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  1. Article ; Online: Prisoners as living organ donors: the case of the Scott sisters.

    Goldberg, Aviva M / Frader, Joel

    The American journal of bioethics : AJOB

    2011  Volume 11, Issue 10, Page(s) 15–16

    MeSH term(s) Capital Punishment ; Humans ; Organ Transplantation/ethics ; Prisoners ; Tissue Donors/supply & distribution ; Tissue and Organ Harvesting/ethics ; Tissue and Organ Procurement/standards
    Language English
    Publishing date 2011-10
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2011.603806
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  2. Article ; Online: The authors reply.

    Klompas, Michael / Goldberg, Scott A

    Critical care medicine

    2023  Volume 51, Issue 4, Page(s) e98–e99

    Language English
    Publishing date 2023-03-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005812
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  3. Article ; Online: Turning Back the Clock: Prehospital Antibiotics for Patients With Septic Shock.

    Klompas, Michael / Goldberg, Scott A

    Critical care medicine

    2022  Volume 50, Issue 10, Page(s) 1537–1540

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Emergency Medical Services ; Emergency Service, Hospital ; Humans ; Shock, Septic/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-09-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005655
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  4. Article ; Online: Patients who use emergency medical services have greater severity of illness or injury compared to those who present to the emergency department via other means: A retrospective cohort study.

    Peters, Gregory A / Goldberg, Scott A / Hayes, Jane M / Cash, Rebecca E

    Journal of the American College of Emergency Physicians open

    2023  Volume 4, Issue 4, Page(s) e13017

    Abstract: Objective: We aimed to evaluate the differences in characteristics and illness/injury severity among patients who present to the emergency department (ED) via emergency medical services (EMS) compared to patients who present via other means.: Methods!# ...

    Abstract Objective: We aimed to evaluate the differences in characteristics and illness/injury severity among patients who present to the emergency department (ED) via emergency medical services (EMS) compared to patients who present via other means.
    Methods: We analyzed a nationwide sample of ED visits from the 2015-2019 National Hospital Ambulatory Medical Care Survey. We excluded patients <18 or >92 years old, who eloped or left against medical advice, or who arrived via interfacility transport. Mode of presentation was dichotomized to those presenting to the ED via EMS versus any other mode of transportation. Using the appropriate survey sampling weights, we described patient characteristics and compared measures of illness/injury severity between groups using a multivariable logistic regression model.
    Results: An unweighted total of 73,397 ED visits, representing a weighted estimate of 528,083,416 ED visits in the United States during 2015-2019, included 18% arriving via EMS and 82% via other means. EMS patients were older, more often male, more often had multiple chronic medical conditions, and less often had private insurance. EMS patients had higher priority triage scores, consumed more resources in the ED, and had longer lengths of stay. Arrival by EMS was associated with higher odds of hospital admission (odds ratio [OR] 2.7, 95% confidence interval [CI] 2.4-2.9) and in-hospital mortality (OR 11.1, 95% CI 7.3-17.2).
    Conclusions: Patients presenting via EMS had significantly different characteristics and outcomes than those presenting via other means. These important differences should be considered when comparing studies of all ED patients versus those who present via EMS.
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article
    ISSN 2688-1152
    ISSN (online) 2688-1152
    DOI 10.1002/emp2.13017
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  5. Article: Perspectives on Opt-Out Versus Opt-In Legislation for Deceased Organ Donation: An Opinion Piece.

    Tennankore, Karthik K / Klarenbach, Scott / Goldberg, Aviva

    Canadian journal of kidney health and disease

    2021  Volume 8, Page(s) 20543581211022151

    Language English
    Publishing date 2021-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2765462-X
    ISSN 2054-3581
    ISSN 2054-3581
    DOI 10.1177/20543581211022151
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  6. Article ; Online: Friend or Foe? Locoregional Therapies and Immunotherapies in the Current Hepatocellular Treatment Landscape.

    Young, Shamar / Hannallah, Jack / Goldberg, Dan / Sanghvi, Tina / Arshad, Junaid / Scott, Aaron / Woodhead, Gregory

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: Over the last several decades, a number of new treatment options for patients with hepatocellular carcinoma (HCC) have been developed. While treatment decisions for some patients remain clear cut, a large numbers of patients have multiple treatment ... ...

