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Article: Characteristics of Ancient Shipwreck Wood from Huaguang Jiao No. 1 after Desalination.

Liu, Xinyou / Zhu, Lulu / Tu, Xinwei / Zhang, Changjun / Huang, Houyi / Varodi, Anca Maria

2023 Volume 16, Issue 2

Abstract: Huaguangjiao I refers to the ancient Chinese wooden shipwreck of the South Song Dynasty (1127-1279 AD) discovered in the South China Sea in 1996. From 2008 to 2017, the archaeological waterlogged wood was desalted using deionized water combined with ... ...

Abstract	Huaguangjiao I refers to the ancient Chinese wooden shipwreck of the South Song Dynasty (1127-1279 AD) discovered in the South China Sea in 1996. From 2008 to 2017, the archaeological waterlogged wood was desalted using deionized water combined with ultrasonic treatment, and desalted using EDTA-2Na, EDTAHO, and NaH
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16020510
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: White matter alterations in heart-kidney imbalance insomnia and Jiao-Tai-Wan treatment: A diffusion-tensor imaging study.

Chen, Jie / Li, Yanxuan / Xia, Nengzhi / Wen, Caiyun / Xia, Tianyi / Zhuang, Yuandi / Jiang, Mengmeng / Xiang, Yilan / Zhang, Mingyue / Zhan, Chenyi / Yang, Yunjun / Yuan, Zhengzhong / Huang, Qun

Brain imaging and behavior

2022 Volume 16, Issue 4, Page(s) 1803–1812

Abstract: ... kidney imbalance insomnia patients who were treated with placebo or Jiao-Tai-Wan ... insomnia patients (8 males; 16 females; 42.5 ± 10.4 years) with Jiao-Tai-Wan and 26 heart-kidney imbalance ... radiata. After being treated with Jiao-Tai-Wan, heart-kidney imbalance insomnia patients showed a trend ...

Abstract	Previous studies have reported changes in white matter microstructures in patients with insomnia. However, few neuroimaging studies have focused specifically on white matter tracts in insomnia patients after having received treatment. In this prospective study, diffusion-tensor imaging was used in two samples of heart-kidney imbalance insomnia patients who were treated with placebo or Jiao-Tai-Wan, a traditional Chinese medicine commonly used to treat heart-kidney imbalance insomnia, to assess the changes in white matter tracts. Tract-based spatial statistical analyses were first applied to compare the changes in mean diffusivity and fractional anisotropy of white matter between 75 heart-kidney imbalance insomnia patients and 41 healthy control participants. In subsequent randomized, double-blind, placebo-controlled trials, comparisons of mean diffusivity and fractional anisotropy were also performed in 24 heart-kidney imbalance insomnia patients (8 males; 16 females; 42.5 ± 10.4 years) with Jiao-Tai-Wan and 26 heart-kidney imbalance insomnia patients (11 males; 15 females; 39.7 ± 9.4 years) with a placebo, with age and sex as covariates. Fractional anisotropy values in left corticospinal tract were increased in heart-kidney imbalance insomnia patients. Heart-kidney imbalance insomnia patients showed lower mean diffusivity and fractional anisotropy values of several white matter tracts than healthy control participants, such as the bilateral anterior limb of internal capsule, bilateral superior longitudinal fasciculus and bilateral posterior corona radiata. After being treated with Jiao-Tai-Wan, heart-kidney imbalance insomnia patients showed a trend towards reduced fractional anisotropy values in the left corticospinal tract. Jiao-Tai-Wan may improve the sleep quality by reversing the structural changes of the left corticospinal tract caused by heart-kidney imbalance insomnia.
MeSH term(s)	Anisotropy ; Drugs, Chinese Herbal ; Female ; Humans ; Kidney ; Leukoaraiosis ; Magnetic Resonance Imaging/methods ; Male ; Prospective Studies ; Sleep Initiation and Maintenance Disorders/diagnostic imaging ; Sleep Initiation and Maintenance Disorders/drug therapy ; White Matter/diagnostic imaging
Chemical Substances	Drugs, Chinese Herbal ; jiao tai wan
Language	English
Publishing date	2022-03-25
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2377165-3
ISSN	1931-7565 ; 1931-7557
ISSN (online)	1931-7565
ISSN	1931-7557
DOI	10.1007/s11682-022-00653-6
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Article ; Online: Chemical profile and miscarriage prevention evaluation of Jiao-Ai Decoction, a classical traditional Chinese formula.

