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  1. Book: Supplement Cerebral revascularization by endovascular techniques

    Cohen, José E.

    (Neurological research ; 27, Suppl. 1)

    2005  

    Title variant Cerebral revascularization by endovascular techniques
    Author's details guest ed. José E. Cohen
    Series title Neurological research ; 27, Suppl. 1
    Collection
    Language English
    Size S135 S. : Ill., graph. Darst.
    Publisher Maney
    Publishing place Leeds
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014536767
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1491 -27,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Quantifying tissue growth, shape and collision via continuum models and Bayesian inference.

    Falcó, Carles / Cohen, Daniel J / Carrillo, José A / Baker, Ruth E

    Journal of the Royal Society, Interface

    2023  Volume 20, Issue 204, Page(s) 20230184

    Abstract: Although tissues are usually studied in isolation, this situation rarely occurs in biology, as cells, tissues and organs coexist and interact across scales to determine both shape and function. Here, we take a quantitative approach combining data from ... ...

    Abstract Although tissues are usually studied in isolation, this situation rarely occurs in biology, as cells, tissues and organs coexist and interact across scales to determine both shape and function. Here, we take a quantitative approach combining data from recent experiments, mathematical modelling and Bayesian parameter inference, to describe the self-assembly of multiple epithelial sheets by growth and collision. We use two simple and well-studied continuum models, where cells move either randomly or following population pressure gradients. After suitable calibration, both models prove to be practically identifiable, and can reproduce the main features of single tissue expansions. However, our findings reveal that whenever tissue-tissue interactions become relevant, the random motion assumption can lead to unrealistic behaviour. Under this setting, a model accounting for population pressure from different cell populations is more appropriate and shows a better agreement with experimental measurements. Finally, we discuss how tissue shape and pressure affect multi-tissue collisions. Our work thus provides a systematic approach to quantify and predict complex tissue configurations with applications in the design of tissue composites and more generally in tissue engineering.
    MeSH term(s) Bayes Theorem ; Models, Theoretical ; Research Design ; Models, Biological
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2156283-0
    ISSN 1742-5662 ; 1742-5689
    ISSN (online) 1742-5662
    ISSN 1742-5689
    DOI 10.1098/rsif.2023.0184
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  3. Book ; Online: Mechanical constraints and cell cycle regulation in models of collective cell migration

    Falcó, Carles / Cohen, Daniel J. / Carrillo, José A. / Baker, Ruth E.

    2024  

    Abstract: The spatiotemporal coordination and regulation of cell proliferation is fundamental in many aspects of development and tissue maintenance. Cells have the ability to adapt their division rates in response to mechanical checkpoints, yet we do not fully ... ...

    Abstract The spatiotemporal coordination and regulation of cell proliferation is fundamental in many aspects of development and tissue maintenance. Cells have the ability to adapt their division rates in response to mechanical checkpoints, yet we do not fully understand how cell proliferation regulation impacts cell migration phenomena. Here, we present a minimal continuum model of cell migration with cell cycle dynamics, which includes mechanical constraints and hence can account for cell proliferation regulation. By combining minimal mathematical modelling, Bayesian inference, and recent experimental data, we quantify the impact of mechanical constraints across different cell cycle stages in epithelial tissue expansion experiments. Our model suggests that cells sense local density and adapt cell cycle progression in response, during G1 and the combined S/G2/M phases, providing an explicit relationship between each cell cycle stage duration and local tissue density, which is consistent with several experimental observations. Finally, we compare our mathematical model predictions to different experiments studying cell cycle regulation and present a quantitative analysis on the impact of mechanical constraints on cell migration patterns. Our work presents a systematic approach for investigating and analysing cell cycle data, providing mechanistic insights into how individual cells regulate proliferation, based on population-based experimental measurements.
    Keywords Quantitative Biology - Quantitative Methods ; Physics - Biological Physics
    Subject code 571 ; 612
    Publishing date 2024-01-16
    Publishing country us
    Document type Book ; Online
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  4. Article ; Online: ICG Flow 800 technology targeted STA-MCA microvascular bypass for exclusion of deep-seated fusiform MCA aneurysm: 2-dimensional operative video.

