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  1. Article ; Online: SARS-CoV-2 likes it cool.

    Soares-Schanoski, Alessandra

    Nature reviews. Immunology

    2020  Volume 20, Issue 7, Page(s) 406

    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-0341-2
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    Zs.A 5565: Show issues Location:
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  3. Article ; Online: SARS-CoV-2 likes it cool

    Soares-Schanoski, Alessandra

    Nature Reviews Immunology

    2020  Volume 20, Issue 7, Page(s) 406–406

    Keywords Immunology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-0341-2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1

    Humblin, Etienne / Korpas, Isabel / Lu, Jiahua / Filipescu, Dan / van der Heide, Verena / Goldstein, Simon / Vaidya, Abishek / Soares-Schanoski, Alessandra / Casati, Beatrice / Selvan, Myvizhi E / Gümüş, Zeynep H / Wieland, Andreas / Corrado, Mauro / Cohen-Gould, Leona / Bernstein, Emily / Homann, Dirk / Chipuk, Jerry / Kamphorst, Alice O

    Science immunology

    2023  Volume 8, Issue 86, Page(s) eadg0878

    Abstract: During persistent antigen stimulation, such as in chronic infections and cancer, CD8 T cells differentiate into a hypofunctional programmed death protein 1-positive (PD- ... ...

    Abstract During persistent antigen stimulation, such as in chronic infections and cancer, CD8 T cells differentiate into a hypofunctional programmed death protein 1-positive (PD-1
    MeSH term(s) T Cell Transcription Factor 1/genetics ; CD28 Antigens ; Programmed Cell Death 1 Receptor ; CD8-Positive T-Lymphocytes ; Cell Differentiation ; Transcription Factors
    Chemical Substances T Cell Transcription Factor 1 ; CD28 Antigens ; Programmed Cell Death 1 Receptor ; Transcription Factors
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adg0878
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  5. Article ; Online: SARS-CoV-2 Seropositivity among US Marine Recruits Attending Basic Training, United States, Spring-Fall 2020.

    Letizia, Andrew G / Ge, Yongchao / Goforth, Carl W / Weir, Dawn L / Lizewski, Rhonda / Lizewski, Stephen / Soares-Schanoski, Alessandra / Vangeti, Sindhu / Marjanovic, Nada / Sealfon, Stuart C / Ramos, Irene

    Emerging infectious diseases

    2021  Volume 27, Issue 4, Page(s) 1188–1192

    Abstract: In a study of US Marine recruits, seroprevalence of severe acute respiratory syndrome coronavirus 2 IgG was 9.0%. Hispanic and non-Hispanic Black participants and participants from states affected earlier in the pandemic had higher seropositivity rates. ... ...

    Abstract In a study of US Marine recruits, seroprevalence of severe acute respiratory syndrome coronavirus 2 IgG was 9.0%. Hispanic and non-Hispanic Black participants and participants from states affected earlier in the pandemic had higher seropositivity rates. These results suggest the need for targeted public health strategies among young adults at increased risk for infection.
    MeSH term(s) Age Factors ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Serological Testing/methods ; COVID-19 Serological Testing/statistics & numerical data ; Cross-Sectional Studies ; Demography ; Female ; Humans ; Male ; Military Health/ethnology ; Military Health/statistics & numerical data ; Military Health Services ; Military Personnel/statistics & numerical data ; Personnel Selection/methods ; Personnel Selection/statistics & numerical data ; Quarantine ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Seroepidemiologic Studies ; United States/epidemiology ; Young Adult
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2704.204732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4778: Show issues Location:
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  6. Article ; Online: Correction: Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A.

    Castro, Julia T / Oliveira, Giuliana S / Nishigasako, Melissa A / Debrie, Anne-Sophie / Miyaji, Eliane N / Soares-Schanoski, Alessandra / Akamatsu, Milena A / Locht, Camille / Ho, Paulo L / Mielcarek, Nathalie / Oliveira, Maria Leonor S

    PloS one

    2020  Volume 15, Issue 2, Page(s) e0229050

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0228055.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0228055.].
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0229050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Author Correction: Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data.