Zhang, Min / Geng, Ting / Jing, Shao-Heng / Li, Lin / Wang, Kan / Zhang, Qiao / Zhang, Yi / Zhou, Shi-Kang / Gao, Ping / Ding, An-Wei / Zhang, Li

Journal of pharmaceutical and biomedical analysis

2022 Volume 217, Page(s) 114832

Abstract: Jiao-Ai Decoction (JAD), a classical traditional Chinese formula composed of seven Chinese herbs ...

Abstract	Jiao-Ai Decoction (JAD), a classical traditional Chinese formula composed of seven Chinese herbs, has been widely used in clinical practice for the treatment of abortion for a long time. However, the material basis and pharmacological mechanism remain unclear. An integrative method combining ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS/MS) analysis and therapeutic effect evaluation based on the hypothalamus-pituitary-ovarian axis (HPOA) was employed to elaborate these problems. Firstly, the chemical profile of JAD was identified by UPLC-Q-TOF-MS. Secondly, the main target ingredients from JAD were determined by UPLC-T-Q-MS. Finally, the miscarriage prevention of JAD on threatened abortion pregnant rats induced by mifepristone was investigated. Threatened abortion model in rats were replicated, uterine bleeding quantity (UBQ) and histopathological sections were measured, the contents of luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E
MeSH term(s)	Abortion, Spontaneous/drug therapy ; Abortion, Threatened/drug therapy ; Abortion, Threatened/prevention & control ; Animals ; China ; Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid ; Drugs, Chinese Herbal/analysis ; Female ; Humans ; Pregnancy ; Rats ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-05-13
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2022.114832
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Article ; Online: Suppression of high bone remodelling by E’Jiao in ovariectomised rats

Sophia Ogechi Ekeuku / Kok-Yong Chin / Jing Qian / Yan Zhang / Haibin Qu / Elvy Suhana Mohd Ramli / Sok Kuan Wong / Mohd Mustazil Mohd Noor / Soelaiman Ima-Nirwana

Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113265- (2022)

2022

Abstract: The current prevention options for postmenopausal osteoporosis are very limited. E’Jiao is ... Jiao in a rat model of osteoporosis caused by ovariectomy. Female Sprague Dawley rats (n = 42) were ... medium dose (0.53 g/kg) and high dose E’Jiao (1.06 g/kg), as well as calcium carbonate (1% w/v) groups ...

Abstract	The current prevention options for postmenopausal osteoporosis are very limited. E’Jiao is a collagen-rich traditional Chinese medicine with the potential to prevent osteoporosis but more comprehensive investigations are lacking. This study aimed to investigate the skeletal protective effects of E’Jiao in a rat model of osteoporosis caused by ovariectomy. Female Sprague Dawley rats (n = 42) were randomly assigned into baseline, sham, ovariectomised (OVX) control, OVX-treated with low-dose (0.26 g/kg), medium dose (0.53 g/kg) and high dose E’Jiao (1.06 g/kg), as well as calcium carbonate (1% w/v) groups. Daily treatment through oral gavage was initiated 7 days after OVX. The rats were euthanised after eight weeks of treatment. Bone mineral density and content were measured at baseline, 1 and 2 months after treatment. Blood was collected for the measurement of bone remodelling markers. Femur and tibial bones were collected for histomorphometry and biomechanical strength analysis. Untreated OVX rats showed high bone remodelling marked by the increased bone formation and bone resorption markers, as well as increased mineralising surface/bone surface ratio. In addition, osteoclast surface and single-labelled surface were increased while mineral apposition rate was reduced in the untreated OVX rats. These changes were antagonised by E’Jiao at all doses. However, the structural, cellular and biomechanical parameters were not affected by ovariectomy and treatment. In conclusion, E’Jiao prevented high bone remodelling during oestrogen deficiency but a long-term study will be required to establish its effects on structural and biomechanical changes due to oestrogen deficiency.
Keywords	Collagen ; Postmenopausal osteoporosis ; Traditional Chinese medicine ; Skeletal health ; Therapeutics. Pharmacology ; RM1-950
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis

Xiaoxiong Yang / Yu Wang / Xueli Ding / Shanshan Ju / Xiaoye An / Bing Zhang / Zhijian Lin

Pharmaceutical Biology, Vol 61, Iss 1, Pp 1525-

2023 Volume 1535

Abstract: ... on patients, which might diminish quality of life. Qin Jiao, a perennial herb found in northwestern China and ... of Qin Jiao on gout and joint inflammation and elucidates its potential mechanism for gouty arthritis ... to assess the applications of Qin Jiao in arthritis treatment. Study 2 was performed to discover ...