    Abstract Over the last several decades, a number of new treatment options for patients with hepatocellular carcinoma (HCC) have been developed. While treatment decisions for some patients remain clear cut, a large numbers of patients have multiple treatment options, and it can be hard for multidisciplinary teams to come to unanimous decisions on which treatment strategy or sequence of treatments is best. This article reviews the available data with regard to two treatment strategies, immunotherapies and locoregional therapies, with a focus on the potential of locoregional therapies to be combined with checkpoint inhibitors to improve outcomes in patients with locally advanced HCC. In this review, the available data on the immunomodulatory effects of locoregional therapies is discussed along with available clinical data on outcomes when the two strategies are combined.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Chemoembolization, Therapeutic ; Immunotherapy ; Immunomodulation
    Language English
    Publishing date 2023-07-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411434
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  7. Article: Liver-Directed Therapy Combined with Systemic Therapy: Current Status and Future Directions.

    Young, Shamar / Hannallah, Jack / Goldberg, Dan / Khreiss, Mohammad / Shroff, Rachna / Arshad, Junaid / Scott, Aaron / Woodhead, Gregory

    Seminars in interventional radiology

    2024  Volume 40, Issue 6, Page(s) 515–523

    Abstract: In the past several decades, major advances in both systemic and locoregional therapies have been made for many cancer patients. This has led to modern cancer treatment algorithms frequently calling for active interventions by multiple subspecialists at ... ...

    Abstract In the past several decades, major advances in both systemic and locoregional therapies have been made for many cancer patients. This has led to modern cancer treatment algorithms frequently calling for active interventions by multiple subspecialists at the same time. One of the areas where this can be clearly seen is the concomitant use of locoregional and systemic therapies in patients with primary or secondary cancers of the liver. These combined algorithms have gained favor over the last decade and are largely focused on the allure of the combined ability to control systemic disease while at the same time addressing refractory/resistant clonal populations. While the general concept has gained favor and is likely to only increase in popularity with the continued establishment of viable immunotherapy treatments, for many patients questions remain. Lingering concerns over the increase in toxicity when combining treatment methods, patient selection, and sequencing remain for multiple cancer patient populations. While further work remains, some of these questions have been addressed in the literature. This article reviews the available data on three commonly treated primary and secondary cancers of the liver, namely, hepatocellular carcinoma, cholangiocarcinoma, and metastatic colorectal cancer. Furthermore, strengths and weaknesses are reviewed and future directions are discussed.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 848341-3
    ISSN 1098-8963 ; 0739-9529
    ISSN (online) 1098-8963
    ISSN 0739-9529
    DOI 10.1055/s-0043-1777711
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    Se 916: Show issues Location:
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  8. Article ; Online: Out-of-Hospital Presentation and Management of Asthma and Chronic Obstructive Pulmonary Disease Exacerbations in the United States: A Nationwide Retrospective Cohort Study.

    Peters, Gregory A / Cash, Rebecca E / Goldberg, Scott A / Ordoobadi, Alexander J / Camargo, Carlos A

    Annals of emergency medicine

    2023  Volume 81, Issue 6, Page(s) 679–690

    Abstract: Study objective: To describe the demographic, clinical, and emergency medical service (EMS) response characteristics associated with EMS activations for asthma and chronic obstructive pulmonary disease (COPD) exacerbations in the US.: Methods: Using ... ...

    Abstract Study objective: To describe the demographic, clinical, and emergency medical service (EMS) response characteristics associated with EMS activations for asthma and chronic obstructive pulmonary disease (COPD) exacerbations in the US.
    Methods: Using a nationwide set of out-of-hospital patient care report data from 2018 to 2019, we analyzed 9-1-1 EMS activations where asthma/COPD exacerbation was indicated by symptom, impression, or treatment provided. We excluded patients with ages less than 2 years or unknown, nonemergency transports, and encounters with any indication of anaphylaxis. Demographic, clinical, and EMS response characteristics were described for pediatric and adult patients with asthma/COPD exacerbations.
    Results: A total of 1,336,988 asthma/COPD exacerbations were included, comprising 5% of qualifying 9-1-1 scene activations from 2018 to 2019. Most patients were adults (96%). Most adult patients were female (55%), whereas most pediatric patients were male (58%). Most activations occurred in urban settings (82%), particularly in pediatric patients (90%). Most asthma/COPD exacerbations were managed by advanced life support units (94%). Inhaled bronchodilators and systemic corticosteroid therapy were administered to 75% and 14% of all patients, respectively. Adults more often had oxygen saturation <92% (43% vs 20% of pediatric patients) and were more often treated with assisted ventilation (9% vs 1%).
    Conclusion: In this large nationwide sample of 9-1-1 activations treated and transported by EMS, 5% were for asthma/COPD exacerbation. Future work should focus on evidence-based standardization of EMS protocols and practice for asthma/COPD exacerbations to improve the quality of EMS care.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Child ; United States/epidemiology ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Retrospective Studies ; Asthma/diagnosis ; Asthma/epidemiology ; Asthma/therapy ; Bronchodilator Agents/therapeutic use ; Hospitals ; Disease Progression
    Chemical Substances Bronchodilator Agents
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2022.10.013
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    Zs.A 1344: Show issues Location:
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  9. Article: Effects of APOE e4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated NACC Database.