    Candanedo, Carlos / Goldstein, Kobi / Cohen, José E / Spektor, Sergey

    Neurosurgical focus: Video

    2022  Volume 6, Issue 1, Page(s) V14

    Abstract: The authors present the case of an 18-year-old male with a deep-seated left fusiform dissecting M3 aneurysm for which endovascular treatment was not applicable. At the open surgery, they used the less commonly reported FLOW 800 fluorescent indocyanine ... ...

    Abstract The authors present the case of an 18-year-old male with a deep-seated left fusiform dissecting M3 aneurysm for which endovascular treatment was not applicable. At the open surgery, they used the less commonly reported FLOW 800 fluorescent indocyanine green (ICG) videoangiography, before and after parental aneurysmal artery temporary clipping, to locate the distal outflow branch of the aneurysm and use it as the recipient artery for a superficial temporal artery-M4 bypass, excluding the aneurysm by clipping the parental artery. Repeated ICG FLOW 800 angiography confirmed bypass patency and adequate blood flow. The aneurysm's exclusion from circulation was confirmed by digital subtraction angiography postoperatively. The video can be found here: https://stream.cadmore.media/r10.3171/2021.10.FOCVID21183.
    Language English
    Publishing date 2022-01-01
    Publishing country United States
    Document type Journal Article
    ISSN 2643-5217
    ISSN (online) 2643-5217
    DOI 10.3171/2021.10.FOCVID21183
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  5. Article: [GLIOBLASTOMA MULTIFORME AFTER STEREOTACTIC RADIOSURGERY TREATMENT FOR ARTERIO-VENOUS MALFORMATION].

    Sarah Houri, Saadit / Vigoda, Marc / Cohen, Jose E / Shoshan, Yigal

    Harefuah

    2022  Volume 162, Issue 4, Page(s) 228–233

    Abstract: Introduction: Stereotactic radiosurgery (SRS) is a minimally invasive option commissioned in the treatment of intracranial arteriovenous malformations (AVMs). As long-term follow-up data became available, some late adverse effects have been reported, ... ...

    Abstract Introduction: Stereotactic radiosurgery (SRS) is a minimally invasive option commissioned in the treatment of intracranial arteriovenous malformations (AVMs). As long-term follow-up data became available, some late adverse effects have been reported, including SRS-induced neoplasia. However, the exact incidence of this adverse effect is unknown. In this article we present and discuss the topic with an unusual case of a young patient who was treated with SRS for AVM and developed a malignant brain tumor.
    MeSH term(s) Humans ; Follow-Up Studies ; Treatment Outcome ; Glioblastoma/etiology ; Glioblastoma/surgery ; Radiosurgery/adverse effects ; Retrospective Studies ; Intracranial Arteriovenous Malformations/surgery ; Intracranial Arteriovenous Malformations/etiology
    Language Hebrew
    Publishing date 2022-01-21
    Publishing country Israel
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 291: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Online: Quantifying tissue growth, shape and collision via continuum models and Bayesian inference

    Falcó, Carles / Cohen, Daniel J. / Carrillo, José A. / Baker, Ruth E.

    2023  

    Abstract: Although tissues are usually studied in isolation, this situation rarely occurs in biology, as cells, tissues, and organs, coexist and interact across scales to determine both shape and function. Here, we take a quantitative approach combining data from ... ...