Abstract	AbstractContext: Gout is a chronic disease that imposes a huge financial and health burden on patients, which might diminish quality of life. Qin Jiao, a perennial herb found in northwestern China and Japan, is commonly used for treating various ailments.Objective: This study investigates the effects of Qin Jiao on gout and joint inflammation and elucidates its potential mechanism for gouty arthritis.Materials and methods: Study 1, a literature review was conducted using PubMed, Web of Science, and CNKI to assess the applications of Qin Jiao in arthritis treatment. Study 2 was performed to discover the component targets and gouty disease targets via TCMSP, OMIM, GeneCards and DRUGBANK, and network pharmacology analysis. Study 3, male Sprague-Dawley (SD) rats were divided into normal, model, colchicine, Qin Jiao low-dose (QJL), and Qin Jiao high-dose group (QJH), oral gavage for 40 d. Serum, synovial fluid, and synovial membrane tissue were collected to measure the expression levels of IL-1β, IL-6, and STAT3.Results: The research also identified potential targets and pharmacological pathways of Qin Jiao for gout treatment. In vivo study demonstrated Qin Jiao can reduce IL-1β levels in serum and ankle flushing fluid. ELISA analysis confirmed that Qin Jiao significantly reduces the protein expression of IL-6 and STAT3.Discussion and conclusion: Qin Jiao exerts anti-inflammatory effects on gouty arthritis by modulating the IL-6/STAT3 pathway. This study provides a biological basis for the use of Qin Jiao in treating arthritis-related diseases and offers experimental evidence for potential future drug development.
Keywords	Joint inflammation ; Chinese herbs ; Kampo medicine ; IL-6/STAT3 pathway ; joint arthritis ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy of Fufang E’jiao Jiang in the Treatment of Patients with Qi and Blood Deficiency Syndrome

Mengjie Zhao / Mengli Xiao / Jiake Ying / Panbo Qiu / Hongxian Wu / Qin Tan / Shiliang Chen / Lulu Zhang / Sanfei Shi / Guida Li / Yang Zhao / Fang Lu

Evidence-Based Complementary and Alternative Medicine, Vol

A Real-World Prospective Multicenter Study with a Patient Registry

2023 Volume 2023

Abstract: ... designed to evaluate the efficacy of Fufang E’jiao Jiang (FEJ) in Chinese patients with Qi and blood ...

Abstract	Objective. This nationwide, multicenter prospective observational study with a patient registry was designed to evaluate the efficacy of Fufang E’jiao Jiang (FEJ) in Chinese patients with Qi and blood deficiency syndrome (QBDS). Methods. QBDS patients were consecutively recruited from 81 investigational sites in China from July, 2019, to December, 2020. Patients who met the eligibility criteria were enrolled in a prospective registry database. Baseline characteristics and changes in scores on the traditional Chinese medicine (TCM) symptom evaluation scale for Qi and blood deficiency, the clinical global impression (CGI) scale, the fatigue scale-14 (FS-14), and the Pittsburgh sleep quality index (PSQI) were analyzed to determine the clinical efficacy of FEJ. Results. A total of 3,203 patients were recruited. The average remission rate (i.e., the sum of the cure rate and improvement rate) of the 20 symptoms of QBDS was 92.49% after 4 weeks of FEJ treatment, which was higher than at baseline; the rate increased to 94.69% at 8 weeks. The CGI scale revealed that the number of total remissions at 4 and 8 weeks was 3,120 (97.41%) and 415 (100%), respectively. The total FS-14 scores decreased by 1.67 ± 4.11 (p<0.001) at 4 weeks and 1.72 ± 3.09 (p<0.001) at 8 weeks of treatment. The PSQI scores were 6.6 ± 4.7 and 6.52 ± 3.07 at 4 and 8 weeks, respectively, which were significantly lower than the baseline scores (p<0.001; p=0.0033). Both the subhealth fatigue (SF) and iron deficiency anemia (IDA) groups showed significantly improved clinical symptoms of QBDS (p<0.01). Between-group comparisons revealed significantly greater improvements in FS-14 and PSQI scores in the SF group than in the IDA group (p<0.05). A multivariate logistic regression analysis showed that disease course, FS-14 score at baseline, and four-week FEJ doses were independent risk factors for the degree of symptom relief in QBDS patients (p<0.05). Conclusion. In real-world settings, FEJ has a promising effect in treating QBDS and can ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Discussion on application of Jiao Xue].