    Goldberg, Terry E / Devanand, D P / Fang, Zhiqian / Kim, Hyun / Rueppel, Elizabeth / Tucker, Aren / Carlson, Scott / Lee, Seonjoo

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Background: Our goal in this study was to identify paths from APOE e4 to neurobehaviors itemized on a neuropsychiatric inventory that involved neuropathologies associated with e4 (amyloid, tau, cerebral amyloid angiopathy, and Lewy bodies) or cognition ... ...

    Abstract Background: Our goal in this study was to identify paths from APOE e4 to neurobehaviors itemized on a neuropsychiatric inventory that involved neuropathologies associated with e4 (amyloid, tau, cerebral amyloid angiopathy, and Lewy bodies) or cognition mediators (memory or global cognitive status), as well as direct paths from e4 to cognition or neurobehaviors.
    Methods: A total of 1199 cases with available neurobehavioral, cognition and neuropathological data were included. We then conducted a series of causal mediation analyses in R in which e4 always served as the independent variable and Neuropsychiatric Inventory (NPI) neurobehavioral items, when included in the mediation, the outcome. Neuropathologies or cognition served as mediators.
    Results: Multiple significant indirect paths from e4 through neuropathologies to neurobehaviors were identified. More refined analyses indicated that neuritic plaques and Braak stage, but not extent of diffuse amyloid plaques, drove the findings. A significant direct effect of e4 to memory was also identified. Additionally, Lewy body disease, when treated as an exposure, had a direct effect on hallucinations in keeping with known features of the disease.
    Conclusions: We found strong evidence for partial mediation of NPI symptoms by cognition, suggesting that cognitive limitations that may have influenced understanding (or misunderstanding) the environment with impacts on maladaptive behavior. In addition, neuritic amyloid plaque levels and Braak stage, but not diffuse amyloid plaque extent, were key in NPI mediated associations suggesting the possibility that synaptic failure play an important role in multiple neurobehavioral symptoms in dementia, including psychosis. Last, we found strong evidence that e4 may have direct effects on cognition when we used verbal episodic memory as an outcome, suggesting that medial temporal regions that support memory may be sensitive to non-amyloidogenic and non-tau related pathophysiological processes.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.30.24301966
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  10. Article ; Online: Effects of APOE e4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated NACC Database.

    Goldberg, Terry E / Devanand, D P / Fang, Zhiqian / Kim, Hyun / Rueppel, Elizabeth / Tucker, Aren / Carlson, Scott / Lee, Seonjoo

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2024  

    Abstract: Background: We sought to identify paths from APOE e4 to neurobehaviors itemized on a neuropsychiatric inventory that involved neuropathologies associated with e4 (amyloid, tau, cerebral amyloid angiopathy, and Lewy bodies) or cognition mediators (memory ...

    Abstract Background: We sought to identify paths from APOE e4 to neurobehaviors itemized on a neuropsychiatric inventory that involved neuropathologies associated with e4 (amyloid, tau, cerebral amyloid angiopathy, and Lewy bodies) or cognition mediators (memory or global cognitive status), as well as direct paths from e4 to neurobehaviors.
    Methods: A total of 1199 cases with available neurobehavioral, cognition and neuropathological data were included. We conducted a series of causal mediation analyses in R in which e4 always served as the independent variable and Neuropsychiatric Inventory (NPI) neurobehavioral items, when included in the mediation, the outcome. Neuropathologies or cognition served as mediators.
    Results: Multiple significant indirect paths from e4 through neuropathologies to neurobehaviors were identified. More refined analyses indicated that neuritic plaques and Braak stage drove the findings. A significant direct effect of e4 to memory was also identified. Additionally, Lewy body disease, when treated as an exposure, had a direct effect on hallucinations consistent with features of the disease.
    Conclusions: We found strong evidence for partial mediation of NPI symptoms by cognition, suggesting that cognitive limitations may have promoted maladaptive behavior. In addition, neuritic amyloid plaque levels and Braak stage, but not diffuse amyloid plaque extent, were key in NPI mediated associations suggesting the possibility that synaptic failure play an important role in multiple neurobehavioral symptoms in dementia, including psychosis. Last, we found strong evidence that e4 may have direct effects on cognition when we used verbal episodic memory but not global cognitive status, as an outcome.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2024.01.012
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