    Chen, Xi / Wang, Yuan / Cappuccio, Antonio / Cheng, Wan-Sze / Zamojski, Frederique Ruf / Nair, Venugopalan D / Miller, Clare M / Rubenstein, Aliza B / Nudelman, German / Tadych, Alicja / Theesfeld, Chandra L / Vornholt, Alexandria / George, Mary-Catherine / Ruffin, Felicia / Dagher, Michael / Chawla, Daniel G / Soares-Schanoski, Alessandra / Spurbeck, Rachel R / Ndhlovu, Lishomwa C /
    Sebra, Robert / Kleinstein, Steven H / Letizia, Andrew G / Ramos, Irene / Fowler, Vance G / Woods, Christopher W / Zaslavsky, Elena / Troyanskaya, Olga G / Sealfon, Stuart C

    Nature computational science

    2023  Volume 3, Issue 9, Page(s) 805

    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Published Erratum
    ISSN 2662-8457
    ISSN (online) 2662-8457
    DOI 10.1038/s43588-023-00523-1
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  8. Article ; Online: Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins.

    Amaral, Murilo Sena / Goulart, Ernesto / Caires-Júnior, Luiz Carlos / Morales-Vicente, David Abraham / Soares-Schanoski, Alessandra / Gomes, Roselane Paiva / Olberg, Giovanna Gonçalves de Oliveira / Astray, Renato Mancini / Kalil, Jorge E / Zatz, Mayana / Verjovski-Almeida, Sergio

    PLoS neglected tropical diseases

    2020  Volume 14, Issue 8, Page(s) e0008424

    Abstract: Zika virus (ZIKV) causes congenital Zika syndrome (CZS), which is characterized by fetal demise, microcephaly and other abnormalities. ZIKV in the pregnant woman circulation must cross the placental barrier that includes fetal endothelial cells and ... ...

    Abstract Zika virus (ZIKV) causes congenital Zika syndrome (CZS), which is characterized by fetal demise, microcephaly and other abnormalities. ZIKV in the pregnant woman circulation must cross the placental barrier that includes fetal endothelial cells and trophoblasts, in order to reach the fetus. CZS occurs in ~1-40% of cases of pregnant women infected by ZIKV, suggesting that mothers' infection by ZIKV during pregnancy is not deterministic for CZS phenotype in the fetus. Therefore, other susceptibility factors might be involved, including the host genetic background. We have previously shown that in three pairs of dizygotic twins discordant for CZS, neural progenitor cells (NPCs) from the CZS-affected twins presented differential in vitro ZIKV susceptibility compared with NPCs from the non-affected. Here, we analyzed human-induced-pluripotent-stem-cell-derived (hiPSC-derived) trophoblasts from these twins and compared by RNA-Seq the trophoblasts from CZS-affected and non-affected twins. Following in vitro exposure to a Brazilian ZIKV strain (ZIKVBR), trophoblasts from CZS-affected twins were significantly more susceptible to ZIKVBR infection when compared with trophoblasts from the non-affected. Transcriptome profiling revealed no differences in gene expression levels of ZIKV candidate attachment factors, IFN receptors and IFN in the trophoblasts, either before or after ZIKVBR infection. Most importantly, ZIKVBR infection caused, only in the trophoblasts from CZS-affected twins, the downregulation of genes related to extracellular matrix organization and to leukocyte activation, which are important for trophoblast adhesion and immune response activation. In addition, only trophoblasts from non-affected twins secreted significantly increased amounts of chemokines RANTES/CCL5 and IP10 after infection with ZIKVBR. Overall, our results showed that trophoblasts from non-affected twins have the ability to more efficiently activate genes that are known to play important roles in cell adhesion and in triggering the immune response to ZIKV infection in the placenta, and this may contribute to predict protection from ZIKV dissemination into fetuses' tissues.
    MeSH term(s) Chemokines/metabolism ; Extracellular Matrix ; Female ; Gene Expression ; Genetic Predisposition to Disease ; Humans ; Induced Pluripotent Stem Cells ; Infant ; Pregnancy ; Pregnancy Complications, Infectious/genetics ; Pregnancy Complications, Infectious/virology ; Trophoblasts/metabolism ; Trophoblasts/virology ; Twins, Dizygotic ; Zika Virus ; Zika Virus Infection/congenital ; Zika Virus Infection/genetics
    Chemical Substances Chemokines
    Language English
    Publishing date 2020-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0008424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A.

    Castro, Julia T / Oliveira, Giuliana S / Nishigasako, Melissa A / Debrie, Anne-Sophie / Miyaji, Eliane N / Soares-Schanoski, Alessandra / Akamatsu, Milena A / Locht, Camille / Ho, Paulo L / Mielcarek, Nathalie / Oliveira, Maria Leonor S

    PloS one

    2020  Volume 15, Issue 1, Page(s) e0228055

    Abstract: Pneumococcal Surface Protein A (PspA) has been successfully tested as vaccine candidate against Streptococcus pneumoniae infections. Vaccines able to induce PspA-specific antibodies and Th1 cytokines usually provide protection in mice. We have shown that ...