Zhao, Jia-You / Zhang, Ying / Zhang, Xue-Song

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2013 Volume 33, Issue 6, Page(s) 560

MeSH term(s)	Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Coronary Disease/therapy ; Humans ; Male ; Middle Aged
Language	Chinese
Publishing date	2013-06
Publishing country	China
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0255-2930
ISSN	0255-2930
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Article ; Online: Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation.

Bai, Guiqin / Qiao, Yiqi / Lo, Po-Chieh / Song, Lei / Yang, Yuna / Duan, Lining / Wei, Sufen / Li, Min / Huang, Shuiqing / Zhang, Beiping / Wang, Qi / Yang, Cong

Journal of ethnopharmacology

2021 Volume 283, Page(s) 114717

Abstract: Ethnopharmacological relevance: Jiao-Tai-Wan (JTW) is a very famous traditional Chinese medicine ...

Abstract	Ethnopharmacological relevance: Jiao-Tai-Wan (JTW) is a very famous traditional Chinese medicine formula for the treatment of psychiatric disorders, especially in anxiety, insomnia and depression. However, its molecular mechanism of treatment remains indistinct. Aim of the study: We aimed to reveal the action mechanism of JTW on anti-depression via inhibiting microglia activation and pro-inflammatory response both in vivo and in vitro. Material and methods: The corticosterone (CORT)-induced depression mouse model was used to evaluate the therapeutic efficacy of JTW. Behavioral tests (open field, elevated plus maze, tail suspension and forced swim test) were conducted to evaluate the effect of JTW on depressive-like behaviors. The levels of inflammatory factors and the concentration of neurotransmitters were detected by RT-qPCR or ELISA assays. Then three hippocampal tissue samples per group (Control, CORT, and JTW group) were sent for RNA sequencing (RNA-seq). Transcriptomics data analysis was used to screen the key potential therapeutic targets and signaling pathways of JTW. Based on 8 bioactive species of JTW by our previous study using High-performance liquid chromatography (HPLC) analysis, molecular docking analyses were used to predict the interaction of JTW-derived compounds and depression targets. Finally, the results of transcriptome and molecular docking analyses were combined to verify the targets, key pathways, and efficacy of JTW treatment in vivo and vitro. Results: JTW ameliorated CORT-induced depressive-like behaviors, neuronal damage and enhanced the levels of monoamine neurotransmitters in the serum of mice. JTW also inhibited CORT-induced inflammatory activation of microglia and decreased the serum levels of interleukin- 6(IL-6) and interleukin- 1β (IL-1β) in vivo. Transcriptomic data analysis showed there were 10 key driver analysis (KDA) genes with the strongest correlation which JTW regulated in depression mice. Molecular docking analysis displayed bioactive compound Magnoflorine had the strongest binding force to the key gene colony-stimulating factor 1 receptor (CSF1R), which is the signaling microglia dependent upon for their survival. Meanwhile, CSF1R staining showed it was consistent with inflammatory activation of microglia. Our vitro experiment also showed JTW and CSF1R inhibitor significantly reduced lipopolysaccharide (LPS)/interferon-gamma (IFNɣ)-induced inflammatory activation response in macrophage cells. Conclusions: Our study suggests that JTW might ameliorate CORT-induced neuronal damage in depression mice by inhibiting CSF1R mediated microglia activation and pro-inflammatory response.
MeSH term(s)	Animals ; Animals, Outbred Strains ; Antidepressive Agents/pharmacology ; Behavior, Animal/drug effects ; Corticosterone/toxicity ; Depression/drug therapy ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Hippocampus/drug effects ; Inflammation/drug therapy ; Male ; Mice ; Microglia/drug effects ; Microglia/metabolism ; Molecular Docking Simulation ; RAW 264.7 Cells
Chemical Substances	Antidepressive Agents ; Drugs, Chinese Herbal ; jiao tai wan ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2021-10-07
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114717
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Article ; Online: Shuai Jiao

Yun Zhang

Revista de Artes Marciales Asiáticas, Vol 1, Iss 2, Pp 24-

An Introduction to the Chinese Throwing Art

2012 Volume 61

Abstract: No abstract ... ...

