade ethanolic hop extracts for food applications. Innovative extractions were carried out by using two ultrasound systems (a laboratory bath [US] and a high-power ultrasound bath [HPUS]), and a high-pressure industrial process (high hydrostatic pressure [HHP]). Conventional extractions (CONV) were performed under dynamic maceration at 25 and 60°C; for ultrasound and conventional methods, the effect of the extraction time was also investigated. Among the extracts, the highest and lowest content of bitter acids was found in CONV 60°C extracts, and HHP and CONV 25°C extracts, respectively. Of the 34 VOCs identified in dry hops, ∼24 compounds were found in US, HPUS and CONV extracts, while only 18 were found in HHP. CONV extractions showed higher selectivity for sesquiterpenes, while US and HPUS showed higher selectivity for esters and monoterpenes. Hierarchical cluster analysis (HCA) and partial least squares-discriminant analysis (PLS-DA) allowed classifying hop extracts based on the extraction methods and also allowed highlighting the technological conditions to produce hop extracts with specific techno-functional and flavoring properties. PRACTICAL APPLICATION: The study showed that different extraction methods can lead to hop products with varying sensory and functional properties. By selecting the right extraction method, companies can produce hop extracts with specific compositions that meet their needs for clean label and sustainable food products, as well as new edible packaging or coatings.
MeSH term(s)	Volatile Organic Compounds ; Taste ; Flavoring Agents/analysis ; Monoterpenes ; Acids/analysis ; Humulus
Chemical Substances	Volatile Organic Compounds ; Flavoring Agents ; Monoterpenes ; Acids
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	241615-3
ISSN	1750-3841 ; 0022-1147
ISSN (online)	1750-3841
ISSN	0022-1147
DOI	10.1111/1750-3841.16487
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Article ; Online: Nausea is the only symptom associated with delayed gastric emptying in pediatric functional dyspepsia patients.

De Keukelaere, Marijke / Carbone, Florencia / van Hoeve, Karen / Tack, Jan / Hoffman, Ilse

Neurogastroenterology and motility

2023 Volume 35, Issue 9, Page(s) e14620

Abstract: Objectives: Functional dyspepsia (FD) is a heterogeneous functional gastrointestinal disorder (FGID) with a highly prevalent symptom complex. The aim of our study is to investigate the relation between symptoms of FD and results of gastric emptying (GE) ...

Abstract	Objectives: Functional dyspepsia (FD) is a heterogeneous functional gastrointestinal disorder (FGID) with a highly prevalent symptom complex. The aim of our study is to investigate the relation between symptoms of FD and results of gastric emptying (GE) breath test in children. Methods: This study included patients (6-17 years old) presented at the general gastroenterology outpatient clinic with dyspeptic symptoms (Rome IV criteria) and underwent careful history taking with clinical examination. A GE breath test with a Results: Thirty nine FD patients (55% girls; mean age: 11.9 ± 3.3 years) participated in the study. Of these, 43% had delayed GE. The overall symptom severity in patients with delayed GE was similar to the symptoms of patients with a normal GE rate (149.5 ± 12.7 points vs. 123.9 ± 9.0; p = 0.19). Individual symptoms scores showed only nausea to be significantly increased in the group with delayed GE (21.5 ± 1.9 points vs. 33.2 ± 4.6; p = 0.048, p < 0.1). Conclusion: Especially in children with nausea as presenting symptom of FD, a low threshold should be withheld to perform a GE breath test.
MeSH term(s)	Female ; Humans ; Child ; Adolescent ; Male ; Dyspepsia/diagnosis ; Gastroparesis ; Nausea/diagnosis ; Abdominal Pain/diagnosis ; Vomiting
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.14620
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Article ; Online: A welcomed invitation: The feasibility of Trauma Adapted Yoga on a psychiatric inpatient adolescent unit.

Khoury, Nayla M / Carbone, Stephanie / Cote, John / LePage, Emily / George, Susan / Zhang-James, Yanli / Duquette, Jacquelynn / Hagen, Kathryn

General hospital psychiatry

2024 Volume 88, Page(s) 81–82

MeSH term(s)	Humans ; Adolescent ; Yoga/psychology ; Inpatients ; Feasibility Studies ; Meditation
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Letter
ZDB-ID	392299-6
ISSN	1873-7714 ; 0163-8343
ISSN (online)	1873-7714
ISSN	0163-8343
DOI	10.1016/j.genhosppsych.2024.02.005
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Article ; Online: Enhancement of UV disinfection of urine matrixes by electrochemical oxidation.

Herraiz-Carboné, Miguel / Cotillas, Salvador / Lacasa, Engracia / Cañizares, Pablo / Rodrigo, Manuel A / Sáez, Cristina

Journal of hazardous materials

2020 Volume 410, Page(s) 124548

Abstract: ... photoelectrolysis of synthetic hospital urine intensified with K. pneumoniae were studied. The influence ... at 50 A m ...

Abstract	This work focuses on the removal of antibiotic-resistant bacteria (ARB) contained in hospital urines by UV disinfection enhanced by electrochemical oxidation to overcome the limitations of both single processes in the disinfection of this type of effluents. UV disinfection, electrolysis, and photoelectrolysis of synthetic hospital urine intensified with K. pneumoniae were studied. The influence of the current density and the anode material was assessed on the disinfection performance of combined processes and the resulting synergies and/or antagonisms of coupling both technologies were also evaluated. Results show that the population of bacteria contained in hospital urine is only reduced by 3 orders of magnitude during UV disinfection. Electrolysis leads to complete disinfection of hospital urine when working at 50 A m
MeSH term(s)	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Diamond ; Disinfection ; Electrodes ; Electrolysis ; Oxidation-Reduction ; Water Pollutants, Chemical/analysis
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Water Pollutants, Chemical ; Diamond (7782-40-3)
Language	English
Publishing date	2020-11-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2020.124548
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