    Abstract Pneumococcal Surface Protein A (PspA) has been successfully tested as vaccine candidate against Streptococcus pneumoniae infections. Vaccines able to induce PspA-specific antibodies and Th1 cytokines usually provide protection in mice. We have shown that the whole cell pertussis vaccine (wP) or components from acellular pertussis vaccines, such as Pertussis Toxin or Filamentous Hemagglutinin (FHA), are good adjuvants to PspA, suggesting that combined pertussis-PspA vaccines would be interesting strategies against the two infections. Here, we evaluated the potential of wP as a delivery vector to PspA. Bordetella pertussis strains producing a PspA from clade 4 (PspA4Pro) fused to the N-terminal region of FHA (Fha44) were constructed and inactivated with formaldehyde for the production of wPPspA4Pro. Subcutaneous immunization of mice with wPPspA4Pro induced low levels of anti-PspA4 IgG, even after 3 doses, and did not protect against a lethal pneumococcal challenge. Prime-boost strategies using wPPspA4Pro and PspA4Pro showed that there was no advantage in using the wPPspA4Pro vaccine. Immunization of mice with purified PspA4Pro induced higher levels of antibodies and protection against pneumococcal infection than the prime-boost strategies. Finally, purified Fha44:PspA4Pro induced high levels of anti-PspA4Pro IgG, but no protection, suggesting that the antibodies induced by the fusion protein were not directed to protective epitopes.
    MeSH term(s) Adhesins, Bacterial/administration & dosage ; Adjuvants, Immunologic/administration & dosage ; Animals ; Antigens, Bacterial/pharmacology ; Antigens, Surface/pharmacology ; Bacterial Proteins/pharmacology ; Drug Carriers/administration & dosage ; Female ; Mice ; Mice, Inbred BALB C ; Pertussis Vaccine/administration & dosage ; Pneumococcal Infections/prevention & control ; Vaccination ; Virulence Factors, Bordetella/administration & dosage
    Chemical Substances Adhesins, Bacterial ; Adjuvants, Immunologic ; Antigens, Bacterial ; Antigens, Surface ; Bacterial Proteins ; Drug Carriers ; Pertussis Vaccine ; Virulence Factors, Bordetella ; filamentous hemagglutinin adhesin, Bordetella pertussis ; pneumococcal surface protein A
    Language English
    Publishing date 2020-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0228055
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  10. Article ; Online: Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data.

    Chen, Xi / Wang, Yuan / Cappuccio, Antonio / Cheng, Wan-Sze / Zamojski, Frederique Ruf / Nair, Venugopalan D / Miller, Clare M / Rubenstein, Aliza B / Nudelman, German / Tadych, Alicja / Theesfeld, Chandra L / Vornholt, Alexandria / George, Mary-Catherine / Ruffin, Felicia / Dagher, Michael / Chawla, Daniel G / Soares-Schanoski, Alessandra / Spurbeck, Rachel R / Ndhlovu, Lishomwa C /
    Sebra, Robert / Kleinstein, Steven H / Letizia, Andrew G / Ramos, Irene / Fowler, Vance G / Woods, Christopher W / Zaslavsky, Elena / Troyanskaya, Olga G / Sealfon, Stuart C

    Nature computational science

    2023  Volume 3, Issue 7, Page(s) 644–657

    Abstract: Resolving chromatin-remodeling-linked gene expression changes at cell-type resolution is important for understanding disease states. Here we describe MAGICAL (Multiome Accessibility Gene Integration Calling and Looping), a hierarchical Bayesian approach ... ...

    Abstract Resolving chromatin-remodeling-linked gene expression changes at cell-type resolution is important for understanding disease states. Here we describe MAGICAL (Multiome Accessibility Gene Integration Calling and Looping), a hierarchical Bayesian approach that leverages paired single-cell RNA sequencing and single-cell transposase-accessible chromatin sequencing from different conditions to map disease-associated transcription factors, chromatin sites, and genes as regulatory circuits. By simultaneously modeling signal variation across cells and conditions in both omics data types, MAGICAL achieved high accuracy on circuit inference. We applied MAGICAL to study
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article
    ISSN 2662-8457
    ISSN (online) 2662-8457
    DOI 10.1038/s43588-023-00476-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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