Abstract	No abstract available
Keywords	Sports ; GV557-1198.995 ; Recreation. Leisure ; GV1-1860 ; Geography. Anthropology. Recreation ; G
Language	English
Publishing date	2012-07-01T00:00:00Z
Publisher	Universidad de León
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation

Bai, Guiqin / Qiao, Yiqi / Lo, Po-Chieh / Song, Lei / Yang, Yuna / Duan, Lining / Wei, Sufen / Li, Min / Huang, Shuiqing / Zhang, Beiping / Wang, Qi / Yang, Cong

Journal of ethnopharmacology. 2022 Jan. 30, v. 283

2022

Abstract: Jiao-Tai-Wan (JTW) is a very famous traditional Chinese medicine formula for the treatment ...

Abstract	Jiao-Tai-Wan (JTW) is a very famous traditional Chinese medicine formula for the treatment of psychiatric disorders, especially in anxiety, insomnia and depression. However, its molecular mechanism of treatment remains indistinct.We aimed to reveal the action mechanism of JTW on anti-depression via inhibiting microglia activation and pro-inflammatory response both in vivo and in vitro.The corticosterone (CORT)-induced depression mouse model was used to evaluate the therapeutic efficacy of JTW. Behavioral tests (open field, elevated plus maze, tail suspension and forced swim test) were conducted to evaluate the effect of JTW on depressive-like behaviors. The levels of inflammatory factors and the concentration of neurotransmitters were detected by RT-qPCR or ELISA assays. Then three hippocampal tissue samples per group (Control, CORT, and JTW group) were sent for RNA sequencing (RNA-seq). Transcriptomics data analysis was used to screen the key potential therapeutic targets and signaling pathways of JTW. Based on 8 bioactive species of JTW by our previous study using High-performance liquid chromatography (HPLC) analysis, molecular docking analyses were used to predict the interaction of JTW-derived compounds and depression targets. Finally, the results of transcriptome and molecular docking analyses were combined to verify the targets, key pathways, and efficacy of JTW treatment in vivo and vitro.JTW ameliorated CORT-induced depressive-like behaviors, neuronal damage and enhanced the levels of monoamine neurotransmitters in the serum of mice. JTW also inhibited CORT-induced inflammatory activation of microglia and decreased the serum levels of interleukin- 6(IL-6) and interleukin- 1β (IL-1β) in vivo. Transcriptomic data analysis showed there were 10 key driver analysis (KDA) genes with the strongest correlation which JTW regulated in depression mice. Molecular docking analysis displayed bioactive compound Magnoflorine had the strongest binding force to the key gene colony-stimulating factor 1 receptor (CSF1R), which is the signaling microglia dependent upon for their survival. Meanwhile, CSF1R staining showed it was consistent with inflammatory activation of microglia. Our vitro experiment also showed JTW and CSF1R inhibitor significantly reduced lipopolysaccharide (LPS)/interferon-gamma (IFNɣ)-induced inflammatory activation response in macrophage cells.Our study suggests that JTW might ameliorate CORT-induced neuronal damage in depression mice by inhibiting CSF1R mediated microglia activation and pro-inflammatory response.
Keywords	Oriental traditional medicine ; RNA ; anxiety ; bioactive compounds ; blood serum ; corticosterone ; forced swimming test ; genes ; high performance liquid chromatography ; inflammation ; interleukin-6 ; lipopolysaccharides ; macrophages ; mice ; neuroglia ; neurons ; neurotransmitters ; sequence analysis ; sleep disorders ; therapeutics ; transcriptome ; transcriptomics
Language	English
Dates of publication	2022-0130
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114717
Database	NAL-Catalogue (AGRICOLA)

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