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  1. Book ; Thesis: Gesundheitsbewusstsein zu Vorhofflimmern und seinen Risikofaktoren bei Patienten mit kardiovaskulären Erkrankungen

    Bauer, Lisa / Dams, Judith / Schnabel, Renate

    2023  

    Institution Universität Hamburg
    Universität Hamburg / Medizinische Fakultät
    Author's details vorgelegt von: Lisa Bauer ; Prüfungsausschuss, die Vorsitzende: PD Dr. Judith Dams, Prüfungsausschuss, zweite Gutachterin: Prof. Dr. Renate Bonin-Schnabel
    Language German
    Size 109 Seiten, Illustrationen, Diagramme
    Publishing place Hamburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Hamburg, 2023
    Note Dissertation angenommen von der Medizinischen Fakultät der Universität Hamburg
    HBZ-ID HT030643698
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Gut microbiota-derived metabolites in atrial fibrillation: risk markers or modifiable risk factors?

    Linz, Dominik / Schnabel, Renate B

    Heart (British Cardiac Society)

    2023  

    Language English
    Publishing date 2023-01-02
    Publishing country England
    Document type Editorial
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-321806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Die Genetik von Vorhofflimmern – auf dem Weg in die Präzisionsmedizin.

    Kany, Shinwan / Schnabel, Renate B

    Herzschrittmachertherapie & Elektrophysiologie

    2023  Volume 35, Issue 1, Page(s) 3–8

    Abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia and has complex genetic underpinnings. Despite advancements in treatment, mortality of AF patients remains high. This review discusses the genetic basis of AF and its implications for ... ...

    Title translation Genetic basis of atrial fibrillation-on the road to precision medicine.
    Abstract Atrial fibrillation (AF) is the most common cardiac arrhythmia and has complex genetic underpinnings. Despite advancements in treatment, mortality of AF patients remains high. This review discusses the genetic basis of AF and its implications for diagnosis and therapy. Although AF pathology has long been known to include a hereditary component, the first genes associated with AF were not identified until the early 2000s. Subsequent research with genome-wide association studies (GWAS) has implicated other genes and numerous genetic variants in AF. These studies have revealed nearly 140 different regions in the DNA with genome-wide significance associated with AF. In addition to common variants, rare variants with large effects have also been identified. The integration of these genetic findings into clinical practice holds promise for improving AF diagnosis and treatment, moving us closer to precision medicine. However, challenges remain, including the need for more diverse genetic data of non-European ancestry and improved genetic analyses of responses to AF therapy.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/genetics ; Atrial Fibrillation/therapy ; Genome-Wide Association Study ; Precision Medicine ; Genetic Predisposition to Disease/genetics
    Language German
    Publishing date 2023-11-06
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1082953-2
    ISSN 1435-1544 ; 0938-7412
    ISSN (online) 1435-1544
    ISSN 0938-7412
    DOI 10.1007/s00399-023-00974-z
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  4. Article ; Online: Atrial fibrillation screening perspectives after STROKESTOP and LOOP.

    Freedman, Ben / Schnabel, Renate B

    Nature reviews. Cardiology

    2022  Volume 20, Issue 1, Page(s) 1–2

    MeSH term(s) Humans ; Atrial Fibrillation ; Electrocardiography ; Heart Rate ; Mass Screening
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-022-00803-9
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  5. Article ; Online: Self-reported Alcohol Consumption and Risk of Atrial Fibrillation.

    Frost, Lars / Schnabel, Renate B

    JAMA network open

    2022  Volume 5, Issue 9, Page(s) e2229808

    MeSH term(s) Alcohol Drinking/epidemiology ; Atrial Fibrillation/epidemiology ; Cohort Studies ; Humans ; Self Report
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.29808
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  6. Article ; Online: Genetics, atrial cardiomyopathy, and stroke: enough components for a sufficient cause?

    Camen, Stephan / Schnabel, Renate B

    European heart journal

    2021  Volume 42, Issue 44, Page(s) 4533–4535

    MeSH term(s) Cardiomyopathies/genetics ; Humans ; Stroke/genetics
    Language English
    Publishing date 2021-09-17
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab523
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  7. Article ; Online: Global Burden of Atrial Fibrillation and Flutter by National Income: Results From the Global Burden of Disease 2019 Database.

    Ohlrogge, Amelie H / Brederecke, Jan / Schnabel, Renate B

    Journal of the American Heart Association

    2023  Volume 12, Issue 17, Page(s) e030438

    Abstract: Background Atrial fibrillation (AF) and atrial flutter (AFL) are common conditions that can lead to significant morbidity and death. We aimed to understand the distribution and disparities of the global burden of AF/AFL as well as the underlying risk ... ...