    Abstract Although tissues are usually studied in isolation, this situation rarely occurs in biology, as cells, tissues, and organs, coexist and interact across scales to determine both shape and function. Here, we take a quantitative approach combining data from recent experiments, mathematical modelling, and Bayesian parameter inference, to describe the self-assembly of multiple epithelial sheets by growth and collision. We use two simple and well-studied continuum models, where cells move either randomly or following population pressure gradients. After suitable calibration, both models prove to be practically identifiable, and can reproduce the main features of single tissue expansions. However, our findings reveal that whenever tissue-tissue interactions become relevant, the random motion assumption can lead to unrealistic behaviour. Under this setting, a model accounting for population pressure from different cell populations is more appropriate and shows a better agreement with experimental measurements. Finally, we discuss how tissue shape and pressure affect multi-tissue collisions. Our work thus provides a systematic approach to quantify and predict complex tissue configurations with applications in the design of tissue composites and more generally in tissue engineering.
    Keywords Quantitative Biology - Tissues and Organs ; Nonlinear Sciences - Pattern Formation and Solitons ; Quantitative Biology - Quantitative Methods
    Subject code 612
    Publishing date 2023-02-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Introduction. Neurosurgical management of stroke, organization of stroke management, and artificial intelligence applications.

    Levy, Elad I / Taussky, Philipp / Cohen, Jose E / Kan, Peter

    Neurosurgical focus

    2021  Volume 51, Issue 1, Page(s) E1

    MeSH term(s) Artificial Intelligence ; Humans ; Stroke/surgery
    Language English
    Publishing date 2021-06-29
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2021.4.FOCUS21264
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  8. Article: Carotid Artery Stenting in Patients with Atrial Fibrillation: Direct Oral Anticoagulants, Brief Double Antiplatelets, and Testing Strategy.

    Cohen, José E / Gomori, John Moshe / Honig, Asaf / Leker, Ronen R

    Journal of clinical medicine

    2021  Volume 10, Issue 22

    Abstract: Carotid endarterectomy is usually preferred over carotid artery stenting (CAS) for patients with atrial fibrillation (AF). We present our experience with short-course periprocedural triple antithrombotic therapy in 32 patients aged >18 years with ... ...

    Abstract Carotid endarterectomy is usually preferred over carotid artery stenting (CAS) for patients with atrial fibrillation (AF). We present our experience with short-course periprocedural triple antithrombotic therapy in 32 patients aged >18 years with nonvalvular AF undergoing CAS. There were no deaths, cardiac events, embolic strokes, hyperperfusion syndrome, intracranial hemorrhage, or stent thrombosis within 30 days. Transient intraprocedural hemodynamic instability in 15/32 (47%) and prolonged instability in 4/32 (13%) was managed conservatively. At a mean 16-month follow-up, there were no new neurological events or deterioration. Mean stenosis was reduced from 78.0% ± 9.7% to 17.3% ± 12.2%. This retrospective study included patients AF who were symptomatic (minor stroke (NIHSS ≤ 5)/TIA) with ICA stenosis >50%, or asymptomatic under DOAC therapy with carotid stenosis >80%, who underwent CAS from 6/2014-10/2020. Patients received double antiplatelets and statins. Antiplatelet therapy effectiveness was monitored. Stenting was performed when P2Y12 reaction units (PRU) were <150. DOACs were discontinued 48 h before angioplasty; one 60 mg dose of subcutaneous enoxaparin was administered in lieu. DOAC was restarted 12-24 h after intervention. Patients were discharged under DOAC and one nonaspirin antiplatelet. 32 patients on DOAC were included (26 male, mean age 71). 19 (59.4%) presented with stroke (ICA stenosis-related in 14); 13 (40.6%) were asymptomatic. Stents were deployed under filter protection following pre-angioplasty; post-angioplasty was performed at least once in 12 patients (37.5%). Our experience suggests that CAS can be safely performed in selected patients with CAS and AF requiring DOAC. The role of CAS in AF patients under DOAC warrants study in rigorous trials.
    Language English
    Publishing date 2021-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10225242
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  9. Article: Effects in Israel of Arab and Jewish Ethnicity on Intracerebral Hemorrhage.

    Simaan, Naaem / Filioglo, Andrei / Cohen, José E / Lorberboum, Yonatan / Leker, Ronen R / Honig, Asaf

    Journal of clinical medicine

    2022  Volume 11, Issue 8

    Abstract: Intracerebral hemorrhages (ICH) characteristics reportedly differ between different ethnic groups. We aimed to compare the characteristics of Jewish and Arab ICH patients in Israel. Consecutive patients with primary ICH were included in a prospective ... ...

    Abstract Intracerebral hemorrhages (ICH) characteristics reportedly differ between different ethnic groups. We aimed to compare the characteristics of Jewish and Arab ICH patients in Israel. Consecutive patients with primary ICH were included in a prospective institutional database. Demographics, vascular risk factors, clinical and radiological parameters were compared between Arab and Jewish ICH patients residing in Jerusalem. The study included 455 patients (311 Jews). Arab patients were younger (66.1 ± 13.4 vs. 72.2 ± 12.2 years, p < 0.001) and had higher rates of diabetes (60% vs. 29%, p < 0.001) and smoking (26% vs. 11%, p < 0.001). Arab patients had higher rates of deep ICH (74% vs. 62%, p = 0.01) and lower rates of lobar ICH (18% vs. 31%, p = 0.003). In a sub-analysis of deep ICH patients only, Arab patients were younger (64.3 ± 12.9 vs. 71.4 ± 11.8 years, p < 0.001) and less frequently male (56% vs. 68%, p = 0.042), with higher rates of diabetes (61% vs. 35%, p < 0.001) and smoking (31% vs. 14%, p < 0.001). In conclusion, the two ethnic populations in Israel differ in the causes and attributes of ICH. Heavy smoking and poorly controlled diabetes are commonly associated with deep ICH in the Arab population and may offer specific targets for secondary prevention in this population.
    Language English
    Publishing date 2022-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11082117
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  10. Article ; Online: Acute middle cerebral artery occlusion: reappraisal of the role of endovascular revascularization.

    Cohen, José E

    International journal of stroke : official journal of the International Stroke Society

    2013  Volume 8, Issue 2, Page(s) 109–110

    Abstract: Intravenous tissue plasminogen activator was the first successful stroke therapy in acute ischaemic stroke, after innumerable failed attempts at neuroprotection and neurorestoration. However, intravenous tissue type plasminogen activator has been shown ... ...

    Abstract Intravenous tissue plasminogen activator was the first successful stroke therapy in acute ischaemic stroke, after innumerable failed attempts at neuroprotection and neurorestoration. However, intravenous tissue type plasminogen activator has been shown to be effective in recanalizing middle cerebral artery occlusions in only about one-third of cases. The natural history of untreated acute middle cerebral artery occlusion is poor, leading to long-term disability in >70% and mortality in 20%. Recanalization alone is not the name of the game. Only timely, very rapid recanalization, achieved within minutes or at most a few hours after stroke has occurred, before irreversible brain damage develops, is effective. Is intravenous tissue type plasminogen activator the best available option we have for these patients? With recently introduced stent-based thrombectomy devices, neurointerventionalists have achieved complete recanalization rates of more than 90% in middle cerebral artery and 'T' occlusions, with a mean procedural recanalization time of less than one-hour and negligible complication rates. More than 80% of patients less than 80 years of age who were treated within eight-hours after stroke onset in our centre achieved a modified Rankin score of 0-2 at three-month follow-up. The site of arterial occlusion is a factor driving the choice between a standard intravenous tissue type plasminogen activator protocol and an alternative intervention such as intravenous and/or mechanical thrombolysis to achieve early recanalization. The role of intravenous tissue type plasminogen activator must be redefined in major occlusions, and the indications for endovascular therapy must also be reappraised.
    MeSH term(s) Acute Disease ; Cerebral Revascularization/methods ; Fibrinolytic Agents/administration & dosage ; Humans ; Infarction, Middle Cerebral Artery/surgery ; Infarction, Middle Cerebral Artery/therapy ; Infusions, Intravenous ; Mechanical Thrombolysis/methods ; Tissue Plasminogen Activator/administration & dosage
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1111/j.1747-4949.2012.00898.x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6582: Show issues Location:
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