    Abstract Background Atrial fibrillation (AF) and atrial flutter (AFL) are common conditions that can lead to significant morbidity and death. We aimed to understand the distribution and disparities of the global burden of AF/AFL as well as the underlying risk factors. Methods and Results Data on the AF/AFL burden from the Global Burden of Disease data set were analyzed for the years 1990 to 2019, with countries grouped into low, lower-middle, upper-middle, and high national income classes according to World Bank categories. Data were supplemented with World Health Organization and World Bank information. The prevalence of AF/AFL has more than doubled (+120.7%) since 1990 in all income groups, though with a larger increment in middle-income countries (+146.6% in lower-middle- and +145.2% in upper-middle-income countries). In absolute numbers, 63.4% of AF/AFL cases originate from upper-middle-income countries, although the relative prevalence is highest in high-income countries. Prevalence of AF/AFL appears to be correlated with medical doctor rate and life expectancy. The most relevant AF/AFL risk factors are unevenly distributed among income classes, with elevated blood pressure as the only risk factor that becomes less common with increasing income. The development of these risk factors differed over time. Conclusions The global burden of AF/AFL is increasing in all income groups and is more pronounced in middle-income countries, with further growth to be expected. Underdiagnosis of AF/AFL in low- and middle-income countries may contribute to lower reported prevalence. The risk factor distribution varies between income groups.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Global Burden of Disease ; Atrial Flutter/diagnosis ; Atrial Flutter/epidemiology ; Dietary Supplements ; Hypertension
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.030438
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  8. Article ; Online: Rationale kardiale Diagnostik nach ischämischem Schlaganfall oder TIA.

    Schnabel, Renate B / Häusler, Karl Georg

    Deutsche medizinische Wochenschrift (1946)

    2021  Volume 146, Issue 12, Page(s) 801–808

    Abstract: Stroke is the most common cause of permanent disability and one of the most common causes of death. Cardio-embolic strokes are associated with a poor prognosis and a high risk of recurrence compared to other stroke etiologies. The most common source of ... ...

    Title translation Cardiac diagnostics after ischemic stroke or transitory ischemic attack.
    Abstract Stroke is the most common cause of permanent disability and one of the most common causes of death. Cardio-embolic strokes are associated with a poor prognosis and a high risk of recurrence compared to other stroke etiologies. The most common source of cardiac embolism is atrial fibrillation which must be quickly identified to optimize secondary stroke prevention. A structured evaluation after ischemic stroke includes taking the medical history, a physical examination, 12-lead ECG recording, rhythm monitoring for 72 h, transthoracic echocardiography and transesophageal echocardiography, if an atrial embolic source of stroke is suspected. Extended cardiac work-up (e. g., MRI/CT, prolonged rhythm monitoring) should be performed in selected patients based on diagnostic findings.
    MeSH term(s) Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Electrocardiography ; Embolism/complications ; Embolism/etiology ; Humans ; Ischemic Attack, Transient/diagnosis ; Ischemic Attack, Transient/etiology ; Ischemic Attack, Transient/prevention & control ; Ischemic Stroke/diagnosis ; Ischemic Stroke/etiology ; Ischemic Stroke/prevention & control
    Language German
    Publishing date 2021-06-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1221-7095
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  9. Article ; Online: New race-free creatinine- and cystatin C-based equations for the estimation of glomerular filtration rate and association with cardiovascular mortality in the AtheroGene study.

    Ntaios, George / Brederecke, Jan / Ojeda, Francisco M / Zeller, Tanja / Blankenberg, Stefan / Schnabel, Renate B

    Internal and emergency medicine

    2024  Volume 19, Issue 3, Page(s) 697–703

    Abstract: Renal function is associated with cardiovascular outcomes and mortality. Among equations used to eGFR, CKD-EPI equations show more accurate association with cardiovascular risk and mortality than MDRD. Recently, new CKD-EPI equations were proposed which ... ...

    Abstract Renal function is associated with cardiovascular outcomes and mortality. Among equations used to eGFR, CKD-EPI equations show more accurate association with cardiovascular risk and mortality than MDRD. Recently, new CKD-EPI equations were proposed which do not include race and would be considered sufficiently accurate to estimate eGFR in clinical practice. It is unknown if these new race-free equations are comparably well associated with cardiovascular outcomes in high-risk individuals. The analysis was performed in the AtheroGene Study cohort including patients at high cardiovascular risk. eGFR was determined using the established as well as the recently developed formulas which are calculated without the otherwise existing coefficient for black race. The outcome was cardiovascular death. Analyses included Cox-proportional hazard regression and area-under-the-curve calculation. The analysis included 2089 patients followed up for a median of 3.8 years with a maximum of 6.9 years, corresponding to an overall period of 7701 patient-years. Cardiovascular death occurred in 93 (4.45%), corresponding to an annualized rate of 1.2/100 person-years. In all Cox regression analyses, the estimated adjusted GFR was an independent predictor of cardiovascular death. The equations which included cystatin C showed higher C-index compared to those which did not include cystatin C (0.75-0.76 vs. 0.71, respectively). The equations for the estimation of eGFR which include cystatin C are better associated with cardiovascular death compared to the race-free equations which include only creatinine. This finding adds on the related literature which supports the elimination of race in GFR-estimating equations, and promotion of the use of cystatin C.
    MeSH term(s) Humans ; Glomerular Filtration Rate ; Cystatin C/blood ; Male ; Female ; Aged ; Creatinine/blood ; Middle Aged ; Cardiovascular Diseases/mortality ; Proportional Hazards Models ; Biomarkers/blood
    Chemical Substances Cystatin C ; Creatinine (AYI8EX34EU) ; Biomarkers
    Language English
    Publishing date 2024-02-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03529-9
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  10. Article ; Online: Diversity 4.0 in the cardiovascular health-care workforce.

    Schnabel, Renate B / Benjamin, Emelia J

    Nature reviews. Cardiology

    2020  Volume 17, Issue 12, Page(s) 751–753

    MeSH term(s) Cardiovascular Diseases/therapy ; Health Workforce/statistics & numerical data ; Humans ; United States
    Keywords covid19
    Language English
    Publishing date 2020-10-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-020-00462-8
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